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Compile Data Set for Download or QSAR

Found 180 hits of ic50 data for polymerid = 2056,2057   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20242
PNG
(4-[(2S)-2-{[(2S)-1-[(1R,2S,5S)-2-{[(1S)-1-(benzylc...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)CCc1ccccc1)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C42H53N6O10P/c1-26(2)21-35(47-40(52)34(45-37(50)20-15-27-9-5-3-6-10-27)22-28-13-16-31(17-14-28)58-59(55,56)57)42(54)48-25-30-23-32(30)38(48)41(53)46-33(18-19-36(43)49)39(51)44-24-29-11-7-4-8-12-29/h3-14,16-17,26,30,32-35,38H,15,18-25H2,1-2H3,(H2,43,49)(H,44,51)(H,45,50)(H,46,53)(H,47,52)(H2,55,56,57)/t30-,32-,33+,34+,35+,38+/m1/s1
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n/an/a 125n/an/an/an/an/an/a



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20193
PNG
(1, Ac-pTyr-Leu-Pro-Gln-Thr-Val-NH2 | 4-[(2S)-2-{[(...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1S/C36H57N8O13P/c1-18(2)16-26(41-33(50)25(39-21(6)46)17-22-9-11-23(12-10-22)57-58(54,55)56)36(53)44-15-7-8-27(44)34(51)40-24(13-14-28(37)47)32(49)43-30(20(5)45)35(52)42-29(19(3)4)31(38)48/h9-12,18-20,24-27,29-30,45H,7-8,13-17H2,1-6H3,(H2,37,47)(H2,38,48)(H,39,46)(H,40,51)(H,41,50)(H,42,52)(H,43,49)(H2,54,55,56)/t20?,24-,25-,26-,27-,29-,30-/m0/s1
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n/an/a 150n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20211
PNG
(18, Ac-pTyr-Leu-cis-3,4-methanoPro-Gln-Thr-NH2-1 |...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C32H48N7O12P/c1-15(2)11-24(37-30(45)23(35-17(4)41)12-18-5-7-20(8-6-18)51-52(48,49)50)32(47)39-14-19-13-21(19)27(39)31(46)36-22(9-10-25(33)42)29(44)38-26(16(3)40)28(34)43/h5-8,15-16,19,21-24,26-27,40H,9-14H2,1-4H3,(H2,33,42)(H2,34,43)(H,35,41)(H,36,46)(H,37,45)(H,38,44)(H2,48,49,50)/t16?,19-,21-,22+,23+,24+,26+,27+/m1/s1
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n/an/a 265n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20200
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)CCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C38H54N7O12P/c1-22(2)20-29(38(53)45-19-7-10-30(45)37(52)42-27(16-17-31(39)47)35(50)44-33(23(3)46)34(40)49)43-36(51)28(41-32(48)18-13-24-8-5-4-6-9-24)21-25-11-14-26(15-12-25)57-58(54,55)56/h4-6,8-9,11-12,14-15,22-23,27-30,33,46H,7,10,13,16-21H2,1-3H3,(H2,39,47)(H2,40,49)(H,41,48)(H,42,52)(H,43,51)(H,44,50)(H2,54,55,56)/t23?,27-,28-,29-,30-,33-/m0/s1
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n/an/a 276n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20193
PNG
(1, Ac-pTyr-Leu-Pro-Gln-Thr-Val-NH2 | 4-[(2S)-2-{[(...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1S/C36H57N8O13P/c1-18(2)16-26(41-33(50)25(39-21(6)46)17-22-9-11-23(12-10-22)57-58(54,55)56)36(53)44-15-7-8-27(44)34(51)40-24(13-14-28(37)47)32(49)43-30(20(5)45)35(52)42-29(19(3)4)31(38)48/h9-12,18-20,24-27,29-30,45H,7-8,13-17H2,1-6H3,(H2,37,47)(H2,38,48)(H,39,46)(H,40,51)(H,41,50)(H,42,52)(H,43,49)(H2,54,55,56)/t20?,24-,25-,26-,27-,29-,30-/m0/s1
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n/an/a 290n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20253
PNG
(LIFR (1001) derived peptide, 9 | Y(p)KPQMH)
Show SMILES CSCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(N)=O
Show InChI InChI=1S/C38H58N11O12PS/c1-22(50)44-30(18-23-8-10-25(11-9-23)61-62(58,59)60)36(55)47-28(6-3-4-15-39)38(57)49-16-5-7-31(49)37(56)46-26(12-13-32(40)51)34(53)45-27(14-17-63-2)35(54)48-29(33(41)52)19-24-20-42-21-43-24/h8-11,20-21,26-31H,3-7,12-19,39H2,1-2H3,(H2,40,51)(H2,41,52)(H,42,43)(H,44,50)(H,45,53)(H,46,56)(H,47,55)(H,48,54)(H2,58,59,60)/t26-,27-,28-,29-,30-,31-/m0/s1
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n/an/a 400n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20266
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](C)C(N)=O
Show InChI InChI=1S/C34H53N8O13P/c1-17(2)15-25(40-31(48)24(38-20(5)44)16-21-8-10-22(11-9-21)55-56(52,53)54)34(51)42-14-6-7-26(42)32(49)39-23(12-13-27(35)45)30(47)41-28(19(4)43)33(50)37-18(3)29(36)46/h8-11,17-19,23-26,28,43H,6-7,12-16H2,1-5H3,(H2,35,45)(H2,36,46)(H,37,50)(H,38,44)(H,39,49)(H,40,48)(H,41,47)(H2,52,53,54)/t18-,19?,23-,24-,25-,26-,28-/m0/s1
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n/an/a 400n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20233
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-1-(benzylcarbamo...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C34H47N6O10P/c1-21(2)18-28(39-32(44)27(37-22(3)41)19-23-11-13-25(14-12-23)50-51(47,48)49)34(46)40-17-7-10-29(40)33(45)38-26(15-16-30(35)42)31(43)36-20-24-8-5-4-6-9-24/h4-6,8-9,11-14,21,26-29H,7,10,15-20H2,1-3H3,(H2,35,42)(H,36,43)(H,37,41)(H,38,45)(H,39,44)(H2,47,48,49)/t26-,27-,28-,29-/m0/s1
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n/an/a 409n/an/an/an/an/an/a



