Found 415 hits of ic50 data for polymerid = 3387 Target (Institution) | Ligand | Target Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM182852
 (US9149492, Compound 1D)Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)CC(=O)C(Cc1ccccc1)Cc1ccc(OC(=O)CN2CCCCCC2=O)cc1 Show InChI InChI=1/C38H46N2O5/c1-26(2)32-14-11-15-33(27(3)4)38(32)39-35(42)24-34(41)30(22-28-12-7-5-8-13-28)23-29-17-19-31(20-18-29)45-37(44)25-40-21-10-6-9-16-36(40)43/h5,7-8,11-15,17-20,26-27,30H,6,9-10,16,21-25H2,1-4H3,(H,39,42) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| PC cid PC sid UniChem AffyNet 
| US Patent
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Trustees of Dartmouth College
US Patent
| Assay Description Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite... |
US Patent US9149492 (2015)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM182851
 (US9149492, Compound 1C)Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)CC(=O)C(Cc1ccccc1)Cc1ccc(OC(=O)CCCCCCN2CCCCCC2=O)cc1 Show InChI InChI=1/C43H56N2O5/c1-31(2)37-18-15-19-38(32(3)4)43(37)44-40(47)30-39(46)35(28-33-16-9-7-10-17-33)29-34-22-24-36(25-23-34)50-42(49)21-12-5-6-13-26-45-27-14-8-11-20-41(45)48/h7,9-10,15-19,22-25,31-32,35H,5-6,8,11-14,20-21,26-30H2,1-4H3,(H,44,47) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| PC cid PC sid UniChem AffyNet 
| US Patent
| n/a | n/a | 3.60 | n/a | n/a | n/a | n/a | n/a | n/a |
Trustees of Dartmouth College
US Patent
| Assay Description Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite... |
US Patent US9149492 (2015)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM182849
 (US9149492, Compound 1A)Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)CC(=O)C(Cc1ccccc1)Cc1ccccc1 Show InChI InChI=1S/C30H35NO2/c1-21(2)26-16-11-17-27(22(3)4)30(26)31-29(33)20-28(32)25(18-23-12-7-5-8-13-23)19-24-14-9-6-10-15-24/h5-17,21-22,25H,18-20H2,1-4H3,(H,31,33) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars AffyNet 
| US Patent
| n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Trustees of Dartmouth College
US Patent
| Assay Description Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite... |
US Patent US9149492 (2015)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50051894
 (1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...)Show SMILES COc1ccc(cc1)N1CCN(CCCCC2(C)COC(OC2)c2nc(c([nH]2)-c2ccccc2)-c2ccccc2)CC1 Show InChI InChI=1S/C35H42N4O3/c1-35(19-9-10-20-38-21-23-39(24-22-38)29-15-17-30(40-2)18-16-29)25-41-34(42-26-35)33-36-31(27-11-5-3-6-12-27)32(37-33)28-13-7-4-8-14-28/h3-8,11-18,34H,9-10,19-26H2,1-2H3,(H,36,37) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ... |
J Med Chem 39: 1423-32 (1996)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM182850
 (US9149492, Compound 1B)Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)CC(=O)C(Cc1ccccc1)Cc1ccc(O)cc1 Show InChI InChI=1/C30H35NO3/c1-20(2)26-11-8-12-27(21(3)4)30(26)31-29(34)19-28(33)24(17-22-9-6-5-7-10-22)18-23-13-15-25(32)16-14-23/h5-16,20-21,24,32H,17-19H2,1-4H3,(H,31,34) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| PC cid PC sid UniChem
Similars AffyNet 
| US Patent
| n/a | n/a | 10.3 | n/a | n/a | n/a | n/a | n/a | n/a |
Trustees of Dartmouth College
US Patent
| Assay Description Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite... |
US Patent US9149492 (2015)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50079715
 (CHEMBL64237 | Tetradecanethioic acid (2,6-diisopro...)Show InChI InChI=1S/C26H45NS/c1-6-7-8-9-10-11-12-13-14-15-16-20-25(28)27-26-23(21(2)3)18-17-19-24(26)22(4)5/h17-19,21-22H,6-16,20H2,1-5H3,(H,27,28) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem AffyNet 
| PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Azwell Inc.
