Compile Data Set for Download or QSAR
(2D       Computed 3D by Vconf -m prep )

Data curated solely by BindingDB

Found 113 hits of affinity data for UniProtKB/TrEMBL: Q07422

Target (Institution)	Ligand	Target Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	pH	Temp °C
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Piritrexim analogue, 10 (5-[3-({2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	0.46	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	TMP derivative with propargyl-based linker, 37 (R) (6-methyl-5-[(3R)-3-(3,4,5-trimethoxyphenyl)but-1-y...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	1.4	n/a	n/a	7	25
Dartmouth College					J Med Chem. 50: 940-50 (2007)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Piritrexim analogue, 6 (2,4-diamino-5-deazapteridine, 4 | 4-[3-({2,4-diami...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	1.9	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Piritrexim analogue, 8 (2,4-diamino-5-deazapteridine, 6 | 6-[3-({2,4-diami...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	2.0	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	thieno[2,3-d]pyrimidine deriv., 2	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	MMDB PC cid PC sid PDB	PubMed	n/a	n/a	2.1	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Piritrexim analogue, 7 (2,4-diamino-5-deazapteridine, 5 | 5-[3-({2,4-diami...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	2.3	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Piritrexim analogue, 9 (4-[2-({2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	2.3	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Piritrexim analogue, 12 (2,4-diamino-5-deazapteridine, 2 | 7-[3-({2,4-diami...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	3.2	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Piritrexim analogue,30 (2,4-diamino-5-deazapteridine, 7 | ethyl 4-[3-({2,4...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	3.4	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Piritrexim analogue, 13 (5-[2-({2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	4.1	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Piritrexim analogue, 55 (6-[(5-iodo-2-methoxyphenyl)methyl]-5-methylpyrido[...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	4.1	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Piritrexim (6-[(2,5-dimethoxyphenyl)methyl]-5-methylpyrido[2,3...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CHEBI CSLS DrugBank MMDB PC cid PC sid PDB	PubMed	n/a	n/a	4.3	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Piritrexim analogue, 11 (2,4-diamino-5-deazapteridine, 10 | 6-[3-({2,4-diam...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	4.3	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Piritrexim analogue, 14 (6-[2-({2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	5.8	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Piritrexim analogue, 56 (6-[(2-iodo-5-methoxyphenyl)methyl]-5-methylpyrido[...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	5.8	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	thieno[2,3-d]pyrimidine deriv., 1	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS MMDB PC cid PC sid PDB	PubMed	n/a	n/a	8.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	thieno[2,3-d]pyrimidine deriv., 2e	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	8.1	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	thieno[2,3-d]pyrimidine deriv., 2g	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	8.4	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	thieno[2,3-d]pyrimidine deriv., 2c	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	8.7	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	thieno[2,3-d]pyrimidine deriv., 2b	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	9.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Trimetrexate (5-methyl-6-{[(3,4,5-trimethoxyphenyl)amino]methyl}...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CHEBI CSLS DrugBank KEGG MMDB PC cid PC sid PDB	PubMed	n/a	n/a	10.0	n/a	n/a	7.4	37
Duquesne University					J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Piritrexim analogue, 45 (ethyl 4-[2-({2,4-diamino-5-methylpyrido[2,3-d]pyri...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	10.0	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Piritrexim analogue,31 (2,4-diamino-5-deazapteridine, 8 | ethyl 5-[3-({2,4...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	11.0	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Methotrexate (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CHEBI CSLS DrugBank KEGG MMDB PC cid PC sid PDB	PubMed	n/a	n/a	11.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 48: 7215-22 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	thieno[2,3-d]pyrimidine deriv., 2k	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	12.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Piritrexim analogue,32 (2,4-diamino-5-deazapteridine, 9 | ethyl 6-[3-({2,4...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	13.0	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	thieno[2,3-d]pyrimidine deriv., 2j	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	13.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	TMP derivative with propargyl-based linker, 38 (S) (6-methyl-5-[(3S)-3-(3,4,5-trimethoxyphenyl)but-1-y...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	13.0	n/a	n/a	7	25
