Compile Data Set for Download or QSAR
maximum 50k data
Found 66 of ic50 for UniProtKB: P0A884
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM31777(thieno[2,3-d]pyrimidine deriv., 2)
Affinity DataIC50:  18nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM18771((2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-...)
Affinity DataIC50:  19nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM18771((2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-...)
Affinity DataIC50:  19nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM31776(thieno[2,3-d]pyrimidine deriv., 1)
Affinity DataIC50:  40nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM242739(US9422297, PDDF)
Affinity DataIC50:  60nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM20676((2S)-2-{[4-({2-amino-6-methyl-4-oxo-3H,4H,5H-pyrro...)
Affinity DataIC50:  69nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM18771((2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-...)
Affinity DataIC50:  72nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM18797((2S)-2-{[4-({2-amino-6-methyl-4-oxo-3H,4H,7H-pyrro...)
Affinity DataIC50:  270nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM18797((2S)-2-{[4-({2-amino-6-methyl-4-oxo-3H,4H,7H-pyrro...)
Affinity DataIC50:  270nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM18798((2S)-2-{[4-({2-amino-6-ethyl-4-oxo-3H,4H,7H-pyrrol...)
Affinity DataIC50:  540nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM31783(thieno[2,3-d]pyrimidine deriv., 2f)
Affinity DataIC50:  1.20E+3nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM31784(thieno[2,3-d]pyrimidine deriv., 2g)
Affinity DataIC50:  1.40E+3nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM20680(2-amino-5-[(4-chlorophenyl)methyl]-6-methyl-3H,4H,...)
Affinity DataIC50:  1.50E+3nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM31780(thieno[2,3-d]pyrimidine deriv., 2c)
Affinity DataIC50:  1.70E+3nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM31789(thieno[2,3-d]pyrimidine deriv., 2l)
Affinity DataIC50:  1.80E+3nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM31790(thieno[2,3-d]pyrimidine deriv., 2m)
Affinity DataIC50:  2.00E+3nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM31785(thieno[2,3-d]pyrimidine deriv., 2h)
Affinity DataIC50:  2.00E+3nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM31787(thieno[2,3-d]pyrimidine deriv., 2j)
Affinity DataIC50:  2.20E+3nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM31788(thieno[2,3-d]pyrimidine deriv., 2k)
Affinity DataIC50:  2.30E+3nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM31782(thieno[2,3-d]pyrimidine deriv., 2e)
Affinity DataIC50:  2.30E+3nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM50027655(CHEBI:5847 | Raltitrexed | Tomudex | US9422297, Ra...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM31779(thieno[2,3-d]pyrimidine deriv., 2b)
Affinity DataIC50:  2.50E+3nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM31786(thieno[2,3-d]pyrimidine deriv., 2i)
Affinity DataIC50:  2.90E+3nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM50161779((S)-2-(5-Dimethylamino-naphthalene-1-sulfonylamino...)
Affinity DataIC50:  5.00E+3nMAssay Description:Affinity assay of specificities of thymidylate synthase (TS)inhibitorsMore data for this Ligand-Target Pair
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM18795((2S)-2-[(5-{methyl[(2-methyl-4-oxo-1,4-dihydroquin...)
Affinity DataIC50:  5.70E+3nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM20684(2-amino-6-methyl-5-{[4-(trifluoromethoxy)phenyl]me...)
Affinity DataIC50:  7.50E+3nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM20681(2-amino-5-[(4-bromophenyl)methyl]-6-methyl-3H,4H,5...)
Affinity DataIC50:  7.50E+3nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM50602555(CHEMBL5194771)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of Escherichia coli N-terminal hexahstidine-tagged TS by steady-state kinetic analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM50602556(CHEMBL5201889)
Affinity DataIC50:  1.14E+4nMAssay Description:Inhibition of Escherichia coli N-terminal hexahstidine-tagged TS by steady-state kinetic analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM20678(2-amino-6-methyl-5-(pyridin-4-ylmethyl)-3H,4H,5H-p...)
Affinity DataIC50:  1.20E+4nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM18808(2-amino-5-[(3,4-dichlorophenyl)sulfanyl]-6-methyl-...)
Affinity DataIC50:  1.30E+4nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM20682(2-amino-6-methyl-5-[(4-nitrophenyl)methyl]-3H,4H,5...)
Affinity DataIC50:  1.40E+4nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM20683(2-amino-5-[(4-methoxyphenyl)methyl]-6-methyl-3H,4H...)
Affinity DataIC50:  1.50E+4nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM50027656(CHEBI:63616 | LY-2315 | LY-231514 | PEMETREXED | U...)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM50602554(CHEMBL525149 | TCMDC-137810)
Affinity DataIC50:  1.86E+4nMAssay Description:Inhibition of Escherichia coli N-terminal hexahstidine-tagged TS by steady-state kinetic analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM18805(2-amino-5-{[3,5-bis(trifluoromethyl)phenyl]sulfany...)
Affinity DataIC50: >2.00E+4nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM20686(2-amino-5-[(3,5-dibromophenyl)methyl]-6-methyl-3H,...)
Affinity DataIC50: >2.00E+4nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM18802(2-amino-5-[(4-bromophenyl)sulfanyl]-6-ethyl-3H,4H,...)
Affinity DataIC50: >2.20E+4nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM18804(2-amino-5-[(3-bromophenyl)sulfanyl]-6-ethyl-3H,4H,...)
Affinity DataIC50: >2.30E+4nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM18799(2-amino-5-[(3,4-dichlorophenyl)sulfanyl]-6-ethyl-3...)
Affinity DataIC50: >2.30E+4nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM31781(thieno[2,3-d]pyrimidine deriv., 2d)
Affinity DataIC50: >2.30E+4nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM18800(2-amino-6-ethyl-5-[(4-nitrophenyl)sulfanyl]-3H,4H,...)
Affinity DataIC50:  2.40E+4nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM50314077(5-(p-tolylthio)-9H-pyrimido[4,5-b]indole-2,4-diami...)
Affinity DataIC50: >2.60E+4nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM20685(2-amino-5-[(3,5-dichlorophenyl)methyl]-6-methyl-3H...)
Affinity DataIC50: >2.60E+4nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM18806(2-amino-5-[(2,6-dimethylphenyl)sulfanyl]-6-ethyl-3...)
Affinity DataIC50: >2.60E+4nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM18803(2-amino-5-[(3-chlorophenyl)sulfanyl]-6-ethyl-3H,4H...)
Affinity DataIC50: >2.60E+4nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM18801(2-amino-6-ethyl-5-[(4-fluorophenyl)sulfanyl]-3H,4H...)
Affinity DataIC50: >2.70E+4nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM20687(2-amino-5-[(3,4-dichlorophenyl)methyl]-6-methyl-3H...)
Affinity DataIC50:  2.70E+4nMAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM50314076(5-(phenylthio)-9H-pyrimido[4,5-b]indole-2,4-diamin...)
Affinity DataIC50: >2.70E+4nMAssay Description:Inhibition of various kinase enzyme.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThymidylate synthase(Escherichia coli)
Duquesne University

LigandPNGBDBM31778(thieno[2,3-d]pyrimidine deriv., 2a)
Affinity DataIC50:  2.80E+4nMpH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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