Affinity DataKi: 0.00100nM Kd: 0.00100nMAssay Description:Binding affinity to amethopterin-resistant Lactobacillus casei thymidylate synthetase in presence of cofactor permitting covalent bond formationMore data for this Ligand-Target Pair
Affinity DataKi: 0.100nMAssay Description:Inhibitory constant against thymidylate synthase from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 0.300nMAssay Description:Inhibitory constant against thymidylate synthase from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 0.5nMAssay Description:Inhibitory constant against thymidylate synthase from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 1.60nMAssay Description:Inhibitory constant against thymidylate synthase from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 1.70nMAssay Description:Inhibitory constant against thymidylate synthase from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Compound was tested for inhibition of Thymidylate Synthase in L. casei,More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...More data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed dTMP formation using dUMP as substrate by spectrophotometri...More data for this Ligand-Target Pair
Affinity DataKi: 15nMAssay Description:The compound was evaluated for the binding affinity against L. casei dTMP synthase using spectrophotometric assayMore data for this Ligand-Target Pair
Affinity DataKi: 17nMAssay Description:Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed dTMP formation using dUMP as substrate by spectrophotometri...More data for this Ligand-Target Pair
Affinity DataKi: 29nMAssay Description:Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...More data for this Ligand-Target Pair
Affinity DataKi: 39nMAssay Description:Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed dTMP formation using dUMP as substrate by spectrophotometri...More data for this Ligand-Target Pair
Affinity DataKi: 39nMAssay Description:Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...More data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...More data for this Ligand-Target Pair
Affinity DataKi: 48nMAssay Description:Inhibition of dichloromethotrexate-resistant Lactobacillus casei thymidylate synthase by Dixon plot methodMore data for this Ligand-Target Pair
Affinity DataKi: 60nM ΔG°: -9.68kcal/molepH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
Affinity DataKi: 60nMAssay Description:Reversible competitive inhibition of dichloromethotrexate-resistant Lactobacillus casei thymidylate synthase using 5-mercapto-2'-deoxyuridylate as su...More data for this Ligand-Target Pair
Affinity DataKi: 60nM ΔG°: -9.68kcal/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
Affinity DataKi: 100nMAssay Description:The compound was evaluated for the inhibition of dTMP synthetase from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 130nMAssay Description:Compound was tested for its ability to inhibit thymidylate synthetase isolated from MTX-resistant Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 172nMAssay Description:Compound was tested for its ability to inhibit thymidylate synthetase isolated from MTX-resistant Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 189nMAssay Description:Compound was tested for its ability to inhibit thymidylate synthetase isolated from MTX-resistant Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 190nMAssay Description:Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...More data for this Ligand-Target Pair
Affinity DataKi: 190nMAssay Description:Inhibition of amethopterin-resistant Lactobacillus casei thymidylate synthetase-catalyzed dTMP formation using dUMP as substrate by spectrophotometri...More data for this Ligand-Target Pair
Affinity DataKi: 200nMAssay Description:The compound was evaluated for the inhibition of dTMP synthetase from Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 205nMAssay Description:Compound was tested for its ability to inhibit thymidylate synthetase isolated from MTX-resistant Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 310nMAssay Description:Inhibitory effect on Lactobacillus casei thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 330nMAssay Description:Tested for binding affinity towards thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 336nMAssay Description:Compound was tested for its ability to inhibit thymidylate synthetase isolated from MTX-resistant Lactobacillus caseiMore data for this Ligand-Target Pair
Affinity DataKi: 390nMAssay Description:Inhibition of Lactobacillus casei thymidylate synthase using MTHF and dUMP as substratesMore data for this Ligand-Target Pair
Affinity DataKi: 500nMAssay Description:Inactivation of thymidylate synthetase measured asKi at 6.8 pH 30 degrees centigrade tempMore data for this Ligand-Target Pair
Affinity DataKi: 500nMAssay Description:Inactivation of thymidylate synthetase measured asKi at 6.8 pH 30 degrees centigrade tempMore data for this Ligand-Target Pair
Affinity DataKi: 550nMAssay Description:Competitive inhibition of thymidylate synthase purified from methotrexate-resistant Lactobacillus casei using 2'-deoxy[5-3H]uridine 5'-phosphate by r...More data for this Ligand-Target Pair
Affinity DataKi: 550nMAssay Description:Binding affinity against TSMore data for this Ligand-Target Pair
Affinity DataKi: 590nMAssay Description:Ability to inhibit the thymidylate synthase from L. casei was determined and expressed as inhibition constant(Ki)More data for this Ligand-Target Pair
Affinity DataKi: 610nMAssay Description:Inhibitory effect on Lactobacillus casei thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 610nMAssay Description:Ability to inhibit the thymidylate synthase from L. casei was determined and expressed as inhibition constant(Ki)More data for this Ligand-Target Pair
Affinity DataKi: 700nM ΔG°: -8.25kcal/molepH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
Affinity DataKi: 700nM ΔG°: -8.25kcal/molepH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
Affinity DataKi: 700nMAssay Description:Inhibition of Lactobacillus casei thymidylate synthase using N5,N10-methylene tetrahydrofolate by chromogenic assayMore data for this Ligand-Target Pair
Affinity DataKi: 800nM ΔG°: -8.17kcal/molepH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
Affinity DataKi: 800nM ΔG°: -8.17kcal/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
Affinity DataKi: 800nMAssay Description:All compounds were screened for inhibitory activity against Lactobacillus casei thymidylate synthase (LcTS) and Escherichia coli thymidylate synthase...More data for this Ligand-Target Pair
Affinity DataKi: 900nM ΔG°: -8.10kcal/molepH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
Affinity DataKi: 960nMAssay Description:Inhibitory effect on Lactobacillus casei thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 1.00E+3nMAssay Description:Inhibition of Lactobacillus casei thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 1.00E+3nM ΔG°: -8.04kcal/molepH: 7.4 T: 2°CAssay Description:TS was assayed spectrophotometrically in the reaction buffer solution containing (6R, 6S)-5, 10-CH2H4folate. The reaction was initiated by the additi...More data for this Ligand-Target Pair
Affinity DataKi: 1.13E+3nMAssay Description:Inhibitory effect on Lactobacillus casei thymidylate synthaseMore data for this Ligand-Target Pair
Affinity DataKi: 1.20E+3nMAssay Description:Inhibition of Lactobacillus casei thymidylate synthase using MTHF and dUMP as substratesMore data for this Ligand-Target Pair