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Compile Data Set for Download or QSAR

Found 137 hits of ki for UniProtKB: Q13547   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463758
PNG
(CHEMBL4250302)
Show SMILES COc1ccc(Nc2c(NC(C)(C)CCCCC(=O)NO)c(=O)c2=O)cc1
Show InChI InChI=1S/C19H25N3O5/c1-19(2,11-5-4-6-14(23)22-26)21-16-15(17(24)18(16)25)20-12-7-9-13(27-3)10-8-12/h7-10,20-21,26H,4-6,11H2,1-3H3,(H,22,23)
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0.0560n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463741
PNG
(CHEMBL4239232)
Show SMILES Cc1ccc(Nc2c(NCCCCCC(=O)NO)c(=O)c2=O)cc1
Show InChI InChI=1S/C17H21N3O4/c1-11-6-8-12(9-7-11)19-15-14(16(22)17(15)23)18-10-4-2-3-5-13(21)20-24/h6-9,18-19,24H,2-5,10H2,1H3,(H,20,21)
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0.0570n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463759
PNG
(CHEMBL4237636)
Show SMILES COc1ccc(Nc2c(NC3(CCCCC(=O)NO)CCC3)c(=O)c2=O)cc1
Show InChI InChI=1S/C20H25N3O5/c1-28-14-8-6-13(7-9-14)21-16-17(19(26)18(16)25)22-20(11-4-12-20)10-3-2-5-15(24)23-27/h6-9,21-22,27H,2-5,10-12H2,1H3,(H,23,24)
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0.0630n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463739
PNG
(CHEMBL4237803)
Show SMILES COc1ccc(Nc2c(NCCCCCC(=O)NO)c(=O)c2=O)cc1
Show InChI InChI=1S/C17H21N3O5/c1-25-12-8-6-11(7-9-12)19-15-14(16(22)17(15)23)18-10-4-2-3-5-13(21)20-24/h6-9,18-19,24H,2-5,10H2,1H3,(H,20,21)
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0.0750n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463736
PNG
(CHEMBL4251203)
Show SMILES CC(CCCCC(=O)NO)Nc1c(Nc2ccc(C)cc2)c(=O)c1=O
Show InChI InChI=1S/C18H23N3O4/c1-11-7-9-13(10-8-11)20-16-15(17(23)18(16)24)19-12(2)5-3-4-6-14(22)21-25/h7-10,12,19-20,25H,3-6H2,1-2H3,(H,21,22)
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0.0970n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463756
PNG
(CHEMBL4246561)
Show SMILES C[C@H](CCCCC(=O)NO)Nc1c(Nc2ccc3cc([nH]c3c2)C(F)(F)F)c(=O)c1=O
Show InChI InChI=1/C20H21F3N4O4/c1-10(4-2-3-5-15(28)27-31)24-16-17(19(30)18(16)29)25-12-7-6-11-8-14(20(21,22)23)26-13(11)9-12/h6-10,24-26,31H,2-5H2,1H3,(H,27,28)/t10-/s2
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0.150n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM19423
PNG
(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Show SMILES CC(=O)Nc1ccc(cc1)C(=O)Nc1cc(ccc1N)-c1cccs1
Show InChI InChI=1S/C19H17N3O2S/c1-12(23)21-15-7-4-13(5-8-15)19(24)22-17-11-14(6-9-16(17)20)18-3-2-10-25-18/h2-11H,20H2,1H3,(H,21,23)(H,22,24)
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<0.200<-13.2 1n/an/an/an/a7.425



Broad Institute of Harvard and MIT



Assay Description
Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...


