PrimarySearch_ki

PrimarySearch_ki

Search and Browse
- Target
  - Sequence
  - Name &
- Compound
  - Chemical Structure
  - Name
  - SMILES
  - Number of Data / Targets
- Data Source
- Other Databases
  - PDB 85% 100% Seq ID
  - UniProtKB/Swiss-Prot
  - UniProtKB/TrEMBL
  - PubMed
Download
- All Compounds & Data
- Target Names &
  - Ki IC50 Kd EC50
  - ΔG° ΔH° -TΔS°
Virtual Screening
Forum
Enter Data

Found 5 hits affinity hit(s) for enzyme = Dihydrofolate Reductase (DHFR) with UniProtKB: P22906
Target (Institution)	Ligand	Target Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	pH	Temp °C
Dihydrofolate Reductase (DHFR) Candida albicans	GW345 (1,3-DIAMINO-7-(1-ETHYEPROPYE)-7H-PYRRALO-[3,2-F]QU...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt	B.MOAD CSLS PDB PubChem	B.MOAD PDB PubMed	n/a	n/a	4.0	n/a	n/a	6.4	30
GSK		B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt	B.MOAD CSLS PDB PubChem	B.MOAD PDB PubMed	J Med Chem. 44: 2928-32 (2001)
Dihydrofolate Reductase (DHFR) Candida albicans	GW995 (5-[(4-TERT-BUTYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDI...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt	B.MOAD CSLS DrugBank PDB PubChem	B.MOAD DrugBank PDB PubMed	n/a	n/a	8.0	n/a	n/a	6.4	30
GSK		B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt	B.MOAD CSLS DrugBank PDB PubChem	B.MOAD DrugBank PDB PubMed	J Med Chem. 44: 2928-32 (2001)
Dihydrofolate Reductase (DHFR) Candida albicans	GW578 (5-[(4-METHYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMIN...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt	B.MOAD CSLS DrugBank PDB PubChem	B.MOAD DrugBank PDB PubMed	n/a	n/a	23.0	n/a	n/a	6.4	30
GSK		B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt	B.MOAD CSLS DrugBank PDB PubChem	B.MOAD DrugBank PDB PubMed	J Med Chem. 44: 2928-32 (2001)
Dihydrofolate Reductase (DHFR) Candida albicans	GW997 (5-(PHENYLSULFANYL)-2,4-QUINAZOLINEDIAMINE \| 5-(ph...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt	B.MOAD CSLS DrugBank PDB PubChem	B.MOAD DrugBank PDB PubMed	n/a	n/a	34.0	n/a	n/a	6.4	30
GSK		B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt	B.MOAD CSLS DrugBank PDB PubChem	B.MOAD DrugBank PDB PubMed	J Med Chem. 44: 2928-32 (2001)
Dihydrofolate Reductase (DHFR) Candida albicans	GW2021 (5-{[4-(4-MORPHOLINYL)PHENYL]SULFANYL}-2,4-QUINAZOL...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt	B.MOAD CSLS DrugBank PDB PubChem	B.MOAD DrugBank PDB PubMed	n/a	n/a	130.0	n/a	n/a	6.4	30
GSK		B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt	B.MOAD CSLS DrugBank PDB PubChem	B.MOAD DrugBank PDB PubMed	J Med Chem. 44: 2928-32 (2001)

Reorder this table by ec50
Reorder this table by ic50
Reorder this table by kd
Reorder this table by pH
Reorder this table by T
Change energy unit to: kcal/mole