Found 62 hits of affinity data for UniProtKB/TrEMBL: P16184Target (Institution) | Ligand | Target Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | pH | Temp °C |
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Piritrexim analogue, 10
 (5-[3-({2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 0.097 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Piritrexim analogue, 9
 (4-[2-({2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 0.17 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Piritrexim analogue, 6
 (2,4-diamino-5-deazapteridine, 4 | 4-[3-({2,4-diami...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 0.43 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Piritrexim analogue, 7
 (2,4-diamino-5-deazapteridine, 5 | 5-[3-({2,4-diami...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 0.51 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Piritrexim analogue, 13
 (5-[2-({2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 0.65 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Diaminopyrimidine analogue, 3
 (6-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4,5-dimet...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 1.0 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Piritrexim analogue, 14
 (6-[2-({2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 1.2 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Piritrexim analogue, 8
 (2,4-diamino-5-deazapteridine, 6 | 6-[3-({2,4-diami...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 1.3 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Piritrexim analogue, 11
 (2,4-diamino-5-deazapteridine, 10 | 6-[3-({2,4-diam...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 1.4 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Piritrexim analogue, 12
 (2,4-diamino-5-deazapteridine, 2 | 7-[3-({2,4-diami...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 1.8 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Piritrexim analogue, 56
 (6-[(2-iodo-5-methoxyphenyl)methyl]-5-methylpyrido[...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 3.8 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Piritrexim analogue, 55
 (6-[(5-iodo-2-methoxyphenyl)methyl]-5-methylpyrido[...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 5.8 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Piritrexim analogue,30
 (2,4-diamino-5-deazapteridine, 7 | ethyl 4-[3-({2,4...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 6.5 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Pteridine analogue, 19
 (4-{2-[(2,4-diaminopteridin-6-yl)methyl]-2-azatricy...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 9.4 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Pteridine analogue, 21
 (6-{2-[(2,4-diaminopteridin-6-yl)methyl]-2-azatricy...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 12.0 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Piritrexim
 (6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| B.MOAD CHEBI CSLS DrugBank MMDB PC cid PC sid PDB
| PubMed
| n/a | n/a | 13.0 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Piritrexim analogue,31
 (2,4-diamino-5-deazapteridine, 8 | ethyl 5-[3-({2,4...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 28.0 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Piritrexim analogue,32
 (2,4-diamino-5-deazapteridine, 9 | ethyl 6-[3-({2,4...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 35.0 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Trimetrexate
 (5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CHEBI CSLS DrugBank KEGG MMDB PC cid PC sid PDB
| PubMed
| n/a | n/a | 42.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
J Med Chem. 50: 3046-3053 (2007)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Diaminopyrimidine analogue, 22
 (5-{2-bromo-5-[(2,4-diaminopyrimidin-5-yl)methyl]-3...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 71.0 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Piritrexim analogue, 45
 (ethyl 4-[2-({2,4-diamino-5-methylpyrido[2,3-d]pyri...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 83.0 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Piritrexim analogue,38
 (6-{[2-(benzyloxy)-5-methoxyphenyl]methyl}-5-methyl...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 96.0 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Pteridine analogue, 20
 (5-{2-[(2,4-diaminopteridin-6-yl)methyl]-2-azatricy...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 230.0 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Iclaprim
 (5-[(2-cyclopropyl-7,8-dimethoxy-2H-chromen-5-yl)me...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 2400.0 | n/a | n/a | 7 | 30 |
GSK
|
Bioorg Med Chem Lett. 13: 4217-21 (2003)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Pyrrolo[2, 3-d]pyrimidine analogue, 7
 (6-[(3-chlorophenyl)sulfanyl]-5-ethyl-7H-pyrrolo[2,...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 4020.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
J Med Chem. 50: 3046-3053 (2007)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Pyrrolo[2, 3-d]pyrimidine analogue, 13
 (6-[(2,5-dimethoxyphenyl)sulfanyl]-5-ethyl-7H-pyrro...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 6040.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
J Med Chem. 50: 3046-3053 (2007)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Pyrrolo[2, 3-d]pyrimidine analogue, 10
 (6-[(2,4-dichlorophenyl)sulfanyl]-5-ethyl-7H-pyrrol...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 7190.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
J Med Chem. 50: 3046-3053 (2007)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Pyrrolo[2, 3-d]pyrimidine analogue, 5
 (5-ethyl-6-[(4-nitrophenyl)sulfanyl]-7H-pyrrolo[2,3...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 8680.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
J Med Chem. 50: 3046-3053 (2007)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Pyrrolo[2, 3-d]pyrimidine analogue, 16
 (5-ethyl-6-(quinolin-8-ylsulfanyl)-7H-pyrrolo[2,3-d...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 9580.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