ACS Chem Biol 11: 363-74 (2016)


Article DOI: 10.1021/acschembio.5b00640
BindingDB Entry DOI: 10.7270/Q2BZ64T2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50005711
PNG
(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Show SMILES C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C
Show InChI InChI=1/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/s2
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0.200n/an/an/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1


Bioorg Med Chem 23: 5151-5 (2015)


Article DOI: 10.1016/j.bmc.2014.12.066
BindingDB Entry DOI: 10.7270/Q2B859V9
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM19423
PNG
(HDAC inhibitor, Compound 1 | N-[2-amino-5-(thiophe...)
Show SMILES CC(=O)Nc1ccc(cc1)C(=O)Nc1cc(ccc1N)-c1cccs1
Show InChI InChI=1S/C19H17N3O2S/c1-12(23)21-15-7-4-13(5-8-15)19(24)22-17-11-14(6-9-16(17)20)18-3-2-10-25-18/h2-11H,20H2,1H3,(H,21,23)(H,22,24)
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<0.200n/an/an/an/an/an/an/an/a



Broad Institute of MIT and Harvard

Curated by ChEMBL


Assay Description
Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus coexpressed in fall armyw...


Bioorg Med Chem 24: 4008-4015 (2016)


Article DOI: 10.1016/j.bmc.2016.06.040
BindingDB Entry DOI: 10.7270/Q23B6220
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone deacetylase 1


(Homo sapiens (Human))
BDBM19130
PNG
((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)
Show SMILES CC(C=CC(=O)NO)C=C(C)C(=O)c1ccc(cc1)N(C)C
Show InChI InChI=1/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-12,22H,1-4H3,(H,18,20)/b10-5+,13-11+
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0.230n/an/an/an/an/an/an/an/a



Universit£ de Poitiers

Curated by ChEMBL


Assay Description
Inhibition of recombinant HDAC1


Eur J Med Chem 45: 2095-116 (2010)


Article DOI: 10.1016/j.ejmech.2010.02.030
BindingDB Entry DOI: 10.7270/Q2BR8SCS
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463750
PNG
(CHEMBL4241807)
Show SMILES ONC(=O)CCCCCNc1c(Nc2ccc(cc2)C(F)(F)F)c(=O)c1=O
Show InChI InChI=1S/C17H18F3N3O4/c18-17(19,20)10-5-7-11(8-6-10)22-14-13(15(25)16(14)26)21-9-3-1-2-4-12(24)23-27/h5-8,21-22,27H,1-4,9H2,(H,23,24)
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0.230n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50437405
PNG
(CHEMBL2408778)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Cl)cc3)c12)-c1cccc(c1)-c1cnnn1CCCCCC(=O)NO
Show InChI InChI=1S/C25H24ClN9O2/c26-18-10-8-16(9-11-18)23-22-24(27)28-15-29-25(22)35(31-23)19-6-4-5-17(13-19)20-14-30-33-34(20)12-3-1-2-7-21(36)32-37/h4-6,8-11,13-15,37H,1-3,7,12H2,(H,32,36)(H2,27,28,29)
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0.260n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of HDAC1 (unknown origin) by Fluor de Lys based assay


ACS Med Chem Lett 4: 779-783 (2013)


Article DOI: 10.1021/ml400175d
BindingDB Entry DOI: 10.7270/Q2CZ38KR
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50437405
PNG
(CHEMBL2408778)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Cl)cc3)c12)-c1cccc(c1)-c1cnnn1CCCCCC(=O)NO
Show InChI InChI=1S/C25H24ClN9O2/c26-18-10-8-16(9-11-18)23-22-24(27)28-15-29-25(22)35(31-23)19-6-4-5-17(13-19)20-14-30-33-34(20)12-3-1-2-7-21(36)32-37/h4-6,8-11,13-15,37H,1-3,7,12H2,(H,32,36)(H2,27,28,29)
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0.260n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Ac-Leu-Gly-Lys(Ac)AMCA as substrate after 30 mins by fluorescence assay


ACS Med Chem Lett 4: 779-783 (2013)


