Compile Data Set for Download or QSAR

Found 4611 hits for UniProtKB: Q07343   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14774 (3-(cyclopropylmethoxy)-N-(3,5-dichloropyridin-4-yl...) Show SMILES FC(F)Oc1ccc(cc1OCC1CC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.398	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Amsterdam Curated by ChEMBL					Assay Description Inhibition of full length recombinant human PDE4B1 expressed in Sf21 insect cells using cAMP as substrate by scintillation proximity assay				J Med Chem 61: 3870-3888 (2018) Article DOI: 10.1021/acs.jmedchem.7b01670 BindingDB Entry DOI: 10.7270/Q2P84FF9
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM14775 (3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...) Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rh£ne-Poulenc Rorer Central Research Curated by ChEMBL					Assay Description Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assay				Bioorg Med Chem Lett 8: 1867-72 (1998) Article DOI: 10.1016/s0960-894x(98)00324-2 BindingDB Entry DOI: 10.7270/Q2CJ8GPB
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM14775 (3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...) Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rh£ne-Poulenc Rorer Central Research Curated by ChEMBL					Assay Description Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)				Bioorg Med Chem Lett 8: 3053-8 (1998) Article DOI: 10.1016/s0960-894x(98)00572-1 BindingDB Entry DOI: 10.7270/Q2PV6NK6
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50228247 (CHEMBL38017 | LY-197055) Show SMILES CC1CC(=O)NN=C1c1ccc2NC(=O)C(C)(C)c2c1 Show InChI InChI=1S/C15H17N3O2/c1-8-6-12(19)17-18-13(8)9-4-5-11-10(7-9)15(2,3)14(20)16-11/h4-5,7-8H,6H2,1-3H3,(H,16,20)(H,17,19)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	0.540	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Displacement [3H]LY-186,126 from phosphodiesterase 4 of myocardial vesicles				J Med Chem 32: 1476-80 (1989) Article DOI: 10.1021/jm00127a014 BindingDB Entry DOI: 10.7270/Q2P271B2
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50427452 (CHEMBL2326941) Show SMILES COc1ccc(cc1OCCCCOc1ccc(cc1)-c1nnn[nH]1)C1=NN(C2CCCCCC2)C(=O)[C@@H]2CC=CC[C@H]12 Show InChI InChI=1S/C33H40N6O4/c1-41-29-19-16-24(31-27-12-6-7-13-28(27)33(40)39(36-31)25-10-4-2-3-5-11-25)22-30(29)43-21-9-8-20-42-26-17-14-23(15-18-26)32-34-37-38-35-32/h6-7,14-19,22,25,27-28H,2-5,8-13,20-21H2,1H3,(H,34,35,37,38)/t27-,28+/m0/s1	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid PDB UniChem Similars	PDB Article PubMed	0.631	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Amsterdam Curated by ChEMBL					Assay Description Inhibition of full length recombinant human PDE4B1 expressed in Sf21 insect cells using cAMP as substrate by scintillation proximity assay				J Med Chem 61: 3870-3888 (2018) Article DOI: 10.1021/acs.jmedchem.7b01670 BindingDB Entry DOI: 10.7270/Q2P84FF9
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM14775 (3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...) Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	0.850	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding to phosphodiesterase 4				Bioorg Med Chem Lett 13: 2347-50 (2003) Article DOI: 10.1016/s0960-894x(03)00438-4 BindingDB Entry DOI: 10.7270/Q2HQ4236
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM14775 (3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...) Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SW 8 Rh£ne-Poulenc Rorer Central Research Curated by ChEMBL					Assay Description Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes.				J Med Chem 41: 4216-23 (1998) Article DOI: 10.1021/jm970575f BindingDB Entry DOI: 10.7270/Q2K35XCX
