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Compile Data Set for Download or QSAR

Found 22 hits of ic50 data for polymerid = 256   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic initiation factor 4A-III


(Human)
BDBM65493
PNG
(eIF4A3 inhibitor, 2)
Show SMILES Clc1ccc(cc1)[C@H]1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1cnn2cc(Br)ccc12
Show InChI InChI=1S/C25H19Br2ClN4O2/c26-18-5-1-17(2-6-18)24(33)31-12-11-30(15-23(31)16-3-8-20(28)9-4-16)25(34)21-13-29-32-14-19(27)7-10-22(21)32/h1-10,13-14,23H,11-12,15H2/t23-/m1/s1
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n/an/a 110n/an/an/an/an/an/a



BC Cancer Agency



Assay Description
Inhibitory activity was assessed under the following conditions: 350 uM ATP/1.5 ug mL−1 RNA indicated by black; 35 uM ATP/1.5 ug mL−1 RNA...


ACS Chem Biol 12: 1760-1768 (2017)


Article DOI: 10.1021/acschembio.7b00041
BindingDB Entry DOI: 10.7270/Q2T151TG
More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Human)
BDBM50235737
PNG
(CHEMBL4070102)
Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O
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n/an/a 360n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 expressed in Escherichia coli BL21(DE3) using 1.5 ug/ml ...


Bioorg Med Chem 25: 2200-2209 (2017)

More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Human)
BDBM50235737
PNG
(CHEMBL4070102)
Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1F)C(O)=O
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n/an/a 970n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...


Bioorg Med Chem 25: 2200-2209 (2017)

More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Human)
BDBM50235741
PNG
(CHEMBL4099717)
Show SMILES CC(C)c1cc(Cl)c2cc([nH]c2c1)C(O)=O
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n/an/a 1.90E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...


Bioorg Med Chem 25: 2200-2209 (2017)

More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Human)
BDBM65492
PNG
(eIF4A3 inhibitor, 1)
Show SMILES Clc1ccc(cc1)C1CN(CCN1C(=O)c1ccc(Cl)cc1)C(=O)c1cnc(o1)-c1ccccc1
Show InChI InChI=1S/C27H21Cl2N3O3/c28-21-10-6-18(7-11-21)23-17-31(14-15-32(23)26(33)20-8-12-22(29)13-9-20)27(34)24-16-30-25(35-24)19-4-2-1-3-5-19/h1-13,16,23H,14-15,17H2
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n/an/a 2.20E+3n/an/an/an/an/an/a



BC Cancer Agency



Assay Description
Inhibitory activity was assessed under the following conditions: 350 uM ATP/1.5 ug mL−1 RNA indicated by black; 35 uM ATP/1.5 ug mL−1 RNA...


ACS Chem Biol 12: 1760-1768 (2017)


Article DOI: 10.1021/acschembio.7b00041
BindingDB Entry DOI: 10.7270/Q2T151TG
More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Human)
BDBM50235795
PNG
(CHEMBL4089069)
Show SMILES CC(C)c1cc(F)c2cc([nH]c2c1)C(O)=O
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n/an/a 5.00E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...


Bioorg Med Chem 25: 2200-2209 (2017)

More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Human)
BDBM50235740
PNG
(CHEMBL4061441)
Show SMILES CC(C)c1ccc2cc([nH]c2c1F)C(O)=O
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n/an/a 6.90E+3n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Antagonism of batrachotoxin-mediated sodium ion uptake into cultured neuroblastoma cells


Bioorg Med Chem 25: 2200-2209 (2017)

More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Human)
BDBM50235794
PNG
(CHEMBL4067856)
Show SMILES CC(C)c1ccc2c(F)c([nH]c2c1)C(O)=O
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n/an/a 2.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Compound was evaluated for the binding affinity towards Opioid receptor delta 1 in rat brain homogenates using [3H]naltrindole as radioligand


Bioorg Med Chem 25: 2200-2209 (2017)

More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Human)
BDBM50235739
PNG
(CHEMBL4079731)
Show SMILES CC(C)c1ccc2cc([nH]c2c1)C(O)=O
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n/an/a 2.70E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...


Bioorg Med Chem 25: 2200-2209 (2017)

More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Human)
BDBM50235792
PNG
(CHEMBL4101109)
Show SMILES CC(C)c1ccc2cc([nH]c2c1)-c1nnn[nH]1
Show InChI InChI=1S/C12H11N5/c1-7(2)8-3-4-9-6-11(13-10(9)5-8)12-14-16-17-15-12/h3-7H,1-2H3
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n/an/a 3.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...