Curated by ChEMBL
| Assay Description Compound was tested for inhibitory activity against ACAT from rabbit liver |
Bioorg Med Chem Lett 9: 2039-42 (1999)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50360307
 (CHEMBL449307)Show SMILES CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1 Show InChI InChI=1S/C33H45N3O5/c1-6-8-15-22(4)26-20-27(37)35-30(28(24-16-11-9-12-17-24)25-18-13-10-14-19-25)32(39)34-23(5)31(38)36-29(21(3)7-2)33(40)41-26/h9-14,16-19,21-23,26,28-30H,6-8,15,20H2,1-5H3,(H,34,39)(H,35,37)(H,36,38)/t21-,22-,23+,26-,29+,30-/m0/s1 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku University
Curated by ChEMBL
| Assay Description Inhibition of ACAT1- mediated cholesteryl ester synthesis in macrophages |
Bioorg Med Chem Lett 22: 696-9 (2011)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50175765
 (1-(4-amino-2,6-diisopropylphenyl)-3-(1-butyl-4-(3-...)Show SMILES CCCCn1c2ncccc2c(-c2cccc(OCCCO)c2)c(NC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)c1=O Show InChI InChI=1S/C34H43N5O4/c1-6-7-15-39-32-26(13-9-14-36-32)29(23-11-8-12-25(18-23)43-17-10-16-40)31(33(39)41)38-34(42)37-30-27(21(2)3)19-24(35)20-28(30)22(4)5/h8-9,11-14,18-22,40H,6-7,10,15-17,35H2,1-5H3,(H2,37,38,42) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of ACAT in human HepG2 cells |
Bioorg Med Chem Lett 19: 1062-5 (2009)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50276493
 (1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...)Show SMILES COc1ccccc1N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1cccc(c1)C(F)(F)F Show InChI InChI=1S/C33H41F3N4O2/c1-21(2)26-18-25(37)19-27(22(3)4)30(26)39-31(41)38-20-32(23-9-8-10-24(17-23)33(34,35)36)13-15-40(16-14-32)28-11-6-7-12-29(28)42-5/h6-12,17-19,21-22H,13-16,20,37H2,1-5H3,(H2,38,39,41) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of ACAT in human HepG2 cells |
Bioorg Med Chem Lett 19: 1062-5 (2009)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50276562
 (1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-butoxyp...)Show SMILES CCCCOc1ccccc1N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1cccc(OC)c1 Show InChI InChI=1S/C36H50N4O3/c1-7-8-20-43-33-15-10-9-14-32(33)40-18-16-36(17-19-40,27-12-11-13-29(21-27)42-6)24-38-35(41)39-34-30(25(2)3)22-28(37)23-31(34)26(4)5/h9-15,21-23,25-26H,7-8,16-20,24,37H2,1-6H3,(H2,38,39,41) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of ACAT in human HepG2 cells |
Bioorg Med Chem Lett 19: 1062-5 (2009)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50436124
 (CHEMBL2397474)Show SMILES CCCCCCCCCN(CC(C)(C)C)C(=O)N[C@H]1CCCC[C@@H]1OC(=O)CCNC(=O)[C@@H]1OC(C)(C)OCC1(C)C Show InChI InChI=1S/C33H61N3O6/c1-9-10-11-12-13-14-17-22-36(23-31(2,3)4)30(39)35-25-18-15-16-19-26(25)41-27(37)20-21-34-29(38)28-32(5,6)24-40-33(7,8)42-28/h25-26,28H,9-24H2,1-8H3,(H,34,38)(H,35,39)/t25-,26-,28-/m0/s1 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem AffyNet 
| Article PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Kumamoto University
Curated by ChEMBL
| Assay Description Inhibition of macrophage ACAT (unknown origin) |
Bioorg Med Chem 21: 3831-8 (2013)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50051901
 (1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)Show SMILES Cc1cc(C)n(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1 Show InChI InChI=1S/C25H28N4S/c1-19-18-20(2)29(28-19)16-10-5-11-17-30-25-26-23(21-12-6-3-7-13-21)24(27-25)22-14-8-4-9-15-22/h3-4,6-9,12-15,18H,5,10-11,16-17H2,1-2H3,(H,26,27) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Patents
Similars AffyNet 
| Article
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration required for the inhibition of Cholesterol O-acyl transferase from human liver |
Bioorg Med Chem Lett 2: 375-380 (1992)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50276483
 (1-(2,6-diisopropylphenyl)-3-((4-(3-methoxyphenyl)-...)Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cccc2C(C)C)C(C)C)CCN(CC1)c1ccccc1 Show InChI InChI=1S/C32H41N3O2/c1-23(2)28-15-10-16-29(24(3)4)30(28)34-31(36)33-22-32(25-11-9-14-27(21-25)37-5)17-19-35(20-18-32)26-12-7-6-8-13-26/h6-16,21,23-24H,17-20,22H2,1-5H3,(H2,33,34,36) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of ACAT in human HepG2 cells |
Bioorg Med Chem Lett 19: 1062-5 (2009)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50079716
 ((5E,8E,11E,14E,17E,20E)-Docosa-5,8,11,14,17,20-hex...)Show SMILES C\C=C\C\C=C\C\C=C\C\C=C\C\C=C\C\C=C\CCCC(=O)Nc1c(cccc1C(C)C)C(C)C Show InChI InChI=1S/C34H49NO/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-28-33(36)35-34-31(29(2)3)26-25-27-32(34)30(4)5/h6-7,9-10,12-13,15-16,18-19,21-22,25-27,29-30H,8,11,14,17,20,23-24,28H2,1-5H3,(H,35,36)/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+ | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| PubMed
| n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Azwell Inc.