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM14775 (3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...) Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rh£ne-Poulenc Rorer Curated by ChEMBL					Assay Description Inhibition of Rolipram binding to Phosphodiesterase 4				Bioorg Med Chem Lett 8: 2737-42 (1998) Article DOI: 10.1016/s0960-894x(98)00497-1 BindingDB Entry DOI: 10.7270/Q2GB267S
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50220984 (CHEMBL554636) Show SMILES Cl.COc1cc2cc(CO)nc(-c3ccnc(c3)-n3nc(-c4cccs4)c4ccccc4c3=O)c2cc1OC Show InChI InChI=1S/C29H22N4O4S/c1-36-23-13-18-12-19(16-34)31-27(22(18)15-24(23)37-2)17-9-10-30-26(14-17)33-29(35)21-7-4-3-6-20(21)28(32-33)25-8-5-11-38-25/h3-15,34H,16H2,1-2H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding to phosphodiesterase 4				Bioorg Med Chem Lett 13: 2347-50 (2003) Article DOI: 10.1016/s0960-894x(03)00438-4 BindingDB Entry DOI: 10.7270/Q2HQ4236
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50220990 (CHEMBL556179) Show SMILES Cl.COc1cc2cc(CO)nc(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OC Show InChI InChI=1S/C30H23N5O4/c1-38-25-13-20-12-21(17-36)33-28(24(20)15-26(25)39-2)18-9-11-32-27(14-18)35-30(37)23-8-4-3-7-22(23)29(34-35)19-6-5-10-31-16-19/h3-16,36H,17H2,1-2H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding to phosphodiesterase 4				Bioorg Med Chem Lett 13: 2347-50 (2003) Article DOI: 10.1016/s0960-894x(03)00438-4 BindingDB Entry DOI: 10.7270/Q2HQ4236
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM14775 (3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...) Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Zambon Group Curated by ChEMBL					Assay Description Inhibition of rolipram binding to Phosphodiesterase 4				Bioorg Med Chem Lett 12: 5-8 (2002) Article DOI: 10.1016/s0960-894x(01)00668-0 BindingDB Entry DOI: 10.7270/Q2SB47Z5
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM14775 (3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...) Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Zambon Group Curated by ChEMBL					Assay Description Inhibition of rolipram binding to PDE4 from human neutrophils				Bioorg Med Chem Lett 10: 2235-8 (2000) Article DOI: 10.1016/s0960-894x(00)00449-2 BindingDB Entry DOI: 10.7270/Q2J105BG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50220985 (CHEMBL553502) Show SMILES Cl.COc1cc2C[C@@H](CO)N=C(c3ccnc(c3)-n3ccc4c(OCc5cccnc5)cccc4c3=O)c2cc1OC Show InChI InChI=1S/C32H28N4O5.ClH/c1-39-28-14-22-13-23(18-37)35-31(26(22)16-29(28)40-2)21-8-11-34-30(15-21)36-12-9-24-25(32(36)38)6-3-7-27(24)41-19-20-5-4-10-33-17-20;/h3-12,14-17,23,37H,13,18-19H2,1-2H3;1H/t23-;/m0./s1	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding to phosphodiesterase 4				Bioorg Med Chem Lett 13: 2347-50 (2003) Article DOI: 10.1016/s0960-894x(03)00438-4 BindingDB Entry DOI: 10.7270/Q2HQ4236
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM14775 (3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...) Show SMILES COc1ccc(cc1OC1CCCC1)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C18H18Cl2N2O3/c1-24-15-7-6-11(8-16(15)25-12-4-2-3-5-12)18(23)22-17-13(19)9-21-10-14(17)20/h6-10,12H,2-5H2,1H3,(H,21,22,23)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Zambon Group Curated by ChEMBL					Assay Description Inhibition of human VCAM and Ramos cell VLA-4 interaction				Bioorg Med Chem Lett 11: 33-7 (2001) Article DOI: 10.1016/s0960-894x(00)00587-4 BindingDB Entry DOI: 10.7270/Q2MS3VZ5
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEBI CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Zambon Group Curated by ChEMBL					Assay Description Inhibition of rolipram binding to Phosphodiesterase 4				Bioorg Med Chem Lett 12: 5-8 (2002) Article DOI: 10.1016/s0960-894x(01)00668-0 BindingDB Entry DOI: 10.7270/Q2SB47Z5
