Compile Data Set for Download or QSAR
(2D       Computed 3D by Vconf -m prep )

Data curated solely by BindingDB

Found 83 hits of affinity data for UniProtKB/TrEMBL: P0ABQ5

Target (Institution)	Ligand	Target Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	pH	Temp °C
Dihydrofolate Reductase (DHFR) Escherichia coli	imidothiocarbamate analogue, 1 (3-({[(4-{[(carbamimidamidomethanimidoyl)sulfanyl]m...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS MMDB PC cid PC sid PDB	B.MOAD PDB PubMed	11.50	-45.31	n/a	n/a	n/a	7.5	25
University of Prince Edward Island					J Med Chem. 49: 6977-86 (2006)
Dihydrofolate Reductase (DHFR) Escherichia coli	Pyrrolo[2, 3-d]pyrimidine analogue, 2 ((2S)-2-{[4-({2,4-diamino-5-ethyl-7H-pyrrolo[2,3-d]...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	2.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Escherichia coli	Methotrexate (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CHEBI CSLS DrugBank KEGG MMDB PC cid PC sid PDB	B.MOAD MMDB PDB PubMed	n/a	n/a	3.0	n/a	n/a	7	30
University of Prince Edward Island					J Med Chem. 49: 6977-86 (2006)
Dihydrofolate Reductase (DHFR) Escherichia coli	Methotrexate (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CHEBI CSLS DrugBank KEGG MMDB PC cid PC sid PDB	B.MOAD MMDB PDB PubMed	n/a	n/a	6.6	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 48: 7215-22 (2005)
Dihydrofolate Reductase (DHFR) Escherichia coli	Methotrexate (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CHEBI CSLS DrugBank KEGG MMDB PC cid PC sid PDB	B.MOAD MMDB PDB PubMed	n/a	n/a	6.6	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Escherichia coli	Iclaprim (5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)me...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	7.0	n/a	n/a	7	30
GSK					Bioorg Med Chem Lett. 13: 4217-21 (2003)
Dihydrofolate Reductase (DHFR) Escherichia coli	Trimethoprim (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CHEBI CSLS DrugBank KEGG MMDB PC cid PC sid PDB	PubMed	n/a	n/a	7.0	n/a	n/a	7	30
GSK					Bioorg Med Chem Lett. 13: 4217-21 (2003)
Dihydrofolate Reductase (DHFR) Escherichia coli	Methotrexate (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CHEBI CSLS DrugBank KEGG MMDB PC cid PC sid PDB	B.MOAD MMDB PDB PubMed	n/a	n/a	8.8	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 51: 68-76 (2008)
Dihydrofolate Reductase (DHFR) Escherichia coli	Methotrexate (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CHEBI CSLS DrugBank KEGG MMDB PC cid PC sid PDB	B.MOAD MMDB PDB PubMed	n/a	n/a	8.8	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Escherichia coli	Trimethoprim (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CHEBI CSLS DrugBank KEGG MMDB PC cid PC sid PDB	PubMed	n/a	n/a	10.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Escherichia coli	Trimethoprim (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CHEBI CSLS DrugBank KEGG MMDB PC cid PC sid PDB	PubMed	n/a	n/a	10.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 51: 68-76 (2008)
Dihydrofolate Reductase (DHFR) Escherichia coli	Pyrrolo[2, 3-d]pyrimidine analogue, 1a ((2S)-2-{[4-({2,4-diamino-5-methyl-7H-pyrrolo[2,3-d...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	16.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 48: 7215-22 (2005)
Dihydrofolate Reductase (DHFR) Escherichia coli	Pyrrolo[2, 3-d]pyrimidine analogue, 1a ((2S)-2-{[4-({2,4-diamino-5-methyl-7H-pyrrolo[2,3-d...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	16.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Escherichia coli	Trimethoprim (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CHEBI CSLS DrugBank KEGG MMDB PC cid PC sid PDB	PubMed	n/a	n/a	20.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Escherichia coli	amidinothiouronium, 22 (3-({[(3-{[(carbamimidamidomethanimidoyl)sulfanyl]m...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	75.0	n/a	n/a	7	30
University of Prince Edward Island					J Med Chem. 49: 6977-86 (2006)
Dihydrofolate Reductase (DHFR) Escherichia coli	imidothiocarbamate analogue, 1 (3-({[(4-{[(carbamimidamidomethanimidoyl)sulfanyl]m...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS MMDB PC cid PC sid PDB	B.MOAD PDB PubMed	n/a	n/a	75.0	n/a	n/a	7	30