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20210
PNG
(17, Ac-pTyr-Leu-4-hydroxy-Pro-Gln-Thr-NH2 | 4-[(2S...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1C[C@H](O)C[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C31H48N7O13P/c1-15(2)11-23(36-29(45)22(34-17(4)40)12-18-5-7-20(8-6-18)51-52(48,49)50)31(47)38-14-19(41)13-24(38)30(46)35-21(9-10-25(32)42)28(44)37-26(16(3)39)27(33)43/h5-8,15-16,19,21-24,26,39,41H,9-14H2,1-4H3,(H2,32,42)(H2,33,43)(H,34,40)(H,35,46)(H,36,45)(H,37,44)(H2,48,49,50)/t16?,19-,21+,22+,23+,24+,26+/m1/s1
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n/an/a 484n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20198
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CCC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C32H50N7O12P/c1-5-26(42)35-22(16-19-8-10-20(11-9-19)51-52(48,49)50)30(45)37-23(15-17(2)3)32(47)39-14-6-7-24(39)31(46)36-21(12-13-25(33)41)29(44)38-27(18(4)40)28(34)43/h8-11,17-18,21-24,27,40H,5-7,12-16H2,1-4H3,(H2,33,41)(H2,34,43)(H,35,42)(H,36,46)(H,37,45)(H,38,44)(H2,48,49,50)/t18?,21-,22-,23-,24-,27-/m0/s1
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n/an/a 497n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20234
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)c1ccccc1
Show InChI InChI=1S/C35H49N6O10P/c1-21(2)19-29(40-33(45)28(38-23(4)42)20-24-12-14-26(15-13-24)51-52(48,49)50)35(47)41-18-8-11-30(41)34(46)39-27(16-17-31(36)43)32(44)37-22(3)25-9-6-5-7-10-25/h5-7,9-10,12-15,21-22,27-30H,8,11,16-20H2,1-4H3,(H2,36,43)(H,37,44)(H,38,42)(H,39,46)(H,40,45)(H2,48,49,50)/t22-,27-,28-,29-,30-/m0/s1
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n/an/a 596n/an/an/an/an/an/a