Curated by ChEMBL
| Assay Description Compound was tested for inhibitory activity against ACAT from U937 microsome in human |
Bioorg Med Chem Lett 9: 2039-42 (1999)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50079716
 ((5E,8E,11E,14E,17E,20E)-Docosa-5,8,11,14,17,20-hex...)Show SMILES C\C=C\C\C=C\C\C=C\C\C=C\C\C=C\C\C=C\CCCC(=O)Nc1c(cccc1C(C)C)C(C)C Show InChI InChI=1S/C34H49NO/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-28-33(36)35-34-31(29(2)3)26-25-27-32(34)30(4)5/h6-7,9-10,12-13,15-16,18-19,21-22,25-27,29-30H,8,11,14,17,20,23-24,28H2,1-5H3,(H,35,36)/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+ | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Azwell Inc.
Curated by ChEMBL
| Assay Description Compound was tested for inhibitory activity against ACAT from canine adrenal gland |
Bioorg Med Chem Lett 9: 2039-42 (1999)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50079716
 ((5E,8E,11E,14E,17E,20E)-Docosa-5,8,11,14,17,20-hex...)Show SMILES C\C=C\C\C=C\C\C=C\C\C=C\C\C=C\C\C=C\CCCC(=O)Nc1c(cccc1C(C)C)C(C)C Show InChI InChI=1S/C34H49NO/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-28-33(36)35-34-31(29(2)3)26-25-27-32(34)30(4)5/h6-7,9-10,12-13,15-16,18-19,21-22,25-27,29-30H,8,11,14,17,20,23-24,28H2,1-5H3,(H,35,36)/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+ | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Azwell Inc.
Curated by ChEMBL
| Assay Description Compound was tested for inhibitory activity against ACAT from HepG2 microsome in human |
Bioorg Med Chem Lett 9: 2039-42 (1999)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50276487
 (1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...)Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OC Show InChI InChI=1S/C33H44N4O3/c1-22(2)27-19-25(34)20-28(23(3)4)31(27)36-32(38)35-21-33(24-10-9-11-26(18-24)39-5)14-16-37(17-15-33)29-12-7-8-13-30(29)40-6/h7-13,18-20,22-23H,14-17,21,34H2,1-6H3,(H2,35,36,38) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of ACAT in human HepG2 cells |
Bioorg Med Chem Lett 19: 1062-5 (2009)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM182848
 (US9149492, Eflucimibe (F12511))Show SMILES CCCCCCCCCCCCS[C@H](C(=O)Nc1cc(C)c(O)c(C)c1C)c1ccccc1 Show InChI InChI=1/C29H43NO2S/c1-5-6-7-8-9-10-11-12-13-17-20-33-28(25-18-15-14-16-19-25)29(32)30-26-21-22(2)27(31)24(4)23(26)3/h14-16,18-19,21,28,31H,5-13,17,20H2,1-4H3,(H,30,32)/t28-/s2 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| PC cid PC sid UniChem AffyNet 
| US Patent
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
Trustees of Dartmouth College
US Patent
| Assay Description Methods for assessing the selectively of ACAT1 inhibitors are known in the art and can be based upon any conventional assay including, but not limite... |
US Patent US9149492 (2015)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50028866
 (CHEMBL297271 | N-[(1S,2R)-2-(4-Hydroxy-phenyl)-ind...)Show SMILES Oc1ccc(cc1)[C@H]1Cc2ccccc2[C@H]1NC(=O)C(c1ccccc1)c1ccccc1 Show InChI InChI=1S/C29H25NO2/c31-24-17-15-20(16-18-24)26-19-23-13-7-8-14-25(23)28(26)30-29(32)27(21-9-3-1-4-10-21)22-11-5-2-6-12-22/h1-18,26-28,31H,19H2,(H,30,32)/t26-,28-/m1/s1 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Patents
Similars AffyNet 
| PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of Acyl coenzyme A:cholesterol acyltransferase (ACAT) |
J Med Chem 24: 496-9 (1981)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50360306
