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Compile Data Set for Download or QSAR

Found 195 hits of ec50 data for polymerid = 2289   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50127601
PNG
(2-(1H-Imidazol-4-yl)-cyclopropylamine | CHEMBL5938...)
Show SMILES N[C@@H]1C[C@@H]1c1cnc[nH]1
Show InChI InChI=1S/C6H9N3/c7-5-1-4(5)6-2-8-3-9-6/h2-5H,1,7H2,(H,8,9)/t4-,5+/m0/s1
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n/an/an/an/a>0.000100n/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of human Histamine H4 receptor


J Med Chem 46: 1980-8 (2003)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50127604
PNG
(C-[2-(1H-Imidazol-4-yl)-cyclopropyl]-methylamine |...)
Show SMILES NC[C@@H]1C[C@@H]1c1cnc[nH]1
Show InChI InChI=1S/C7H11N3/c8-2-5-1-6(5)7-3-9-4-10-7/h3-6H,1-2,8H2,(H,9,10)/t5-,6-/m0/s1
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n/an/an/an/a>0.000100n/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of human Histamine H4 receptor


J Med Chem 46: 1980-8 (2003)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50127608
PNG
(2-[2-(1H-Imidazol-4-yl)-cyclopropyl]-ethylamine | ...)
Show SMILES NCC[C@H]1C[C@H]1c1cnc[nH]1
Show InChI InChI=1S/C8H13N3/c9-2-1-6-3-7(6)8-4-10-5-11-8/h4-7H,1-3,9H2,(H,10,11)/t6-,7+/m0/s1
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n/an/an/an/a>0.000100n/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of human Histamine H4 receptor


J Med Chem 46: 1980-8 (2003)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50127605
PNG
((1S,2S)-2-(1H-Imidazol-4-yl)-cyclopropylamine | (1...)
Show SMILES N[C@H]1C[C@@H]1c1cnc[nH]1
Show InChI InChI=1S/C6H9N3/c7-5-1-4(5)6-2-8-3-9-6/h2-5H,1,7H2,(H,8,9)/t4-,5-/m0/s1
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n/an/an/an/a>0.000100n/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of human Histamine H4 receptor


J Med Chem 46: 1980-8 (2003)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50127607
PNG
((1R,2R)-2-(1H-Imidazol-4-yl)-cyclopropylamine | (1...)
Show SMILES N[C@@H]1C[C@H]1c1cnc[nH]1
Show InChI InChI=1S/C6H9N3/c7-5-1-4(5)6-2-8-3-9-6/h2-5H,1,7H2,(H,8,9)/t4-,5-/m1/s1
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n/an/an/an/a>0.000100n/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of human Histamine H4 receptor


J Med Chem 46: 1980-8 (2003)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50127606
PNG
(2-(1H-Imidazol-4-yl)-cyclopropylamine | CHEMBL2940...)
Show SMILES N[C@H]1C[C@H]1c1cnc[nH]1
Show InChI InChI=1S/C6H9N3/c7-5-1-4(5)6-2-8-3-9-6/h2-5H,1,7H2,(H,8,9)/t4-,5+/m1/s1
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n/an/an/an/a>0.000100n/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of human Histamine H4 receptor


J Med Chem 46: 1980-8 (2003)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50127602
PNG
(C-[2-(1H-Imidazol-4-yl)-cyclopropyl]-methylamine |...)
Show SMILES NC[C@H]1C[C@H]1c1cnc[nH]1
Show InChI InChI=1S/C7H11N3/c8-2-5-1-6(5)7-3-9-4-10-7/h3-6H,1-2,8H2,(H,9,10)/t5-,6-/m1/s1
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n/an/an/an/a>0.000100n/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of human Histamine H4 receptor


J Med Chem 46: 1980-8 (2003)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50127609
PNG
(C-[2-(1H-Imidazol-4-yl)-cyclopropyl]-methylamine |...)
Show SMILES NC[C@@H]1C[C@H]1c1cnc[nH]1
Show InChI InChI=1S/C7H11N3/c8-2-5-1-6(5)7-3-9-4-10-7/h3-6H,1-2,8H2,(H,9,10)/t5-,6+/m0/s1
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n/an/an/an/a>0.000100n/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of human Histamine H4 receptor