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20195
PNG
(2, Ac-pTyr-Leu-Pro-Gln-Thr-NH2 | 4-[(2S)-2-{[(2S)-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C31H48N7O12P/c1-16(2)14-23(36-29(44)22(34-18(4)40)15-19-7-9-20(10-8-19)50-51(47,48)49)31(46)38-13-5-6-24(38)30(45)35-21(11-12-25(32)41)28(43)37-26(17(3)39)27(33)42/h7-10,16-17,21-24,26,39H,5-6,11-15H2,1-4H3,(H2,32,41)(H2,33,42)(H,34,40)(H,35,45)(H,36,44)(H,37,43)(H2,47,48,49)/t17?,21-,22-,23-,24-,26-/m0/s1
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n/an/a 600n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20205
PNG
(12, Ac-pTyr-Nle-Pro-Gln-Thr-NH2 | 4-[(2S)-2-{[(2S)...)
Show SMILES CCCC[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C31H48N7O12P/c1-4-5-7-22(36-29(44)23(34-18(3)40)16-19-9-11-20(12-10-19)50-51(47,48)49)31(46)38-15-6-8-24(38)30(45)35-21(13-14-25(32)41)28(43)37-26(17(2)39)27(33)42/h9-12,17,21-24,26,39H,4-8,13-16H2,1-3H3,(H2,32,41)(H2,33,42)(H,34,40)(H,35,45)(H,36,44)(H,37,43)(H2,47,48,49)/t17?,21-,22-,23-,24-,26-/m0/s1
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n/an/a 717n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20195
PNG
(2, Ac-pTyr-Leu-Pro-Gln-Thr-NH2 | 4-[(2S)-2-{[(2S)-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C31H48N7O12P/c1-16(2)14-23(36-29(44)22(34-18(4)40)15-19-7-9-20(10-8-19)50-51(47,48)49)31(46)38-13-5-6-24(38)30(45)35-21(11-12-25(32)41)28(43)37-26(17(3)39)27(33)42/h7-10,16-17,21-24,26,39H,5-6,11-15H2,1-4H3,(H2,32,41)(H2,33,42)(H,34,40)(H,35,45)(H,36,44)(H,37,43)(H2,47,48,49)/t17?,21-,22-,23-,24-,26-/m0/s1
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n/an/a 739n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20236
PNG
((2S)-4-carbamoyl-2-{[(2S)-1-[(2S)-2-[(2S)-2-acetam...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(O)=O
Show InChI InChI=1S/C27H40N5O11P/c1-15(2)13-21(26(37)32-12-4-5-22(32)25(36)30-19(27(38)39)10-11-23(28)34)31-24(35)20(29-16(3)33)14-17-6-8-18(9-7-17)43-44(40,41)42/h6-9,15,19-22H,4-5,10-14H2,1-3H3,(H2,28,34)(H,29,33)(H,30,36)(H,31,35)(H,38,39)(H2,40,41,42)/t19-,20-,21-,22-/m0/s1
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PubMed
n/an/a 748n/an/an/an/an/an/a



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20199
PNG
(4-[(2S)-2-{[(benzyloxy)carbonyl]amino}-2-{[(2S)-1-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C37H52N7O13P/c1-21(2)18-28(36(51)44-17-7-10-29(44)35(50)40-26(15-16-30(38)46)33(48)43-31(22(3)45)32(39)47)41-34(49)27(42-37(52)56-20-24-8-5-4-6-9-24)19-23-11-13-25(14-12-23)57-58(53,54)55/h4-6,8-9,11-14,21-22,26-29,31,45H,7,10,15-20H2,1-3H3,(H2,38,46)(H2,39,47)(H,40,50)(H,41,49)(H,42,52)(H,43,48)(H2,53,54,55)/t22?,26-,27-,28-,29-,31-/m0/s1
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PubMed
n/an/a 750n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20265
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1S/C35H55N8O12P/c1-18(2)16-26(41-33(49)25(39-21(6)44)17-22-9-11-23(12-10-22)55-56(52,53)54)35(51)43-15-7-8-27(43)34(50)40-24(13-14-28(36)45)32(48)38-20(5)31(47)42-29(19(3)4)30(37)46/h9-12,18-20,24-27,29H,7-8,13-17H2,1-6H3,(H2,36,45)(H2,37,46)(H,38,48)(H,39,44)(H,40,50)(H,41,49)(H,42,47)(H2,52,53,54)/t20-,24-,25-,26-,27-,29-/m0/s1
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PubMed
n/an/a 800n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20235
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C)c1ccccc1
Show InChI InChI=1S/C35H49N6O10P/c1-21(2)19-29(40-33(45)28(38-23(4)42)20-24-12-14-26(15-13-24)51-52(48,49)50)35(47)41-18-8-11-30(41)34(46)39-27(16-17-31(36)43)32(44)37-22(3)25-9-6-5-7-10-25/h5-7,9-10,12-15,21-22,27-30H,8,11,16-20H2,1-4H3,(H2,36,43)(H,37,44)(H,38,42)(H,39,46)(H,40,45)(H2,48,49,50)/t22-,27+,28+,29+,30+/m1/s1
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n/an/a 801n/an/an/an/an/an/a