Article DOI: 10.1021/ml400175d
BindingDB Entry DOI: 10.7270/Q2CZ38KR
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463743
PNG
(CHEMBL4241370)
Show SMILES CC(C)(CCCCC(=O)NO)Nc1c(Nc2ccc(cc2)C(F)(F)F)c(=O)c1=O
Show InChI InChI=1S/C19H22F3N3O4/c1-18(2,10-4-3-5-13(26)25-29)24-15-14(16(27)17(15)28)23-12-8-6-11(7-9-12)19(20,21)22/h6-9,23-24,29H,3-5,10H2,1-2H3,(H,25,26)
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0.270n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463753
PNG
(CHEMBL4250739)
Show SMILES COc1ccc(Nc2c(NC(C)CCCCC(=O)NO)c(=O)c2=O)cc1
Show InChI InChI=1S/C18H23N3O5/c1-11(5-3-4-6-14(22)21-25)19-15-16(18(24)17(15)23)20-12-7-9-13(26-2)10-8-12/h7-11,19-20,25H,3-6H2,1-2H3,(H,21,22)
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0.270n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463752
PNG
(CHEMBL4247370)
Show SMILES Cc1cc2ccc(Nc3c(NCCCCCC(=O)NO)c(=O)c3=O)cc2[nH]1
Show InChI InChI=1S/C19H22N4O4/c1-11-9-12-6-7-13(10-14(12)21-11)22-17-16(18(25)19(17)26)20-8-4-2-3-5-15(24)23-27/h6-7,9-10,20-22,27H,2-5,8H2,1H3,(H,23,24)
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0.270n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463754
PNG
(CHEMBL4240635)
Show SMILES CC(CCCCC(=O)NO)Nc1c(Nc2ccc(cc2)C(F)(F)F)c(=O)c1=O
Show InChI InChI=1S/C18H20F3N3O4/c1-10(4-2-3-5-13(25)24-28)22-14-15(17(27)16(14)26)23-12-8-6-11(7-9-12)18(19,20)21/h6-10,22-23,28H,2-5H2,1H3,(H,24,25)
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0.280n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463740
PNG
(CHEMBL4251365)
Show SMILES ONC(=O)CCCCCNc1c(Nc2ccccc2)c(=O)c1=O
Show InChI InChI=1S/C16H19N3O4/c20-12(19-23)9-5-2-6-10-17-13-14(16(22)15(13)21)18-11-7-3-1-4-8-11/h1,3-4,7-8,17-18,23H,2,5-6,9-10H2,(H,19,20)
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0.290n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463739
PNG
(CHEMBL4237803)
Show SMILES COc1ccc(Nc2c(NCCCCCC(=O)NO)c(=O)c2=O)cc1
Show InChI InChI=1S/C17H21N3O5/c1-25-12-8-6-11(7-9-12)19-15-14(16(22)17(15)23)18-10-4-2-3-5-13(21)20-24/h6-9,18-19,24H,2-5,10H2,1H3,(H,20,21)
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0.340n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using fluorogenic HDAC substrate after 15 mins by fluorimetrc method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463763
PNG
(CHEMBL4248374)
Show SMILES Cc1cccc(Nc2c(NCCCCCC(=O)NO)c(=O)c2=O)c1
Show InChI InChI=1S/C17H21N3O4/c1-11-6-5-7-12(10-11)19-15-14(16(22)17(15)23)18-9-4-2-3-8-13(21)20-24/h5-7,10,18-19,24H,2-4,8-9H2,1H3,(H,20,21)
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0.390n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50105327
PNG
(JNJ-26481585 | QUISINOSTAT | Quisinostat)
Show SMILES Cn1cc(CNCC2CCN(CC2)c2ncc(cn2)C(=O)NO)c2ccccc12
Show InChI InChI=1S/C21H26N6O2/c1-26-14-17(18-4-2-3-5-19(18)26)11-22-10-15-6-8-27(9-7-15)21-23-12-16(13-24-21)20(28)25-29/h2-5,12-15,22,29H,6-11H2,1H3,(H,25,28)
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0.480n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463751
PNG
(CHEMBL4244350)
Show SMILES COc1cc(Nc2c(NCCCCCC(=O)NO)c(=O)c2=O)ccc1N(C)C
Show InChI InChI=1S/C19H26N4O5/c1-23(2)13-9-8-12(11-14(13)28-3)21-17-16(18(25)19(17)26)20-10-6-4-5-7-15(24)22-27/h8-9,11,20-21,27H,4-7,10H2,1-3H3,(H,22,24)
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0.5n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463757
PNG
(CHEMBL4249385)
Show SMILES CCC(CCCCC(=O)NO)Nc1c(Nc2ccc(cc2)C(F)(F)F)c(=O)c1=O
Show InChI InChI=1S/C19H22F3N3O4/c1-2-12(5-3-4-6-14(26)25-29)23-15-16(18(28)17(15)27)24-13-9-7-11(8-10-13)19(20,21)22/h7-10,12,23-24,29H,2-6H2,1H3,(H,25,26)
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0.510n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM29589
PNG
(Faridak | LBH-589 | LBH-589B | Panobinostat)
Show SMILES Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+
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0.540n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463764
PNG
(CHEMBL4245007)
Show SMILES ONC(=O)CCCCCCNc1c(Nc2ccccc2)c(=O)c1=O
Show InChI InChI=1S/C17H21N3O4/c21-13(20-24)10-6-1-2-7-11-18-14-15(17(23)16(14)22)19-12-8-4-3-5-9-12/h3-5,8-9,18-19,24H,1-2,6-7,10-11H2,(H,20,21)
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0.560n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463742
PNG
(CHEMBL4242292)
Show SMILES C[C@H](CCCCC(=O)NO)Nc1c(Nc2ccc(OC(F)(F)F)cc2)c(=O)c1=O
Show InChI InChI=1S/C18H20F3N3O5/c1-10(4-2-3-5-13(25)24-28)22-14-15(17(27)16(14)26)23-11-6-8-12(9-7-11)29-18(19,20)21/h6-10,22-23,28H,2-5H2,1H3,(H,24,25)/t10-/m1/s1
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0.580n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Histone deacetylase 1


