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Compile Data Set for Download or QSAR

Found 1076 hits of ic50 for UniProtKB: Q9BUB5   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM50263270
PNG
(CHEMBL4086747)
Show SMILES Nc1ncnc(Nc2cc(Cl)c3C(=O)NC4(CCCCC4)n3c2=O)c1Cl
Show InChI InChI=1S/C16H16Cl2N6O2/c17-8-6-9(22-13-10(18)12(19)20-7-21-13)15(26)24-11(8)14(25)23-16(24)4-2-1-3-5-16/h6-7H,1-5H2,(H,23,25)(H3,19,20,21,22)
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n/an/a 0.0840n/an/an/an/an/an/a



eFFECTOR Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assay


J Med Chem 61: 3516-3540 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01795
BindingDB Entry DOI: 10.7270/Q2NC63PS
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM168214
PNG
(US9669031, 207 6′-((6-aminopyrimidin-4-yl)am...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C20H21ClN6O3/c21-12-8-13(24-14-9-15(23-10-22-14)25-17(28)11-4-5-11)19(30)27-16(12)18(29)26-20(27)6-2-1-3-7-20/h8-11H,1-7H2,(H,26,29)(H2,22,23,24,25,28)
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n/an/a 0.310n/an/an/an/an/an/a



eFFECTOR Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assay


J Med Chem 61: 3516-3540 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01795
BindingDB Entry DOI: 10.7270/Q2NC63PS
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM168214
PNG
(US9669031, 207 6′-((6-aminopyrimidin-4-yl)am...)
Show SMILES Clc1cc(Nc2cc(NC(=O)C3CC3)ncn2)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C20H21ClN6O3/c21-12-8-13(24-14-9-15(23-10-22-14)25-17(28)11-4-5-11)19(30)27-16(12)18(29)26-20(27)6-2-1-3-7-20/h8-11H,1-7H2,(H,26,29)(H2,22,23,24,25,28)
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eFFECTOR Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...


J Med Chem 61: 3516-3540 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01795
BindingDB Entry DOI: 10.7270/Q2NC63PS
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM50263254
PNG
(CHEMBL4094975)
Show SMILES Nc1cc(Nc2cc(Cl)c3C(=O)NC4(CCCC4)n3c2=O)ncn1
Show InChI InChI=1S/C15H15ClN6O2/c16-8-5-9(20-11-6-10(17)18-7-19-11)14(24)22-12(8)13(23)21-15(22)3-1-2-4-15/h5-7H,1-4H2,(H,21,23)(H3,17,18,19,20)
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n/an/a 0.620n/an/an/an/an/an/a



eFFECTOR Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assay


J Med Chem 61: 3516-3540 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01795
BindingDB Entry DOI: 10.7270/Q2NC63PS
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50263269
PNG
(CHEMBL4076439)
Show SMILES Nc1cc(Nc2cc(Cl)c3C(=O)NC4(CCCCC4)n3c2=O)ncn1
Show InChI InChI=1S/C16H17ClN6O2/c17-9-6-10(21-12-7-11(18)19-8-20-12)15(25)23-13(9)14(24)22-16(23)4-2-1-3-5-16/h6-8H,1-5H2,(H,22,24)(H3,18,19,20,21)
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eFFECTOR Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...


J Med Chem 61: 3516-3540 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01795
BindingDB Entry DOI: 10.7270/Q2NC63PS
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM50263269
PNG
(CHEMBL4076439)
Show SMILES Nc1cc(Nc2cc(Cl)c3C(=O)NC4(CCCCC4)n3c2=O)ncn1
Show InChI InChI=1S/C16H17ClN6O2/c17-9-6-10(21-12-7-11(18)19-8-20-12)15(25)23-13(9)14(24)22-16(23)4-2-1-3-5-16/h6-8H,1-5H2,(H,22,24)(H3,18,19,20,21)
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n/an/a 0.790n/an/an/an/an/an/a



eFFECTOR Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assay


J Med Chem 61: 3516-3540 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01795
BindingDB Entry DOI: 10.7270/Q2NC63PS
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50263254
PNG
(CHEMBL4094975)
Show SMILES Nc1cc(Nc2cc(Cl)c3C(=O)NC4(CCCC4)n3c2=O)ncn1
Show InChI InChI=1S/C15H15ClN6O2/c16-8-5-9(20-11-6-10(17)18-7-19-11)14(24)22-12(8)13(23)21-15(22)3-1-2-4-15/h5-7H,1-4H2,(H,21,23)(H3,17,18,19,20)
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eFFECTOR Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...


