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Found 279 of ki for UniProtKB: P04062
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM85134(Isofagomine derivative, 7)
Affinity DataKi:  0.0700nMpH: 7.0Assay Description:Fluorescene-based assay using beta-glucocerebrosidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM85134(Isofagomine derivative, 7)
Affinity DataKi:  0.200nMpH: 5.5Assay Description:Fluorescene-based assay using beta-glucocerebrosidase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50383315(CHEMBL2029773)
Affinity DataKi:  0.400nMpH: 5.0Assay Description:Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108418(US8604206, 13 | US8604206, 14)
Affinity DataKi:  0.900nM IC50:  17.1nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM162702(US9056847, Fluorophore 1-cyclophellitol)
Affinity DataKi:  0.950nM IC50:  2nMpH: 5.2Assay Description:Activity of GBA was measured at 37° C. with 4-methylumbelliferyl β-D-glucopyranoside as substrate as reported previously. To determine the IC50 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50394827(CHEMBL2164231)
Affinity DataKi:  1nMAssay Description:Binding affinity to recombinant imiglucerase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 30 mins before substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50394827(CHEMBL2164231)
Affinity DataKi:  1nMAssay Description:Binding affinity to recombinant imiglucerase using 4-methylumbelliferyl-beta-D-glucopyranoside as substrate preincubated for 30 mins before substrate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50254115(CHEMBL4080589)
Affinity DataKi:  1nMAssay Description:Competitive inhibition of recombinant beta-glucocerebrosidase (unknown origin) using 4-nitrophenyl beta-D-galactopyranoside as substrate pre-incubate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50018014(CHEMBL3289676)
Affinity DataKi:  1nMAssay Description:Inhibition of human lysosomal beta-glucocerebrosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108220(5-(hydroxymethyl)-2-[3-(4-methoxyphenyl)propyl]- 5...)
Affinity DataKi:  1.17nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50099006(7-Diethylamino-2-oxo-2H-chromene-3-carboxylic acid...)
Affinity DataKi:  1.20nMAssay Description:Tested for inhibitory activity of the compound against Beta-glucosidase from Agrobacterium speciesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108219(5-(hydroxymethyl)-2-[3-(4-methylphenyl)propyl]- 5H...)
Affinity DataKi:  1.46nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM60418(US9056847, Fluorophore 2-cyclophellitol)
Affinity DataKi:  1.56nMpH: 5.2Assay Description:Activity of GBA was measured at 37° C. with 4-methylumbelliferyl β-D-glucopyranoside as substrate as reported previously. To determine the IC50 ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50182801((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Affinity DataKi:  1.70nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50182801((3R,4R,5R)-5-(Hydroxymethyl)piperidine-3,4-diol, 8...)
Affinity DataKi:  1.70nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50383327(CHEMBL2029772)
Affinity DataKi:  1.80nMpH: 5.0Assay Description:Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108222(2-[3-(4-cyclohexylphenyl)propyl]-5-(hydroxymethyl)...)
Affinity DataKi:  1.93nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM285821((6R,7R,8S)-8-(fluoromethyl)-4-azaspiro[2.5]octane-...)
Affinity DataKi:  2.10nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM285821((6R,7R,8S)-8-(fluoromethyl)-4-azaspiro[2.5]octane-...)
Affinity DataKi:  2.10nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50100428(6-(5-Dimethylamino-naphthalene-1-sulfonylamino)-he...)
Affinity DataKi:  2.10nMAssay Description:Inhibitory activity against Agrobacterium sp. Beta-glucosidase employing fluorescence spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50315250((2R,3S,4S,5R)-2-nonylpiperidine-3,4,5-triol | CHEM...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of human recombinant beta-glucocerebrosidase assessed as p-nitrophenolate accumulation preincubated for 10 mins before p-nitrophenyl-beta-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50315250((2R,3S,4S,5R)-2-nonylpiperidine-3,4,5-triol | CHEM...)
Affinity DataKi:  2.20nMAssay Description:Inhibition of human lysosomal beta-glucocerebrosidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50100426(5-Dimethylamino-naphthalene-1-sulfonic acid ((3S,4...)
Affinity DataKi:  2.40nMAssay Description:Inhibitory activity against Agrobacterium sp. Beta-glucosidase employing fluorescence spectrometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM285819((6R,7R,8S)-8-methyl-4-azaspiro[2.5]octane-6,7-diol...)
Affinity DataKi:  2.60nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM285819((6R,7R,8S)-8-methyl-4-azaspiro[2.5]octane-6,7-diol...)