J Med Chem 46: 1980-8 (2003)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50127603
PNG
(C-[2-(1H-Imidazol-4-yl)-cyclopropyl]-methylamine |...)
Show SMILES NC[C@H]1C[C@@H]1c1cnc[nH]1
Show InChI InChI=1S/C7H11N3/c8-2-5-1-6(5)7-3-9-4-10-7/h3-6H,1-2,8H2,(H,9,10)/t5-,6+/m1/s1
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n/an/an/an/a>0.000100n/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of human Histamine H4 receptor


J Med Chem 46: 1980-8 (2003)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50127610
PNG
((1S,2S)-2-(2-aminoethyl)-1-(1H-imidazol-4-yl)cyclo...)
Show SMILES NCC[C@@H]1C[C@@H]1c1cnc[nH]1
Show InChI InChI=1S/C8H13N3/c9-2-1-6-3-7(6)8-4-10-5-11-8/h4-7H,1-3,9H2,(H,10,11)/t6-,7+/m1/s1
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n/an/an/an/a>0.000100n/an/an/an/a



Hokkaido University

Curated by ChEMBL


Assay Description
Inhibition of human Histamine H4 receptor


J Med Chem 46: 1980-8 (2003)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50319300
PNG
(CHEMBL1083162 | N-(2-(1H-imidazol-4-yl)ethyl)-3-(4...)
Show SMILES Cc1cc(OCCCNCCc2cnc[nH]2)ccc1-c1nc2ccc(F)c(C)c2[nH]1
Show InChI InChI=1S/C23H26FN5O/c1-15-12-18(30-11-3-9-25-10-8-17-13-26-14-27-17)4-5-19(15)23-28-21-7-6-20(24)16(2)22(21)29-23/h4-7,12-14,25H,3,8-11H2,1-2H3,(H,26,27)(H,28,29)
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n/an/an/an/a 0.560n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forsko...


Bioorg Med Chem Lett 20: 3367-71 (2010)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50418058
PNG
(CHEMBL1688946)
Show SMILES C(Cc1cnc[nH]1)Cn1cc(CC2CCCCC2)nn1
Show InChI InChI=1S/C15H23N5/c1-2-5-13(6-3-1)9-15-11-20(19-18-15)8-4-7-14-10-16-12-17-14/h10-13H,1-9H2,(H,16,17)
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n/an/an/an/a 1n/an/an/an/a



VU University Amsterdam

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in HEK293 cells assessed by forskolin induced cAMP response element activation by luciferas...


J Med Chem 54: 1693-703 (2011)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50413499
PNG
(CHEMBL465170 | UR-PI295)
Show SMILES CCCC(=O)NC(N)=NCCCc1cnc[nH]1
Show InChI InChI=1S/C11H19N5O/c1-2-4-10(17)16-11(12)14-6-3-5-9-7-13-8-15-9/h7-8H,2-6H2,1H3,(H,13,15)(H3,12,14,16,17)
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n/an/an/an/a 2.60n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415917
PNG
(CHEMBL1096429)
Show SMILES C[C@@H](CC(=O)NC(N)=NCCCc1cnc[nH]1)c1ccccc1
Show InChI InChI=1S/C17H23N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h2-4,6-7,11-13H,5,8-10H2,1H3,(H,19,21)(H3,18,20,22,23)/t13-/m0/s1
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n/an/an/an/a 2.63n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activ...


Bioorg Med Chem Lett 20: 3173-6 (2010)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50413498
PNG
(CHEMBL475621 | UR-PI294)
Show SMILES CCC(=O)NC(N)=NCCCc1cnc[nH]1
Show InChI InChI=1S/C10H17N5O/c1-2-9(16)15-10(11)13-5-3-4-8-6-12-7-14-8/h6-7H,2-5H2,1H3,(H,12,14)(H3,11,13,15,16)
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n/an/an/an/a 3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50319302
PNG
(5-(3-(4-(5-fluoro-4-methyl-1H-benzo[d]imidazol-2-y...)
Show SMILES Cc1cc(OCCCN2CCc3nc[nH]c3C2)ccc1-c1nc2ccc(F)c(C)c2[nH]1
Show InChI InChI=1S/C24H26FN5O/c1-15-12-17(31-11-3-9-30-10-8-20-22(13-30)27-14-26-20)4-5-18(15)24-28-21-7-6-19(25)16(2)23(21)29-24/h4-7,12,14H,3,8-11,13H2,1-2H3,(H,26,27)(H,28,29)
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n/an/an/an/a 3.30n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forsko...