Bioorg Med Chem 25: 2200-2209 (2017)

More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Human)
BDBM50235796
PNG
(CHEMBL4081704)
Show SMILES CC(C)c1cc2[nH]c(cc2cc1F)C(O)=O
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n/an/a 3.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Antagonism of batrachotoxin-mediated sodium ion uptake into cultured neuroblastoma cells


Bioorg Med Chem 25: 2200-2209 (2017)

More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Human)
BDBM50235738
PNG
(HIPPURISTANOL | Hippuristanol)
Show SMILES C[C@H]1C[C@@]2(O[C@H]3C[C@H]4[C@@H]5CC[C@H]6C[C@H](O)CC[C@]6(C)[C@H]5[C@@H](O)C[C@]4(C)[C@H]3[C@@]2(C)O)OC1(C)C
Show InChI InChI=1S/C28H46O5/c1-15-13-28(33-24(15,2)3)27(6,31)23-21(32-28)12-19-18-8-7-16-11-17(29)9-10-25(16,4)22(18)20(30)14-26(19,23)5/h15-23,29-31H,7-14H2,1-6H3/t15-,16-,17+,18-,19-,20-,21-,22+,23-,25-,26-,27+,28+/m0/s1
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n/an/a 4.00E+4n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...


Bioorg Med Chem 25: 2200-2209 (2017)

More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Human)
BDBM65494
PNG
(eIF4A3 inhibitor, 3)
Show SMILES Clc1ccc(cc1)[C@@H]1CN(CCN1C(=O)c1ccc(Br)cc1)C(=O)c1cnn2cc(Br)ccc12
Show InChI InChI=1S/C25H19Br2ClN4O2/c26-18-5-1-17(2-6-18)24(33)31-12-11-30(15-23(31)16-3-8-20(28)9-4-16)25(34)21-13-29-32-14-19(27)7-10-22(21)32/h1-10,13-14,23H,11-12,15H2/t23-/m0/s1
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n/an/a 6.00E+4n/an/an/an/an/an/a



BC Cancer Agency



Assay Description
Inhibitory activity was assessed under the following conditions: 350 uM ATP/1.5 ug mL−1 RNA indicated by black; 35 uM ATP/1.5 ug mL−1 RNA...


ACS Chem Biol 12: 1760-1768 (2017)


Article DOI: 10.1021/acschembio.7b00041
BindingDB Entry DOI: 10.7270/Q2T151TG
More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Human)
BDBM50235791
PNG
(CHEMBL4084655)
Show SMILES CC(C)c1ccc2cc([nH]c2c1)C(N)=O
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Compound was evaluated for the binding affinity towards Opioid receptor delta 1 in rat brain homogenates using [3H]DIDI as radioligand


Bioorg Med Chem 25: 2200-2209 (2017)

More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Human)
BDBM50305666
PNG
(6-methyl-1H-indole-2-carboxylic acid | CHEMBL59600...)
Show SMILES Cc1ccc2cc([nH]c2c1)C(O)=O
Show InChI InChI=1S/C10H9NO2/c1-6-2-3-7-5-9(10(12)13)11-8(7)4-6/h2-5,11H,1H3,(H,12,13)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Ability to displace radioligand [3H]N-0437 from human dopamine D2 receptor transfected chinese hamster ovary cell membranes.


Bioorg Med Chem 25: 2200-2209 (2017)

More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Human)
BDBM50235793
PNG
(CHEMBL4074367)
Show SMILES CC(C)c1ccc2cc(C(O)=O)n(C)c2c1
Show InChI InChI=1S/C13H15NO2/c1-8(2)9-4-5-10-7-12(13(15)16)14(3)11(10)6-9/h4-8H,1-3H3,(H,15,16)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...


Bioorg Med Chem 25: 2200-2209 (2017)

More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Human)
BDBM50235789
PNG
(CHEMBL4075940)
Show SMILES CC(C)c1cccc2cc([nH]c12)C(O)=O
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...


Bioorg Med Chem 25: 2200-2209 (2017)

More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Human)
BDBM50235742
PNG
(CHEMBL4082138)
Show SMILES CCc1ccc2cc([nH]c2c1)C(O)=O
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Ability to displace radioligand [3H]N-0437 from human dopamine D2 receptor transfected chinese hamster ovary cell membranes.


Bioorg Med Chem 25: 2200-2209 (2017)

More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Human)
BDBM50235797
PNG
(CHEMBL4089574)
Show SMILES CC(C)c1ccc2cc([nH]c2c1Cl)C(O)=O
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...


Bioorg Med Chem 25: 2200-2209 (2017)

More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Human)
BDBM50235744
PNG
(CHEMBL4071613)
Show SMILES CC(C)c1ccc2[nH]c(cc2c1)C(O)=O
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...


Bioorg Med Chem 25: 2200-2209 (2017)

More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Human)
BDBM50235790
PNG
(CHEMBL4062984)
Show SMILES COC(=O)c1cc2ccc(cc2[nH]1)C(C)C
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Compound was evaluated for the binding affinity towards Opioid receptor delta 1 in rat brain homogenates using [3H]DIDI as radioligand


Bioorg Med Chem 25: 2200-2209 (2017)

More data for this
Ligand-Target Pair
Eukaryotic initiation factor 4A-III


(Human)
BDBM50235743
PNG
(CHEMBL23134)
Show SMILES OC(=O)c1cc2ccc(Cl)cc2[nH]1
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n/an/a>1.00E+5n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

Curated by ChEMBL


Assay Description
Inhibition of MLN51-induced full length recombinant human N-terminal His6/SUMO-tagged eIF4A3 RNA dependent ATPase activity expressed in Escherichia c...


Bioorg Med Chem 25: 2200-2209 (2017)

More data for this
Ligand-Target Pair