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEBI CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Zambon Group Curated by ChEMBL					Assay Description Inhibition of rolipram binding to PDE4 from human neutrophils				Bioorg Med Chem Lett 10: 2235-8 (2000) Article DOI: 10.1016/s0960-894x(00)00449-2 BindingDB Entry DOI: 10.7270/Q2J105BG
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEBI CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Zambon Group Curated by ChEMBL					Assay Description Inhibition of human VCAM and Ramos cell VLA-4 interaction				Bioorg Med Chem Lett 11: 33-7 (2001) Article DOI: 10.1016/s0960-894x(00)00587-4 BindingDB Entry DOI: 10.7270/Q2MS3VZ5
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50220988 (CHEMBL544766) Show SMILES Cl.COc1cc2cc(CO)nc(-c3ccnc(c3)-n3nc(-c4nccs4)c4ccccc4c3=O)c2cc1OC Show InChI InChI=1S/C28H21N5O4S/c1-36-22-12-17-11-18(15-34)31-25(21(17)14-23(22)37-2)16-7-8-29-24(13-16)33-28(35)20-6-4-3-5-19(20)26(32-33)27-30-9-10-38-27/h3-14,34H,15H2,1-2H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding to phosphodiesterase 4				Bioorg Med Chem Lett 13: 2347-50 (2003) Article DOI: 10.1016/s0960-894x(03)00438-4 BindingDB Entry DOI: 10.7270/Q2HQ4236
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50220989 (CHEMBL542299) Show SMILES Cl.COc1cc2C[C@@H](CO)N=C(c3ccnc(c3)-n3ccc4c(OCCN5CCOCC5)cccc4c3=O)c2cc1OC Show InChI InChI=1S/C32H34N4O6.ClH/c1-39-28-17-22-16-23(20-37)34-31(26(22)19-29(28)40-2)21-6-8-33-30(18-21)36-9-7-24-25(32(36)38)4-3-5-27(24)42-15-12-35-10-13-41-14-11-35;/h3-9,17-19,23,37H,10-16,20H2,1-2H3;1H/t23-;/m0./s1	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding to phosphodiesterase 4				Bioorg Med Chem Lett 13: 2347-50 (2003) Article DOI: 10.1016/s0960-894x(03)00438-4 BindingDB Entry DOI: 10.7270/Q2HQ4236
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50074893 (2-[4-(6,7-Diethoxy-2,3-bis-hydroxymethyl-naphthale...) Show SMILES CCOc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OCC Show InChI InChI=1S/C34H30N4O5/c1-3-42-29-15-23-14-24(19-39)28(20-40)32(27(23)17-30(29)43-4-2)21-11-13-36-31(16-21)38-34(41)26-10-6-5-9-25(26)33(37-38)22-8-7-12-35-18-22/h5-18,39-40H,3-4,19-20H2,1-2H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Company, Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]- rolipram binding to guinea pig brain				J Med Chem 42: 1088-99 (1999) Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50074898 (2-[4-(3-Hydroxymethyl-6,7-dimethoxy-naphthalen-1-y...) Show SMILES COc1cc2cc(CO)cc(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OC Show InChI InChI=1S/C31H24N4O4/c1-38-27-14-22-12-19(18-36)13-25(26(22)16-28(27)39-2)20-9-11-33-29(15-20)35-31(37)24-8-4-3-7-23(24)30(34-35)21-6-5-10-32-17-21/h3-17,36H,18H2,1-2H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding to phosphodiesterase 4				Bioorg Med Chem Lett 13: 2347-50 (2003) Article DOI: 10.1016/s0960-894x(03)00438-4 BindingDB Entry DOI: 10.7270/Q2HQ4236
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50220986 (CHEMBL542650) Show SMILES Cl.COc1cc2C[C@@H](CO)N=C(c3ccnc(c3)-n3nc(Cc4cccnc4)c4ccccc4c3=O)c2cc1OC Show InChI InChI=1S/C31H27N5O4.ClH/c1-39-27-14-21-13-22(18-37)34-30(25(21)16-28(27)40-2)20-9-11-33-29(15-20)36-31(38)24-8-4-3-7-23(24)26(35-36)12-19-6-5-10-32-17-19;/h3-11,14-17,22,37H,12-13,18H2,1-2H3;1H/t22-;/m0./s1	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding to phosphodiesterase 4				Bioorg Med Chem Lett 13: 2347-50 (2003) Article DOI: 10.1016/s0960-894x(03)00438-4 BindingDB Entry DOI: 10.7270/Q2HQ4236