Bioorg Med Chem Lett 20: 3367-71 (2010)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50319295
PNG
(3-(4-(5-fluoro-4-methyl-1H-benzo[d]imidazol-2-yl)-...)
Show SMILES Cc1cc(OCCCNCc2cccnc2)ccc1-c1nc2ccc(F)c(C)c2[nH]1
Show InChI InChI=1S/C24H25FN4O/c1-16-13-19(30-12-4-11-27-15-18-5-3-10-26-14-18)6-7-20(16)24-28-22-9-8-21(25)17(2)23(22)29-24/h3,5-10,13-14,27H,4,11-12,15H2,1-2H3,(H,28,29)
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n/an/an/an/a 3.30n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forsko...


Bioorg Med Chem Lett 20: 3367-71 (2010)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50413500
PNG
(CHEMBL471724 | UR-PI287)
Show SMILES CC(C)C(=O)NC(N)=NCCCc1cnc[nH]1
Show InChI InChI=1S/C11H19N5O/c1-8(2)10(17)16-11(12)14-5-3-4-9-6-13-7-15-9/h6-8H,3-5H2,1-2H3,(H,13,15)(H3,12,14,16,17)
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n/an/an/an/a 3.70n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50061056
PNG
(CHEMBL3393542)
Show SMILES CCCCNc1nccc(n1)N1CC[C@H](C1)NC
Show InChI InChI=1/C13H23N5/c1-3-4-7-15-13-16-8-5-12(17-13)18-9-6-11(10-18)14-2/h5,8,11,14H,3-4,6-7,9-10H2,1-2H3,(H,15,16,17)/t11-/s2
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n/an/an/an/a 4n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated repor...


Bioorg Med Chem Lett 25: 956-9 (2015)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415915
PNG
(CHEMBL1096431)
Show SMILES C[C@@H](CC(=O)NC(N)=NCCCc1cnc[nH]1)C1CCCCC1
Show InChI InChI=1S/C17H29N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h11-14H,2-10H2,1H3,(H,19,21)(H3,18,20,22,23)/t13-/m0/s1
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n/an/an/an/a 4.57n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activ...


Bioorg Med Chem Lett 20: 3173-6 (2010)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50413497
PNG
(CHEMBL443896 | UR-PI288)
Show SMILES CC(=O)NC(N)=NCCCc1cnc[nH]1
Show InChI InChI=1S/C9H15N5O/c1-7(15)14-9(10)12-4-2-3-8-5-11-6-13-8/h5-6H,2-4H2,1H3,(H,11,13)(H3,10,12,14,15)
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n/an/an/an/a 4.90n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50276073
PNG
(CHEMBL502339 | N1-[3-(1H-Imidazol-4-yl)propyl]-N2-...)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1cccs1
Show InChI InChI=1S/C15H21N5OS/c1-11(13-5-3-7-22-13)8-14(21)20-15(16)18-6-2-4-12-9-17-10-19-12/h3,5,7,9-11H,2,4,6,8H2,1H3,(H,17,19)(H3,16,18,20,21)
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n/an/an/an/a 6.30n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-s...


J Med Chem 51: 7193-204 (2009)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50319307
PNG
((+/-)-3-(4-(5-fluoro-4-methyl-1H-benzo[d]imidazol-...)
Show SMILES Cc1cc(OCCCNCC2CCCNC2)ccc1-c1nc2ccc(F)c(C)c2[nH]1
Show InChI InChI=1S/C24H31FN4O/c1-16-13-19(30-12-4-11-27-15-18-5-3-10-26-14-18)6-7-20(16)24-28-22-9-8-21(25)17(2)23(22)29-24/h6-9,13,18,26-27H,3-5,10-12,14-15H2,1-2H3,(H,28,29)
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n/an/an/an/a 6.90n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor in SK-N-MC cells assessed as forskolin-stimulated cAMP release preincubated for 10 mins before forsko...