 (CHEMBL505016)Show SMILES CCCC[C@H](C)[C@@H]1CC(=O)N[C@@H](C(c2ccccc2)c2ccccc2)C(=O)N[C@@H](C)C(=O)N[C@H]([C@@H](C)CC)C(=O)O1 Show InChI InChI=1S/C33H45N3O5/c1-6-8-15-22(4)26-20-27(37)35-30(28(24-16-11-9-12-17-24)25-18-13-10-14-19-25)32(39)34-23(5)31(38)36-29(21(3)7-2)33(40)41-26/h9-14,16-19,21-23,26,28-30H,6-8,15,20H2,1-5H3,(H,34,39)(H,35,37)(H,36,38)/t21-,22-,23-,26-,29+,30-/m0/s1 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Tohoku University
Curated by ChEMBL
| Assay Description Inhibition of ACAT1- mediated cholesteryl ester synthesis in macrophages |
Bioorg Med Chem Lett 22: 696-9 (2011)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50276485
 (1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-methoxy...)Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1 Show InChI InChI=1S/C32H42N4O2/c1-22(2)28-19-25(33)20-29(23(3)4)30(28)35-31(37)34-21-32(24-10-9-13-27(18-24)38-5)14-16-36(17-15-32)26-11-7-6-8-12-26/h6-13,18-20,22-23H,14-17,21,33H2,1-5H3,(H2,34,35,37) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of ACAT in human HepG2 cells |
Bioorg Med Chem Lett 19: 1062-5 (2009)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50051901
 (1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)Show SMILES Cc1cc(C)n(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1 Show InChI InChI=1S/C25H28N4S/c1-19-18-20(2)29(28-19)16-10-5-11-17-30-25-26-23(21-12-6-3-7-13-21)24(27-25)22-14-8-4-9-15-22/h3-4,6-9,12-15,18H,5,10-11,16-17H2,1-2H3,(H,26,27) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Patents
Similars AffyNet 
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ... |
J Med Chem 39: 1423-32 (1996)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50051901
 (1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)Show SMILES Cc1cc(C)n(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1 Show InChI InChI=1S/C25H28N4S/c1-19-18-20(2)29(28-19)16-10-5-11-17-30-25-26-23(21-12-6-3-7-13-21)24(27-25)22-14-8-4-9-15-22/h3-4,6-9,12-15,18H,5,10-11,16-17H2,1-2H3,(H,26,27) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Patents
Similars AffyNet 
| Article
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration required for the inhibition of Cholesterol O-acyl transferase from HepG2 microsomes |
Bioorg Med Chem Lett 2: 375-380 (1992)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50276494
 (1-(4-amino-2,6-diisopropylphenyl)-3-((1,4-bis(2-me...)Show SMILES COc1ccccc1N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1ccccc1OC Show InChI InChI=1S/C33H44N4O3/c1-22(2)25-19-24(34)20-26(23(3)4)31(25)36-32(38)35-21-33(27-11-7-9-13-29(27)39-5)15-17-37(18-16-33)28-12-8-10-14-30(28)40-6/h7-14,19-20,22-23H,15-18,21,34H2,1-6H3,(H2,35,36,38) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of ACAT in human HepG2 cells |
Bioorg Med Chem Lett 19: 1062-5 (2009)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50079716
 ((5E,8E,11E,14E,17E,20E)-Docosa-5,8,11,14,17,20-hex...)Show SMILES C\C=C\C\C=C\C\C=C\C\C=C\C\C=C\C\C=C\CCCC(=O)Nc1c(cccc1C(C)C)C(C)C Show InChI InChI=1S/C34H49NO/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-28-33(36)35-34-31(29(2)3)26-25-27-32(34)30(4)5/h6-7,9-10,12-13,15-16,18-19,21-22,25-27,29-30H,8,11,14,17,20,23-24,28H2,1-5H3,(H,35,36)/b7-6+,10-9+,13-12+,16-15+,19-18+,22-21+ | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| PubMed
| n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Azwell Inc.