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20197
PNG
(4, Benzoyl-pTyr-Leu -Pro-Gln-Thr-NH2 | 4-[(2S)-2-{...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)c1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C36H50N7O12P/c1-20(2)18-27(36(51)43-17-7-10-28(43)35(50)39-25(15-16-29(37)45)33(48)42-30(21(3)44)31(38)46)41-34(49)26(40-32(47)23-8-5-4-6-9-23)19-22-11-13-24(14-12-22)55-56(52,53)54/h4-6,8-9,11-14,20-21,25-28,30,44H,7,10,15-19H2,1-3H3,(H2,37,45)(H2,38,46)(H,39,50)(H,40,47)(H,41,49)(H,42,48)(H2,52,53,54)/t21?,25-,26-,27-,28-,30-/m0/s1
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PubMed
n/an/a 814n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20196
PNG
(3, Ac-pTyr-Leu-Pro-Gln-NH2 | 4-[(2S)-2-{[(2S)-1-[(...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(N)=O
Show InChI InChI=1S/C27H41N6O10P/c1-15(2)13-21(27(39)33-12-4-5-22(33)26(38)31-19(24(29)36)10-11-23(28)35)32-25(37)20(30-16(3)34)14-17-6-8-18(9-7-17)43-44(40,41)42/h6-9,15,19-22H,4-5,10-14H2,1-3H3,(H2,28,35)(H2,29,36)(H,30,34)(H,31,38)(H,32,37)(H2,40,41,42)/t19-,20-,21-,22-/m0/s1
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PubMed
n/an/a 856n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20232
PNG
(39, Ac-pTyr-Leu-Pro-Gln-NHMe | 4-[(2S)-2-{[(2S)-1-...)
Show SMILES CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O
Show InChI InChI=1S/C28H43N6O10P/c1-16(2)14-22(28(40)34-13-5-6-23(34)27(39)32-20(25(37)30-4)11-12-24(29)36)33-26(38)21(31-17(3)35)15-18-7-9-19(10-8-18)44-45(41,42)43/h7-10,16,20-23H,5-6,11-15H2,1-4H3,(H2,29,36)(H,30,37)(H,31,35)(H,32,39)(H,33,38)(H2,41,42,43)/t20-,21-,22-,23-/m0/s1
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PubMed
n/an/a 882n/an/an/an/an/an/a



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20204
PNG
(11, Ac-pTyr-Cha-Pro-Gln-Thr-NH2 | 4-[(2S)-2-{[(2S)...)
Show SMILES CC(O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C34H52N7O12P/c1-19(42)29(30(36)45)40-31(46)24(14-15-28(35)44)38-33(48)27-9-6-16-41(27)34(49)26(18-21-7-4-3-5-8-21)39-32(47)25(37-20(2)43)17-22-10-12-23(13-11-22)53-54(50,51)52/h10-13,19,21,24-27,29,42H,3-9,14-18H2,1-2H3,(H2,35,44)(H2,36,45)(H,37,43)(H,38,48)(H,39,47)(H,40,46)(H2,50,51,52)/t19?,24-,25-,26-,27-,29-/m0/s1
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PubMed
n/an/a 910n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20254
PNG
(4-[(2S)-2-{[(2S)-5-carbamimidamido-1-[(2S)-2-{[(1S...)
Show SMILES CSCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C35H56N11O12PS/c1-19(30(50)43-23(29(37)49)14-17-60-3)41-31(51)24(12-13-28(36)48)44-33(53)27-7-5-16-46(27)34(54)25(6-4-15-40-35(38)39)45-32(52)26(42-20(2)47)18-21-8-10-22(11-9-21)58-59(55,56)57/h8-11,19,23-27H,4-7,12-18H2,1-3H3,(H2,36,48)(H2,37,49)(H,41,51)(H,42,47)(H,43,50)(H,44,53)(H,45,52)(H4,38,39,40)(H2,55,56,57)/t19-,23-,24-,25-,26-,27-/m0/s1
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PubMed
n/an/a 1.00E+3n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20196
PNG
(3, Ac-pTyr-Leu-Pro-Gln-NH2 | 4-[(2S)-2-{[(2S)-1-[(...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(N)=O
Show InChI InChI=1S/C27H41N6O10P/c1-15(2)13-21(27(39)33-12-4-5-22(33)26(38)31-19(24(29)36)10-11-23(28)35)32-25(37)20(30-16(3)34)14-17-6-8-18(9-7-17)43-44(40,41)42/h6-9,15,19-22H,4-5,10-14H2,1-3H3,(H2,28,35)(H2,29,36)(H,30,34)(H,31,38)(H,32,37)(H2,40,41,42)/t19-,20-,21-,22-/m0/s1
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PubMed
n/an/a 1.00E+3n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20202
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CCC(C)[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C31H48N7O12P/c1-5-16(2)25(36-29(44)22(34-18(4)40)15-19-8-10-20(11-9-19)50-51(47,48)49)31(46)38-14-6-7-23(38)30(45)35-21(12-13-24(32)41)28(43)37-26(17(3)39)27(33)42/h8-11,16-17,21-23,25-26,39H,5-7,12-15H2,1-4H3,(H2,32,41)(H2,33,42)(H,34,40)(H,35,45)(H,36,44)(H,37,43)(H2,47,48,49)/t16?,17?,21-,22-,23-,25-,26-/m0/s1
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PubMed
n/an/a 1.07E+3n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20241
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C32H50N7O12P/c1-17(2)15-24(37-29(44)23(35-19(4)41)16-20-8-10-21(11-9-20)51-52(48,49)50)32(47)39-14-6-7-25(39)30(45)36-22(12-13-26(33)42)31(46)38(5)27(18(3)40)28(34)43/h8-11,17-18,22-25,27,40H,6-7,12-16H2,1-5H3,(H2,33,42)(H2,34,43)(H,35,41)(H,36,45)(H,37,44)(H2,48,49,50)/t18?,22-,23-,24-,25-,27-/m0/s1
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n/an/a 1.22E+3n/an/an/an/an/an/a