J Med Chem 61: 3516-3540 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01795
BindingDB Entry DOI: 10.7270/Q2NC63PS
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50042936
PNG
(CHEMBL3355000)
Show SMILES COc1cc2[nH]ncc2cc1Nc1ncnc2[nH]c3CCC(Cc3c12)C(=O)NCc1ccccc1
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Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Inhibition of human full-length MKNK1 using biotin-Ahx-IKKRKLTRRKSLKG substrate by TR-FRET-based high ATP assay


ACS Med Chem Lett 6: 9-10 (2015)


Article DOI: 10.1021/ml5003025
BindingDB Entry DOI: 10.7270/Q2BP04DN
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50042938
PNG
(CHEMBL3355002)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2[nH]c3CCC(Cc3c12)C(=O)NCCCS(C)(=O)=O
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Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Inhibition of human full-length MKNK1 using biotin-Ahx-IKKRKLTRRKSLKG substrate by TR-FRET-based high ATP assay


ACS Med Chem Lett 6: 9-10 (2015)


Article DOI: 10.1021/ml5003025
BindingDB Entry DOI: 10.7270/Q2BP04DN
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM333402
PNG
(2-{[3-(Furo[3,2-c]pyridin-2-yl)imidazo[1,2-b]pyrid...)
Show SMILES CN(CC(O)c1ccccc1)c1ccc2ncc(-c3cc4cnccc4o3)n2n1
Show InChI InChI=1S/C22H19N5O2/c1-26(14-18(28)15-5-3-2-4-6-15)22-8-7-21-24-13-17(27(21)25-22)20-11-16-12-23-10-9-19(16)29-20/h2-13,18,28H,14H2,1H3
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Bayer Intellectual Property GmbH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)


BindingDB Entry DOI: 10.7270/Q28S4S1H
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM333401
PNG
(2-{[3-(Furo[2,3-c]pyridin-2-yl)imidazo[1,2-b]pyrid...)
Show SMILES CN(CC(O)c1ccccc1)c1ccc2ncc(-c3cc4ccncc4o3)n2n1
Show InChI InChI=1S/C22H19N5O2/c1-26(14-18(28)15-5-3-2-4-6-15)22-8-7-21-24-12-17(27(21)25-22)19-11-16-9-10-23-13-20(16)29-19/h2-13,18,28H,14H2,1H3
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Bayer Intellectual Property GmbH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)


BindingDB Entry DOI: 10.7270/Q28S4S1H
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50263255
PNG
(CHEMBL4065802)
Show SMILES Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCC(F)(F)CC1
Show InChI InChI=1S/C17H18F2N6O2/c1-9-6-10(23-12-7-11(20)21-8-22-12)15(27)25-13(9)14(26)24-17(25)4-2-16(18,19)3-5-17/h6-8H,2-5H2,1H3,(H,24,26)(H3,20,21,22,23)
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eFFECTOR Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...


J Med Chem 61: 3516-3540 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01795
BindingDB Entry DOI: 10.7270/Q2NC63PS
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50500931
PNG
(CHEMBL3797873)
Show SMILES C[C@H]1CN(CCN1)c1cccc2nc(-c3nc(cnc3N)-c3cccc(c3)C(=O)N(C)C)n(C)c12
Show InChI InChI=1S/C26H30N8O/c1-16-15-34(12-11-28-16)21-10-6-9-19-23(21)33(4)25(31-19)22-24(27)29-14-20(30-22)17-7-5-8-18(13-17)26(35)32(2)3/h5-10,13-14,16,28H,11-12,15H2,1-4H3,(H2,27,29)/t16-/m0/s1
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Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of ERK2-activated full length wild type MNK1a (unknown origin) using biotin-SGSGKRREILSRRPSYR-NH2 as substrate after 2 hrs by HTRF assay