Curated by ChEMBL
| Assay Description Compound was tested for inhibitory activity against ACAT from Caco-2 microsome in human |
Bioorg Med Chem Lett 9: 2039-42 (1999)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50276484
 (1-(2,6-diisopropylphenyl)-3-((1-(2-methoxyphenyl)-...)Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cccc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OC Show InChI InChI=1S/C33H43N3O3/c1-23(2)27-13-10-14-28(24(3)4)31(27)35-32(37)34-22-33(25-11-9-12-26(21-25)38-5)17-19-36(20-18-33)29-15-7-8-16-30(29)39-6/h7-16,21,23-24H,17-20,22H2,1-6H3,(H2,34,35,37) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of ACAT in human HepG2 cells |
Bioorg Med Chem Lett 19: 1062-5 (2009)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50276488
 (1-(4-amino-2,6-diisopropylphenyl)-3-((1,4-bis(3-me...)Show SMILES COc1cccc(c1)N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1cccc(OC)c1 Show InChI InChI=1S/C33H44N4O3/c1-22(2)29-18-25(34)19-30(23(3)4)31(29)36-32(38)35-21-33(24-9-7-11-27(17-24)39-5)13-15-37(16-14-33)26-10-8-12-28(20-26)40-6/h7-12,17-20,22-23H,13-16,21,34H2,1-6H3,(H2,35,36,38) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of ACAT in human HepG2 cells |
Bioorg Med Chem Lett 19: 1062-5 (2009)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50276565
 (1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-methoxy...)Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OCC(F)(F)F Show InChI InChI=1S/C34H43F3N4O3/c1-22(2)27-18-25(38)19-28(23(3)4)31(27)40-32(42)39-20-33(24-9-8-10-26(17-24)43-5)13-15-41(16-14-33)29-11-6-7-12-30(29)44-21-34(35,36)37/h6-12,17-19,22-23H,13-16,20-21,38H2,1-5H3,(H2,39,40,42) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of ACAT in human HepG2 cells |
Bioorg Med Chem Lett 19: 1062-5 (2009)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50276563
 (1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...)Show SMILES COc1ccc(cc1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OC Show InChI InChI=1S/C33H44N4O3/c1-22(2)27-19-25(34)20-28(23(3)4)31(27)36-32(38)35-21-33(24-11-13-26(39-5)14-12-24)15-17-37(18-16-33)29-9-7-8-10-30(29)40-6/h7-14,19-20,22-23H,15-18,21,34H2,1-6H3,(H2,35,36,38) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of ACAT in human HepG2 cells |
Bioorg Med Chem Lett 19: 1062-5 (2009)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50051898
 (1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...)Show SMILES CC1(CCCCN2CCN(CC2)c2nccs2)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C31H37N5O2S/c1-31(14-8-9-16-35-17-19-36(20-18-35)30-32-15-21-39-30)22-37-29(38-23-31)28-33-26(24-10-4-2-5-11-24)27(34-28)25-12-6-3-7-13-25/h2-7,10-13,15,21,29H,8-9,14,16-20,22-23H2,1H3,(H,33,34) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem AffyNet 
| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ... |
J Med Chem 39: 1423-32 (1996)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50051888
 (CHEMBL284378 | {4-[2-(4,5-Diphenyl-1H-imidazol-2-y...)Show SMILES CN(CCCCC1(C)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1)c1ccccn1 Show InChI InChI=1S/C30H34N4O2/c1-30(18-10-12-20-34(2)25-17-9-11-19-31-25)21-35-29(36-22-30)28-32-26(23-13-5-3-6-14-23)27(33-28)24-15-7-4-8-16-24/h3-9,11,13-17,19,29H,10,12,18,20-22H2,1-2H3,(H,32,33) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ... |
J Med Chem 39: 1423-32 (1996)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50051901
 (1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)Show SMILES Cc1cc(C)n(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1 Show InChI InChI=1S/C25H28N4S/c1-19-18-20(2)29(28-19)16-10-5-11-17-30-25-26-23(21-12-6-3-7-13-21)24(27-25)22-14-8-4-9-15-22/h3-4,6-9,12-15,18H,5,10-11,16-17H2,1-2H3,(H,26,27) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Patents
