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Compile Data Set for Download or QSAR

Found 2127 hits of ic50 for UniProtKB: P10721   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50297394
PNG
(CHEMBL4171115)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)NN4C(SCC4=O)c4c(F)cccc4F)c(F)c3)ccnc2cc1OCCCN1CCCC1
Show InChI InChI=1S/C33H32F3N5O5S/c1-44-28-17-21-26(18-29(28)45-15-5-14-40-12-2-3-13-40)37-11-10-27(21)46-20-8-9-25(24(36)16-20)38-33(43)39-41-30(42)19-47-32(41)31-22(34)6-4-7-23(31)35/h4,6-11,16-18,32H,2-3,5,12-15,19H2,1H3,(H2,38,39,43)
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n/an/a 0.0290n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of [125I]VCAM-Ig binding to VLA-4 of Jurkat cells in the presence of [Ca2+]


Eur J Med Chem 146: 368-380 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50021574
PNG
(BMS-907351 | CABOZANTINIB | CHEBI:72317 | Cabomety...)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)C4(CC4)C(=O)Nc4ccc(F)cc4)cc3)c2cc1OC
Show InChI InChI=1S/C28H24FN3O5/c1-35-24-15-21-22(16-25(24)36-2)30-14-11-23(21)37-20-9-7-19(8-10-20)32-27(34)28(12-13-28)26(33)31-18-5-3-17(29)4-6-18/h3-11,14-16H,12-13H2,1-2H3,(H,31,33)(H,32,34)
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n/an/a 0.0530n/an/an/an/an/an/a



Zhuhai Campus of Zunyi Medical University

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) using poly (Glu,Tyr) 4:1 as substrate after 1 hr by ELISA


Eur J Med Chem 146: 368-380 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM139540
PNG
(US10189849, staurosporine | US10307427, Staurospor...)
Show SMILES CN[C@@H]1CC2OC([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C27H24N4O3/c1-28-16-11-19-30-17-9-5-4-8-14(17)21-22-15(12-29-26(22)32)20-13-7-3-6-10-18(13)31(23(20)24(21)30)27(34-19)25(16)33-2/h3-10,16,19,25,27-28H,11-12H2,1-2H3,(H,29,32)/t16-,19?,25-,27?/m1/s1
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n/an/a 0.180n/an/an/an/an/an/a



Temple University

US Patent


Assay Description
The compound of Example 39, 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one, was subjected to a kinase...


US Patent US8889696 (2014)


BindingDB Entry DOI: 10.7270/Q2930RVR
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397887
PNG
(US9994552, Compound 98)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCNCC1
Show InChI InChI=1S/C30H35N7O2/c1-38-27-17-26-25(16-28(27)39-20-23-7-9-31-10-8-23)29(35-21-34-26)36-11-13-37(14-12-36)30-32-18-24(19-33-30)15-22-5-3-2-4-6-22/h2-6,16-19,21,23,31H,7-15,20H2,1H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50329427
PNG
(5-(2-Amino-pyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-c...)
Show SMILES NC(=O)c1cc([nH]c1-c1ccccc1)-c1ccnc(N)n1
Show InChI InChI=1S/C15H13N5O/c16-14(21)10-8-12(11-6-7-18-15(17)20-11)19-13(10)9-4-2-1-3-5-9/h1-8,19H,(H2,16,21)(H2,17,18,20)
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n/an/a>1n/an/an/an/an/an/a



Nerviano Medical Sciences srl

Curated by ChEMBL


Assay Description
Inhibition of KIT


J Med Chem 53: 7296-315 (2010)