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20214
PNG
(21, Ac-pTyr-Leu-Pip-Gln-Thr-NH2 | 4-[(2S)-2-{[(2S)...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C32H50N7O12P/c1-17(2)15-24(37-30(45)23(35-19(4)41)16-20-8-10-21(11-9-20)51-52(48,49)50)32(47)39-14-6-5-7-25(39)31(46)36-22(12-13-26(33)42)29(44)38-27(18(3)40)28(34)43/h8-11,17-18,22-25,27,40H,5-7,12-16H2,1-4H3,(H2,33,42)(H2,34,43)(H,35,41)(H,36,46)(H,37,45)(H,38,44)(H2,48,49,50)/t18?,22-,23-,24-,25-,27-/m0/s1
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n/an/a 1.24E+3n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20230
PNG
(37, Ac-pTyr-Leu-Pro-Cmpi-NH2 | 4-[(2S)-2-{[(2S)-1-...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N1CCN(CC(N)=O)CC1
Show InChI InChI=1S/C28H43N6O9P/c1-18(2)15-23(27(38)34-10-4-5-24(34)28(39)33-13-11-32(12-14-33)17-25(29)36)31-26(37)22(30-19(3)35)16-20-6-8-21(9-7-20)43-44(40,41)42/h6-9,18,22-24H,4-5,10-17H2,1-3H3,(H2,29,36)(H,30,35)(H,31,37)(H2,40,41,42)/t22-,23-,24-/m0/s1
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n/an/a 1.40E+3n/an/an/an/an/an/a



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20251
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-1,3-dicarbamoylp...)
Show SMILES CSCC[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(N)=O
Show InChI InChI=1S/C26H39N6O10PS/c1-15(33)29-20(14-16-5-7-17(8-6-16)42-43(39,40)41)24(36)31-19(11-13-44-2)26(38)32-12-3-4-21(32)25(37)30-18(23(28)35)9-10-22(27)34/h5-8,18-21H,3-4,9-14H2,1-2H3,(H2,27,34)(H2,28,35)(H,29,33)(H,30,37)(H,31,36)(H2,39,40,41)/t18-,19-,20-,21-/m0/s1
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n/an/a 1.50E+3n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20201
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C30H46N7O12P/c1-15(2)24(35-28(43)21(33-17(4)39)14-18-7-9-19(10-8-18)49-50(46,47)48)30(45)37-13-5-6-22(37)29(44)34-20(11-12-23(31)40)27(42)36-25(16(3)38)26(32)41/h7-10,15-16,20-22,24-25,38H,5-6,11-14H2,1-4H3,(H2,31,40)(H2,32,41)(H,33,39)(H,34,44)(H,35,43)(H,36,42)(H2,46,47,48)/t16?,20-,21-,22-,24-,25-/m0/s1
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n/an/a 1.54E+3n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20262
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-{[...)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(C)O)C(N)=O
Show InChI InChI=1S/C33H51N8O13P/c1-16(2)26(28(35)45)39-32(49)27(18(4)42)40-29(46)22(12-13-25(34)44)38-31(48)24-7-6-14-41(24)33(50)17(3)36-30(47)23(37-19(5)43)15-20-8-10-21(11-9-20)54-55(51,52)53/h8-11,16-18,22-24,26-27,42H,6-7,12-15H2,1-5H3,(H2,34,44)(H2,35,45)(H,36,47)(H,37,43)(H,38,48)(H,39,49)(H,40,46)(H2,51,52,53)/t17-,18?,22-,23-,24-,26-,27-/m0/s1
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n/an/a 1.60E+3n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20213
PNG
(20, Ac-pTyr-Leu-Azt-Gln-Thr-NH2 | 4-[(2S)-2-{[(2S)...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C30H46N7O12P/c1-15(2)13-22(35-28(43)21(33-17(4)39)14-18-5-7-19(8-6-18)49-50(46,47)48)30(45)37-12-11-23(37)29(44)34-20(9-10-24(31)40)27(42)36-25(16(3)38)26(32)41/h5-8,15-16,20-23,25,38H,9-14H2,1-4H3,(H2,31,40)(H2,32,41)(H,33,39)(H,34,44)(H,35,43)(H,36,42)(H2,46,47,48)/t16?,20-,21-,22-,23-,25-/m0/s1
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n/an/a 1.66E+3n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20231
PNG
(38, Ac-pTyr-Leu-Pro-PyA-NH2 | 4-[(2S)-2-{[(2S)-1-[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N1CCC(CC(N)=O)C1
Show InChI InChI=1S/C28H42N5O9P/c1-17(2)13-23(27(37)33-11-4-5-24(33)28(38)32-12-10-20(16-32)15-25(29)35)31-26(36)22(30-18(3)34)14-19-6-8-21(9-7-19)42-43(39,40)41/h6-9,17,20,22-24H,4-5,10-16H2,1-3H3,(H2,29,35)(H,30,34)(H,31,36)(H2,39,40,41)/t20?,22-,23-,24-/m0/s1
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n/an/a 1.69E+3n/an/an/an/an/an/a



