Compile Data Set for Download or QSAR
(2D       Computed 3D by Vconf -m prep )

Data curated solely by BindingDB

Found 361 hits of affinity data for UniProtKB/TrEMBL: P43235

Target (Institution)	Ligand	Target Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	pH	Temp °C
Cathepsin K Homo sapiens (human)	Azepan-3-one compound 2 ((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	0.009900	-62.17	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 49: 1597-612 (2006)
Cathepsin K Homo sapiens (human)	Azepan-3-one compound 10 ((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)	B.MOAD GoogleScholar MMDB PDB	CHEBI CSLS PC cid PC sid	PubMed	0.04100	-58.69	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 49: 1597-612 (2006)
Cathepsin K Homo sapiens (human)	Azepan-3-one compound 7 ((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	0.1400	-55.67	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 49: 1597-612 (2006)
Cathepsin K Homo sapiens (human)	Azepan-3-one compound 1 ((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)	B.MOAD GoogleScholar MMDB PDB	CHEBI CSLS PC cid PC sid PDB	PDB PubMed	0.1600	-55.34	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 49: 1597-612 (2006)
Cathepsin K Homo sapiens (human)	pyrrolidinone analogue, 25 (benzyl N-[(1S)-1-({1-[(2S)-2-{[(benzyloxy)carbonyl...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	0.6000	-52.10	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 44: 725-36 (2001)
Cathepsin K Homo sapiens (human)	Azepan-3-one compound 12 ((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	1.400	-50.02	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 49: 1597-612 (2006)
Cathepsin K Homo sapiens (human)	Azepan-3-one compound 3 ((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	1.500	-49.85	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 49: 1597-612 (2006)
Cathepsin K Homo sapiens (human)	pyrrolidinone analogue, 33 (benzyl N-[(2S)-4-methyl-1-{3-[(2S)-4-methyl-2-(qui...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	1.600	-49.69	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 44: 725-36 (2001)
Cathepsin K Homo sapiens (human)	piperidinone analogue, 28 (benzyl N-[(1S)-1-({1-[(2S)-2-{[(benzyloxy)carbonyl...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	1.900	-49.27	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 44: 725-36 (2001)
Cathepsin K Homo sapiens (human)	pyrrolidinone analogue, 24 (benzyl N-[(1S)-1-({1-[(2S)-2-{[(benzyloxy)carbonyl...)	B.MOAD GoogleScholar MMDB PDB	CHEBI CSLS PC cid PC sid PDB	PDB PubMed	2.300	-48.80	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 44: 725-36 (2001)
Cathepsin K Homo sapiens (human)	Azepan-3-one compound 11 ((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	2.500	-48.60	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 49: 1597-612 (2006)
Cathepsin K Homo sapiens (human)	piperidinone analogue, 27 (benzyl N-[(1S)-1-({1-[(2S)-2-{[(benzyloxy)carbonyl...)	B.MOAD GoogleScholar MMDB PDB	CHEBI CSLS PC cid PC sid	PubMed	2.600	-48.50	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 44: 725-36 (2001)