J Med Chem 59: 3034-45 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01657
BindingDB Entry DOI: 10.7270/Q2RB77MH
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50263264
PNG
(CHEMBL4094080)
Show SMILES N[C@H]1C[C@@H](C1)Oc1ccc2ncc(-c3ccc4cnccc4c3)n2n1
Show InChI InChI=1S/C19H17N5O/c20-15-8-16(9-15)25-19-4-3-18-22-11-17(24(18)23-19)13-1-2-14-10-21-6-5-12(14)7-13/h1-7,10-11,15-16H,8-9,20H2/t15-,16-
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eFFECTOR Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...


J Med Chem 61: 3516-3540 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01795
BindingDB Entry DOI: 10.7270/Q2NC63PS
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM168222
PNG
(US9669031, 51 N-[6-[[8-chloro-3-(3-chlorophenyl)-3...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1cccc(Cl)c1
Show InChI InChI=1S/C22H18Cl2N6O3/c1-22(12-3-2-4-13(23)7-12)29-20(32)18-14(24)8-15(21(33)30(18)22)27-16-9-17(26-10-25-16)28-19(31)11-5-6-11/h2-4,7-11H,5-6H2,1H3,(H,29,32)(H2,25,26,27,28,31)
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eFFECTOR Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...


J Med Chem 61: 3516-3540 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01795
BindingDB Entry DOI: 10.7270/Q2NC63PS
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM168222
PNG
(US9669031, 51 N-[6-[[8-chloro-3-(3-chlorophenyl)-3...)
Show SMILES CC1(NC(=O)c2c(Cl)cc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12)c1cccc(Cl)c1
Show InChI InChI=1S/C22H18Cl2N6O3/c1-22(12-3-2-4-13(23)7-12)29-20(32)18-14(24)8-15(21(33)30(18)22)27-16-9-17(26-10-25-16)28-19(31)11-5-6-11/h2-4,7-11H,5-6H2,1H3,(H,29,32)(H2,25,26,27,28,31)
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n/an/a 1.80n/an/an/an/an/an/a



eFFECTOR Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assay


J Med Chem 61: 3516-3540 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01795
BindingDB Entry DOI: 10.7270/Q2NC63PS
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM297345
PNG
(N-(6-((1-oxoisoindolin-5-yl)amino)pyrimidin-4-yl)c...)
Show SMILES O=C(Nc1cc(Nc2ccc3C(=O)NCc3c2)ncn1)C1CC1
Show InChI InChI=1S/C16H15N5O2/c22-15(9-1-2-9)21-14-6-13(18-8-19-14)20-11-3-4-12-10(5-11)7-17-16(12)23/h3-6,8-9H,1-2,7H2,(H,17,23)(H2,18,19,20,21,22)
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eFFECTOR Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...


J Med Chem 61: 3516-3540 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01795
BindingDB Entry DOI: 10.7270/Q2NC63PS
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM333390
PNG
(2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES CN(CC(O)c1cccnc1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C22H19N5O2/c1-26(14-18(28)16-6-4-10-23-12-16)22-9-8-21-24-13-17(27(21)25-22)20-11-15-5-2-3-7-19(15)29-20/h2-13,18,28H,14H2,1H3
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Bayer Intellectual Property GmbH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)


BindingDB Entry DOI: 10.7270/Q28S4S1H
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50500936
PNG
(CHEMBL3798762)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cnc(N)c(n1)-c1nc2cccc(N3CCNCC3)c2n1C
Show InChI InChI=1S/C25H28N8O/c1-31(2)25(34)17-7-4-6-16(14-17)19-15-28-23(26)21(29-19)24-30-18-8-5-9-20(22(18)32(24)3)33-12-10-27-11-13-33/h4-9,14-15,27H,10-13H2,1-3H3,(H2,26,28)
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Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of ERK2-activated full length wild type MNK1a (unknown origin) using biotin-SGSGKRREILSRRPSYR-NH2 as substrate after 2 hrs by HTRF assay