Article DOI: 10.1021/jm100504d
BindingDB Entry DOI: 10.7270/Q24T6JM3
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397894
PNG
(US9994552, Compound 105)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CNCCO1
Show InChI InChI=1S/C29H33N7O3/c1-37-26-15-25-24(14-27(26)39-19-23-18-30-7-12-38-23)28(34-20-33-25)35-8-10-36(11-9-35)29-31-16-22(17-32-29)13-21-5-3-2-4-6-21/h2-6,14-17,20,23,30H,7-13,18-19H2,1H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397897
PNG
(US9994552, Compound 108)
Show SMILES COCCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCCOC
Show InChI InChI=1S/C29H34N6O4/c1-36-12-14-38-26-17-24-25(18-27(26)39-15-13-37-2)32-21-33-28(24)34-8-10-35(11-9-34)29-30-19-23(20-31-29)16-22-6-4-3-5-7-22/h3-7,17-21H,8-16H2,1-2H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397898
PNG
(US9994552, Compound 109)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCNC(=O)C1
Show InChI InChI=1S/C30H33N7O3/c1-39-26-16-25-24(15-27(26)40-19-22-7-8-31-28(38)14-22)29(35-20-34-25)36-9-11-37(12-10-36)30-32-17-23(18-33-30)13-21-5-3-2-4-6-21/h2-6,15-18,20,22H,7-14,19H2,1H3,(H,31,38)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397899
PNG
(US9994552, Compound 110)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCCN1CCCC1=O
Show InChI InChI=1S/C30H33N7O3/c1-39-26-18-25-24(17-27(26)40-15-14-35-9-5-8-28(35)38)29(34-21-33-25)36-10-12-37(13-11-36)30-31-19-23(20-32-30)16-22-6-3-2-4-7-22/h2-4,6-7,17-21H,5,8-16H2,1H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397900
PNG
(US9994552, Compound 111)
Show SMILES COc1cc2c(ncnc2cc1OCCN1CCCC1=O)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1
Show InChI InChI=1S/C30H33N7O3/c1-39-26-17-24-25(18-27(26)40-15-14-35-9-5-8-28(35)38)33-21-34-29(24)36-10-12-37(13-11-36)30-31-19-23(20-32-30)16-22-6-3-2-4-7-22/h2-4,6-7,17-21H,5,8-16H2,1H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397901
PNG
(US9994552, Compound 112)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C31H37N7O2/c1-36-10-8-24(9-11-36)21-40-29-17-26-27(18-28(29)39-2)34-22-35-30(26)37-12-14-38(15-13-37)31-32-19-25(20-33-31)16-23-6-4-3-5-7-23/h3-7,17-20,22,24H,8-16,21H2,1-2H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397902
PNG
(US9994552, Compound 113)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OC[C@@H]1CCCN(C)C1
Show InChI InChI=1S/C31H37N7O2/c1-36-10-6-9-24(20-36)21-40-29-16-26-27(17-28(29)39-2)34-22-35-30(26)37-11-13-38(14-12-37)31-32-18-25(19-33-31)15-23-7-4-3-5-8-23/h3-5,7-8,16-19,22,24H,6,9-15,20-21H2,1-2H3/t24-/m1/s1
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397903
PNG
(US9994552, Compound 114)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCCN(C)C1
Show InChI InChI=1S/C31H37N7O2/c1-36-10-6-9-24(20-36)21-40-29-16-26-27(17-28(29)39-2)34-22-35-30(26)37-11-13-38(14-12-37)31-32-18-25(19-33-31)15-23-7-4-3-5-8-23/h3-5,7-8,16-19,22,24H,6,9-15,20-21H2,1-2H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397906
PNG
(US9994552, Compound 117)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CN(C)CCO1
Show InChI InChI=1S/C30H35N7O3/c1-35-12-13-39-24(19-35)20-40-28-15-25-26(16-27(28)38-2)33-21-34-29(25)36-8-10-37(11-9-36)30-31-17-23(18-32-30)14-22-6-4-3-5-7-22/h3-7,15-18,21,24H,8-14,19-20H2,1-2H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397908
PNG
(US9994552, Compound 119)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OCC1CNCCO1
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397909
PNG
(US9994552, Compound 120)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OC[C@H]1CNCCO1
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397910
PNG
(US9994552, Compound 121)
Show SMILES COc1cc2ncnc(N3CC4CCC(C3)N4c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CNCCO1
