Compile Data Set for Download or QSAR
maximum 50k data
Found 1805 of ic50 data for polymerid = 2619
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM575655((S)-(6-((2-amino-3-chloropyridin-4-yl)thio)- 3-(5-...)
Affinity DataIC50:  0.600nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM497145(US11001561, Compound 119b | US11702392, Compound 1...)
Affinity DataIC50:  0.800nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM575622((6-((2-amino-3-chloropyridin-4-yl)thio)-3- ((3S,4S...)
Affinity DataIC50:  0.900nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM503414((5P)-6-amino-2-[(1S)-1-amino-1,3- dihydrospiro[ind...)
Affinity DataIC50:  1nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM497088(US11001561, Compound 74a | US11702392, Compound 10...)
Affinity DataIC50:  1nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM503416((5M)-2-[(1S)-1-amino-1,3- dihydrospiro[indene-2,4'...)
Affinity DataIC50:  1nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM497078(US11001561, Compound 66b | US11702392, Compound 66...)
Affinity DataIC50:  1nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM527818((2R,4R)-4-amino-8- (8-((2,3- dichlorophenyl)thio) ...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM497106(US11001561, Compound 81b | US11702392, Compound 81...)
Affinity DataIC50:  1.40nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM527838((3S,4S)-8-(8- ((2,3- dichlorophenyl) thio)imidazo[...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM527920((S)-1'-(8- (thieno[3,2- b]pyridin-7- ylthio)imidaz...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM527927((S)-1'-(8-((2,3- dichlorophenyl)thio) imidazo[1,2-...)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM527922((S)-1'-(8-((2- (methylthio)phenyl) thio)imidazo[1,...)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM497134(US11001561, Compound 109 | US11702392, Compound 10...)
Affinity DataIC50:  2nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM479328((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  2nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM503416((5M)-2-[(1S)-1-amino-1,3- dihydrospiro[indene-2,4'...)
Affinity DataIC50:  2nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM497135(US11001561, Compound 110 | US11702392, Compound 11...)
Affinity DataIC50:  2nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM479328((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  2nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM527868((S)-1'-(8-((2,3- dichlorophenyl)thio) imidazo[1,2-...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM527919((S)-1'-(8-(thieno[2,3- b]pyridin-4- ylthio)imidazo...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM479344((3-((3S,4)S-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  2.30nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM527921((S)-1'-(8- (benzo[d]isothiazol- 7-ylthio) imidazo[...)
Affinity DataIC50:  2.60nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM479347((3-((S)-5-amino-5,7-dihydrospiro[cyclo- penta[b]py...)
Affinity DataIC50:  2.70nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM527761((3S,4S)-8-(8-(2,3- dichlorophenyl)-7- methylimidaz...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM527827((R)-8-(8-((2,3- dichlorophenyl)thio) imidazo[1,2- ...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM527926((S)-1'-(8- (quinolin-4- ylthio)imidazo[1, 2-c]pyri...)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM479312((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  3nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM479327((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  3nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM408072(US10336774, Example 57)
Affinity DataIC50:  3nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM575630((3S,4S)-8-(5-((6-amino-2,3-dichloropyridin- 4-yl)t...)
Affinity DataIC50:  3nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM479312((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  3nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM575653((6-((2-amino-3-chloropyridin-4-yl)thio)-3- (4-amin...)
Affinity DataIC50:  3nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM527829((R)-8-(8-((2,3- dichloropyridin-4- yl)thio)imidazo...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM527816((2R,4R)-4-amino-8- (8-(2,3- dichlorophenyl)-7- met...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM527852((R)-8-(7-chloro-8- (2,3- dichlorophenyl)- imidazo[...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM527817((2S,4R)-4-amino-8- (8-(2,3- dichlorophenyl)-7- met...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM527859((3S,4S)-8-(8-((2,3- dichlorophenyl)thio)- 7-methyl...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM479359((3-((S)-5-amino-5,7-dihydro- spiro[cyclopenta[b]py...)
Affinity DataIC50:  3.30nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM527891((3S,4S)-8-(8-((3- chloro-2- (methylthio)phenyl) th...)
Affinity DataIC50:  3.30nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM575657(3-((5-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[...)
Affinity DataIC50:  3.5nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM479361((3-((3S,4S)-4-amino-3-methyl-2-oxa- 8-azaspiro[4.5...)
Affinity DataIC50:  3.5nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM527793((Saxial,R)-8-(8-(2,3- dichlorophenyl)-7- methylimi...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM527925((S)-1'-(8-((1,5- naphthyridin-4- yl)thio)imidazo[1...)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM479340((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  3.60nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM479363((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  3.70nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM527890((3S,4S)-8-(8- (benzo[d]isothiazol- 7-ylthio)imidaz...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM479341((3-((3S,4S)-4-amino-3-methyl-2-oxa-8- azaspiro[4.5...)
Affinity DataIC50:  3.80nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM527858((2R,4R)-4-amino-8- (8-((2,3- dichlorophenyl)thio)-...)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of SHP-2 activity by small molecule inhibitors was monitored by a biochemical DiFMUP pseudosubstrate-fluorogenic assay. SHP-2 enzyme at fi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM479357((S)-1'-(5-(((6aS,8S)-8-((methoxy- methoxy)methyl)-...)
Affinity DataIC50:  3.90nMAssay Description:SHP2 possesses two N-terminal Src homology 2 (SH2) domains, a central protein-tyrosine phosphatase (PTP) domain, and C-terminal tail. At the basal st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Nikang Therapeutics

US Patent
LigandPNGBDBM408075(US10336774, Example 60)
Affinity DataIC50:  4nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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