Bioorg Med Chem Lett 20: 3367-71 (2010)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50413503
PNG
(CHEMBL514641 | UR-PI141)
Show SMILES NC(NC(=O)CCc1c[nH]c2ccccc12)=NCCCc1cnc[nH]1
Show InChI InChI=1S/C18H22N6O/c19-18(21-9-3-4-14-11-20-12-23-14)24-17(25)8-7-13-10-22-16-6-2-1-5-15(13)16/h1-2,5-6,10-12,22H,3-4,7-9H2,(H,20,23)(H3,19,21,24,25)
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n/an/an/an/a 7.10n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50121205
PNG
(CHEBI:18295 | HISTAMINE | Histamine)
Show SMILES NCCc1c[nH]cn1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 7.90n/an/an/an/a



Friedrich-Alexander-Universit£t Erlangen-N£rnberg

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine 4 receptor expressed in Sf9 cell membranes co-expressing Galphai2 and Gbeta1gamma2 assessed as [35S]GTPgammaS ...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50413501
PNG
(CHEMBL325327 | SK&F-91486 | SK-91486)
Show SMILES NC(N)=NCCCc1cnc[nH]1
Show InChI InChI=1S/C7H13N5/c8-7(9)11-3-1-2-6-4-10-5-12-6/h4-5H,1-3H2,(H,10,12)(H4,8,9,11)
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n/an/an/an/a 8.10n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415916
PNG
(CHEMBL1096430)
Show SMILES C[C@H](CC(=O)NC(N)=NCCCc1cnc[nH]1)C1CCCCC1
Show InChI InChI=1S/C17H29N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h11-14H,2-10H2,1H3,(H,19,21)(H3,18,20,22,23)/t13-/m1/s1
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n/an/an/an/a 8.32n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activ...


Bioorg Med Chem Lett 20: 3173-6 (2010)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50394694
PNG
(CHEMBL2165642)
Show SMILES NC(NC(=O)CCCCCCCCC(=O)NC(=N)NCCCc1cnc[nH]1)=NCCCc1cnc[nH]1
Show InChI InChI=1S/C24H40N10O2/c25-23(29-13-7-9-19-15-27-17-31-19)33-21(35)11-5-3-1-2-4-6-12-22(36)34-24(26)30-14-8-10-20-16-28-18-32-20/h15-18H,1-14H2,(H,27,31)(H,28,32)(H3,25,29,33,35)(H3,26,30,34,36)
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n/an/an/an/a 8.51n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay


J Med Chem 55: 1147-60 (2012)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50394703
PNG
(CHEMBL2165628)
Show SMILES Cc1nc(N)sc1CCCN=C(N)NC(=O)CCCCCCCCC(=O)NC(N)=NCCCc1cnc[nH]1
Show InChI InChI=1S/C25H42N10O2S/c1-18-20(38-25(28)33-18)11-9-15-31-24(27)35-22(37)13-7-5-3-2-4-6-12-21(36)34-23(26)30-14-8-10-19-16-29-17-32-19/h16-17H,2-15H2,1H3,(H2,28,33)(H,29,32)(H3,26,30,34,36)(H3,27,31,35,37)
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n/an/an/an/a 8.51n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4R-RGS19 Galphai2 Gbeta1gamma2 expressed in Sf9 cells at 0.1 nM to 1 mM by steady state GTPase activity assay


J Med Chem 55: 1147-60 (2012)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50275884
PNG
(CHEMBL471413 | N1-(3,3-Diphenylpropanoyl)-N2-[3-(1...)
Show SMILES NC(NC(=O)CC(c1ccccc1)c1ccccc1)=NCCCc1cnc[nH]1
Show InChI InChI=1S/C22H25N5O/c23-22(25-13-7-12-19-15-24-16-26-19)27-21(28)14-20(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-6,8-11,15-16,20H,7,12-14H2,(H,24,26)(H3,23,25,27,28)
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n/an/an/an/a 8.60n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-s...


J Med Chem 51: 7193-204 (2009)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM7966
PNG
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Show SMILES NCCc1cnc[nH]1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 9.12n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activ...