Show InChI InChI=1S/C31H35N7O3/c1-39-28-13-27-26(12-29(28)41-19-25-16-32-9-10-40-25)30(36-20-35-27)37-17-23-7-8-24(18-37)38(23)31-33-14-22(15-34-31)11-21-5-3-2-4-6-21/h2-6,12-15,20,23-25,32H,7-11,16-19H2,1H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397911
PNG
(US9994552, Compound 122)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C32H39N7O2/c1-3-40-30-19-28-27(18-29(30)41-22-25-9-11-37(2)12-10-25)31(36-23-35-28)38-13-15-39(16-14-38)32-33-20-26(21-34-32)17-24-7-5-4-6-8-24/h4-8,18-21,23,25H,3,9-17,22H2,1-2H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397913
PNG
(US9994552, Compound 124)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OC[C@@H]1CCCN(C)C1
Show InChI InChI=1S/C31H38N8O2/c1-37-10-6-9-23(19-37)20-41-28-16-25-26(17-27(28)40-2)34-21-35-30(25)38-11-13-39(14-12-38)31-33-18-24(29(32)36-31)15-22-7-4-3-5-8-22/h3-5,7-8,16-18,21,23H,6,9-15,19-20H2,1-2H3,(H2,32,33,36)/t23-/m1/s1
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397914
PNG
(US9994552, Compound 125)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C31H38N8O2/c1-37-10-8-23(9-11-37)20-41-28-17-25-26(18-27(28)40-2)34-21-35-30(25)38-12-14-39(15-13-38)31-33-19-24(29(32)36-31)16-22-6-4-3-5-7-22/h3-7,17-19,21,23H,8-16,20H2,1-2H3,(H2,32,33,36)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397916
PNG
(US9994552, Compound 127)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C31H37N7O3/c1-36-10-8-23(9-11-36)20-41-28-17-25-26(18-27(28)40-2)33-21-34-29(25)37-12-14-38(15-13-37)31-32-19-24(30(39)35-31)16-22-6-4-3-5-7-22/h3-7,17-19,21,23H,8-16,20H2,1-2H3,(H,32,35,39)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397920
PNG
(US9994552, Compound 131)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1(F)CCN(C)CC1
Show InChI InChI=1S/C31H36FN7O2/c1-37-10-8-31(32,9-11-37)21-41-28-17-25-26(18-27(28)40-2)35-22-36-29(25)38-12-14-39(15-13-38)30-33-19-24(20-34-30)16-23-6-4-3-5-7-23/h3-7,17-20,22H,8-16,21H2,1-2H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397923
PNG
(US9994552, Compound 134)
Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCN(C)CC1)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1
Show InChI InChI=1S/C32H40N8O2/c1-37-10-12-38(13-11-37)9-6-18-42-30-21-28-27(20-29(30)41-2)31(36-24-35-28)39-14-16-40(17-15-39)32-33-22-26(23-34-32)19-25-7-4-3-5-8-25/h3-5,7-8,20-24H,6,9-19H2,1-2H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397924
PNG
(US9994552, Compound 135)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C32H40N8O2/c1-3-41-29-19-27-26(18-28(29)42-21-24-9-11-38(2)12-10-24)31(36-22-35-27)39-13-15-40(16-14-39)32-34-20-25(30(33)37-32)17-23-7-5-4-6-8-23/h4-8,18-20,22,24H,3,9-17,21H2,1-2H3,(H2,33,34,37)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397925
PNG
(US9994552, Compound 136)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C32H40N8O2/c1-37-10-12-38(13-11-37)9-6-18-42-30-20-27-28(21-29(30)41-2)35-24-36-31(27)39-14-16-40(17-15-39)32-33-22-26(23-34-32)19-25-7-4-3-5-8-25/h3-5,7-8,20-24H,6,9-19H2,1-2H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397927
PNG
(US9994552, Compound 138)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C32H39N7O3/c1-3-41-29-19-27-26(18-28(29)42-21-24-9-11-37(2)12-10-24)30(35-22-34-27)38-13-15-39(16-14-38)32-33-20-25(31(40)36-32)17-23-7-5-4-6-8-23/h4-8,18-20,22,24H,3,9-17,21H2,1-2H3,(H,33,36,40)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397893
PNG
(US9994552, Compound 104)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OC[C@H]1CNCCO1
Show InChI InChI=1S/C29H33N7O3/c1-37-26-15-25-24(14-27(26)39-19-23-18-30-7-12-38-23)28(34-20-33-25)35-8-10-36(11-9-35)29-31-16-22(17-32-29)13-21-5-3-2-4-6-21/h2-6,14-17,20,23,30H,7-13,18-19H2,1H3/t23-/m1/s1
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a>1n/an/an/an/an/an/a