J Med Chem. 50: 3046-3053 (2007)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Pyrrolo[2, 3-d]pyrimidine analogue, 8
 (6-[(4-chlorophenyl)sulfanyl]-5-ethyl-7H-pyrrolo[2,...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 11900.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
J Med Chem. 50: 3046-3053 (2007)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Trimethoprim
 (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| B.MOAD CHEBI CSLS DrugBank KEGG MMDB PC cid PC sid PDB
| B.MOAD PDB PubMed
| n/a | n/a | 12000.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
J Med Chem. 50: 3046-3053 (2007)
 |
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | 2,4-diaminofuro[2,3-d]pyrimidine, 10
 | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 12500.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
Bioorg Med Chem. 17: 7324-36 (2009)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Trimethoprim
 (5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| B.MOAD CHEBI CSLS DrugBank KEGG MMDB PC cid PC sid PDB
| B.MOAD PDB PubMed
| n/a | n/a | 13000.0 | n/a | n/a | 7.4 | 37 |
Harvard Medical School
|
J Med Chem. 48: 4420-31 (2005)
 |
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Pyrrolo[2, 3-d]pyrimidine analogue, 4
 (5-ethyl-6-(naphthalen-2-ylsulfanyl)-7H-pyrrolo[2,3...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 13880.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
J Med Chem. 50: 3046-3053 (2007)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Pyrrolo[2, 3-d]pyrimidine analogue, 1i
 (6-[(2,5-dimethoxyphenyl)sulfanyl]-5-methyl-7H-pyrr...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CHEBI CSLS PC cid PC sid
| PubMed
| n/a | n/a | 14600.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
J Med Chem. 50: 3046-3053 (2007)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Pyrrolo[2, 3-d]pyrimidine analogue, 1d
 (6-[(4-chlorophenyl)sulfanyl]-5-methyl-7H-pyrrolo[2...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CHEBI CSLS PC cid PC sid
| PubMed
| n/a | n/a | 16700.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
J Med Chem. 50: 3046-3053 (2007)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Pyrrolo[2, 3-d]pyrimidine analogue, 3
 (5-ethyl-6-(naphthalen-1-ylsulfanyl)-7H-pyrrolo[2,3...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 18400.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
J Med Chem. 50: 3046-3053 (2007)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Pyrrolo[2, 3-d]pyrimidine analogue, 1h
 (6-[(3,4-dichlorophenyl)sulfanyl]-5-methyl-7H-pyrro...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 20000.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
J Med Chem. 50: 3046-3053 (2007)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Pyrrolo[2, 3-d]pyrimidine analogue, 11
 (6-[(2,6-dichlorophenyl)sulfanyl]-5-ethyl-7H-pyrrol...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 20600.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
J Med Chem. 50: 3046-3053 (2007)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Pyrrolo[2, 3-d]pyrimidine analogue, 9
 (6-[(3,4-dichlorophenyl)sulfanyl]-5-ethyl-7H-pyrrol...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 20700.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
J Med Chem. 50: 3046-3053 (2007)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Pyrrolo[2, 3-d]pyrimidine analogue, 15
 (5-ethyl-6-(phenylsulfanyl)-7H-pyrrolo[2,3-d]pyrimi...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 21800.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
J Med Chem. 50: 3046-3053 (2007)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | 2,4-diaminofuro[2,3-d]pyrimidine, 4
 (E/Z ratio=2:1) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 22200.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
Bioorg Med Chem. 17: 7324-36 (2009)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | 2,4-diaminofuro[2,3-d]pyrimidine, 5
 (E/Z ratio=3:2) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 25900.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
Bioorg Med Chem. 17: 7324-36 (2009)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Pyrrolo[2, 3-d]pyrimidine analogue, 6
 (6-[(4-bromophenyl)sulfanyl]-5-ethyl-7H-pyrrolo[2,3...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 26600.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
J Med Chem. 50: 3046-3053 (2007)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Pyrrolo[2, 3-d]pyrimidine analogue, 14
 (5-ethyl-6-[(3-methoxyphenyl)sulfanyl]-7H-pyrrolo[2...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 28300.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
J Med Chem. 50: 3046-3053 (2007)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | 2,4-diaminofuro[2,3-d]pyrimidine, 1b
 (Z-isomer) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| CSLS PC cid PC sid
| PubMed
| n/a | n/a | 30000.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
Bioorg Med Chem. 17: 7324-36 (2009)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | Pyrrolo[2, 3-d]pyrimidine analogue, 17
 (6-[(2,6-dimethylphenyl)sulfanyl]-5-ethyl-7H-pyrrol...) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 30200.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
J Med Chem. 50: 3046-3053 (2007)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | 2,4-diaminofuro[2,3-d]pyrimidine, 11
 | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 30900.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
Bioorg Med Chem. 17: 7324-36 (2009)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | 2,4-diaminofuro[2,3-d]pyrimidine, 3
 (E/Z ratio=3:1) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 34000.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
Bioorg Med Chem. 17: 7324-36 (2009)
|
Dihydrofolate Reductase (DHFR)
Pneumocystis carinii | 2,4-diaminofuro[2,3-d]pyrimidine, 2
 (E/Z ratio=2:1) | B.MOAD DrugBank GoogleScholar MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL
| PC cid PC sid
| PubMed
| n/a | n/a | 37000.0 | n/a | n/a | 7.4 | 37 |
Duquesne University
|
Bioorg Med Chem. 17: 7324-36 (2009)
|