J Med Chem 59: 3034-45 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01657
BindingDB Entry DOI: 10.7270/Q2RB77MH
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM333382
PNG
(3-[(1R)-1-{[3-(1- Benzofuran-2- yl)imidazo[1,2-b]p...)
Show SMILES CN(C[C@H](O)c1cccc(O)c1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C23H20N4O3/c1-26(14-19(29)15-6-4-7-17(28)11-15)23-10-9-22-24-13-18(27(22)25-23)21-12-16-5-2-3-8-20(16)30-21/h2-13,19,28-29H,14H2,1H3/t19-/m0/s1
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Bayer Intellectual Property GmbH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)


BindingDB Entry DOI: 10.7270/Q28S4S1H
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50263263
PNG
(CHEMBL4073443)
Show SMILES Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C17H20N6O2/c1-10-7-11(21-13-8-12(18)19-9-20-13)16(25)23-14(10)15(24)22-17(23)5-3-2-4-6-17/h7-9H,2-6H2,1H3,(H,22,24)(H3,18,19,20,21)
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n/an/a 2n/an/an/an/an/an/a



China Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of MNK1 (unknown origin) expressed in HEK293 cells assessed as decrease in eIF4E phosphorylation at Ser209 residues by Western blot analys...


Eur J Med Chem 163: 413-427 (2019)


Article DOI: 10.1016/j.ejmech.2018.11.072
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50263253
PNG
(CHEMBL4067557)
Show SMILES CC1(C)NC(=O)c2c(Cl)cc(Nc3cc(N)ncn3)c(=O)n12
Show InChI InChI=1S/C13H13ClN6O2/c1-13(2)19-11(21)10-6(14)3-7(12(22)20(10)13)18-9-4-8(15)16-5-17-9/h3-5H,1-2H3,(H,19,21)(H3,15,16,17,18)
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n/an/a 2.20n/an/an/an/an/an/a



eFFECTOR Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...


J Med Chem 61: 3516-3540 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01795
BindingDB Entry DOI: 10.7270/Q2NC63PS
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50263263
PNG
(CHEMBL4073443)
Show SMILES Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C17H20N6O2/c1-10-7-11(21-13-8-12(18)19-9-20-13)16(25)23-14(10)15(24)22-17(23)5-3-2-4-6-17/h7-9H,2-6H2,1H3,(H,22,24)(H3,18,19,20,21)
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n/an/a 2.40n/an/an/an/an/an/a



eFFECTOR Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...


J Med Chem 61: 3516-3540 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01795
BindingDB Entry DOI: 10.7270/Q2NC63PS
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM164271
PNG
(US9669031, 10 N-(6-((3,3-dimethyl-1,5-dioxo-1,2,3,...)
Show SMILES CC1(C)NC(=O)c2ccc(Nc3cc(NC(=O)C4CC4)ncn3)c(=O)n12
Show InChI InChI=1S/C17H18N6O3/c1-17(2)22-15(25)11-6-5-10(16(26)23(11)17)20-12-7-13(19-8-18-12)21-14(24)9-3-4-9/h5-9H,3-4H2,1-2H3,(H,22,25)(H2,18,19,20,21,24)
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n/an/a 2.70n/an/an/an/an/an/a



eFFECTOR Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...


J Med Chem 61: 3516-3540 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01795
BindingDB Entry DOI: 10.7270/Q2NC63PS
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50500934
PNG
(CHEMBL3800585)
Show SMILES C[C@H]1CN(CCN1)c1cccc2nc(-c3nc(cnc3N)-c3cc(ccn3)C(=O)N(C)C)n(C)c12
Show InChI InChI=1S/C25H29N9O/c1-15-14-34(11-10-27-15)20-7-5-6-17-22(20)33(4)24(31-17)21-23(26)29-13-19(30-21)18-12-16(8-9-28-18)25(35)32(2)3/h5-9,12-13,15,27H,10-11,14H2,1-4H3,(H2,26,29)/t15-/m0/s1
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n/an/a 3n/an/an/an/an/an/a



Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of ERK2-activated full length wild type MNK1a (unknown origin) using biotin-SGSGKRREILSRRPSYR-NH2 as substrate after 2 hrs by HTRF assay


J Med Chem 59: 3034-45 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01657
BindingDB Entry DOI: 10.7270/Q2RB77MH
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM333403
PNG
(2-{[3-(4-Methoxyfuro[3,2-c]pyridin-2-yl)imidazo[1,...)
Show SMILES COc1nccc2oc(cc12)-c1cnc2ccc(nn12)N(C)CC(O)c1ccccc1
Show InChI InChI=1S/C23H21N5O3/c1-27(14-18(29)15-6-4-3-5-7-15)22-9-8-21-25-13-17(28(21)26-22)20-12-16-19(31-20)10-11-24-23(16)30-2/h3-13,18,29H,14H2,1-2H3
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n/an/a 3n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)


BindingDB Entry DOI: 10.7270/Q28S4S1H
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM168216
PNG
(US9669031, 181 3,3-dimethyl-1,5-dioxo-6-(pyrimidin...)
Show SMILES CC1(C)NC(=O)c2c(Cl)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C13H12ClN5O2/c1-13(2)18-11(20)10-7(14)5-8(12(21)19(10)13)17-9-3-4-15-6-16-9/h3-6H,1-2H3,(H,18,20)(H,15,16,17)
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n/an/a 3.30n/an/an/an/an/an/a



eFFECTOR Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...


J Med Chem 61: 3516-3540 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01795
BindingDB Entry DOI: 10.7270/Q2NC63PS
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM168281
PNG
(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C16H16ClN5O2/c17-10-8-11(20-12-4-7-18-9-19-12)15(24)22-13(10)14(23)21-16(22)5-2-1-3-6-16/h4,7-9H,1-3,5-6H2,(H,21,23)(H,18,19,20)
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n/an/a 3.5n/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E derived peptide as substrate at concentration of 10XKm in presence...


Bioorg Med Chem Lett 29: 2650-2654 (2019)


Article DOI: 10.1016/j.bmcl.2019.07.043
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM333391
PNG
((−)-2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]p...)
Show SMILES CN(CC(O)c1ccccc1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C23H20N4O2/c1-26(15-19(28)16-7-3-2-4-8-16)23-12-11-22-24-14-18(27(22)25-23)21-13-17-9-5-6-10-20(17)29-21/h2-14,19,28H,15H2,1H3
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n/an/a 4n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)


BindingDB Entry DOI: 10.7270/Q28S4S1H
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM333389
PNG
(2-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES CN(CC(O)c1ccccc1)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C23H20N4O2/c1-26(15-19(28)16-7-3-2-4-8-16)23-12-11-22-24-14-18(27(22)25-23)21-13-17-9-5-6-10-20(17)29-21/h2-14,19,28H,15H2,1H3
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Bayer Intellectual Property GmbH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)


BindingDB Entry DOI: 10.7270/Q28S4S1H
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM333388
PNG
(3-[(1R)-1-Hydroxy-2- {[3-(4-methoxy-1- benzofuran-...)
Show SMILES COc1cccc2oc(cc12)-c1cnc2ccc(nn12)N(C)C[C@H](O)c1cccc(O)c1
Show InChI InChI=1S/C24H22N4O4/c1-27(14-19(30)15-5-3-6-16(29)11-15)24-10-9-23-25-13-18(28(23)26-24)22-12-17-20(31-2)7-4-8-21(17)32-22/h3-13,19,29-30H,14H2,1-2H3/t19-/m0/s1
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Bayer Intellectual Property GmbH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)


BindingDB Entry DOI: 10.7270/Q28S4S1H
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM168281
PNG
(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C16H16ClN5O2/c17-10-8-11(20-12-4-7-18-9-19-12)15(24)22-13(10)14(23)21-16(22)5-2-1-3-6-16/h4,7-9H,1-3,5-6H2,(H,21,23)(H,18,19,20)
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University of South Australia

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E derived peptide as substrate in presence of ATP at concentration o...