Chiron Corporation

Curated by ChEMBL


Assay Description
Inhibition of Kit


Bioorg Med Chem Lett 16: 4163-8 (2006)


Article DOI: 10.1016/j.bmcl.2006.05.092
BindingDB Entry DOI: 10.7270/Q24M945C
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50260888
PNG
(3-(2-aminoquinazolin-6-yl)-1-(2-cyclopentylethyl)-...)
Show SMILES Cc1ccn(CCC2CCCC2)c(=O)c1-c1ccc2nc(N)ncc2c1
Show InChI InChI=1S/C21H24N4O/c1-14-8-10-25(11-9-15-4-2-3-5-15)20(26)19(14)16-6-7-18-17(12-16)13-23-21(22)24-18/h6-8,10,12-13,15H,2-5,9,11H2,1H3,(H2,22,23,24)
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Amgen Inc

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) by TR-FRET assay


J Med Chem 51: 3065-8 (2008)


Article DOI: 10.1021/jm800188g
BindingDB Entry DOI: 10.7270/Q2DN44TT
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50215791
PNG
(2-((2-acetamidopyridin-4-yl)methylamino)-N-(2,2-di...)
Show SMILES CC(=O)Nc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1
Show InChI InChI=1S/C22H18F2N4O4/c1-13(29)27-20-10-14(8-9-25-20)12-26-17-5-3-2-4-16(17)21(30)28-15-6-7-18-19(11-15)32-22(23,24)31-18/h2-11,26H,12H2,1H3,(H,28,30)(H,25,27,29)
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n/an/a 1n/an/an/an/an/an/a



Bayer Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cKit by FRET assay


Bioorg Med Chem Lett 17: 4378-81 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.075
BindingDB Entry DOI: 10.7270/Q28K78S7
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50215758
PNG
(2-((2-aminopyridin-4-yl)methylamino)-N-(2,2-difluo...)
Show SMILES Nc1cc(CNc2ccccc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)ccn1
Show InChI InChI=1S/C20H16F2N4O3/c21-20(22)28-16-6-5-13(10-17(16)29-20)26-19(27)14-3-1-2-4-15(14)25-11-12-7-8-24-18(23)9-12/h1-10,25H,11H2,(H2,23,24)(H,26,27)
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n/an/a 1n/an/an/an/an/an/a



Bayer Research Center

Curated by ChEMBL


Assay Description
Inhibition of human recombinant cKit by FRET assay


Bioorg Med Chem Lett 17: 4378-81 (2007)


Article DOI: 10.1016/j.bmcl.2007.02.075
BindingDB Entry DOI: 10.7270/Q28K78S7
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50184772
PNG
(CHEMBL3822591 | US10294227, Code 113)
Show SMILES CN(C)CCC1CCN(CCn2nc(-c3ccc(C)cc3)c3c(N)ncnc23)CC1
Show InChI InChI=1S/C23H33N7/c1-17-4-6-19(7-5-17)21-20-22(24)25-16-26-23(20)30(27-21)15-14-29-12-9-18(10-13-29)8-11-28(2)3/h4-7,16,18H,8-15H2,1-3H3,(H2,24,25,26)
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University of Edinburgh

Curated by ChEMBL


Assay Description
Inhibition of human KIT using poly[Glu,Tyr]4:1 as substrate in presence of [gamma-33P]ATP


J Med Chem 59: 4697-710 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00065
BindingDB Entry DOI: 10.7270/Q2B85B2D
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50184770
PNG
(CHEMBL3823849 | US10294227, Code 112)
Show SMILES CN(C)CC1CCN(CCn2nc(-c3ccc(C)cc3)c3c(N)ncnc23)CC1
Show InChI InChI=1S/C22H31N7/c1-16-4-6-18(7-5-16)20-19-21(23)24-15-25-22(19)29(26-20)13-12-28-10-8-17(9-11-28)14-27(2)3/h4-7,15,17H,8-14H2,1-3H3,(H2,23,24,25)
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University of Edinburgh