Bioorg Med Chem Lett 20: 3173-6 (2010)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50170126
PNG
(CHEMBL3805361)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@H]1CC[C@@H](C1)c1c[nH]cn1
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/s2
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n/an/an/an/a 11n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50121205
PNG
(CHEBI:18295 | HISTAMINE | Histamine)
Show SMILES NCCc1c[nH]cn1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 11n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50343016
PNG
(CHEMBL1770966 | N2-cyclopentyl-4-(4-methylpiperazi...)
Show SMILES CN1CCN(CC1)c1cc(N)nc(NC2CCCC2)c1
Show InChI InChI=1S/C15H25N5/c1-19-6-8-20(9-7-19)13-10-14(16)18-15(11-13)17-12-4-2-3-5-12/h10-12H,2-9H2,1H3,(H3,16,17,18)
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n/an/an/an/a 11n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM7966
PNG
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Show SMILES NCCc1cnc[nH]1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 11.6n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-s...


J Med Chem 51: 7193-204 (2009)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50342987
PNG
(CHEMBL1770998 | N4-isopropyl-6-(4-methylpiperazin-...)
Show SMILES CC(C)Nc1cc(nc(N)n1)N1CCN(C)CC1
Show InChI InChI=1S/C12H22N6/c1-9(2)14-10-8-11(16-12(13)15-10)18-6-4-17(3)5-7-18/h8-9H,4-7H2,1-3H3,(H3,13,14,15,16)
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n/an/an/an/a 12n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM7966
PNG
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Show SMILES NCCc1cnc[nH]1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 12n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM7966
PNG
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Show SMILES NCCc1cnc[nH]1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 12.0n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in Sf9 cells coexpressing RGS19 protein by steady-state GTPase assay


J Med Chem 52: 6297-313 (2009)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM22911
PNG
(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Show SMILES NC(=N)SCCc1cnc[nH]1
Show InChI InChI=1S/C6H10N4S/c7-6(8)11-2-1-5-3-9-4-10-5/h3-4H,1-2H2,(H3,7,8)(H,9,10)
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n/an/an/an/a 12.6n/an/an/an/a


TBA

Assay Description
Agonist activity at human histamine H4 receptor


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50121205
PNG
(CHEBI:18295 | HISTAMINE | Histamine)
Show SMILES NCCc1c[nH]cn1
Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8)
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n/an/an/an/a 13n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human SF-His6-tagged histamine H4 receptor expressed in HEK293 cells assessed as inhibition of forskolin-stimulated response incu...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50170126
PNG
(CHEMBL3805361)
Show SMILES N#C\N=C(\NCCSc1ccccc1)NC[C@H]1CC[C@@H](C1)c1c[nH]cn1
Show InChI InChI=1/C19H24N6S/c20-13-24-19(22-8-9-26-17-4-2-1-3-5-17)23-11-15-6-7-16(10-15)18-12-21-14-25-18/h1-5,12,14-16H,6-11H2,(H,21,25)(H2,22,23,24)/t15-,16-/s2
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n/an/an/an/a 14n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50170122
PNG
(CHEMBL3806255)
Show SMILES CC(C)CN\C(NC[C@H]1CC[C@@H](C1)c1c[nH]cn1)=N\C#N
Show InChI InChI=1/C15H24N6/c1-11(2)6-18-15(20-9-16)19-7-12-3-4-13(5-12)14-8-17-10-21-14/h8,10-13H,3-7H2,1-2H3,(H,17,21)(H2,18,19,20)/t12-,13-/s2
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n/an/an/an/a 15n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in sf9 cell membrane co-expressing mammalian Galphai2 and Gbeta1gamma2 incubated for 90 min...


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50377986
PNG
(CHEMBL483406 | UR-AK24)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1ccccc1
Show InChI InChI=1S/C17H23N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h2-4,6-7,11-13H,5,8-10H2,1H3,(H,19,21)(H3,18,20,22,23)
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n/an/an/an/a 15n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50061060
PNG
(CHEMBL3393539)
Show SMILES CN[C@@H]1CCN(C1)c1ccnc(NCC(C)C)n1
Show InChI InChI=1/C13H23N5/c1-10(2)8-16-13-15-6-4-12(17-13)18-7-5-11(9-18)14-3/h4,6,10-11,14H,5,7-9H2,1-3H3,(H,15,16,17)/t11-/s2
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n/an/an/an/a 15n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated repor...