(Homo sapiens (Human))
BDBM19428
PNG
((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)
Show SMILES OCCN(CCc1c[nH]c2ccccc12)Cc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C22H25N3O3/c26-14-13-25(12-11-19-15-23-21-4-2-1-3-20(19)21)16-18-7-5-17(6-8-18)9-10-22(27)24-28/h1-10,15,23,26,28H,11-14,16H2,(H,24,27)/b10-9+
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0.600n/an/an/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1


Bioorg Med Chem 23: 5151-5 (2015)


Article DOI: 10.1016/j.bmc.2014.12.066
BindingDB Entry DOI: 10.7270/Q2B859V9
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50005012
PNG
(CHEMBL2408777)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Cl)cc3)c12)-c1cccc(c1)-c1cn(CCCCCC(=O)NO)nn1
Show InChI InChI=1S/C25H24ClN9O2/c26-18-10-8-16(9-11-18)23-22-24(27)28-15-29-25(22)35(31-23)19-6-4-5-17(13-19)20-14-34(33-30-20)12-3-1-2-7-21(36)32-37/h4-6,8-11,13-15,37H,1-3,7,12H2,(H,32,36)(H2,27,28,29)
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0.620n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of HDAC1 (unknown origin) by Fluor de Lys based assay


ACS Med Chem Lett 4: 779-783 (2013)


Article DOI: 10.1021/ml400175d
BindingDB Entry DOI: 10.7270/Q2CZ38KR
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50005711
PNG
(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Show SMILES C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C
Show InChI InChI=1/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/s2
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0.640n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human C-terminal FLAG/His-tagged HDAC1 expressed in baculovirus-infected Sf21 insect cells using RHKK(Ac)AMC as substrate a...


