Found 27 hits of affinity data for UniProtKB/TrEMBL: O68891Target
(Institution) | Ligand | Target
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | pH | Temp
°C |
|---|
DNA Topoisomerase IV
Escherichia coli (strain K12) | Benzimidazole urea analogue, 20
(1-(6-(4-(Cyclopropylcarbamoyl)-1H-imidazol-1-yl)-4...) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| PC cid
PC sid
| PubMed
| 7.000 | -47.32 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
|
DNA Topoisomerase IV
Escherichia coli (strain K12) | Benzimidazole urea analogue, 21
(3-ethyl-1-[7-(3-fluoropyridin-2-yl)-5-(1-methyl-2-...) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| PC cid
PC sid
| PubMed
| 11.00 | -46.18 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
|
DNA Topoisomerase IV
Escherichia coli (strain K12) | Benzimidazole urea analogue, 19
(N-cyclopropyl-1-{2-[(ethylcarbamoyl)amino]-7-(1H-p...) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| CSLS
PC cid
PC sid
| PubMed
| 12.00 | -45.96 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
|
DNA Topoisomerase IV
Escherichia coli (strain K12) | Benzimidazole urea analogue, 13
(3-ethyl-1-[7-(pyridin-2-yl)-5-(pyridin-3-yl)-1H-1,...) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| CSLS
PC cid
PC sid
| PubMed
| 14.00 | -45.57 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
|
DNA Topoisomerase IV
Escherichia coli (strain K12) | Benzimidazole urea analogue, 15
(3-ethyl-1-[7-(3-fluoropyridin-2-yl)-5-(pyridin-3-y...) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| CSLS
PC cid
PC sid
| PubMed
| 23.00 | -44.32 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
|
DNA Topoisomerase IV
Escherichia coli (strain K12) | Benzimidazole urea analogue, 10
(methyl 2-[(ethylcarbamoyl)amino]-5-(pyridin-3-yl)-...) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| CSLS
PC cid
PC sid
| PubMed
| 35.00 | -43.27 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
|
DNA Topoisomerase IV
Escherichia coli (strain K12) | Benzimidazole urea analogue, 12
(3-ethyl-1-[7-(1H-pyrazol-1-yl)-5-(pyridin-3-yl)-1H...) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| CSLS
PC cid
PC sid
| PubMed
| 46.00 | -42.58 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
|
DNA Topoisomerase IV
Escherichia coli (strain K12) | Benzimidazole urea analogue, 18
(3-ethyl-1-[7-(1H-pyrazol-1-yl)-5-(pyrimidin-5-yl)-...) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| CSLS
PC cid
PC sid
| PubMed
| 58.00 | -41.99 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
|
DNA Topoisomerase IV
Escherichia coli (strain K12) | Benzimidazole urea analogue, 5
(N-cyclopropyl-1-{2-[(ethylcarbamoyl)amino]-6-fluor...) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| PC cid
PC sid
| PubMed
| 78.00 | -41.25 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
|
DNA Topoisomerase IV
Escherichia coli (strain K12) | Novobiocin
((3R,4S,5R,6R)-5-hydroxy-6-[(2-hydroxy-3-{[4-hydrox...) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| B.MOAD
CSLS
DrugBank
MMDB
PC cid
PC sid
PDB
| B.MOAD
MMDB
PDB
PubMed
| 110.0 | -40.38 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
 |
DNA Topoisomerase IV
Escherichia coli (strain K12) | Benzimidazole urea analogue, 11
(2-[(ethylcarbamoyl)amino]-N-methyl-5-(pyridin-3-yl...) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| CSLS
PC cid
PC sid
| PubMed
| 150.0 | -39.60 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
|
DNA Topoisomerase IV
Escherichia coli (strain K12) | Benzimidazole urea analogue, 16
(1-[7-(benzyloxy)-5-(pyridin-3-yl)-1H-1,3-benzodiaz...) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| PC cid
PC sid
| PubMed
| 390.0 | -37.19 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
|
DNA Topoisomerase IV
Escherichia coli (strain K12) | Benzimidazole urea analogue, 17
(3-ethyl-1-[6-methoxy-5-(2-methoxypyrimidin-5-yl)-1...) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| CSLS
PC cid
PC sid
| PubMed
| 680.0 | -35.79 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
|
DNA Topoisomerase IV
Escherichia coli (strain K12) | Benzimidazole urea analogue, 6
(3-ethyl-1-[6-fluoro-5-(pyridin-3-yl)-1H-1,3-benzod...) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| PC cid
PC sid
| PubMed
| 680.0 | -35.79 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
|