Dartmouth College					J Med Chem. 50: 940-50 (2007)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	thieno[2,3-d]pyrimidine deriv., 2d	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	14.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	thieno[2,3-d]pyrimidine deriv., 2f	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	14.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Diaminopyrimidine analogue, 22 (5-{2-bromo-5-[(2,4-diaminopyrimidin-5-yl)methyl]-3...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	15.0	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Piritrexim analogue,38 (6-{[2-(benzyloxy)-5-methoxyphenyl]methyl}-5-methyl...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	16.0	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	thieno[2,3-d]pyrimidine deriv., 2h	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	17.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Pteridine analogue, 21 (6-{2-[(2,4-diaminopteridin-6-yl)methyl]-2-azatricy...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	21.0	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Pyrrolo[3,2-d]pyrimidine analogue, 4 ((2S)-2-{[4-({2-amino-6-methyl-4-oxo-3H,4H,5H-pyrro...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	23.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 51: 68-76 (2008)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	thieno[2,3-d]pyrimidine deriv., 2l	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	24.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	thieno[2,3-d]pyrimidine deriv., 2i	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	25.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	thieno[2,3-d]pyrimidine deriv., 2m	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	27.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Methotrexate (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CHEBI CSLS DrugBank KEGG MMDB PC cid PC sid PDB	PubMed	n/a	n/a	33.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 51: 68-76 (2008)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Methotrexate (2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	B.MOAD CHEBI CSLS DrugBank KEGG MMDB PC cid PC sid PDB	PubMed	n/a	n/a	33.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	thieno[2,3-d]pyrimidine deriv., 2a	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	33.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 52: 4892-902 (2009)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Diaminopyrimidine analogue, 3 (6-{3-[(2,4-diaminopyrimidin-5-yl)methyl]-4,5-dimet...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	34.0	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Pteridine analogue, 20 (5-{2-[(2,4-diaminopteridin-6-yl)methyl]-2-azatricy...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	77.0	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Pteridine analogue, 19 (4-{2-[(2,4-diaminopteridin-6-yl)methyl]-2-azatricy...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	100.0	n/a	n/a	7.4	37
Harvard Medical School					J Med Chem. 48: 4420-31 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	TMP derivative with propargyl-based linker, 21 (6-methyl-5-[3-(3,4,5-trimethoxyphenyl)but-1-yn-1-y...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	120.0	n/a	n/a	7	25
Dartmouth College					J Med Chem. 50: 940-50 (2007)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Pyrrolo[2, 3-d]pyrimidine analogue, 13 (6-[(2,5-dimethoxyphenyl)sulfanyl]-5-ethyl-7H-pyrro...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	120.0	n/a	n/a	7.4	37
Duquesne University					J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Pyrrolo[2, 3-d]pyrimidine analogue, 1b (5-methyl-6-(naphthalen-2-ylsulfanyl)-7H-pyrrolo[2,...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	160.0	n/a	n/a	7.4	37
Duquesne University					J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Pyrrolo[2, 3-d]pyrimidine analogue, 16 (5-ethyl-6-(quinolin-8-ylsulfanyl)-7H-pyrrolo[2,3-d...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	PC cid PC sid	PubMed	n/a	n/a	160.0	n/a	n/a	7.4	37
Duquesne University					J Med Chem. 50: 3046-3053 (2007)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Pyrrolo[2, 3-d]pyrimidine analogue, 1a ((2S)-2-{[4-({2,4-diamino-5-methyl-7H-pyrrolo[2,3-d...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	n/a	n/a	170.0	n/a	n/a	7.4	30
Duquesne University					J Med Chem. 48: 7215-22 (2005)
Dihydrofolate Reductase (DHFR) Toxoplasma gondii	Pyrrolo[2, 3-d]pyrimidine analogue, 1i (6-[(2,5-dimethoxyphenyl)sulfanyl]-5-methyl-7H-pyrr...)	GoogleScholar KEGG UniProtKB/SwissProt UniProtKB/TrEMBL	CHEBI CSLS PC cid PC sid	PubMed	n/a	n/a	170.0	n/a	n/a	7.4	37
Duquesne University					J Med Chem. 50: 3046-3053 (2007)

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