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20224
PNG
(31, Ac-pTyr-Leu-Pro-Gaba | 4-[(2S)-2-{[(2S)-1-[(2S...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)NCCCC(N)=O
Show InChI InChI=1S/C26H40N5O9P/c1-16(2)14-21(26(36)31-13-5-6-22(31)25(35)28-12-4-7-23(27)33)30-24(34)20(29-17(3)32)15-18-8-10-19(11-9-18)40-41(37,38)39/h8-11,16,20-22H,4-7,12-15H2,1-3H3,(H2,27,33)(H,28,35)(H,29,32)(H,30,34)(H2,37,38,39)/t20-,21-,22-/m0/s1
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n/an/a 1.78E+3n/an/an/an/an/an/a



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20237
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-(d...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N(C)C
Show InChI InChI=1S/C29H45N6O10P/c1-17(2)15-23(33-26(38)22(31-18(3)36)16-19-8-10-20(11-9-19)45-46(42,43)44)29(41)35-14-6-7-24(35)27(39)32-21(12-13-25(30)37)28(40)34(4)5/h8-11,17,21-24H,6-7,12-16H2,1-5H3,(H2,30,37)(H,31,36)(H,32,39)(H,33,38)(H2,42,43,44)/t21-,22-,23-,24-/m0/s1
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n/an/a 1.85E+3n/an/an/an/an/an/a



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20209
PNG
(16, Ac-pTyr-Leu-alpha-Me-Pro-Gln-Thr-NH2 | 4-[(2S)...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@@]1(C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C32H50N7O12P/c1-17(2)15-24(36-29(45)23(35-19(4)41)16-20-7-9-21(10-8-20)51-52(48,49)50)30(46)39-14-6-13-32(39,5)31(47)37-22(11-12-25(33)42)28(44)38-26(18(3)40)27(34)43/h7-10,17-18,22-24,26,40H,6,11-16H2,1-5H3,(H2,33,42)(H2,34,43)(H,35,41)(H,36,45)(H,37,47)(H,38,44)(H2,48,49,50)/t18?,22-,23-,24-,26-,32-/m0/s1
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n/an/a 1.87E+3n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20203
PNG
(10, Ac-pTyr-Phe-Pro-Gln-Thr-NH2 | 4-[(2S)-2-{[(2S)...)
Show SMILES CC(O)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(N)=O
Show InChI InChI=1S/C34H46N7O12P/c1-19(42)29(30(36)45)40-31(46)24(14-15-28(35)44)38-33(48)27-9-6-16-41(27)34(49)26(18-21-7-4-3-5-8-21)39-32(47)25(37-20(2)43)17-22-10-12-23(13-11-22)53-54(50,51)52/h3-5,7-8,10-13,19,24-27,29,42H,6,9,14-18H2,1-2H3,(H2,35,44)(H2,36,45)(H,37,43)(H,38,48)(H,39,47)(H,40,46)(H2,50,51,52)/t19?,24-,25-,26-,27-,29-/m0/s1
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n/an/a 1.89E+3n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20272
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-2-carbamoyl-1-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1S/C35H55N8O13P/c1-17(2)14-25(40-31(48)23(38-20(6)45)15-21-9-11-22(12-10-21)56-57(53,54)55)35(52)43-13-7-8-26(43)33(50)39-24(16-27(36)46)32(49)42-29(19(5)44)34(51)41-28(18(3)4)30(37)47/h9-12,17-19,23-26,28-29,44H,7-8,13-16H2,1-6H3,(H2,36,46)(H2,37,47)(H,38,45)(H,39,50)(H,40,48)(H,41,51)(H,42,49)(H2,53,54,55)/t19?,23-,24-,25-,26-,28-,29-/m0/s1
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n/an/a 2.00E+3n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20239
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(2S)-4-carbamoyl-1-ox...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCCC1
Show InChI InChI=1S/C31H47N6O10P/c1-19(2)17-25(35-28(40)24(33-20(3)38)18-21-8-10-22(11-9-21)47-48(44,45)46)31(43)37-16-6-7-26(37)29(41)34-23(12-13-27(32)39)30(42)36-14-4-5-15-36/h8-11,19,23-26H,4-7,12-18H2,1-3H3,(H2,32,39)(H,33,38)(H,34,41)(H,35,40)(H2,44,45,46)/t23-,24-,25-,26-/m0/s1
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n/an/a 2.11E+3n/an/an/an/an/an/a