Cathepsin K Homo sapiens (human)	Azepan-3-one compound 13 ((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	4.000	-47.45	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 49: 1597-612 (2006)
Cathepsin K Homo sapiens (human)	Azepan-3-one compound 9 ((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	4.500	-47.16	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 49: 1597-612 (2006)
Cathepsin K Homo sapiens (human)	4-amidotetrahydropyran-3-one, 39 ((2S)-2-(1-benzothiophen-2-ylformamido)-4-methyl-N-...)	B.MOAD GoogleScholar MMDB PDB	CHEBI CSLS PC cid PC sid	PubMed	11.00	-44.96	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 44: 725-36 (2001)
Cathepsin K Homo sapiens (human)	Azepan-3-one compound 4 ((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	19.00	-43.62	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 49: 1597-612 (2006)
Cathepsin K Homo sapiens (human)	Azepan-3-one compound 6 ((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	29.00	-42.58	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 49: 1597-612 (2006)
Cathepsin K Homo sapiens (human)	Azepan-3-one compound 8 ((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	30.00	-42.50	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 49: 1597-612 (2006)
Cathepsin K Homo sapiens (human)	dipeptidyl nitrile, 1 (Cbz-Leu-NH-CH2-CN | JMC487688 Compound 8 | benzyl ...)	B.MOAD GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	35.00	-44.26	n/a	n/a	n/a	5	37
Rheinische Friedrich-Wilhelms-Universitat Bonn					J Med Chem. 48: 7688-707 (2005)
Cathepsin K Homo sapiens (human)	Azepan-3-one compound 5 ((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	42.00	-41.68	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 49: 1597-612 (2006)
Cathepsin K Homo sapiens (human)	arylaminoethyl amide, 1 ((2S)-N-{2-[(4-methoxyphenyl)amino]ethyl}-4-methyl-...)	B.MOAD GoogleScholar MMDB PDB	CHEBI CSLS PC cid PC sid	PubMed	43.00	-43.73	n/a	n/a	n/a	5.5	37
GNF					Bioorg Med Chem Lett. 15: 4979-84 (2005)
Cathepsin K Homo sapiens (human)	3-amidotetrahydrofuran-4-one, 16 ((2S)-4-methyl-N-(4-oxooxolan-3-yl)-2-(quinolin-2-y...)	B.MOAD GoogleScholar MMDB PDB	CHEBI CSLS PC cid PC sid	PubMed	44.00	-41.56	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 44: 725-36 (2001)
Cathepsin K Homo sapiens (human)	arylaminoethyl amide, 8l ((2S)-N-[(2S)-1-(5-fluoro-2,3-dihydro-1H-indol-1-yl...)	B.MOAD GoogleScholar MMDB PDB	PC cid PC sid	PubMed	47.00	-43.50	n/a	n/a	n/a	5.5	37
GNF					Bioorg Med Chem Lett. 16: 1486-90 (2006)
Cathepsin K Homo sapiens (human)	arylaminoethyl amide, 7a ((2S)-N-[(2S)-1-[(4-methoxyphenyl)amino]propan-2-yl...)	B.MOAD GoogleScholar MMDB PDB	PC cid PC sid	PubMed	55.00	-43.10	n/a	n/a	n/a	5.5	37
GNF					Bioorg Med Chem Lett. 16: 1486-90 (2006)
Cathepsin K Homo sapiens (human)	arylaminoethyl amide, 6 ((2S)-3-cyclohexyl-N-{2-[(4-methoxyphenyl)amino]eth...)	B.MOAD GoogleScholar MMDB PDB	PC cid PC sid	PubMed	55.00	-43.10	n/a	n/a	n/a	5.5	37
GNF					Bioorg Med Chem Lett. 15: 4979-84 (2005)
Cathepsin K Homo sapiens (human)	arylaminoethyl amide, 7 ((2S)-2-[(5-chloro-1-benzofuran-2-yl)formamido]-3-c...)	B.MOAD GoogleScholar MMDB PDB	PC cid PC sid	PubMed	58.00	-42.96	n/a	n/a	n/a	5.5	37