J Med Chem 61: 3454-3477 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463767
PNG
(CHEMBL4246919)
Show SMILES CC(CCCCC(=O)NO)Nc1c(Nc2ccccc2)c(=O)c1=O
Show InChI InChI=1S/C17H21N3O4/c1-11(7-5-6-10-13(21)20-24)18-14-15(17(23)16(14)22)19-12-8-3-2-4-9-12/h2-4,8-9,11,18-19,24H,5-7,10H2,1H3,(H,20,21)
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0.690n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50005013
PNG
(CHEMBL2408779)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Cl)cc3)c12)-c1cccc(c1)-c1cnnn1CCCCCCC(=O)NO
Show InChI InChI=1S/C26H26ClN9O2/c27-19-11-9-17(10-12-19)24-23-25(28)29-16-30-26(23)36(32-24)20-7-5-6-18(14-20)21-15-31-34-35(21)13-4-2-1-3-8-22(37)33-38/h5-7,9-12,14-16,38H,1-4,8,13H2,(H,33,37)(H2,28,29,30)
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0.820n/an/an/an/an/an/an/an/a



University of Michigan

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Ac-Leu-Gly-Lys(Ac)AMCA as substrate after 30 mins by fluorescence assay


ACS Med Chem Lett 4: 779-783 (2013)


Article DOI: 10.1021/ml400175d
BindingDB Entry DOI: 10.7270/Q2CZ38KR
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50005711
PNG
(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)
Show SMILES C[C@H](\C=C(/C)\C=C\C(=O)NO)C(=O)c1ccc(cc1)N(C)C
Show InChI InChI=1/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/s2
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0.870n/an/an/an/an/an/an/an/a



University of Connecticut

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 by Michaelis-Menten equation analysis


ACS Med Chem Lett 4: 757-61 (2013)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM25150
PNG
((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)
Show SMILES ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C15H14N2O4S/c18-15(16-19)10-9-12-5-4-8-14(11-12)22(20,21)17-13-6-2-1-3-7-13/h1-11,17,19H,(H,16,18)/b10-9+
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0.900n/an/an/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1


Bioorg Med Chem 23: 5151-5 (2015)


Article DOI: 10.1016/j.bmc.2014.12.066
BindingDB Entry DOI: 10.7270/Q2B859V9
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463749
PNG
(CHEMBL4242426)
Show SMILES CN(C)c1ccc(Nc2c(NCCCCCC(=O)NO)c(=O)c2=O)cc1
Show InChI InChI=1S/C18H24N4O4/c1-22(2)13-9-7-12(8-10-13)20-16-15(17(24)18(16)25)19-11-5-3-4-6-14(23)21-26/h7-10,19-20,26H,3-6,11H2,1-2H3,(H,21,23)
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0.910n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463743
PNG
(CHEMBL4241370)
Show SMILES CC(C)(CCCCC(=O)NO)Nc1c(Nc2ccc(cc2)C(F)(F)F)c(=O)c1=O
Show InChI InChI=1S/C19H22F3N3O4/c1-18(2,10-4-3-5-13(26)25-29)24-15-14(16(27)17(15)28)23-12-8-6-11(7-9-12)19(20,21)22/h6-9,23-24,29H,3-5,10H2,1-2H3,(H,25,26)
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1n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using fluorogenic HDAC substrate after 15 mins by fluorimetrc method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM29589
PNG
(Faridak | LBH-589 | LBH-589B | Panobinostat)
Show SMILES Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+
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1n/an/an/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1


Bioorg Med Chem 23: 5151-5 (2015)


Article DOI: 10.1016/j.bmc.2014.12.066
BindingDB Entry DOI: 10.7270/Q2B859V9
More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50123957
PNG
((E)-5-(3-Benzenesulfonylamino-phenyl)-pent-2-en-4-...)
Show SMILES ONC(=O)\C=C\C#Cc1ccc(NS(=O)(=O)c2ccccc2)cc1
Show InChI InChI=1S/C17H14N2O4S/c20-17(18-21)9-5-4-6-14-10-12-15(13-11-14)19-24(22,23)16-7-2-1-3-8-16/h1-3,5,7-13,19,21H,(H,18,20)/b9-5+
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1.30n/an/an/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1


Bioorg Med Chem 23: 5151-5 (2015)


