Compile Data Set for Download or QSAR
maximum 50k data
Found 297 of ec50 for UniProtKB: A0A024R6A3
TargetPresenilin-1(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50521243(CHEMBL4532868)
Affinity DataEC50:  0.00590nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50521238(CHEMBL4589937)
Affinity DataEC50:  0.00640nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50521241(CHEMBL4456936)
Affinity DataEC50:  0.00920nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50521242(CHEMBL4456488)
Affinity DataEC50:  0.0103nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50521239(CHEMBL4443026)
Affinity DataEC50:  0.0114nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50521244(CHEMBL4525398)
Affinity DataEC50:  0.0117nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50521245(CHEMBL4547187)
Affinity DataEC50:  0.0130nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50521240(CHEMBL4535601)
Affinity DataEC50:  0.0139nMAssay Description:Inhibition of gamma-secretase (unknown origin) assessed as decrease in amyloid beta-42 secretion by cell based AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM29005((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  0.0600nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM29004((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  0.0600nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50241259((2S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetam...)
Affinity DataEC50:  0.114nMAssay Description:Reduction of human wild type PS1-induced amyloid beta40 level in CHO cells overexpressing human APP751 after 24 hrs by liquid phase electrochemilumin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50241259((2S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetam...)
Affinity DataEC50:  0.135nMAssay Description:Reduction of human wild type PS1-induced amyloid beta42 level in CHO cells overexpressing human APP751 after 24 hrs by liquid phase electrochemilumin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28989(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataEC50:  0.150nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28987(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataEC50:  0.25nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM29011((2R)-2-[(4-chlorobenzene)(2,5-dichlorophenyl)sulfo...)
Affinity DataEC50:  0.270nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM29012(N-[(4R)-4-{[5-chloro-2-(hydroxymethyl)phenyl](4-ch...)
Affinity DataEC50:  0.320nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28980(1-[({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoro...)
Affinity DataEC50:  0.360nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM29009((2R)-2-[(4-chlorobenzene)(2,5-dichlorophenyl)sulfo...)
Affinity DataEC50:  0.410nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM29010((2R)-2-[(4-chlorobenzene)(2,5-dichlorophenyl)sulfo...)
Affinity DataEC50:  0.480nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28966(cyclohexyl sulfone-based compound, 9 | {4-[(4-chlo...)
Affinity DataEC50:  0.510nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM29013(4-chloro-N-[5-chloro-2-(hydroxymethyl)phenyl]-N-[(...)
Affinity DataEC50:  0.510nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28976(2-{1-[(4-chlorobenzene)sulfonyl]-4-{[(2-methoxyben...)
Affinity DataEC50:  0.510nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28986(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataEC50:  0.650nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
LigandPNGBDBM28975(2-[({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoro...)
Affinity DataEC50:  0.650nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28988(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataEC50:  0.660nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM29008((2R)-2-[(5-chloro-2-fluorophenyl)(4-chlorobenzene)...)
Affinity DataEC50:  0.660nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28985(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataEC50:  0.820nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM29001((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  0.930nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28968(({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluorophe...)
Affinity DataEC50:  1nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28971(1-({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluorop...)
Affinity DataEC50:  1nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28979(cyclohexyl sulfone-based compound, 23 | {4-[(4-chl...)
Affinity DataEC50:  1.10nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM29007((2R)-2-[(4-chlorobenzene)(2,5-difluorophenyl)sulfo...)
Affinity DataEC50:  1.20nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28967(N-({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluorop...)
Affinity DataEC50:  1.30nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28972(2-{1-[(4-chlorobenzene)sulfonyl]-4-[(cyclopropanes...)
Affinity DataEC50:  1.40nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28970([({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataEC50:  1.70nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM29000((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  1.80nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28982(cyclohexyl sulfone-based compound, 28 | {4-[(4-chl...)
Affinity DataEC50:  1.90nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28977(2-[({4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoro...)
Affinity DataEC50:  2.10nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28994((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  2.10nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28969(cyclohexyl sulfone-based compound, 12 | methyl N-(...)
Affinity DataEC50:  2.20nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28993((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  2.30nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM29002((3R)-3-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  4nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28978(cyclohexyl sulfone-based compound, 22 | {4-[(4-chl...)
Affinity DataEC50:  4.20nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28984(N-{4-[(4-chlorobenzene)sulfonyl]-4-(2,5-difluoroph...)
Affinity DataEC50:  4.20nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28962(cyclohexyl sulfone-based compound, 5 | {4-[(4-chlo...)
Affinity DataEC50:  4.70nMAssay Description:A whole-cell gamma-secretase inhibition assay using SHSY5Y neuroblastoma cells in which human gamma-secretase catalyzes the breakdown of the overexpr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50577524(CHEMBL4862666)
Affinity DataEC50:  5nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing human wild type APP751 assessed as reduction in amyloid beta42 level incubated overnight b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50533417(RO 4929097 | RO-4929097 | Rg 4733 | Rg-4733 | Ro49...)
Affinity DataEC50:  5nMAssay Description:Inhibition of gamma secretase mediated Notch1 signaling in HEK293 cells expressing truncated human Notch1 by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50465355(CHEMBL4285214 | US10669276, Example 1)
Affinity DataEC50:  5nMAssay Description:Inhibition of gamma-secretase in human H4 cells harboring APP695 K595N/M596L swedish mutant after 24 hrs by AlphaLisa assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM28997((2R)-2-{[5-chloro-2-(hydroxymethyl)phenyl](4-chlor...)
Affinity DataEC50:  5.60nMAssay Description:H4 human neuroglioma cells expressing beta-APP were aliquoted into a 96-well plate, and after attachment the medium was replaced with the conditioned...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50534353(CHEMBL4578751)
Affinity DataEC50:  6nMAssay Description:Modulation of gamma-secretase in human H4 cells expressing APP Swedish mutant assessed as inhibition of amyloid beta (1 to 42 residues) productionMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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