Similars AffyNet 
| Article
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration required for the inhibition of Cholesterol O-acyl transferase from HepG2 sonicate |
Bioorg Med Chem Lett 2: 375-380 (1992)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50089627
 (12-hydroxy-4,6a,12b-trimethyl-3,6-di(methylcarbony...)Show SMILES CC(=O)OC[C@]1(C)[C@H](CC[C@@]2(C)C1C[C@H](OC(C)=O)[C@@]1(C)Oc3cc(oc(=O)c3[C@H](O)C21)-c1cccnc1)OC(C)=O Show InChI InChI=1S/C31H37NO10/c1-16(33)38-15-30(5)22-13-24(40-18(3)35)31(6)27(29(22,4)10-9-23(30)39-17(2)34)26(36)25-21(42-31)12-20(41-28(25)37)19-8-7-11-32-14-19/h7-8,11-12,14,22-24,26-27,36H,9-10,13,15H2,1-6H3/t22?,23-,24-,26-,27?,29-,30-,31+/m0/s1 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Patents
Similars AffyNet 
| PubMed
| n/a | n/a | 58 | n/a | n/a | n/a | n/a | n/a | n/a |
Kitasato University
Curated by ChEMBL
| Assay Description Inhibitory activity of the compound against acyl-CoA:cholesterol acyltransferase (ACAT) |
Bioorg Med Chem Lett 10: 1315-6 (2000)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50051890
 (2-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...)Show SMILES CC1(CCCCN2CCc3ccccc3C2)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C33H37N3O2/c1-33(19-10-11-20-36-21-18-25-12-8-9-17-28(25)22-36)23-37-32(38-24-33)31-34-29(26-13-4-2-5-14-26)30(35-31)27-15-6-3-7-16-27/h2-9,12-17,32H,10-11,18-24H2,1H3,(H,34,35) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ... |
J Med Chem 39: 1423-32 (1996)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50051883
 (1-{5-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...)Show SMILES Cc1cc(C)n(CCCCCC2(C)COC(OC2)c2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1 Show InChI InChI=1S/C30H36N4O2/c1-22-19-23(2)34(33-22)18-12-6-11-17-30(3)20-35-29(36-21-30)28-31-26(24-13-7-4-8-14-24)27(32-28)25-15-9-5-10-16-25/h4-5,7-10,13-16,19,29H,6,11-12,17-18,20-21H2,1-3H3,(H,31,32) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the activity of human Acyl coenzyme A:cholesterol ... |
J Med Chem 39: 1423-32 (1996)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50051901
 (1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)Show SMILES Cc1cc(C)n(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1 Show InChI InChI=1S/C25H28N4S/c1-19-18-20(2)29(28-19)16-10-5-11-17-30-25-26-23(21-12-6-3-7-13-21)24(27-25)22-14-8-4-9-15-22/h3-4,6-9,12-15,18H,5,10-11,16-17H2,1-2H3,(H,26,27) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Patents
Similars AffyNet 
| Article
| n/a | n/a | 62 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration required for the inhibition of Cholesterol O-acyl transferase from marmoset adrenal |
Bioorg Med Chem Lett 2: 375-380 (1992)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50284874
 (1-(2,6-Diisopropyl-phenyl)-3-((4R,5R)-4,5-dimethyl...)Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)NCC1(O[C@H](C)[C@@H](C)O1)c1ccccc1 Show InChI InChI=1S/C25H34N2O3/c1-16(2)21-13-10-14-22(17(3)4)23(21)27-24(28)26-15-25(20-11-8-7-9-12-20)29-18(5)19(6)30-25/h7-14,16-19H,15H2,1-6H3,(H2,26,27,28)/t18-,19-/m1/s1 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Patents
Similars AffyNet 
| Article
| n/a | n/a | 63 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity against acylcoA: cholesterol acyltransferase (ACAT) in microsomes from monkey liver |
Bioorg Med Chem Lett 5: 1581-1586 (1995)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50276564
 (1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-methoxy...)Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)CCN(CC1)c1ccccc1OC(F)(F)F Show InChI InChI=1S/C33H41F3N4O3/c1-21(2)26-18-24(37)19-27(22(3)4)30(26)39-31(41)38-20-32(23-9-8-10-25(17-23)42-5)13-15-40(16-14-32)28-11-6-7-12-29(28)43-33(34,35)36/h6-12,17-19,21-22H,13-16,20,37H2,1-5H3,(H2,38,39,41) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of ACAT in human HepG2 cells |