Bioorg Med Chem Lett 29: 2650-2654 (2019)


Article DOI: 10.1016/j.bmcl.2019.07.043
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM168281
PNG
(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C16H16ClN5O2/c17-10-8-11(20-12-4-7-18-9-19-12)15(24)22-13(10)14(23)21-16(22)5-2-1-3-6-16/h4,7-9H,1-3,5-6H2,(H,21,23)(H,18,19,20)
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University of South Australia

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E derived peptide as substrate in presence of ATP at Km concentratio...


Bioorg Med Chem Lett 29: 2650-2654 (2019)


Article DOI: 10.1016/j.bmcl.2019.07.043
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50500933
PNG
(CHEMBL3797828)
Show SMILES CN(C)C(=O)c1cccc(c1)-c1cnc(N)c(c1)-c1nc2cccc(N3CCNCC3)c2[nH]1
Show InChI InChI=1S/C25H27N7O/c1-31(2)25(33)17-6-3-5-16(13-17)18-14-19(23(26)28-15-18)24-29-20-7-4-8-21(22(20)30-24)32-11-9-27-10-12-32/h3-8,13-15,27H,9-12H2,1-2H3,(H2,26,28)(H,29,30)
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Novartis Institutes for BioMedical Research

Curated by ChEMBL


Assay Description
Inhibition of ERK2-activated full length wild type MNK1a (unknown origin) using biotin-SGSGKRREILSRRPSYR-NH2 as substrate after 2 hrs by HTRF assay


J Med Chem 59: 3034-45 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01657
BindingDB Entry DOI: 10.7270/Q2RB77MH
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM168281
PNG
(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C16H16ClN5O2/c17-10-8-11(20-12-4-7-18-9-19-12)15(24)22-13(10)14(23)21-16(22)5-2-1-3-6-16/h4,7-9H,1-3,5-6H2,(H,21,23)(H,18,19,20)
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n/an/a 4.70n/an/an/an/an/an/a



University of South Australia

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E derived peptide as substrate at concentration of Km/10 in presence...


Bioorg Med Chem Lett 29: 2650-2654 (2019)


Article DOI: 10.1016/j.bmcl.2019.07.043
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50042934
PNG
(CHEMBL3354998)
Show SMILES CC(C)Oc1cc2[nH]ncc2cc1Nc1ncnc2[nH]c3CCCCc3c12
Show InChI InChI=1S/C20H22N6O/c1-11(2)27-17-8-15-12(9-23-26-15)7-16(17)25-20-18-13-5-3-4-6-14(13)24-19(18)21-10-22-20/h7-11H,3-6H2,1-2H3,(H,23,26)(H2,21,22,24,25)
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n/an/a 5n/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Inhibition of human full-length MKNK1 using biotin-Ahx-IKKRKLTRRKSLKG substrate by TR-FRET-based high ATP assay


ACS Med Chem Lett 6: 9-10 (2015)


Article DOI: 10.1021/ml5003025
BindingDB Entry DOI: 10.7270/Q2BP04DN
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM333404
PNG
(2-{[3-(4-Ethoxyfuro[3,2-c]pyridin-2-yl)imidazo[1,2...)
Show SMILES CCOc1nccc2oc(cc12)-c1cnc2ccc(nn12)N(C)CC(O)c1ccccc1
Show InChI InChI=1S/C24H23N5O3/c1-3-31-24-17-13-21(32-20(17)11-12-25-24)18-14-26-22-9-10-23(27-29(18)22)28(2)15-19(30)16-7-5-4-6-8-16/h4-14,19,30H,3,15H2,1-2H3
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n/an/a 5n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)


BindingDB Entry DOI: 10.7270/Q28S4S1H
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM2579
PNG
((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Show SMILES CN[C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1
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n/an/a 5.30n/an/an/an/an/an/a



University of Florida

Curated by ChEMBL


Assay Description
Inhibition of human MNK1 using MBP as substrate by [gamma-33P]-ATP assay


Eur J Med Chem 161: 456-467 (2019)


Article DOI: 10.1016/j.ejmech.2018.10.052
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM168281
PNG
(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C16H16ClN5O2/c17-10-8-11(20-12-4-7-18-9-19-12)15(24)22-13(10)14(23)21-16(22)5-2-1-3-6-16/h4,7-9H,1-3,5-6H2,(H,21,23)(H,18,19,20)
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University of South Australia

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E derived peptide as substrate at Km concentration in presence of AT...