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20228
PNG
(35, Ac-pTyr-Leu-Pro-Nip-NH2 | 4-[(2S)-2-{[(2S)-1-[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N1CCC(CC1)C(N)=O
Show InChI InChI=1S/C28H42N5O9P/c1-17(2)15-23(27(37)33-12-4-5-24(33)28(38)32-13-10-20(11-14-32)25(29)35)31-26(36)22(30-18(3)34)16-19-6-8-21(9-7-19)42-43(39,40)41/h6-9,17,20,22-24H,4-5,10-16H2,1-3H3,(H2,29,35)(H,30,34)(H,31,36)(H2,39,40,41)/t22-,23-,24-/m0/s1
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n/an/a 3.02E+3n/an/an/an/an/an/a



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20211
PNG
(18, Ac-pTyr-Leu-cis-3,4-methanoPro-Gln-Thr-NH2-1 |...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1C[C@H]2C[C@H]2[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(N)=O
Show InChI InChI=1S/C32H48N7O12P/c1-15(2)11-24(37-30(45)23(35-17(4)41)12-18-5-7-20(8-6-18)51-52(48,49)50)32(47)39-14-19-13-21(19)27(39)31(46)36-22(9-10-25(33)42)29(44)38-26(16(3)40)28(34)43/h5-8,15-16,19,21-24,26-27,40H,9-14H2,1-4H3,(H2,33,42)(H2,34,43)(H,35,41)(H,36,46)(H,37,45)(H,38,44)(H2,48,49,50)/t16?,19-,21-,22+,23+,24+,26+,27+/m1/s1
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n/an/a 3.11E+3n/an/an/an/a7.522



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20263
PNG
(4-[(2S)-2-{[(1S)-1-{[(1S)-1-{[(1S)-3-carbamoyl-1-{...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1S/C34H55N8O13P/c1-16(2)14-24(40-33(50)25(38-20(7)44)15-21-8-10-22(11-9-21)55-56(52,53)54)32(49)37-18(5)30(47)39-23(12-13-26(35)45)31(48)42-28(19(6)43)34(51)41-27(17(3)4)29(36)46/h8-11,16-19,23-25,27-28,43H,12-15H2,1-7H3,(H2,35,45)(H2,36,46)(H,37,49)(H,38,44)(H,39,47)(H,40,50)(H,41,51)(H,42,48)(H2,52,53,54)/t18-,19?,23-,24-,25-,27-,28-/m0/s1
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n/an/a 4.00E+3n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20238
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-3-carbamoyl-1-(d...)
Show SMILES CCN(CC)C(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O
Show InChI InChI=1S/C31H49N6O10P/c1-6-36(7-2)30(42)23(14-15-27(32)39)34-29(41)26-9-8-16-37(26)31(43)25(17-19(3)4)35-28(40)24(33-20(5)38)18-21-10-12-22(13-11-21)47-48(44,45)46/h10-13,19,23-26H,6-9,14-18H2,1-5H3,(H2,32,39)(H,33,38)(H,34,41)(H,35,40)(H2,44,45,46)/t23-,24-,25-,26-/m0/s1
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n/an/a 4.22E+3n/an/an/an/an/an/a



The University of Texas at Houston



Assay Description
Fluorescence polarization (FP) binding assay is utilizing the intrinsic property of the fluorescent probe, which will have low polarization value whe...


J Med Chem 48: 6661-70 (2005)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM50337198
PNG
((S)-3-(((S)-1-((5-(Benzylcarbamoyl)-4'-carbamoyl-[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)c1ccc(cc1)C#N)C(=O)Nc1cc(cc(c1)-c1ccc(cc1)C(N)=O)C(=O)NCc1ccccc1
Show InChI InChI=1S/C44H43N6O9P/c1-27(2)20-38(50-44(55)39(49-42(53)33-12-8-29(25-45)9-13-33)21-28-10-18-37(19-11-28)59-60(56,57)58)43(54)48-36-23-34(31-14-16-32(17-15-31)40(46)51)22-35(24-36)41(52)47-26-30-6-4-3-5-7-30/h3-19,22-24,27,38-39H,20-21,26H2,1-2H3,(H2,46,51)(H,47,52)(H,48,54)(H,49,53)(H,50,55)(H2,56,57,58)/t38-,39-/m0/s1
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Article
PubMed
n/an/a 5.00E+3n/an/an/an/an/an/a



University of Toronto

Curated by ChEMBL


Assay Description
Inhibition of STAT3 dimerization in mouse NIH3T3 cells expressing v-Src assessed as disruption of STAT3-STAT3: DNA complexation in nucleus after 30 m...