Bioorg Med Chem Lett 19: 1062-5 (2009)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50051901
 (1-[5-(4,5-Diphenyl-1H-imidazol-2-ylsulfanyl)-penty...)Show SMILES Cc1cc(C)n(CCCCCSc2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1 Show InChI InChI=1S/C25H28N4S/c1-19-18-20(2)29(28-19)16-10-5-11-17-30-25-26-23(21-12-6-3-7-13-21)24(27-25)22-14-8-4-9-15-22/h3-4,6-9,12-15,18H,5,10-11,16-17H2,1-2H3,(H,26,27) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Patents
Similars AffyNet 
| Article
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration required for the inhibition of Cholesterol O-acyl transferase from marmoset gut |
Bioorg Med Chem Lett 2: 375-380 (1992)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50051891
 (1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...)Show SMILES CC1(CCCCN2CCN(CC2)c2ccccc2)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C34H40N4O2/c1-34(19-11-12-20-37-21-23-38(24-22-37)29-17-9-4-10-18-29)25-39-33(40-26-34)32-35-30(27-13-5-2-6-14-27)31(36-32)28-15-7-3-8-16-28/h2-10,13-18,33H,11-12,19-26H2,1H3,(H,35,36) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the activity of human Acyl coenzyme A:cholesterol ... |
J Med Chem 39: 1423-32 (1996)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50051904
 (4-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...)Show SMILES CC1(CCCCN2CCSCC2)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C28H35N3O2S/c1-28(14-8-9-15-31-16-18-34-19-17-31)20-32-27(33-21-28)26-29-24(22-10-4-2-5-11-22)25(30-26)23-12-6-3-7-13-23/h2-7,10-13,27H,8-9,14-21H2,1H3,(H,29,30) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ... |
J Med Chem 39: 1423-32 (1996)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50051884
 (1-[5-(4,5-Diphenyl-1H-imidazole-2-sulfinyl)-pentyl...)Show SMILES Cc1cc(C)n(CCCCCS(=O)c2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1 Show InChI InChI=1S/C25H28N4OS/c1-19-18-20(2)29(28-19)16-10-5-11-17-31(30)25-26-23(21-12-6-3-7-13-21)24(27-25)22-14-8-4-9-15-22/h3-4,6-9,12-15,18H,5,10-11,16-17H2,1-2H3,(H,26,27) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| Purchase
CHEMBL PC cid PC sid UniChem
Patents
Similars AffyNet 
| Article PubMed
| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% activity of the rabbit liver Acyl coenzyme A:choleste... |
J Med Chem 39: 1423-32 (1996)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50051908
 (2-(4-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methy...)Show SMILES CC1(CCCCN2CCN(CC2)c2ncccn2)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C32H38N6O2/c1-32(15-8-9-18-37-19-21-38(22-20-37)31-33-16-10-17-34-31)23-39-30(40-24-32)29-35-27(25-11-4-2-5-12-25)28(36-29)26-13-6-3-7-14-26/h2-7,10-14,16-17,30H,8-9,15,18-24H2,1H3,(H,35,36) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ... |
J Med Chem 39: 1423-32 (1996)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50051881
 (1-{4-[2-(4,5-Diphenyl-1H-imidazol-2-yl)-5-methyl-[...)Show SMILES Cc1cc(C)n(CCCCC2(C)COC(OC2)c2nc(c([nH]2)-c2ccccc2)-c2ccccc2)n1 Show InChI InChI=1S/C29H34N4O2/c1-21-18-22(2)33(32-21)17-11-10-16-29(3)19-34-28(35-20-29)27-30-25(23-12-6-4-7-13-23)26(31-27)24-14-8-5-9-15-24/h4-9,12-15,18,28H,10-11,16-17,19-20H2,1-3H3,(H,30,31) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the Acyl coenzyme A:cholesterol acyltransferase 1 ... |
J Med Chem 39: 1423-32 (1996)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50276492