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50074901 (2-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...) Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OC Show InChI InChI=1S/C32H26N4O5/c1-40-27-13-21-12-22(17-37)26(18-38)30(25(21)15-28(27)41-2)19-9-11-34-29(14-19)36-32(39)24-8-4-3-7-23(24)31(35-36)20-6-5-10-33-16-20/h3-16,37-38H,17-18H2,1-2H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding to phosphodiesterase 4				Bioorg Med Chem Lett 13: 2347-50 (2003) Article DOI: 10.1016/s0960-894x(03)00438-4 BindingDB Entry DOI: 10.7270/Q2HQ4236
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50074901 (2-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...) Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OC Show InChI InChI=1S/C32H26N4O5/c1-40-27-13-21-12-22(17-37)26(18-38)30(25(21)15-28(27)41-2)19-9-11-34-29(14-19)36-32(39)24-8-4-3-7-23(24)31(35-36)20-6-5-10-33-16-20/h3-16,37-38H,17-18H2,1-2H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	3.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Company, Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]- rolipram binding to guinea pig brain				J Med Chem 42: 1088-99 (1999) Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEBI CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	3.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding to phosphodiesterase 4				Bioorg Med Chem Lett 13: 2347-50 (2003) Article DOI: 10.1016/s0960-894x(03)00438-4 BindingDB Entry DOI: 10.7270/Q2HQ4236
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEBI CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	3.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Company, Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]- rolipram binding to guinea pig brain				J Med Chem 42: 1088-99 (1999) Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50216147 (CHEMBL134237) Show SMILES COc1ccc(cc1OC1CCCC1)C1(Cc2ccncc2)CCN(Cc2ccc3ccccc3c2)C1=O Show InChI InChI=1S/C33H34N2O3/c1-37-30-13-12-28(21-31(30)38-29-8-4-5-9-29)33(22-24-14-17-34-18-15-24)16-19-35(32(33)36)23-25-10-11-26-6-2-3-7-27(26)20-25/h2-3,6-7,10-15,17-18,20-21,29H,4-5,8-9,16,19,22-23H2,1H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rh£ne-Poulenc Rorer Central Research Curated by ChEMBL					Assay Description Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.				Bioorg Med Chem Lett 8: 399-404 (1998) Article DOI: 10.1016/s0960-894x(98)00036-5 BindingDB Entry DOI: 10.7270/Q2222WZ0
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEBI CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	4.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rh£ne-Poulenc Rorer Central Research Curated by ChEMBL					Assay Description Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assay				Bioorg Med Chem Lett 8: 1867-72 (1998) Article DOI: 10.1016/s0960-894x(98)00324-2 BindingDB Entry DOI: 10.7270/Q2CJ8GPB
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEBI CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	4.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rh£ne-Poulenc Rorer Central Research Curated by ChEMBL					Assay Description Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)				Bioorg Med Chem Lett 8: 3053-8 (1998) Article DOI: 10.1016/s0960-894x(98)00572-1 BindingDB Entry DOI: 10.7270/Q2PV6NK6
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	Purchase CHEBI CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	4.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rh£ne-Poulenc Rorer Central Research Curated by ChEMBL					Assay Description Inhibition of rolipram binding to Phosphodiesterase 4				Bioorg Med Chem Lett 8: 175-8 (1998) Article DOI: 10.1016/s0960-894x(97)10206-2 BindingDB Entry DOI: 10.7270/Q26T0PTS