Bioorg Med Chem Lett 29: 2650-2654 (2019)


Article DOI: 10.1016/j.bmcl.2019.07.043
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM168281
PNG
(US9669031, 109 8-chloro-6-(pyrimidin-4-ylamino)spi...)
Show SMILES Clc1cc(Nc2ccncn2)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C16H16ClN5O2/c17-10-8-11(20-12-4-7-18-9-19-12)15(24)22-13(10)14(23)21-16(22)5-2-1-3-6-16/h4,7-9H,1-3,5-6H2,(H,21,23)(H,18,19,20)
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University of South Australia

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant GST-tagged MNK1 (unknown origin) using eIF4E derived peptide as substrate in presence of ATP at concentration o...


Bioorg Med Chem Lett 29: 2650-2654 (2019)


Article DOI: 10.1016/j.bmcl.2019.07.043
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50042933
PNG
(CHEMBL3354997)
Show SMILES COc1cc(Cl)c(Cl)cc1Nc1ncnc2[nH]c3CCC(Cc3c12)C(=O)NC1CC1
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n/an/a 6n/an/an/an/an/an/a



Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Inhibition of human full-length MKNK1 using biotin-Ahx-IKKRKLTRRKSLKG substrate by TR-FRET-based high ATP assay


ACS Med Chem Lett 6: 9-10 (2015)


Article DOI: 10.1021/ml5003025
BindingDB Entry DOI: 10.7270/Q2BP04DN
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM50042935
PNG
(CHEMBL3354999)
Show SMILES CCNC(=O)C1CCc2[nH]c3ncnc(Nc4cc5cn[nH]c5cc4OC)c3c2C1
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Dart Neuroscience LLC

Curated by ChEMBL


Assay Description
Inhibition of human full-length MKNK1 using biotin-Ahx-IKKRKLTRRKSLKG substrate by TR-FRET-based high ATP assay


ACS Med Chem Lett 6: 9-10 (2015)


Article DOI: 10.1021/ml5003025
BindingDB Entry DOI: 10.7270/Q2BP04DN
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1/2


(Homo sapiens (Human))
BDBM50263263
PNG
(CHEMBL4073443)
Show SMILES Cc1cc(Nc2cc(N)ncn2)c(=O)n2c1C(=O)NC21CCCCC1
Show InChI InChI=1S/C17H20N6O2/c1-10-7-11(21-13-8-12(18)19-9-20-13)16(25)23-14(10)15(24)22-17(23)5-3-2-4-6-17/h7-9H,2-6H2,1H3,(H,22,24)(H3,18,19,20,21)
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n/an/a 6n/an/an/an/an/an/a



eFFECTOR Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of MNK1/2 in human HCT116 cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by HTRF assay


J Med Chem 61: 3516-3540 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01795
BindingDB Entry DOI: 10.7270/Q2NC63PS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM475241
PNG
(US10851082, NUCC-0176343 | US10851082, NUCC-020095...)
Show SMILES N#Cc1cnc(NCCc2ccncc2)nc1-n1cnc2ccccc12
Show InChI InChI=1S/C19H15N7/c20-11-15-12-23-19(22-10-7-14-5-8-21-9-6-14)25-18(15)26-13-24-16-3-1-2-4-17(16)26/h1-6,8-9,12-13H,7,10H2,(H,22,23,25)
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n/an/a 6.5n/an/an/an/an/an/a



Northwestern University

US Patent


Assay Description
The synthesized compounds then were tested for inhibition of the kinase activity (IC50) of Mnk1 and/or Mnk2 using the ADP monitoring assay for kinase...