University of Prince Edward Island					J Med Chem. 49: 6977-86 (2006)
Dihydrofolate Reductase (DHFR) Escherichia coli	Pyrrolo[2, 3-d]pyrimidine analogue, 5 (5-ethyl-6-[(4-nitrophenyl)sulfanyl]-7H-pyrrolo[2,3...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	90.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Escherichia coli	Pyrrolo[2, 3-d]pyrimidine analogue, 6 (6-[(4-bromophenyl)sulfanyl]-5-ethyl-7H-pyrrolo[2,3...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	140.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Escherichia coli	Pyrrolo[2, 3-d]pyrimidine analogue, 10 (6-[(2,4-dichlorophenyl)sulfanyl]-5-ethyl-7H-pyrrol...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	140.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Escherichia coli	Pyrrolo[2, 3-d]pyrimidine analogue, 4 (5-ethyl-6-(naphthalen-2-ylsulfanyl)-7H-pyrrolo[2,3...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	150.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Escherichia coli	Pyrrolo[2, 3-d]pyrimidine analogue, 3 (5-ethyl-6-(naphthalen-1-ylsulfanyl)-7H-pyrrolo[2,3...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	150.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Escherichia coli	Pyrrolo[2, 3-d]pyrimidine analogue, 16 (5-ethyl-6-(quinolin-8-ylsulfanyl)-7H-pyrrolo[2,3-d...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	160.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Escherichia coli	Pyrrolo[2, 3-d]pyrimidine analogue, 7 (6-[(3-chlorophenyl)sulfanyl]-5-ethyl-7H-pyrrolo[2,...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	160.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Escherichia coli	Pyrrolo[2, 3-d]pyrimidine analogue, 15 (5-ethyl-6-(phenylsulfanyl)-7H-pyrrolo[2,3-d]pyrimi...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	170.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Escherichia coli	thieno[2,3-d]pyrimidine deriv., 1	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS MMDB PC cid PC sid PDB	PubMed	n/a	n/a	200.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Escherichia coli	Pyrrolo[2, 3-d]pyrimidine analogue, 9 (6-[(3,4-dichlorophenyl)sulfanyl]-5-ethyl-7H-pyrrol...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	280.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Escherichia coli	Pyrrolo[2, 3-d]pyrimidine analogue, 14 (5-ethyl-6-[(3-methoxyphenyl)sulfanyl]-7H-pyrrolo[2...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	320.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Escherichia coli	Pyrrolo[2, 3-d]pyrimidine analogue, 12 (5-ethyl-6-[(4-methoxyphenyl)sulfanyl]-7H-pyrrolo[2...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	320.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Escherichia coli	Pyrrolo[2, 3-d]pyrimidine analogue, 13 (6-[(2,5-dimethoxyphenyl)sulfanyl]-5-ethyl-7H-pyrro...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	870.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Escherichia coli	thieno[2,3-d]pyrimidine deriv., 2	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	MMDB PC cid PC sid PDB	PubMed	n/a	n/a	1000.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Escherichia coli	thieno[2,3-d]pyrimidine deriv., 2f	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	>2800.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Escherichia coli	thieno[2,3-d]pyrimidine deriv., 2k	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	>3000.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Escherichia coli	Pyrrolo[2, 3-d]pyrimidine analogue, 17 (6-[(2,6-dimethylphenyl)sulfanyl]-5-ethyl-7H-pyrrol...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	3200.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Escherichia coli	amidinothiouronium, 10 (3-({[(4-methoxyphenyl)methyl]sulfanyl}methanimidoy...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	3300.0	n/a	n/a	7	30
University of Prince Edward Island					J Med Chem. 49: 6977-86 (2006)
Dihydrofolate Reductase (DHFR) Escherichia coli	amidinothiouronium, 11 (3-({[(3,4-dichlorophenyl)methyl]sulfanyl}methanimi...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	3700.0	n/a	n/a	7	30