Bioorg Med Chem Lett 25: 956-9 (2015)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50377986
PNG
(CHEMBL483406 | UR-AK24)
Show SMILES CC(CC(=O)NC(N)=NCCCc1cnc[nH]1)c1ccccc1
Show InChI InChI=1S/C17H23N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h2-4,6-7,11-13H,5,8-10H2,1H3,(H,19,21)(H3,18,20,22,23)
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n/an/an/an/a 15.3n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant histamine H4 receptor-RGS4 fusion protein expressed in Sf9 cells coexpressing Galphai2 and G-beta-1-gamma-2 by steady-s...


J Med Chem 51: 7193-204 (2009)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM22542
PNG
(4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...)
Show SMILES C(C1CCNCC1)c1cnc[nH]1
Show InChI InChI=1S/C9H15N3/c1-3-10-4-2-8(1)5-9-6-11-7-12-9/h6-8,10H,1-5H2,(H,11,12)
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n/an/an/an/a 15.8n/an/an/an/a


TBA

Assay Description
Agonist activity at human histamine H4 receptor


Citation and Details
More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50343002
PNG
(CHEMBL1770987 | N2-cyclopentyl-6-(4-methylpiperazi...)
Show SMILES CN1CCN(CC1)c1cc(N)nc(NC2CCCC2)n1
Show InChI InChI=1S/C14H24N6/c1-19-6-8-20(9-7-19)13-10-12(15)17-14(18-13)16-11-4-2-3-5-11/h10-11H,2-9H2,1H3,(H3,15,16,17,18)
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n/an/an/an/a 16n/an/an/an/a



Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human histamine H4 receptor expressed in human SK-N-MC cells assessed as effect on forskolin-induced cAMP accumulation after 6 hr...


Bioorg Med Chem Lett 21: 3113-6 (2011)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50413502
PNG
(CHEMBL474447 | UR-PI104)
Show SMILES NC(NC(=O)Cc1c[nH]c2ccccc12)=NCCCc1cnc[nH]1
Show InChI InChI=1S/C17H20N6O/c18-17(20-7-3-4-13-10-19-11-22-13)23-16(24)8-12-9-21-15-6-2-1-5-14(12)15/h1-2,5-6,9-11,21H,3-4,7-8H2,(H,19,22)(H3,18,20,23,24)
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n/an/an/an/a 19n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human H4 receptor expressed in insect Sf9 cells co-expressing RGS19 fusion protein and Gialpha2, Gbeta1gamma2 assessed as gamma[3...


J Med Chem 52: 2623-7 (2009)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50061018
PNG
(CHEMBL3393546)
Show SMILES CN1CCN(CC1)c1ccnc(NC2CC3CCC2C3)n1
Show InChI InChI=1/C16H25N5/c1-20-6-8-21(9-7-20)15-4-5-17-16(19-15)18-14-11-12-2-3-13(14)10-12/h4-5,12-14H,2-3,6-11H2,1H3,(H,17,18,19)
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n/an/an/an/a 20n/an/an/an/a



Janssen Pharmaceutical Research& Development, LLC

Curated by ChEMBL


Assay Description
Agonist activity at human recombinant histamine H4 receptor expressed in SK-N-MC cells assessed as effect on forskolin-stimulated cAMP-mediated repor...


Bioorg Med Chem Lett 25: 956-9 (2015)

More data for this
Ligand-Target Pair
Histamine receptor (H4)


(Homo sapiens (human))
BDBM50415918
PNG
(CHEMBL1096428)
Show SMILES C[C@H](CC(=O)NC(N)=NCCCc1cnc[nH]1)c1ccccc1
Show InChI InChI=1S/C17H23N5O/c1-13(14-6-3-2-4-7-14)10-16(23)22-17(18)20-9-5-8-15-11-19-12-21-15/h2-4,6-7,11-13H,5,8-10H2,1H3,(H,19,21)(H3,18,20,22,23)/t13-/m1/s1
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n/an/an/an/a 22.9n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Activity at human recombinant GAIP-fused histamine H4 receptor expressed in Sf9 cells coexpressing Galphai, Gbeta1gamma2 by steady-state GTPase activ...


Bioorg Med Chem Lett 20: 3173-6 (2010)

More data for this
Ligand-Target Pair
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