US Patent US10851082 (2020)

More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM168241
PNG
(US9669031, 69 8-fluoro-3,3-dimethyl-6-(pyrimidin-4...)
Show SMILES CC1(C)NC(=O)c2c(F)cc(Nc3ccncn3)c(=O)n12
Show InChI InChI=1S/C13H12FN5O2/c1-13(2)18-11(20)10-7(14)5-8(12(21)19(10)13)17-9-3-4-15-6-16-9/h3-6H,1-2H3,(H,18,20)(H,15,16,17)
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n/an/a 6.5n/an/an/an/an/an/a



eFFECTOR Therapeutics

Curated by ChEMBL


Assay Description
Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect cells using Ac-TATKSGSTTKNR-NH2 as substrate preincubated for 5 mins ...


J Med Chem 61: 3516-3540 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01795
BindingDB Entry DOI: 10.7270/Q2NC63PS
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345109
PNG
((trans-3-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyri...)
Show SMILES OC[C@H]1C[C@@H](C1)Nc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C19H18N4O2/c24-11-12-7-14(8-12)21-18-5-6-19-20-10-15(23(19)22-18)17-9-13-3-1-2-4-16(13)25-17/h1-6,9-10,12,14,24H,7-8,11H2,(H,21,22)/t12-,14-
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n/an/a 8n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)


BindingDB Entry DOI: 10.7270/Q2HM5BK4
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM345110
PNG
(3-(1-Benzofur-2-yl)-6-chloroimidazo[1,2-b]pyridazi...)
Show SMILES Clc1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C14H8ClN3O/c15-13-5-6-14-16-8-10(18(14)17-13)12-7-9-3-1-2-4-11(9)19-12/h1-8H
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n/an/a 9n/an/an/an/an/an/a



Bayer Pharma Aktiengesellschaft

US Patent


Assay Description
For the assay 50 nL of a 100 fold concentrated solution of the test compound in DMSO was pipetted into a black low volume 384 well microtiter plate (...


US Patent US9783543 (2017)


BindingDB Entry DOI: 10.7270/Q2HM5BK4
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM375523
PNG
(4-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)ph...)
Show SMILES CN(C)C1CCN(CC1)C(=O)c1ccc(cc1)-c1ccc2ncc(-c3ccc(cc3)C#N)n2n1
Show InChI InChI=1S/C27H26N6O/c1-31(2)23-13-15-32(16-14-23)27(34)22-9-7-20(8-10-22)24-11-12-26-29-18-25(33(26)30-24)21-5-3-19(17-28)4-6-21/h3-12,18,23H,13-16H2,1-2H3
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n/an/a 9n/an/an/an/an/an/a



Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL


Assay Description
Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...


J Med Chem 61: 4348-4369 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01714
BindingDB Entry DOI: 10.7270/Q20004P7
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM333393
PNG
(1-{[3-(1-Benzofuran-2-yl)imidazo[1,2-b]pyridazin-6...)
Show SMILES CC(O)CN(C)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H18N4O2/c1-12(23)11-21(2)18-8-7-17-19-10-14(22(17)20-18)16-9-13-5-3-4-6-15(13)24-16/h3-10,12,23H,11H2,1-2H3
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n/an/a 9n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)


BindingDB Entry DOI: 10.7270/Q28S4S1H
More data for this
Ligand-Target Pair
MAP kinase-interacting serine/threonine-protein kinase 1


(Homo sapiens (Human))
BDBM333384
PNG
(2-{[3-(1- Benzofuran-2- yl)imidazo[1,2-b]pyridazi...)
Show SMILES CN(CC(O)CO)c1ccc2ncc(-c3cc4ccccc4o3)n2n1
Show InChI InChI=1S/C18H18N4O3/c1-21(10-13(24)11-23)18-7-6-17-19-9-14(22(17)20-18)16-8-12-4-2-3-5-15(12)25-16/h2-9,13,23-24H,10-11H2,1H3
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n/an/a 9n/an/an/an/an/an/a



Bayer Intellectual Property GmbH

US Patent


Assay Description
A recombinant fusion protein of Glutathione-S-Transferase (GST, N-terminally) and human full-length MKNK1 (amino acids 1-424 and T344D of accession n...


US Patent US9730929 (2017)


BindingDB Entry DOI: 10.7270/Q28S4S1H
More data for this
Ligand-Target Pair
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