University of Prince Edward Island					J Med Chem. 49: 6977-86 (2006)
Dihydrofolate Reductase (DHFR) Escherichia coli	amidinothiouronium, 6 (3-({[(3-methoxyphenyl)methyl]sulfanyl}methanimidoy...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	3800.0	n/a	n/a	7	30
University of Prince Edward Island					J Med Chem. 49: 6977-86 (2006)
Dihydrofolate Reductase (DHFR) Escherichia coli	MS-SH08-17 (3-[({[3-(trifluoromethyl)phenyl]methyl}sulfanyl)me...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS MMDB PC cid PC sid PDB	PDB PubMed	n/a	n/a	4300.0	n/a	n/a	7	30
University of Prince Edward Island					J Med Chem. 49: 6977-86 (2006)
Dihydrofolate Reductase (DHFR) Escherichia coli	amidinothiouronium, 19 (3-[({[3,5-bis(trifluoromethyl)phenyl]methyl}sulfan...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	5600.0	n/a	n/a	7	30
University of Prince Edward Island					J Med Chem. 49: 6977-86 (2006)
Dihydrofolate Reductase (DHFR) Escherichia coli	amidinothiouronium, 12 (3-({[(4-methylphenyl)methyl]sulfanyl}methanimidoyl...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	12600.0	n/a	n/a	7	30
University of Prince Edward Island					J Med Chem. 49: 6977-86 (2006)
Dihydrofolate Reductase (DHFR) Escherichia coli	amidinothiouronium, 13 (3-[({[4-(trifluoromethyl)phenyl]methyl}sulfanyl)me...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	13000.0	n/a	n/a	7	30
University of Prince Edward Island					J Med Chem. 49: 6977-86 (2006)
Dihydrofolate Reductase (DHFR) Escherichia coli	amidinothiouronium, 14 (3-({[(4-chlorophenyl)methyl]sulfanyl}methanimidoyl...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	14200.0	n/a	n/a	7	30
University of Prince Edward Island					J Med Chem. 49: 6977-86 (2006)
Dihydrofolate Reductase (DHFR) Escherichia coli	amidinothiouronium, 17 (3-({[(2-hydroxy-5-nitrophenyl)methyl]sulfanyl}meth...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	15100.0	n/a	n/a	7	30
University of Prince Edward Island					J Med Chem. 49: 6977-86 (2006)
Dihydrofolate Reductase (DHFR) Escherichia coli	amidinothiouronium, 8 (3-({[(3-nitrophenyl)methyl]sulfanyl}methanimidoyl)...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	18900.0	n/a	n/a	7	30
University of Prince Edward Island					J Med Chem. 49: 6977-86 (2006)
Dihydrofolate Reductase (DHFR) Escherichia coli	amidinothiouronium, 20 (3-({[(2E)-3-phenylprop-2-en-1-yl]sulfanyl}methanim...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	19800.0	n/a	n/a	7	30
University of Prince Edward Island					J Med Chem. 49: 6977-86 (2006)
Dihydrofolate Reductase (DHFR) Escherichia coli	Pyrrolo[2,3-d]pyrimidine analogue, 1 ((2S)-2-{[4-({2-amino-6-methyl-4-oxo-3H,4H,7H-pyrro...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	CHEBI CSLS PC cid PC sid	PubMed	n/a	n/a	21000.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 51: 68-76 (2008)
Dihydrofolate Reductase (DHFR) Escherichia coli	Pyrrolo[2,3-d]pyrimidine analogue, 4 ((2S)-2-{[4-({2-amino-6-ethyl-4-oxo-3H,4H,7H-pyrrol...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	>21000.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 49: 1055-65 (2006)
Dihydrofolate Reductase (DHFR) Escherichia coli	Pyrrolo[2,3-d]pyrimidine analogue, 1 ((2S)-2-{[4-({2-amino-6-methyl-4-oxo-3H,4H,7H-pyrro...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	CHEBI CSLS PC cid PC sid	PubMed	n/a	n/a	21000.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 49: 1055-65 (2006)
Dihydrofolate Reductase (DHFR) Escherichia coli	thieno[2,3-d]pyrimidine deriv., 2e	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	22000.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Escherichia coli	CB3717 ((2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS MMDB PC cid PC sid PDB	PubMed	n/a	n/a	23000.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 48: 7215-22 (2005)
Dihydrofolate Reductase (DHFR) Escherichia coli	Raltitrexed ((2S)-2-[(5-{methyl[(2-methyl-4-oxo-1,4-dihydroquin...)	B.MOAD DrugBank GoogleScholar KEGG MMDB PDB Protherm UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CSLS DrugBank MMDB PC cid PC sid PDB	PubMed	n/a	n/a	23000.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 48: 7215-22 (2005)

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