Article DOI: 10.1016/j.bmc.2014.12.066
BindingDB Entry DOI: 10.7270/Q2B859V9
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463766
PNG
(CHEMBL4242750)
Show SMILES ONC(=O)CCCCCNc1c(NC2CCCCC2)c(=O)c1=O
Show InChI InChI=1S/C16H25N3O4/c20-12(19-23)9-5-2-6-10-17-13-14(16(22)15(13)21)18-11-7-3-1-4-8-11/h11,17-18,23H,1-10H2,(H,19,20)
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1.40n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463737
PNG
(CHEMBL4238353)
Show SMILES ONC(=O)CCCCC(Cc1ccccc1)Nc1c(Nc2ccc(cc2)C(F)(F)F)c(=O)c1=O
Show InChI InChI=1S/C24H24F3N3O4/c25-24(26,27)16-10-12-17(13-11-16)28-20-21(23(33)22(20)32)29-18(8-4-5-9-19(31)30-34)14-15-6-2-1-3-7-15/h1-3,6-7,10-13,18,28-29,34H,4-5,8-9,14H2,(H,30,31)
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1.90n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50105329
PNG
(CHEMBL1213492)
Show SMILES CCN(CC)Cc1ccc2cc(COC(=O)Nc3ccc(cc3)C(=O)NO)ccc2c1
Show InChI InChI=1S/C24H27N3O4/c1-3-27(4-2)15-17-5-7-21-14-18(6-8-20(21)13-17)16-31-24(29)25-22-11-9-19(10-12-22)23(28)26-30/h5-14,30H,3-4,15-16H2,1-2H3,(H,25,29)(H,26,28)
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2n/an/an/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1


Bioorg Med Chem 23: 5151-5 (2015)


Article DOI: 10.1016/j.bmc.2014.12.066
BindingDB Entry DOI: 10.7270/Q2B859V9
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463746
PNG
(CHEMBL4245840)
Show SMILES C[C@H](Nc1c(NCCCCCC(=O)NO)c(=O)c1=O)c1ccccc1C
Show InChI InChI=1S/C19H25N3O4/c1-12-8-5-6-9-14(12)13(2)21-17-16(18(24)19(17)25)20-11-7-3-4-10-15(23)22-26/h5-6,8-9,13,20-21,26H,3-4,7,10-11H2,1-2H3,(H,22,23)/t13-/m0/s1
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2.30n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463748
PNG
(CHEMBL4241014)
Show SMILES C[C@H](Nc1c(NCCCCCC(=O)NO)c(=O)c1=O)c1ccc(C)cc1
Show InChI InChI=1S/C19H25N3O4/c1-12-7-9-14(10-8-12)13(2)21-17-16(18(24)19(17)25)20-11-5-3-4-6-15(23)22-26/h7-10,13,20-21,26H,3-6,11H2,1-2H3,(H,22,23)/t13-/m0/s1
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2.30n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM29589
PNG
(Faridak | LBH-589 | LBH-589B | Panobinostat)
Show SMILES Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+
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2.5n/an/an/an/an/an/an/an/a



S*BIO Pte Ltd

Curated by ChEMBL


Assay Description
Competitive inhibition of HDAC1 using KI-104 as substrate by fluorescence assay


J Med Chem 54: 4694-720 (2011)


Article DOI: 10.1021/jm2003552
BindingDB Entry DOI: 10.7270/Q29S1RD6
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463762
PNG
(CHEMBL4244537)
Show SMILES C[C@H](Nc1c(NCCCCCC(=O)NO)c(=O)c1=O)c1ccccc1
Show InChI InChI=1S/C18H23N3O4/c1-12(13-8-4-2-5-9-13)20-16-15(17(23)18(16)24)19-11-7-3-6-10-14(22)21-25/h2,4-5,8-9,12,19-20,25H,3,6-7,10-11H2,1H3,(H,21,22)/t12-/m0/s1
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2.5n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463768
PNG
(CHEMBL4240163)
Show SMILES C[C@H](CCCCC(=O)NO)Nc1c(Nc2ccc(cc2)N(C)C)c(=O)c1=O
Show InChI InChI=1S/C19H26N4O4/c1-12(6-4-5-7-15(24)22-27)20-16-17(19(26)18(16)25)21-13-8-10-14(11-9-13)23(2)3/h8-12,20-21,27H,4-7H2,1-3H3,(H,22,24)/t12-/m1/s1
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2.70n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM178095
PNG
(BRD2492)
Show SMILES CC(=O)Nc1ccc(cc1)C(=O)Nc1cc(ccc1N)-c1ccncc1
Show InChI InChI=1S/C20H18N4O2/c1-13(25)23-17-5-2-15(3-6-17)20(26)24-19-12-16(4-7-18(19)21)14-8-10-22-11-9-14/h2-12H,21H2,1H3,(H,23,25)(H,24,26)
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3 -11.6 2n/an/an/an/a7.425