Curated by ChEMBL


Assay Description
Inhibition of human KIT using poly[Glu,Tyr]4:1 as substrate in presence of [gamma-33P]ATP


J Med Chem 59: 4697-710 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00065
BindingDB Entry DOI: 10.7270/Q2B85B2D
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50184769
PNG
(CHEMBL3823212 | US10294227, Code 109)
Show SMILES CN(C)C1CCN(CCn2nc(-c3ccc(C)cc3)c3c(N)ncnc23)CC1
Show InChI InChI=1S/C21H29N7/c1-15-4-6-16(7-5-15)19-18-20(22)23-14-24-21(18)28(25-19)13-12-27-10-8-17(9-11-27)26(2)3/h4-7,14,17H,8-13H2,1-3H3,(H2,22,23,24)
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University of Edinburgh

Curated by ChEMBL


Assay Description
Inhibition of human KIT using poly[Glu,Tyr]4:1 as substrate in presence of [gamma-33P]ATP


J Med Chem 59: 4697-710 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00065
BindingDB Entry DOI: 10.7270/Q2B85B2D
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50184767
PNG
(CHEMBL3824089 | US10294227, Code 506)
Show SMILES COc1cc(ccc1NC(=O)OC(C)(C)C)-c1nn(CCN2CCC(CC2)N(C)C)c2ncnc(N)c12
Show InChI InChI=1S/C26H38N8O3/c1-26(2,3)37-25(35)30-19-8-7-17(15-20(19)36-6)22-21-23(27)28-16-29-24(21)34(31-22)14-13-33-11-9-18(10-12-33)32(4)5/h7-8,15-16,18H,9-14H2,1-6H3,(H,30,35)(H2,27,28,29)
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University of Edinburgh

Curated by ChEMBL


Assay Description
Inhibition of human KIT using poly[Glu,Tyr]4:1 as substrate in presence of [gamma-33P]ATP


J Med Chem 59: 4697-710 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00065
BindingDB Entry DOI: 10.7270/Q2B85B2D
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50184766
PNG
(CHEMBL3823861 | US10294227, Code 221)
Show SMILES CN(C)CC1CCN(CCn2nc(-c3cnc4[nH]ccc4c3)c3c(N)ncnc23)CC1
Show InChI InChI=1S/C22H29N9/c1-29(2)13-15-4-7-30(8-5-15)9-10-31-22-18(20(23)26-14-27-22)19(28-31)17-11-16-3-6-24-21(16)25-12-17/h3,6,11-12,14-15H,4-5,7-10,13H2,1-2H3,(H,24,25)(H2,23,26,27)
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University of Edinburgh

Curated by ChEMBL


Assay Description
Inhibition of human KIT using poly[Glu,Tyr]4:1 as substrate in presence of [gamma-33P]ATP