GNF					Bioorg Med Chem Lett. 15: 4979-84 (2005)
Cathepsin K Homo sapiens (human)	acyclic alkoxymethyl ketone inhibitor, 2 (benzyl N-[(1S)-1-{[(2S)-4-methoxy-3-oxobutan-2-yl]...)	B.MOAD GoogleScholar MMDB PDB	CHEBI CSLS PC cid PC sid	PubMed	60.00	-40.80	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 44: 725-36 (2001)
Cathepsin K Homo sapiens (human)	arylaminoethyl amide, 5b ((2S)-2-cyclohexyl-N-{2-[(4-methoxyphenyl)amino]eth...)	B.MOAD GoogleScholar MMDB PDB	PC cid PC sid	PubMed	66.00	-42.63	n/a	n/a	n/a	5.5	37
GNF					Bioorg Med Chem Lett. 15: 4979-84 (2005)
Cathepsin K Homo sapiens (human)	dipeptidyl aldehyde, 52 (tert-butyl N-[(1S)-1-[(2-oxoethyl)carbamoyl]-2-phe...)	B.MOAD GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	74.00	-42.33	n/a	n/a	n/a	5	37
Rheinische Friedrich-Wilhelms-Universitat Bonn					J Med Chem. 48: 7688-707 (2005)
Cathepsin K Homo sapiens (human)	pyrrolidinone analogue, 29 ([(2S)-1-{3-[(2S)-2-{[(benzyloxy)carbonyl]amino}-4-...)	B.MOAD GoogleScholar MMDB PDB	PC cid PC sid	PubMed	77.00	-40.19	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 44: 725-36 (2001)
Cathepsin K Homo sapiens (human)	arylaminoethyl amide, 3h ((2S)-N-[2-(5-fluoro-2,3-dihydro-1H-indol-1-yl)ethy...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	80.00	-42.13	n/a	n/a	n/a	5.5	37
GNF					Bioorg Med Chem Lett. 16: 1486-90 (2006)
Cathepsin K Homo sapiens (human)	arylaminoethyl amide, 1 ((2S)-N-{2-[(4-methoxyphenyl)amino]ethyl}-4-methyl-...)	B.MOAD GoogleScholar MMDB PDB	CHEBI CSLS PC cid PC sid	PubMed	91.00	-41.80	n/a	n/a	n/a	5.5	37
GNF					Bioorg Med Chem Lett. 16: 1486-90 (2006)
Cathepsin K Homo sapiens (human)	dipeptide-derived nitrile, 7 (tert-butyl N-[(1S)-1-[(cyanomethyl)carbamoyl]-3-me...)	B.MOAD GoogleScholar KEGG MMDB PDB UniProtKB/SwissProt UniProtKB/TrEMBL	CSLS PC cid PC sid	PubMed	120.0	-41.09	n/a	n/a	n/a	5	37
Rheinische Friedrich-Wilhelms-Universitat Bonn					J Med Chem. 48: 7688-707 (2005)
Cathepsin K Homo sapiens (human)	arylaminoethyl amide, 5f ((2S)-N-{2-[(4-methoxyphenyl)amino]ethyl}-2-[(3-met...)	B.MOAD GoogleScholar MMDB PDB	PC cid PC sid	PubMed	123.0	-41.02	n/a	n/a	n/a	5.5	37
GNF					Bioorg Med Chem Lett. 15: 4979-84 (2005)
Cathepsin K Homo sapiens (human)	arylaminoethyl amide, 3a ((2S)-N-{2-[(4-methoxy-3,5-dimethylphenyl)amino]eth...)	B.MOAD GoogleScholar MMDB PDB	PC cid PC sid	PubMed	125.0	-40.98	n/a	n/a	n/a	5.5	37
GNF					Bioorg Med Chem Lett. 16: 1486-90 (2006)
Cathepsin K Homo sapiens (human)	arylaminoethyl amide, 3c ((2S)-4-methyl-2-[(3-methylphenyl)formamido]-N-(2-{...)	B.MOAD GoogleScholar MMDB PDB	PC cid PC sid	PubMed	125.0	-40.98	n/a	n/a	n/a	5.5	37
GNF					Bioorg Med Chem Lett. 16: 1486-90 (2006)
Cathepsin K Homo sapiens (human)	arylaminoethyl amide deriv. 29 ((2S)-3-cyclohexyl-2-(morpholin-4-ylcarbonylamino)-...)	B.MOAD GoogleScholar MMDB PDB	PC cid PC sid	PubMed	130.0	-40.88	n/a	n/a	n/a	5.5	37
GNF					Bioorg Med Chem Lett. 16: 5112-7 (2006)
Cathepsin K Homo sapiens (human)	arylaminoethyl amide, 3b ((2S)-N-{2-[(4-methoxy-2,6-dimethylphenyl)amino]eth...)	B.MOAD GoogleScholar MMDB PDB	PC cid PC sid	PubMed	131.0	-40.86	n/a	n/a	n/a	5.5	37