					More data for this Ligand-Target Pair				3D Structure (crystal)
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50219407 (CHEMBL84350) Show SMILES COc1ccc2C(Cc3c(Cl)cncc3Cl)=NN(Cc2c1OC1CCCC1)S(C)(=O)=O Show InChI InChI=1S/C21H23Cl2N3O4S/c1-29-20-8-7-14-16(21(20)30-13-5-3-4-6-13)12-26(31(2,27)28)25-19(14)9-15-17(22)10-24-11-18(15)23/h7-8,10-11,13H,3-6,9,12H2,1-2H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Zambon Group Curated by ChEMBL					Assay Description Affinity for rolipram binding site (RBS) of human neutrophil phosphodiesterase type IV (PDE4)				Bioorg Med Chem Lett 12: 5-8 (2002) Article DOI: 10.1016/s0960-894x(01)00668-0 BindingDB Entry DOI: 10.7270/Q2SB47Z5
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14381 (4-{2-[6-Amino-3-(3-cyclopentyloxy-4-methoxy-benzyl...) Show SMILES COC(=O)c1ccc(COC(C)(C)c2nc3c(N)ncn(Cc4ccc(OC)c(OC5CCCC5)c4)c3n2)cc1 Show InChI InChI=1S/C30H35N5O5/c1-30(2,39-17-19-9-12-21(13-10-19)28(36)38-4)29-33-25-26(31)32-18-35(27(25)34-29)16-20-11-14-23(37-3)24(15-20)40-22-7-5-6-8-22/h9-15,18,22H,5-8,16-17,31H2,1-4H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	5.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50228246 (INDOLIDAN | Indolidan) Show SMILES CC1(C)C(=O)Nc2ccc(cc12)C1=NNC(=O)CC1 Show InChI InChI=1S/C14H15N3O2/c1-14(2)9-7-8(3-4-11(9)15-13(14)19)10-5-6-12(18)17-16-10/h3-4,7H,5-6H2,1-2H3,(H,15,19)(H,17,18)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	5.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Eli Lilly and Company Curated by ChEMBL					Assay Description Displacement [3H]LY-186,126 from phosphodiesterase 4 of myocardial vesicles				J Med Chem 32: 1476-80 (1989) Article DOI: 10.1021/jm00127a014 BindingDB Entry DOI: 10.7270/Q2P271B2
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50220992 (CHEMBL545700) Show SMILES Cl.COc1cc2C[C@@H](CO)N=C(c3ccnc(c3)-n3nc(-c4cncnc4)c4ccccc4c3=O)c2cc1OC Show InChI InChI=1S/C29H24N6O4.ClH/c1-38-24-10-18-9-20(15-36)33-27(23(18)12-25(24)39-2)17-7-8-32-26(11-17)35-29(37)22-6-4-3-5-21(22)28(34-35)19-13-30-16-31-14-19;/h3-8,10-14,16,20,36H,9,15H2,1-2H3;1H/t20-;/m0./s1	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding to phosphodiesterase 4				Bioorg Med Chem Lett 13: 2347-50 (2003) Article DOI: 10.1016/s0960-894x(03)00438-4 BindingDB Entry DOI: 10.7270/Q2HQ4236
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM50314557 ((4-(3-(4-(3-nitrophenyl)pyridazino[4,5-b]indolizin...) Show SMILES [O-][N+](=O)c1cccc(c1)-c1nnc(NCCCN2CCN(CC2)C(=O)c2cnccn2)c2cc3ccccn3c12 Show InChI InChI=1S/C28H27N9O3/c38-28(24-19-29-9-10-30-24)35-15-13-34(14-16-35)11-4-8-31-27-23-18-21-6-1-2-12-36(21)26(23)25(32-33-27)20-5-3-7-22(17-20)37(39)40/h1-3,5-7,9-10,12,17-19H,4,8,11,13-16H2,(H,31,33)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	5.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description Displacement of [methyl-3H]rolipram from PDE4B3 expressed in CHO cells after 1 hr by scintillation counting				Bioorg Med Chem Lett 20: 2163-7 (2010) Article DOI: 10.1016/j.bmcl.2010.02.044 BindingDB Entry DOI: 10.7270/Q2NK3F54
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14379 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-tert...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccc(cc2)C(C)(C)C)cc1OC1CCCC1 Show InChI InChI=1S/C32H41N5O3/c1-31(2,3)23-14-11-21(12-15-23)19-39-32(4,5)30-35-27-28(33)34-20-37(29(27)36-30)18-22-13-16-25(38-6)26(17-22)40-24-9-7-8-10-24/h11-17,20,24H,7-10,18-19,33H2,1-6H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	5.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50074889 (1-[4-(2,3-Bis-hydroxymethyl-6,7-dimethoxy-naphthal...) Show SMILES COc1cc2cc(CO)c(CO)c(-c3ccnc(c3)-n3c4ccccc4ccc3=O)c2cc1OC Show InChI InChI=1S/C28H24N2O5/c1-34-24-12-19-11-20(15-31)22(16-32)28(21(19)14-25(24)35-2)18-9-10-29-26(13-18)30-23-6-4-3-5-17(23)7-8-27(30)33/h3-14,31-32H,15-16H2,1-2H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	6.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Company, Ltd. Curated by ChEMBL					Assay Description Displacement of [3H]- rolipram binding to guinea pig brain				J Med Chem 42: 1088-99 (1999) Article DOI: 10.1021/jm980314l BindingDB Entry DOI: 10.7270/Q25M66DH