J Med Chem 59: 4697-710 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00065
BindingDB Entry DOI: 10.7270/Q2B85B2D
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397818
PNG
(US9994552, Compound 29)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OC
Show InChI InChI=1S/C25H27N7O2/c1-33-21-13-19-20(14-22(21)34-2)28-16-29-24(19)31-8-10-32(11-9-31)25-27-15-18(23(26)30-25)12-17-6-4-3-5-7-17/h3-7,13-16H,8-12H2,1-2H3,(H2,26,27,30)
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397824
PNG
(US9994552, Compound 35)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(O)n3)c2cc1OC
Show InChI InChI=1S/C25H26N6O3/c1-33-21-13-19-20(14-22(21)34-2)27-16-28-23(19)30-8-10-31(11-9-30)25-26-15-18(24(32)29-25)12-17-6-4-3-5-7-17/h3-7,13-16H,8-12H2,1-2H3,(H,26,29,32)
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397846
PNG
(US9994552, Compound 57)
Show SMILES COc1cccc(Cc2cnc(nc2)N2CCN(CC2)c2ncnc3cc(OC)c(OC)cc23)c1
Show InChI InChI=1S/C26H28N6O3/c1-33-20-6-4-5-18(12-20)11-19-15-27-26(28-16-19)32-9-7-31(8-10-32)25-21-13-23(34-2)24(35-3)14-22(21)29-17-30-25/h4-6,12-17H,7-11H2,1-3H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397878
PNG
(US9994552, Compound 89)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCNC1
Show InChI InChI=1S/C29H33N7O2/c1-37-26-15-25-24(14-27(26)38-19-22-7-8-30-16-22)28(34-20-33-25)35-9-11-36(12-10-35)29-31-17-23(18-32-29)13-21-5-3-2-4-6-21/h2-6,14-15,17-18,20,22,30H,7-13,16,19H2,1H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397879
PNG
(US9994552, Compound 90)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CN(C)C1
Show InChI InChI=1S/C29H33N7O2/c1-34-17-23(18-34)19-38-27-13-24-25(14-26(27)37-2)32-20-33-28(24)35-8-10-36(11-9-35)29-30-15-22(16-31-29)12-21-6-4-3-5-7-21/h3-7,13-16,20,23H,8-12,17-19H2,1-2H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397885
PNG
(US9994552, Compound 96)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCN(C)C1
Show InChI InChI=1S/C30H35N7O2/c1-35-9-8-23(19-35)20-39-28-15-25-26(16-27(28)38-2)33-21-34-29(25)36-10-12-37(13-11-36)30-31-17-24(18-32-30)14-22-6-4-3-5-7-22/h3-7,15-18,21,23H,8-14,19-20H2,1-2H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM397886
PNG
(US9994552, Compound 97)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCCNC1
Show InChI InChI=1S/C30H35N7O2/c1-38-27-16-26-25(15-28(27)39-20-23-8-5-9-31-17-23)29(35-21-34-26)36-10-12-37(13-11-36)30-32-18-24(19-33-30)14-22-6-3-2-4-7-22/h2-4,6-7,15-16,18-19,21,23,31H,5,8-14,17,20H2,1H3
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n/an/a<1n/an/an/an/an/an/a



BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...


US Patent US9994552 (2018)

More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM25118
PNG
((3Z)-4-amino-5-fluoro-3-[5-(4-methylpiperazino)-1,...)
Show SMILES CN1CCN(CC1)c1ccc2nc([nH]c2c1)-c1c(N)c2c(F)cccc2[nH]c1=O
Show InChI InChI=1S/C21H21FN6O/c1-27-7-9-28(10-8-27)12-5-6-14-16(11-12)25-20(24-14)18-19(23)17-13(22)3-2-4-15(17)26-21(18)29/h2-6,11H,7-10H2,1H3,(H,24,25)(H3,23,26,29)
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The First Affiliated Hospital of Zhengzhou University

Curated by ChEMBL


Assay Description
Inhibition of recombinant human N-terminal GST/His6-tagged c-KIT (544 to 976 residues) expressed in baculovirus infected sf9 cells using biotinylated...


Eur J Med Chem 126: 476-490 (2017)


Article DOI: 10.1016/j.ejmech.2016.11.052
BindingDB Entry DOI: 10.7270/Q2445PQT
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50331029
PNG
((R,Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-yliden...)
Show SMILES Cc1c(\C=C2/C(=O)Nc3ccc(F)cc23)[nH]c2CCN(C[C@H](O)CN3CCOCC3)C(=O)c12
Show InChI InChI=1S/C24H27FN4O4/c1-14-21(11-18-17-10-15(25)2-3-19(17)27-23(18)31)26-20-4-5-29(24(32)22(14)20)13-16(30)12-28-6-8-33-9-7-28/h2-3,10-11,16,26,30H,4-9,12-13H2,1H3,(H,27,31)/b18-11-/t16-/m1/s1
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n/an/a 1n/an/an/an/an/an/a



Shanghai Hengrui Pharmaceuticals Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of c-Kit after 30 mins by ELISA


J Med Chem 53: 8140-9 (2010)