Broad Institute of Harvard and MIT



Assay Description
Purified HDAC1-9 (0.5~5 nM) were incubated with 2 μM carboxyfluorescein (FAM)-labeled acetylated peptide substrate A or B and test compound for ...


ACS Chem Biol 11: 363-74 (2016)


Article DOI: 10.1021/acschembio.5b00640
BindingDB Entry DOI: 10.7270/Q2BZ64T2
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM29589
PNG
(Faridak | LBH-589 | LBH-589B | Panobinostat)
Show SMILES Cc1[nH]c2ccccc2c1CCNCc1ccc(\C=C\C(=O)NO)cc1
Show InChI InChI=1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+
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3n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using fluorogenic HDAC substrate after 15 mins by fluorimetrc method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM50105327
PNG
(JNJ-26481585 | QUISINOSTAT | Quisinostat)
Show SMILES Cn1cc(CNCC2CCN(CC2)c2ncc(cn2)C(=O)NO)c2ccccc12
Show InChI InChI=1S/C21H26N6O2/c1-26-14-17(18-4-2-3-5-19(18)26)11-22-10-15-6-8-27(9-7-15)21-23-12-16(13-24-21)20(28)25-29/h2-5,12-15,22,29H,6-11H2,1H3,(H,25,28)
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3n/an/an/an/an/an/an/an/a



St. Jude Children's Research Hospital

Curated by ChEMBL


Assay Description
Inhibition of human HDAC1


Bioorg Med Chem 23: 5151-5 (2015)


Article DOI: 10.1016/j.bmc.2014.12.066
BindingDB Entry DOI: 10.7270/Q2B859V9
More data for this
Ligand-Target Pair
Cereblon/Histone deacetylase 1


(Homo sapiens (Human))
BDBM50463738
PNG
(CHEMBL4244764)
Show SMILES CC(Nc1c(NCCCCCC(=O)NO)c(=O)c1=O)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C22H33N3O4/c1-13(22-10-14-7-15(11-22)9-16(8-14)12-22)24-19-18(20(27)21(19)28)23-6-4-2-3-5-17(26)25-29/h13-16,23-24,29H,2-12H2,1H3,(H,25,26)
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3.80n/an/an/an/an/an/an/an/a



Nestle Skin Health R&D

Curated by ChEMBL


Assay Description
Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence method


Bioorg Med Chem Lett 28: 2985-2992 (2018)

More data for this
Ligand-Target Pair
Histone deacetylase 1


(Homo sapiens (Human))
BDBM24621
PNG
(CG-003 | N-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-...)
Show SMILES ONC(=O)c1ccc(OCCNC(=O)c2cc3ccccc3o2)cc1
Show InChI InChI=1S/C18H16N2O5/c21-17(20-23)12-5-7-14(8-6-12)24-10-9-19-18(22)16-11-13-3-1-2-4-15(13)25-16/h1-8,11,23H,9-10H2,(H,19,22)(H,20,21)
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4 -11.3n/an/an/an/an/a7.422



Celera Genomics



Assay Description
HDAC activity was measured using a continuous trypsin-coupled assay. For inhibitor characterization, measurements were done using 96-well assay plat...


Mol Cancer Ther 5: 1309-17 (2006)


Article DOI: 10.1158/1535-7163.MCT-05-0442
BindingDB Entry DOI: 10.7270/Q2DF6PJJ
More data for this
Ligand-Target Pair
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