Affinity DataEC50: 0.0600nMAssay Description:Agonist activity at THR in HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0800nMAssay Description:Agonist activity at THR in HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 0.760nM EC50: 0.300nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.300nMAssay Description:Agonist activity at THR in HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nM EC50: 0.380nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nM EC50: 0.380nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.410nMAssay Description:Agonist activity at human thyroid hormone receptor alpha expressed in HEK293 cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 2.70E+3nM EC50: 0.420nMpH: 7.0 T: 2°CAssay Description:IIC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to...More data for this Ligand-Target Pair
Affinity DataEC50: 0.5nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.5nMAssay Description:Agonist activity at human THRalpha expressed in baculovirus infected SF9 cells after 15 mins by gel electrophoresisMore data for this Ligand-Target Pair
Affinity DataIC50: 460nM EC50: 0.530nMpH: 7.0 T: 2°CAssay Description:IIC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nM EC50: 0.600nMpH: 7.0 T: 2°CAssay Description:IIC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to...More data for this Ligand-Target Pair
Affinity DataIC50: 5.20E+3nM EC50: 0.700nMpH: 7.0 T: 2°CAssay Description:IIC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to...More data for this Ligand-Target Pair
Affinity DataIC50: 6.90E+3nM EC50: 0.820nMpH: 7.0 T: 2°CAssay Description:IIC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to...More data for this Ligand-Target Pair
Affinity DataEC50: 1.01nMAssay Description:Human epithelial kidney cells (HEK 293) were grown to 80% confluency in Dubelcco's modified Eagles 4.5 g/L glucose medium (high glucose DMEM) con...More data for this Ligand-Target Pair
Affinity DataEC50: 1.20nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 1.30nMAssay Description:Efficacy against TRAF-alpha-1 reporter cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30nM EC50: 1.40nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to ...More data for this Ligand-Target Pair
Affinity DataIC50: 5.5nM EC50: 1.5nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to ...More data for this Ligand-Target Pair
Affinity DataIC50: 25nM EC50: 1.70nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to ...More data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Effective concentration of the compound binding towards TRalpha in E25B2 cells (agonistic activity)More data for this Ligand-Target Pair
Affinity DataEC50: 2nMAssay Description:Half-maximum activation of human Thyroid hormone receptor alpha1 (hTRalpha1)More data for this Ligand-Target Pair
Affinity DataEC50: 2.10nMAssay Description:Agonist activity at human recombinant TRalpha1 transfected in CV-1 cells after 8 to 10 hrs by alkaline phosphatase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.80nM EC50: 2.30nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to ...More data for this Ligand-Target Pair
Affinity DataEC50: 2.40nMAssay Description:Effect on human TRalpha transactivation activity in U2OS cells by luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.40nMAssay Description:Effect on human TRalpha transactivation activity in HeLa cells by luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.40nMAssay Description:TRE-driven dual-luciferase reporter assay in human bone osteosarcoma epithelial (U2OS) cell line.More data for this Ligand-Target Pair
Affinity DataEC50: 2.40nMAssay Description:TRE-driven dual-luciferase reporter assay in human uterine cervical cancer (Hela) cell lineMore data for this Ligand-Target Pair
Affinity DataEC50: 2.60nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
Affinity DataEC50: 3nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 3.20nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 3.40nMAssay Description:Agonist activity at human THRalpha expressed in CHO cells after 24 hrs by luciferase assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 4nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 4.10nMAssay Description:Efficacy against TRAF-alpha-1 reporter cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 4.5nMAssay Description:Agonist activity at human thyroid hormone receptor alpha expressed in CV1 cells by TRE-luciferase assayMore data for this Ligand-Target Pair
Affinity DataEC50: 4.80nMAssay Description:Agonist activity at wild type human TR alpha LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of N-terminal biotinylated coactivato...More data for this Ligand-Target Pair
Affinity DataEC50: 5nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
Affinity DataEC50: 5.10nMAssay Description:Agonist activity at THR in HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
Affinity DataEC50: 7nMAssay Description:Agonist activity at THR in HepG2 cells by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10nM EC50: 7.20nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of each compound required to inhibit 50% binding of 125I-T3 to hTRalpha. EC50 is the concentration of compound required to ...More data for this Ligand-Target Pair
Affinity DataEC50: 7.80nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 7.82nMAssay Description:Human epithelial kidney cells (HEK 293) were grown to 80% confluency in Dubelcco's modified Eagles 4.5 g/L glucose medium (high glucose DMEM) con...More data for this Ligand-Target Pair
Affinity DataEC50: 7.96nMAssay Description:Human epithelial kidney cells (HEK 293) were grown to 80% confluency in Dubelcco's modified Eagles 4.5 g/L glucose medium (high glucose DMEM) con...More data for this Ligand-Target Pair
Affinity DataEC50: 8nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 8nMAssay Description:Agonist activity towards thyroid hormone receptor expressed in human HepG2 cellsMore data for this Ligand-Target Pair
Affinity DataEC50: 8.40nMAssay Description:Effect on human TRalpha transactivation activity in HeLa cells by luciferase reporter assayMore data for this Ligand-Target Pair