Bioorg Med Chem 19: 1823-38 (2011)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20249
PNG
(4-[(2S)-2-{[(1S)-4-carbamimidamido-1-{[(1S)-1-{[(1...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(N)=O
Show InChI InChI=1S/C38H58N13O12P/c1-20(2)31(37(59)51-15-5-7-29(51)32(40)54)50-34(56)26(12-13-30(39)53)48-36(58)28(17-23-18-43-19-45-23)49-33(55)25(6-4-14-44-38(41)42)47-35(57)27(46-21(3)52)16-22-8-10-24(11-9-22)63-64(60,61)62/h8-11,18-20,25-29,31H,4-7,12-17H2,1-3H3,(H2,39,53)(H2,40,54)(H,43,45)(H,46,52)(H,47,57)(H,48,58)(H,49,55)(H,50,56)(H4,41,42,44)(H2,60,61,62)/t25-,26-,27-,28-,29-,31-/m0/s1
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n/an/a 6.00E+3n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20258
PNG
((4S)-4-[(2S)-2-[(2S)-6-amino-2-[(2S)-2-[(2S)-2-ace...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C36H58N9O15P/c1-19(2)16-26(44-36(56)27(40-20(3)47)17-21-7-9-22(10-8-21)60-61(57,58)59)35(55)41-23(6-4-5-15-37)32(52)42-24(11-13-29(38)48)33(53)43-25(12-14-30(49)50)34(54)45-28(18-46)31(39)51/h7-10,19,23-28,46H,4-6,11-18,37H2,1-3H3,(H2,38,48)(H2,39,51)(H,40,47)(H,41,55)(H,42,52)(H,43,53)(H,44,56)(H,45,54)(H,49,50)(H2,57,58,59)/t23-,24-,25-,26-,27-,28-/m0/s1
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n/an/a 6.00E+3n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20252
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-1-{[(1S)-1-{[(1S...)
Show SMILES C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N[C@@H](CCCCN)C(N)=O
Show InChI InChI=1S/C35H55N10O13P/c1-19(31(50)42-23(30(39)49)6-3-4-16-36)40-32(51)24(12-14-28(37)47)43-34(53)27-7-5-17-45(27)35(54)25(13-15-29(38)48)44-33(52)26(41-20(2)46)18-21-8-10-22(11-9-21)58-59(55,56)57/h8-11,19,23-27H,3-7,12-18,36H2,1-2H3,(H2,37,47)(H2,38,48)(H2,39,49)(H,40,51)(H,41,46)(H,42,50)(H,43,53)(H,44,52)(H2,55,56,57)/t19-,23-,24-,25-,26-,27-/m0/s1
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n/an/a 6.00E+3n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20261
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-carbamoylpyrrolidin-1-y...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(N)=O
Show InChI InChI=1S/C22H33N4O8P/c1-13(2)11-18(22(30)26-10-4-5-19(26)20(23)28)25-21(29)17(24-14(3)27)12-15-6-8-16(9-7-15)34-35(31,32)33/h6-9,13,17-19H,4-5,10-12H2,1-3H3,(H2,23,28)(H,24,27)(H,25,29)(H2,31,32,33)/t17-,18-,19-/m0/s1
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n/an/a>6.00E+3n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20264
PNG
(4-[(2S)-2-{[(2S)-1-[(2S)-2-{[(1S)-1-{[(1S,2S)-1-{[...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1S/C34H54N7O12P/c1-17(2)15-25(38-31(46)24(37-21(7)43)16-22-10-12-23(13-11-22)53-54(50,51)52)34(49)41-14-8-9-26(41)32(47)36-19(5)30(45)40-28(20(6)42)33(48)39-27(18(3)4)29(35)44/h10-13,17-20,24-28,42H,8-9,14-16H2,1-7H3,(H2,35,44)(H,36,47)(H,37,43)(H,38,46)(H,39,48)(H,40,45)(H2,50,51,52)/t19-,20?,24-,25-,26-,27-,28-/m0/s1
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n/an/a>6.00E+3n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
Transcription Factor STAT3


(Mus musculus (mouse))
BDBM20271
PNG
((4S)-4-{[(1S,2S)-1-{[(1S)-1-carbamoyl-2-methylprop...)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](C(C)C)C(N)=O
Show InChI InChI=1S/C36H56N7O14P/c1-18(2)16-26(40-33(50)25(38-21(6)45)17-22-9-11-23(12-10-22)57-58(54,55)56)36(53)43-15-7-8-27(43)34(51)39-24(13-14-28(46)47)32(49)42-30(20(5)44)35(52)41-29(19(3)4)31(37)48/h9-12,18-20,24-27,29-30,44H,7-8,13-17H2,1-6H3,(H2,37,48)(H,38,45)(H,39,51)(H,40,50)(H,41,52)(H,42,49)(H,46,47)(H2,54,55,56)/t20?,24-,25-,26-,27-,29-,30-/m0/s1
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n/an/a>6.00E+3n/an/an/an/a7.822



The University of Texas at Houston



Assay Description
His10-Stat3 was expressed in Sf9 cells from a baculovirus encoding the recombinant protein. A nuclear extract of the Sf9 cells was incubated with 32P...


Bioorg Med Chem Lett 13: 633-6 (2003)

More data for this
Ligand-Target Pair
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