Article DOI: 10.1021/jm101036c
BindingDB Entry DOI: 10.7270/Q2BV7GWF
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50184774
PNG
(CHEMBL3799221)
Show SMILES CCOC(Cn1nc(-c2cnc3[nH]ccc3c2)c2c(N)ncnc12)OCC
Show InChI InChI=1S/C18H21N7O2/c1-3-26-13(27-4-2)9-25-18-14(16(19)22-10-23-18)15(24-25)12-7-11-5-6-20-17(11)21-8-12/h5-8,10,13H,3-4,9H2,1-2H3,(H,20,21)(H2,19,22,23)
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University of Edinburgh

Curated by ChEMBL


Assay Description
Inhibition of human KIT using poly[Glu,Tyr]4:1 as substrate in presence of [gamma-33P]ATP


J Med Chem 59: 4697-710 (2016)


Article DOI: 10.1021/acs.jmedchem.6b00065
BindingDB Entry DOI: 10.7270/Q2B85B2D
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50331026
PNG
((Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenem...)
Show SMILES CN(C)CCN1CCc2[nH]c(\C=C3/C(=O)Nc4ccc(F)cc34)c(C)c2C1=O
Show InChI InChI=1S/C21H23FN4O2/c1-12-18(11-15-14-10-13(22)4-5-16(14)24-20(15)27)23-17-6-7-26(9-8-25(2)3)21(28)19(12)17/h4-5,10-11,23H,6-9H2,1-3H3,(H,24,27)/b15-11-
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Shanghai Hengrui Pharmaceuticals Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of c-Kit after 30 mins by ELISA


J Med Chem 53: 8140-9 (2010)


Article DOI: 10.1021/jm101036c
BindingDB Entry DOI: 10.7270/Q2BV7GWF
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50331028
PNG
((Z)-2-(5-Fluoro-2-oxo-1,2-dihydro-indol-3-ylidenem...)
Show SMILES Cc1c(\C=C2/C(=O)Nc3ccc(F)cc23)[nH]c2CCN(CCN3CCOCC3)C(=O)c12
Show InChI InChI=1S/C23H25FN4O3/c1-14-20(13-17-16-12-15(24)2-3-18(16)26-22(17)29)25-19-4-5-28(23(30)21(14)19)7-6-27-8-10-31-11-9-27/h2-3,12-13,25H,4-11H2,1H3,(H,26,29)/b17-13-
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Shanghai Hengrui Pharmaceuticals Co., Ltd

Curated by ChEMBL


Assay Description
Inhibition of c-Kit after 30 mins by ELISA


J Med Chem 53: 8140-9 (2010)


Article DOI: 10.1021/jm101036c
BindingDB Entry DOI: 10.7270/Q2BV7GWF
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50129829
PNG
(CHEMBL3628797)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4ccccc34)cc2)c1
Show InChI InChI=1S/C21H16BrN5O/c22-14-4-3-5-17(12-14)27-21(28)26-16-10-8-15(9-11-16)25-20-18-6-1-2-7-19(18)23-13-24-20/h1-13H,(H,23,24,25)(H2,26,27,28)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)


Article DOI: 10.1016/j.bmc.2015.10.035
BindingDB Entry DOI: 10.7270/Q2BZ67VR
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM50129830
PNG
(CHEMBL3628798)
Show SMILES Brc1cccc(NC(=O)Nc2ccc(Nc3ncnc4sccc34)cc2)c1
Show InChI InChI=1S/C19H14BrN5OS/c20-12-2-1-3-15(10-12)25-19(26)24-14-6-4-13(5-7-14)23-17-16-8-9-27-18(16)22-11-21-17/h1-11H,(H,21,22,23)(H2,24,25,26)
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Univ. Lille

Curated by ChEMBL


Assay Description
Inhibition of c-Kit (unknown origin) by radiometric protein kinase assay


Bioorg Med Chem 23: 7340-7 (2015)


Article DOI: 10.1016/j.bmc.2015.10.035
BindingDB Entry DOI: 10.7270/Q2BZ67VR
More data for this
Ligand-Target Pair
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