GNF					Bioorg Med Chem Lett. 16: 1486-90 (2006)
Cathepsin K Homo sapiens (human)	arylaminoethyl amide, 3g ((2S)-N-[2-(5-chloro-2,3-dihydro-1H-indol-1-yl)ethy...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	139.0	-40.71	n/a	n/a	n/a	5.5	37
GNF					Bioorg Med Chem Lett. 16: 1486-90 (2006)
Cathepsin K Homo sapiens (human)	arylaminoethyl amide deriv. 30 ((2S)-3-cyclohexyl-N-[(2S)-4-methanesulfonyl-1-{[4-...)	B.MOAD GoogleScholar MMDB PDB	PC cid PC sid	PubMed	139.0	-40.71	n/a	n/a	n/a	5.5	37
GNF					Bioorg Med Chem Lett. 16: 5112-7 (2006)
Cathepsin K Homo sapiens (human)	3-amidotetrahydrofuran-4-one, 3 (benzyl N-[(1S)-3-methyl-1-[(4-oxooxolan-3-yl)carba...)	B.MOAD GoogleScholar MMDB PDB	CHEBI CSLS PC cid PC sid	PubMed	140.0	-38.72	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 44: 725-36 (2001)
Cathepsin K Homo sapiens (human)	4-amidotetrahydropyran-3-one, 4 (benzyl N-[(1S)-3-methyl-1-[(3-oxooxan-4-yl)carbamo...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	150.0	-38.55	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 44: 725-36 (2001)
Cathepsin K Homo sapiens (human)	arylaminoethyl amide deriv. 16 ((2S)-2-(1-benzofuran-2-ylformamido)-3-cyclohexyl-N...)	B.MOAD GoogleScholar MMDB PDB	PC cid PC sid	PubMed	150.0	-40.51	n/a	n/a	n/a	5.5	37
GNF					Bioorg Med Chem Lett. 16: 5112-7 (2006)
Cathepsin K Homo sapiens (human)	pyrrolidinone analogue, 26 (benzyl N-[(1S)-1-({1-[(2S)-2-{[(benzyloxy)carbonyl...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	180.0	-38.10	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 44: 725-36 (2001)
Cathepsin K Homo sapiens (human)	succinamide peptidomimetic, 27 ((2R)-N-[(2S)-3-methyl-1-{[4-(trifluoromethoxy)phen...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	184.0	-39.99	n/a	n/a	n/a	5.5	37
GNF					Bioorg Med Chem Lett. 17: 2899-903 (2007)
Cathepsin K Homo sapiens (human)	arylaminoethyl amide compound 12 (ethyl (3S)-4-(5-fluoro-2,3-dihydro-1H-indol-1-yl)-...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	184.0	-39.99	n/a	n/a	n/a	5.5	37
GNF					Bioorg Med Chem Lett. 16: 1486-90 (2006)
Cathepsin K Homo sapiens (human)	arylaminoethyl amide, 5c ((2S)-3-cyclohexyl-N-{2-[(4-methoxyphenyl)amino]eth...)	B.MOAD GoogleScholar MMDB PDB	PC cid PC sid	PubMed	205.0	-39.71	n/a	n/a	n/a	5.5	37
GNF					Bioorg Med Chem Lett. 15: 4979-84 (2005)
Cathepsin K Homo sapiens (human)	succinamide peptidomimetic, 19 ((2R)-2-(cyclopentylmethyl)-4-(morpholin-4-yl)-4-ox...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	217.0	-39.56	n/a	n/a	n/a	5.5	37
GNF					Bioorg Med Chem Lett. 17: 2899-903 (2007)
Cathepsin K Homo sapiens (human)	piperidinone analogue, 23 (benzyl N-[(1S)-1-[(1-acetyl-3-oxopiperidin-4-yl)ca...)	B.MOAD GoogleScholar MMDB PDB	CSLS PC cid PC sid	PubMed	230.0	-37.50	n/a	n/a	n/a	5.5	22
GSK					J Med Chem. 44: 725-36 (2001)
Cathepsin K Homo sapiens (human)	arylaminoethyl amide, 5a ((2S)-N-{2-[(4-methoxyphenyl)amino]ethyl}-4,4-dimet...)	B.MOAD GoogleScholar MMDB PDB	PC cid PC sid	PubMed	246.0	-39.24	n/a	n/a	n/a	5.5	37
GNF					Bioorg Med Chem Lett. 15: 4979-84 (2005)

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