DNA Topoisomerase IV
Escherichia coli (strain K12) | Benzimidazole urea analogue, 4
(3-ethyl-1-[5-(pyrimidin-5-yl)-1H-1,3-benzodiazol-2...) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| PC cid
PC sid
| PubMed
| 1100 | -34.58 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
|
DNA Topoisomerase IV
Escherichia coli (strain K12) | Benzimidazole urea analogue, 14
(1-[5,7-bis(pyridin-3-yl)-1H-1,3-benzodiazol-2-yl]-...) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| PC cid
PC sid
| PubMed
| 1300 | -34.15 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
|
DNA Topoisomerase IV
Escherichia coli (strain K12) | Benzimidazole urea analogue, 7
(3-ethyl-1-[6-methyl-5-(pyridin-3-yl)-1H-1,3-benzod...) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| PC cid
PC sid
| PubMed
| 1400 | -33.97 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
|
DNA Topoisomerase IV
Escherichia coli (strain K12) | Benzimidazole urea analogue, 2
(3-ethyl-1-[5-(pyridin-3-yl)-1H-1,3-benzodiazol-2-y...) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| PC cid
PC sid
| PubMed
| 2300 | -32.72 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
|
DNA Topoisomerase IV
Escherichia coli (strain K12) | Benzimidazole urea analogue, 9
(3-ethyl-1-[6-(piperidin-1-yl)-5-(pyridin-3-yl)-1H-...) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| PC cid
PC sid
| PubMed
| 3300 | -31.81 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
|
DNA Topoisomerase IV
Escherichia coli (strain K12) | Benzimidazole urea analogue, 8
(3-ethyl-1-[6-methoxy-5-(pyridin-3-yl)-1H-1,3-benzo...) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| PC cid
PC sid
| PubMed
| 3500 | -31.66 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
|
DNA Topoisomerase IV
Escherichia coli (strain K12) | Benzimidazole urea analogue, 3
(3-ethyl-1-(5-phenyl-1H-1,3-benzodiazol-2-yl)urea) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| CSLS
PC cid
PC sid
| PubMed
| 9500 | -29.14 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
|
DNA Topoisomerase IV
Escherichia coli (strain K12) | Benzimidazole carbamate analogue, 1
(ethyl N-{5-[(E)-2-(4-hydroxyphenyl)ethenyl]-1H-1,3...) | B.MOAD
DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| CSLS
PC cid
PC sid
| PubMed
| >60000 | >-24.50 | n/a | n/a | n/a | 7.5 | 30 |
Vertex
|
J Med Chem. 51: 5243-63 (2008)
|
DNA Topoisomerase IV Subunit A/Topoisomerase IV subunit A
Escherichia coli (strain K12) | CHEBI:321927
(7-(3-{4-[(S)-5-(Acetylamino-methyl)-2-oxo-oxazolid...) | DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| CHEBI
CSLS
PC cid
PC sid
| PubMed
| n/a | n/a | 2000.0 | n/a | n/a | n/a | n/a |
Morphochem AG
Curated by ChEMBL
|
Bioorg Med Chem Lett. 13: 4229-33 (2003)
|
DNA Topoisomerase IV Subunit A/Topoisomerase IV subunit A
Escherichia coli (strain K12) | Ciprofloxacin
(1-cyclopropyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,...) | DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| CHEBI
CSLS
DrugBank
KEGG
MMDB
PC cid
PC sid
PDB
| PubMed
| n/a | n/a | 2500.0 | n/a | n/a | n/a | n/a |
Morphochem AG
Curated by ChEMBL
|
Bioorg Med Chem Lett. 13: 4229-33 (2003)
|
DNA Topoisomerase IV Subunit A/Topoisomerase IV subunit A
Escherichia coli (strain K12) | CHEBI:322304
(7-((S)-3-{4-[(S)-5-(Acetylamino-methyl)-2-oxo-oxaz...) | DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| CHEBI
CSLS
PC cid
PC sid
| PubMed
| n/a | n/a | 3000.0 | n/a | n/a | n/a | n/a |
Morphochem AG
Curated by ChEMBL
|
Bioorg Med Chem Lett. 13: 4229-33 (2003)
|
DNA Topoisomerase IV Subunit A/Topoisomerase IV subunit A
Escherichia coli (strain K12) | CHEBI:322308
(7-(4-{4-[(S)-5-(Acetylamino-methyl)-2-oxo-oxazolid...) | DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| CHEBI
CSLS
PC cid
PC sid
| PubMed
| n/a | n/a | 5000.0 | n/a | n/a | n/a | n/a |
Morphochem AG
Curated by ChEMBL
|
Bioorg Med Chem Lett. 13: 4229-33 (2003)
|
DNA Topoisomerase IV Subunit A/Topoisomerase IV subunit A
Escherichia coli (strain K12) | CHEBI:322697
(7-(4-{4-[(S)-5-(Acetylamino-methyl)-2-oxo-oxazolid...) | DrugBank
GoogleScholar
KEGG
MMDB
PDB
UniProtKB/TrEMBL
| CHEBI
CSLS
PC cid
PC sid
| PubMed
| n/a | n/a | 10000.0 | n/a | n/a | n/a | n/a |
Morphochem AG
Curated by ChEMBL
|
Bioorg Med Chem Lett. 13: 4229-33 (2003)
|
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