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50220991 (CHEMBL539265) Show SMILES Cl.COc1cc2C[C@@H](CO)N=C(c3ccnc(c3)-n3nc(-c4cccnc4)c4ccccc4c3=O)c2cc1OC Show InChI InChI=1S/C30H25N5O4.ClH/c1-38-25-13-20-12-21(17-36)33-28(24(20)15-26(25)39-2)18-9-11-32-27(14-18)35-30(37)23-8-4-3-7-22(23)29(34-35)19-6-5-10-31-16-19;/h3-11,13-16,21,36H,12,17H2,1-2H3;1H/t21-;/m0./s1	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	6.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Tanabe Seiyaku Co., Ltd Curated by ChEMBL					Assay Description Inhibition of rolipram binding to phosphodiesterase 4				Bioorg Med Chem Lett 13: 2347-50 (2003) Article DOI: 10.1016/s0960-894x(03)00438-4 BindingDB Entry DOI: 10.7270/Q2HQ4236
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50215950 (CHEMBL55046) Show SMILES Cc1cn(Cc2ccc3ccccc3c2)c2cc(ccc12)C(=O)Nc1c(Cl)cncc1Cl Show InChI InChI=1S/C26H19Cl2N3O/c1-16-14-31(15-17-6-7-18-4-2-3-5-19(18)10-17)24-11-20(8-9-21(16)24)26(32)30-25-22(27)12-29-13-23(25)28/h2-14H,15H2,1H3,(H,29,30,32)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rh£ne-Poulenc Rorer Central Research Curated by ChEMBL					Assay Description Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assay				Bioorg Med Chem Lett 8: 1867-72 (1998) Article DOI: 10.1016/s0960-894x(98)00324-2 BindingDB Entry DOI: 10.7270/Q2CJ8GPB
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50215392 (CHEMBL131565) Show SMILES COc1ccc(cc1OC1CCCC1)C1(Cc2ccncc2)CCN(C(=O)OC(C)(C)C)C1=O Show InChI InChI=1S/C27H34N2O5/c1-26(2,3)34-25(31)29-16-13-27(24(29)30,18-19-11-14-28-15-12-19)20-9-10-22(32-4)23(17-20)33-21-7-5-6-8-21/h9-12,14-15,17,21H,5-8,13,16,18H2,1-4H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	7.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Rh£ne-Poulenc Rorer Central Research Curated by ChEMBL					Assay Description Affinity for phosphodiesterase (PDE IV) in guinea pig brain membrane using [3H]rolipram displacement.				Bioorg Med Chem Lett 8: 399-404 (1998) Article DOI: 10.1016/s0960-894x(98)00036-5 BindingDB Entry DOI: 10.7270/Q2222WZ0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14382 (4-{2-[6-Amino-3-(3-cyclopentyloxy-4-methoxy-benzyl...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccc(cc2)C(N)=O)cc1OC1CCCC1 Show InChI InChI=1S/C29H34N6O4/c1-29(2,38-16-18-8-11-20(12-9-18)26(31)36)28-33-24-25(30)32-17-35(27(24)34-28)15-19-10-13-22(37-3)23(14-19)39-21-6-4-5-7-21/h8-14,17,21H,4-7,15-16,30H2,1-3H3,(H2,31,36)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	7.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14365 (8-(1-Benzyloxy-1-methyl-ethyl)-3-(3-cyclopentyloxy...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccccc2)cc1OC1CCCC1 Show InChI InChI=1S/C28H33N5O3/c1-28(2,35-17-19-9-5-4-6-10-19)27-31-24-25(29)30-18-33(26(24)32-27)16-20-13-14-22(34-3)23(15-20)36-21-11-7-8-12-21/h4-6,9-10,13-15,18,21H,7-8,11-12,16-17,29H2,1-3H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	8.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14386 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1,1-dimet...