 (1-(4-amino-2,6-diisopropylphenyl)-3-((4-(3-fluorop...)Show SMILES COc1ccccc1N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1cccc(F)c1 Show InChI InChI=1S/C32H41FN4O2/c1-21(2)26-18-25(34)19-27(22(3)4)30(26)36-31(38)35-20-32(23-9-8-10-24(33)17-23)13-15-37(16-14-32)28-11-6-7-12-29(28)39-5/h6-12,17-19,21-22H,13-16,20,34H2,1-5H3,(H2,35,36,38) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of ACAT in human HepG2 cells |
Bioorg Med Chem Lett 19: 1062-5 (2009)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50328383
 (CHEMBL1258709 | ethyl 6-(3-benzyl-1,2,4-oxadiazol-...)Show SMILES CCCc1c(-c2nc(Cc3ccccc3)no2)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1 Show InChI InChI=1S/C32H33N5O4/c1-3-11-25-28(31-33-26(35-41-31)20-22-12-7-5-8-13-22)29(32(38)40-4-2)30-24(23-14-9-6-10-15-23)21-27(34-37(25)30)36-16-18-39-19-17-36/h5-10,12-15,21H,3-4,11,16-20H2,1-2H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Patents
Similars AffyNet 
| Article PubMed
| n/a | n/a | 77 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins |
Bioorg Med Chem Lett 20: 6030-3 (2010)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50276486
 (1-(3-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...)Show SMILES COc1cccc(c1)C1(CNC(=O)Nc2c(ccc(N)c2C(C)C)C(C)C)CCN(CC1)c1ccccc1OC Show InChI InChI=1S/C33H44N4O3/c1-22(2)26-14-15-27(34)30(23(3)4)31(26)36-32(38)35-21-33(24-10-9-11-25(20-24)39-5)16-18-37(19-17-33)28-12-7-8-13-29(28)40-6/h7-15,20,22-23H,16-19,21,34H2,1-6H3,(H2,35,36,38) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 81 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of ACAT in human HepG2 cells |
Bioorg Med Chem Lett 19: 1062-5 (2009)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50276491
 (1-(4-amino-2,6-diisopropylphenyl)-3-((1-(2-methoxy...)Show SMILES COc1ccccc1N1CCC(CNC(=O)Nc2c(cc(N)cc2C(C)C)C(C)C)(CC1)c1ccccc1 Show InChI InChI=1S/C32H42N4O2/c1-22(2)26-19-25(33)20-27(23(3)4)30(26)35-31(37)34-21-32(24-11-7-6-8-12-24)15-17-36(18-16-32)28-13-9-10-14-29(28)38-5/h6-14,19-20,22-23H,15-18,21,33H2,1-5H3,(H2,34,35,37) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Dainippon Sumitomo Pharma Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of ACAT in human HepG2 cells |
Bioorg Med Chem Lett 19: 1062-5 (2009)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50328377
 (CHEMBL1258375 | ethyl 6-(3-tert-butyl-1,2,4-oxadia...)Show SMILES CCCc1c(-c2nc(no2)C(C)(C)C)c(C(=O)OCC)c2c(cc(nn12)N1CCOCC1)-c1ccccc1 Show InChI InChI=1S/C29H35N5O4/c1-6-11-21-23(26-30-28(32-38-26)29(3,4)5)24(27(35)37-7-2)25-20(19-12-9-8-10-13-19)18-22(31-34(21)25)33-14-16-36-17-15-33/h8-10,12-13,18H,6-7,11,14-17H2,1-5H3 | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Patents
Similars AffyNet 
| Article PubMed
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Amgen Inc.
Curated by ChEMBL
| Assay Description Inhibition of human full-length flag-tagged ACAT1 expressed in baculovirus infected insect cells after 10 mins |
Bioorg Med Chem Lett 20: 6030-3 (2010)
|
More data for this Ligand-Target Pair | |
Acyl Cholesterol Acyltransferase 1 (ACAT-1)
(Homo sapiens (human)) | BDBM50051899
 (1-Benzyl-4-{4-[2-(4,5-diphenyl-1H-imidazol-2-yl)-5...)Show SMILES CC1(CCCCN2CCN(Cc3ccccc3)CC2)COC(OC1)c1nc(c([nH]1)-c1ccccc1)-c1ccccc1 Show InChI InChI=1S/C35H42N4O2/c1-35(19-11-12-20-38-21-23-39(24-22-38)25-28-13-5-2-6-14-28)26-40-34(41-27-35)33-36-31(29-15-7-3-8-16-29)32(37-33)30-17-9-4-10-18-30/h2-10,13-18,34H,11-12,19-27H2,1H3,(H,36,37) | KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet 
| CHEMBL PC cid PC sid UniChem
Similars AffyNet 
| Article PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Rhône-Poulenc Rorer
Curated by ChEMBL
| Assay Description Inhibitory concentration of the compound was evaluated as concentration required to inhibit 50% of the activity of human Acyl coenzyme A:cholesterol ... |
J Med Chem 39: 1423-32 (1996)
|
More data for this Ligand-Target Pair | |