Affinity DataKi:  2.60nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50383321(CHEMBL2029780)
Affinity DataKi:  3nMpH: 5.0Assay Description:Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108417(US8604206, 6)
Affinity DataKi:  3.06nM IC50:  5.80nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108216(5-(hydroxymethyl)-2-(2-phenylethyl)-5H,6H,7H,8H- i...)
Affinity DataKi:  3.19nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108223(2-[3-(4-fluorophenyl)propyl]-5-(hydroxymethyl)- 5H...)
Affinity DataKi:  3.48nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108221(5-(hydroxymethyl)-2-[3-(4-phenylphenyl)propyl]- 5H...)
Affinity DataKi:  3.62nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108418(US8604206, 13 | US8604206, 14)
Affinity DataKi:  4nM IC50:  7nMpH: 7.0Assay Description:The enzyme inhibition assays used monitored the ability of a test compound to bind and prevent the hydrolysis of a fluorogenic substrate in a concent...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50383323(CHEMBL2029778)
Affinity DataKi:  4nMpH: 5.0Assay Description:Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108224(N-phenyl-4-[6,7,8-trihydroxy-5-(hydroxymethyl)- 5H...)
Affinity DataKi:  4.18nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50383325(CHEMBL2029776)
Affinity DataKi:  4.40nMpH: 5.0Assay Description:Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM636738(US11826435, Compound 1.7)
Affinity DataKi:  5nMAssay Description:Inactivation solutions contained a final concentration of 16.55 nM of Cerezyme (Recombinant GCase) in 200 μL of Reaction Buffer (50 mM acetate, ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50075408(5-(hydroxymethyl)piperidine-3,4-diol | CHEMBL34512...)
Affinity DataKi:  5nMpH: 7.0Assay Description:Fluorescene-based assay using beta-glucocerebrosidase.More data for this Ligand-Target Pair
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108217(2-(3,3-dimethylbutyl)-5-(hydroxymethyl)- 5H,6H,7H,...)
Affinity DataKi:  5.34nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM108218(5-(hydroxymethyl)-2-octyl-5H,6H,7H,8H-imidazo[1,2-...)
Affinity DataKi:  5.38nMpH: 5.2Assay Description:To determine inhibition constant (Ki), substrate (7.5µL, various concentrations in Mcllvaine buffer, pH 5.2) and enzyme (12.5µL, 0.1mg/mL) ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50383324(CHEMBL2029777)
Affinity DataKi:  6nMpH: 5.0Assay Description:Competitive inhibition of wild type human glucocerebrosidase using 4-methylumbelliferyl beta-D-glucopyranoside as substrate after 15 mins by Dixon an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM285839((6R,7R,8S)-8-(prop-1-yn-1-yl)-4-azaspiro[2.5]octan...)
Affinity DataKi:  6.70nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM285839((6R,7R,8S)-8-(prop-1-yn-1-yl)-4-azaspiro[2.5]octan...)
Affinity DataKi:  6.70nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM36514(CID46912122 | MDW933, 5)
Affinity DataKi:  7nM ΔG°:  -11.6kcal/mole IC50:  1.24nMpH: 5.2 T: 2°CAssay Description:Enzymatic activity assay using fluorescent activity-based labeling method.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM285820((6R,7R,8R)-8-(hydroxymethyl)-4-azaspiro[2.5]octane...)
Affinity DataKi:  7nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM285820((6R,7R,8R)-8-(hydroxymethyl)-4-azaspiro[2.5]octane...)
Affinity DataKi:  7nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM50018018(CHEMBL3289679)
Affinity DataKi:  7.5nMAssay Description:Inhibition of human lysosomal beta-glucocerebrosidase using 2,4-dinitrophenyl-beta-D-glucopyranoside as substrate by UV spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM285834((6R,7R,8S)-8-vinyl-4-azaspiro[2.5]octane-6,7-diol ...)
Affinity DataKi:  7.60nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM285834((6R,7R,8S)-8-vinyl-4-azaspiro[2.5]octane-6,7-diol ...)
Affinity DataKi:  7.60nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM285838((6R,7R,8S)-8-ethynyl-4-azaspiro[2.5]octane-6,7-dio...)
Affinity DataKi:  7.90nMAssay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM285838((6R,7R,8S)-8-ethynyl-4-azaspiro[2.5]octane-6,7-dio...)
Affinity DataKi:  7.90nMpH: 7.0Assay Description:Various concentrations of test compounds were prepared in DMSO and then diluted into buffer consisting of 50 mM sodium phosphate 0.25% w/v sodium tau...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM36515(CID46912120 | MDW941, 6)
Affinity DataKi:  8nM ΔG°:  -11.5kcal/mole IC50:  1.94nMpH: 5.2 T: 2°CAssay Description:Enzymatic activity assay using fluorescent activity-based labeling method.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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