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)COc2ccsc2)cc1OC1CCCC1 Show InChI InChI=1S/C26H31N5O3S/c1-26(2,15-33-19-10-11-35-14-19)25-29-22-23(27)28-16-31(24(22)30-25)13-17-8-9-20(32-3)21(12-17)34-18-6-4-5-7-18/h8-12,14,16,18H,4-7,13,15,27H2,1-3H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	9.5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14378 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(3,4-di...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccc(Cl)c(Cl)c2)cc1OC1CCCC1 Show InChI InChI=1S/C28H31Cl2N5O3/c1-28(2,37-15-18-8-10-20(29)21(30)12-18)27-33-24-25(31)32-16-35(26(24)34-27)14-17-9-11-22(36-3)23(13-17)38-19-6-4-5-7-19/h8-13,16,19H,4-7,14-15,31H2,1-3H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	9.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14369 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-meth...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccc(C)cc2)cc1OC1CCCC1 Show InChI InChI=1S/C29H35N5O3/c1-19-9-11-20(12-10-19)17-36-29(2,3)28-32-25-26(30)31-18-34(27(25)33-28)16-21-13-14-23(35-4)24(15-21)37-22-7-5-6-8-22/h9-15,18,22H,5-8,16-17,30H2,1-4H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	9.80	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
Phosphodiesterase 4 (Homo sapiens (Human))	BDBM50471876 (CHEMBL134441) Show SMILES COc1ccc(cc1OC1CCCC1)C1(Cc2ccncc2)C(=O)c2ccccc2C1=O Show InChI InChI=1S/C27H25NO4/c1-31-23-11-10-19(16-24(23)32-20-6-2-3-7-20)27(17-18-12-14-28-15-13-18)25(29)21-8-4-5-9-22(21)26(27)30/h4-5,8-16,20H,2-3,6-7,17H2,1H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
SW 8 Rh£ne-Poulenc Rorer Central Research Curated by ChEMBL					Assay Description Binding affinity at Phosphodiesterase 4 by measuring displacement of (+/-)-[3H]- Rolipram to guinea pig brain membranes.				J Med Chem 41: 4216-23 (1998) Article DOI: 10.1021/jm970575f BindingDB Entry DOI: 10.7270/Q2K35XCX
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14368 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-meth...) Show SMILES COc1ccc(COC(C)(C)c2nc3c(N)ncn(Cc4ccc(OC)c(OC5CCCC5)c4)c3n2)cc1 Show InChI InChI=1S/C29H35N5O4/c1-29(2,37-17-19-9-12-21(35-3)13-10-19)28-32-25-26(30)31-18-34(27(25)33-28)16-20-11-14-23(36-4)24(15-20)38-22-7-5-6-8-22/h9-15,18,22H,5-8,16-17,30H2,1-4H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	10.3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14366 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(2-meth...) Show SMILES COc1ccccc1COC(C)(C)c1nc2c(N)ncn(Cc3ccc(OC)c(OC4CCCC4)c3)c2n1 Show InChI InChI=1S/C29H35N5O4/c1-29(2,37-17-20-9-5-8-12-22(20)35-3)28-32-25-26(30)31-18-34(27(25)33-28)16-19-13-14-23(36-4)24(15-19)38-21-10-6-7-11-21/h5,8-9,12-15,18,21H,6-7,10-11,16-17,30H2,1-4H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14370 (8-{1-[(4-Chlorobenzyl)oxy]-1-methyl-ethyl}-3-[3-cy...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2ccc(Cl)cc2)cc1OC1CCCC1 Show InChI InChI=1S/C28H32ClN5O3/c1-28(2,36-16-18-8-11-20(29)12-9-18)27-32-24-25(30)31-17-34(26(24)33-27)15-19-10-13-22(35-3)23(14-19)37-21-6-4-5-7-21/h8-14,17,21H,4-7,15-16,30H2,1-3H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	Article PubMed	11	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14372 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(3-fluo...) Show SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)(C)OCc2cccc(F)c2)cc1OC1CCCC1 Show InChI InChI=1S/C28H32FN5O3/c1-28(2,36-16-19-7-6-8-20(29)13-19)27-32-24-25(30)31-17-34(26(24)33-27)15-18-11-12-22(35-3)23(14-18)37-21-9-4-5-10-21/h6-8,11-14,17,21H,4-5,9-10,15-16,30H2,1-3H3	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem Patents Similars	Article PubMed	11.6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair

Displayed 1 to 50 (of 4611 total )  |  Next  |  Last  >>

Jump to: