PrimarySearch

Found 132 hits affinity hit(s) for enzyme = Dihydrofolate Reductase (DHFR) with UniProtKB: P00374
Target (Institution)	Ligand	Target Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	pH	Temp °C
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	1,8-naphthalein derivative, 13 (4-(3-bromo-4-hydroxyphenyl)-4-(4-hydroxyphenyl)-3-...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	3400	-31.21	n/a	n/a	n/a	7	25
UNIMORE			CSLS PubChem	PubMed	J Med Chem. 49: 5958-68 (2006)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	1,2-naphthalein derivative, 3 (3,3-bis(4-hydroxy-3-iodophenyl)-4-oxatricyclo[7.4....)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	3900	-30.87	n/a	n/a	n/a	7	25
UNIMORE			CSLS PubChem	PubMed	J Med Chem. 49: 5958-68 (2006)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	A156 (1,8-naphthalein derivative, 10 \| 4,4-bis(3-chloro-...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS PDB PubChem	PubMed	5200	-30.15	n/a	n/a	n/a	7	25
UNIMORE			B.MOAD CSLS PDB PubChem	PubMed	J Med Chem. 49: 5958-68 (2006)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	1,8-naphthalein derivative, 15 (4,4-bis(3,5-dibromo-4-hydroxyphenyl)-3-oxatricyclo...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	9500	-28.66	n/a	n/a	n/a	7	25
UNIMORE			CSLS PubChem	PubMed	J Med Chem. 49: 5958-68 (2006)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	1,8-naphthalein derivative, 18 (8-chloro-4,4-bis(3-fluoro-4-hydroxyphenyl)-3-oxatr...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	12000	-28.08	n/a	n/a	n/a	7	25
UNIMORE			CSLS PubChem	PubMed	J Med Chem. 49: 5958-68 (2006)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	1,8-naphthalein derivative, 16 (4,4-bis(3-bromo-4-hydroxyphenyl)-8-chloro-3-oxatri...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	13000	-27.88	n/a	n/a	n/a	7	25
UNIMORE			CSLS PubChem	PubMed	J Med Chem. 49: 5958-68 (2006)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	1,2-naphthalein derivative, 6 (3,3-bis[4-hydroxy-2-methyl-5-(propan-2-yl)phenyl]-...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	13000	-27.88	n/a	n/a	n/a	7	25
UNIMORE			CSLS PubChem	PubMed	J Med Chem. 49: 5958-68 (2006)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	1,8-naphthalein derivative, 14 (4,4-bis(3-bromo-4-hydroxyphenyl)-3-oxatricyclo[7.3...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	15000	-27.53	n/a	n/a	n/a	7	25
UNIMORE			CSLS PubChem	PubMed	J Med Chem. 49: 5958-68 (2006)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	1,8-naphthalein derivative, 12 (4,4-bis(3,5-dichloro-4-hydroxyphenyl)-3-oxatricycl...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	28000	-25.98	n/a	n/a	n/a	7	25
UNIMORE			CSLS PubChem	PubMed	J Med Chem. 49: 5958-68 (2006)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	1,2-naphthalein derivative, 4 (3,3-bis(3-bromo-4-hydroxyphenyl)-4-oxatricyclo[7.4...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	33000	-25.57	n/a	n/a	n/a	7	25
UNIMORE			CSLS PubChem	PubMed	J Med Chem. 49: 5958-68 (2006)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	1,2-naphthalein derivative, 2 (5,5-bis(4-hydroxyphenyl)-4-oxatricyclo[7.4.0.0^{2,...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	35000	-25.43	n/a	n/a	n/a	7	25
UNIMORE			CSLS PubChem	PubMed	J Med Chem. 49: 5958-68 (2006)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	1,2-naphthalein derivative, 7 (5,5-bis(3-chloro-4-hydroxyphenyl)-4-oxatricyclo[7....)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	35000	-25.43	n/a	n/a	n/a	7	25
UNIMORE			CSLS PubChem	PubMed	J Med Chem. 49: 5958-68 (2006)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	1,8-naphthalein derivative, 17 (4,4-bis(3-fluoro-4-hydroxyphenyl)-3-oxatricyclo[7....)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	42000	-24.98	n/a	n/a	n/a	7	25
UNIMORE			CSLS PubChem	PubMed	J Med Chem. 49: 5958-68 (2006)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	1,2-naphthalein derivative, 5 (3,3-bis(3,5-dibromo-4-hydroxyphenyl)-4-oxatricyclo...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	69000	-23.75	n/a	n/a	n/a	7	25
UNIMORE			CSLS PubChem	PubMed	J Med Chem. 49: 5958-68 (2006)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	1,8-naphthalein derivative, 9 (4,4-bis(4-hydroxy-3-iodophenyl)-3-oxatricyclo[7.3....)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	94000	-22.98	n/a	n/a	n/a	7	25
UNIMORE			CSLS PubChem	PubMed	J Med Chem. 49: 5958-68 (2006)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	1,2-naphthalein derivative, 8 (5,5-bis(3-fluoro-4-hydroxyphenyl)-4-oxatricyclo[7....)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	109000	-22.61	n/a	n/a	n/a	7	25
UNIMORE			CSLS PubChem	PubMed	J Med Chem. 49: 5958-68 (2006)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	1,2-naphthalein derivative, 1 (3,3-bis(4-hydroxyphenyl)-4-oxatricyclo[7.4.0.0^{2,...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	110000	-22.59	n/a	n/a	n/a	7	25
UNIMORE			CSLS PubChem	PubMed	J Med Chem. 49: 5958-68 (2006)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	GW345 (1,3-DIAMINO-7-(1-ETHYEPROPYE)-7H-PYRRALO-[3,2-F]QU...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS PDB PubChem	PubMed	n/a	n/a	6.6	n/a	n/a	7	30
GSK			B.MOAD CSLS PDB PubChem	PubMed	J Med Chem. 44: 2928-32 (2001)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	2,4-diaminopyrimidine-based antagonist, 4c (6-ethyl-5-(4-{[(4-methanesulfonylphenyl)methyl]ami...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	<10.0	n/a	n/a	7.3	37
Abbott Laboratories			CSLS PubChem	PubMed	J Med Chem. 49: 4459-69 (2006)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	thieno[2,3-d]pyrimidine deriv., 2	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PDB PubChem	PDB PubMed	n/a	n/a	19.0	n/a	n/a	7.4	30
Duquesne University	thieno[2,3-d]pyrimidine deriv., 2	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PDB PubChem	PDB PubMed	J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	thieno[2,3-d]pyrimidine deriv., 1	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	CSLS PDB PubChem	PDB PubMed	n/a	n/a	20.0	n/a	n/a	7.4	30
Duquesne University	thieno[2,3-d]pyrimidine deriv., 1	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	CSLS PDB PubChem	PDB PubMed	J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	Methotrexate (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	B.MOAD CSLS PDB PubChem	B.MOAD PDB PubMed	n/a	n/a	20.0	n/a	n/a	7.4	30
Duquesne University		B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	B.MOAD CSLS PDB PubChem	B.MOAD PDB PubMed	J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	Methotrexate (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS PDB PubChem	B.MOAD PDB PubMed	n/a	n/a	20.0	n/a	n/a	7.4	30
Duquesne University			B.MOAD CSLS PDB PubChem	B.MOAD PDB PubMed	J Med Chem. 51: 68-76 (2008)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	Methotrexate (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS PDB PubChem	B.MOAD PDB PubMed	n/a	n/a	22.0	n/a	13.3	7.4	30
Duquesne University			B.MOAD CSLS PDB PubChem	B.MOAD PDB PubMed	J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	Methotrexate (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS PDB PubChem	B.MOAD PDB PubMed	n/a	n/a	22.0	n/a	12.5	7.4	30
Duquesne University			B.MOAD CSLS PDB PubChem	B.MOAD PDB PubMed	J Med Chem. 48: 7215-22 (2005)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	Methotrexate (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS PDB PubChem	B.MOAD PDB PubMed	n/a	n/a	24.3	n/a	n/a	7	30
Oklahoma State University at Stillwater			B.MOAD CSLS PDB PubChem	B.MOAD PDB PubMed	Antimicrob Agents Chemother. 48: 4643-9 (2004)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	Propargyl inhibitor, 20 (6-ethyl-5-[3-(3,4,5-trimethoxyphenyl)prop-1-yn-1-y...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PubChem	PubMed	n/a	n/a	57.0	n/a	n/a	7	25
University of Connecticut			PubChem	PubMed	J Med Chem. 51: 7532-40 (2008)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	Pyrrolo[2, 3-d]pyrimidine analogue, 2 ((2S)-2-{[4-({2,4-diamino-5-ethyl-7H-pyrrolo[2,3-d]...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	66.0	n/a	68.0	7.4	30
Duquesne University			CSLS PubChem	PubMed	J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	Pyrrolo[3,2-d]pyrimidine analogue, 4 ((2S)-2-{[4-({2-amino-6-methyl-4-oxo-3H,4H,5H-pyrro...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PubChem	PubMed	n/a	n/a	120.0	n/a	n/a	7.4	30
Duquesne University			PubChem	PubMed	J Med Chem. 51: 68-76 (2008)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	Propargyl inhibitor, 22 (5-[3-(2,3-dimethoxyphenyl)prop-1-yn-1-yl]-6-ethylp...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PubChem	PubMed	n/a	n/a	130.0	n/a	n/a	7	25
University of Connecticut			PubChem	PubMed	J Med Chem. 51: 7532-40 (2008)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	Pyrrolo[2, 3-d]pyrimidine analogue, 1a ((2S)-2-{[4-({2,4-diamino-5-methyl-7H-pyrrolo[2,3-d...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	210.0	n/a	190.0	7.4	30
Duquesne University			CSLS PubChem	PubMed	J Med Chem. 48: 7215-22 (2005)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	Pyrrolo[2, 3-d]pyrimidine analogue, 1a ((2S)-2-{[4-({2,4-diamino-5-methyl-7H-pyrrolo[2,3-d...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	210.0	n/a	190.0	7.4	30
Duquesne University			CSLS PubChem	PubMed	J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	thieno[2,3-d]pyrimidine deriv., 2c	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	n/a	n/a	260.0	n/a	n/a	7.4	30
Duquesne University	thieno[2,3-d]pyrimidine deriv., 2c	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	thieno[2,3-d]pyrimidine deriv., 2j	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	n/a	n/a	260.0	n/a	n/a	7.4	30
Duquesne University	thieno[2,3-d]pyrimidine deriv., 2j	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	thieno[2,3-d]pyrimidine deriv., 2f	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	n/a	n/a	280.0	n/a	n/a	7.4	30
Duquesne University	thieno[2,3-d]pyrimidine deriv., 2f	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	thieno[2,3-d]pyrimidine deriv., 2e	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	n/a	n/a	290.0	n/a	n/a	7.4	30
Duquesne University	thieno[2,3-d]pyrimidine deriv., 2e	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	thieno[2,3-d]pyrimidine deriv., 2k	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	n/a	n/a	300.0	n/a	n/a	7.4	30
Duquesne University	thieno[2,3-d]pyrimidine deriv., 2k	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	thieno[2,3-d]pyrimidine deriv., 2b	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	n/a	n/a	300.0	n/a	n/a	7.4	30
Duquesne University	thieno[2,3-d]pyrimidine deriv., 2b	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	2,4-diaminopyrimidine derivative, 8a (6-[(benzyloxy)methyl]-5-(4-{[(4-chlorophenyl)methy...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	300.0	n/a	n/a	7.3	37
Abbott Laboratories			CSLS PubChem	PubMed	J Med Chem. 49: 2568-78 (2006)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	thieno[2,3-d]pyrimidine deriv., 2h	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	n/a	n/a	350.0	n/a	n/a	7.4	30
Duquesne University	thieno[2,3-d]pyrimidine deriv., 2h	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	Propargyl inhibitor, 24 (6-ethyl-5-(3-phenylprop-1-yn-1-yl)pyrimidine-2,4-d...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	PubChem	PubMed	n/a	n/a	360.0	n/a	n/a	7	25
University of Connecticut			PubChem	PubMed	J Med Chem. 51: 7532-40 (2008)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	TMP derivative with propargyl-based linker, 16 (6-methyl-5-[3-(3,4,5-trimethoxyphenyl)prop-1-yn-1-...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	400.0	n/a	n/a	7	25
University of Connecticut			CSLS PubChem	PubMed	J Med Chem. 51: 7532-40 (2008)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	Pyrrolo[2,3-d]pyrimidine analogue, 4 ((2S)-2-{[4-({2-amino-6-ethyl-4-oxo-3H,4H,7H-pyrrol...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	420.0	n/a	n/a	7.4	30
Duquesne University			CSLS PubChem	PubMed	J Med Chem. 49: 1055-65 (2006)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	thieno[2,3-d]pyrimidine deriv., 2l	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	n/a	n/a	540.0	n/a	n/a	7.4	30
Duquesne University	thieno[2,3-d]pyrimidine deriv., 2l	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	thieno[2,3-d]pyrimidine deriv., 2m	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	n/a	n/a	600.0	n/a	n/a	7.4	30
Duquesne University	thieno[2,3-d]pyrimidine deriv., 2m	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	GW997 (5-(PHENYLSULFANYL)-2,4-QUINAZOLINEDIAMINE \| 5-(ph...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS DrugBank PDB PubChem	PubMed	n/a	n/a	620.0	n/a	n/a	7	30
GSK			B.MOAD CSLS DrugBank PDB PubChem	PubMed	J Med Chem. 44: 2928-32 (2001)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	thieno[2,3-d]pyrimidine deriv., 2i	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	n/a	n/a	620.0	n/a	n/a	7.4	30
Duquesne University	thieno[2,3-d]pyrimidine deriv., 2i	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	thieno[2,3-d]pyrimidine deriv., 2d	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	n/a	n/a	840.0	n/a	n/a	7.4	30
Duquesne University	thieno[2,3-d]pyrimidine deriv., 2d	B.MOAD DrugBank GoogleScholar PDB UniProtKB/SwissProt	PubChem	PubMed	J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	GW578 (5-[(4-METHYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMIN...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS DrugBank PDB PubChem	PubMed	n/a	n/a	940.0	n/a	n/a	7	30
GSK			B.MOAD CSLS DrugBank PDB PubChem	PubMed	J Med Chem. 44: 2928-32 (2001)
Dihydrofolate Reductase (DHFR) Homo sapiens (human)	TMP derivative with propargyl-based linker, 27 (5-[3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-yn-1...)	B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PubChem	PubMed	n/a	n/a	1160.0	n/a	n/a	7	25
University of Connecticut			CSLS PubChem	PubMed	J Med Chem. 51: 7532-40 (2008)