Compile Data Set for Download or QSAR

Found 33 hits of ec50 for UniProtKB: P04629   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50446394 (CHEMBL3109646 | US9181261, 1) Show SMILES CC(C)N(Cc1c[nH]c2ncccc12)C(=O)Nc1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C19H19F3N4OS/c1-12(2)26(11-13-10-24-17-16(13)4-3-9-23-17)18(27)25-14-5-7-15(8-6-14)28-19(20,21)22/h3-10,12H,11H2,1-2H3,(H,23,24)(H,25,27)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	6.5	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp US Patent					Assay Description TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...				US Patent US9181261 (2015) BindingDB Entry DOI: 10.7270/Q24F1PJ5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50446394 (CHEMBL3109646 | US9181261, 1) Show SMILES CC(C)N(Cc1c[nH]c2ncccc12)C(=O)Nc1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C19H19F3N4OS/c1-12(2)26(11-13-10-24-17-16(13)4-3-9-23-17)18(27)25-14-5-7-15(8-6-14)28-19(20,21)22/h3-10,12H,11H2,1-2H3,(H,23,24)(H,25,27)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.5	n/a	n/a	n/a	n/a
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL					Assay Description Inhibition of TrkA (unknown origin) using fluorescently labeled peptide substrate after 3 hrs				ACS Med Chem Lett 5: 8-9 (2014) Article DOI: 10.1021/ml4005073 BindingDB Entry DOI: 10.7270/Q2B56M6V
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50446392 (CHEMBL3109645 | US9181261, 2) Show SMILES CC(C)N(Cc1c[nH]c2ncccc12)C(=O)Nc1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C19H19F3N4O2/c1-12(2)26(11-13-10-24-17-16(13)4-3-9-23-17)18(27)25-14-5-7-15(8-6-14)28-19(20,21)22/h3-10,12H,11H2,1-2H3,(H,23,24)(H,25,27)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	11	n/a	n/a	n/a	n/a
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL					Assay Description Inhibition of TrkA (unknown origin) using fluorescently labeled peptide substrate after 3 hrs				ACS Med Chem Lett 5: 8-9 (2014) Article DOI: 10.1021/ml4005073 BindingDB Entry DOI: 10.7270/Q2B56M6V
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50446392 (CHEMBL3109645 | US9181261, 2) Show SMILES CC(C)N(Cc1c[nH]c2ncccc12)C(=O)Nc1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C19H19F3N4O2/c1-12(2)26(11-13-10-24-17-16(13)4-3-9-23-17)18(27)25-14-5-7-15(8-6-14)28-19(20,21)22/h3-10,12H,11H2,1-2H3,(H,23,24)(H,25,27)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	11.3	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp US Patent					Assay Description TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...				US Patent US9181261 (2015) BindingDB Entry DOI: 10.7270/Q24F1PJ5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM191135 (US9181261, 5) Show SMILES CC1(C)CCN(C(=O)N1Cc1c[nH]c2ncccc12)c1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C21H21F3N4OS/c1-20(2)9-11-27(15-5-7-16(8-6-15)30-21(22,23)24)19(29)28(20)13-14-12-26-18-17(14)4-3-10-25-18/h3-8,10,12H,9,11,13H2,1-2H3,(H,25,26)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	19.7	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp US Patent					Assay Description TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...				US Patent US9181261 (2015) BindingDB Entry DOI: 10.7270/Q24F1PJ5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM191136 (US9181261, 6) Show SMILES CC(C)N(Cc1n[nH]c2ncccc12)C(=O)Nc1ccc(SC(F)(F)F)cc1 Show InChI InChI=1S/C18H18F3N5OS/c1-11(2)26(10-15-14-4-3-9-22-16(14)25-24-15)17(27)23-12-5-7-13(8-6-12)28-18(19,20)21/h3-9,11H,10H2,1-2H3,(H,23,27)(H,22,24,25)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	24.9	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp US Patent					Assay Description TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...				US Patent US9181261 (2015) BindingDB Entry DOI: 10.7270/Q24F1PJ5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM191137 (US9181261, 10) Show SMILES CC(C#C)N(Cc1cccc(c1)-c1nccs1)C(=O)Nc1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C22H18F3N3O2S/c1-3-15(2)28(14-16-5-4-6-17(13-16)20-26-11-12-31-20)21(29)27-18-7-9-19(10-8-18)30-22(23,24)25/h1,4-13,15H,14H2,2H3,(H,27,29)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	48	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp US Patent					Assay Description TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...				US Patent US9181261 (2015) BindingDB Entry DOI: 10.7270/Q24F1PJ5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50073587 (CHEMBL3408947 | US10358436, Example A185 | US99078...) Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6C[C@H](C)O[C@H](C)C6)cc5)n[nH]c4c3)c2c1 Show InChI	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	84	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of TRKA (unknown origin) by cell-based assay				J Med Chem 58: 147-69 (2015) Article DOI: 10.1021/jm5005336 BindingDB Entry DOI: 10.7270/Q2M0475V
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50073587 (CHEMBL3408947 | US10358436, Example A185 | US99078...) Show SMILES COc1ccc2NC(=O)[C@@]3(C[C@H]3c3ccc4c(\C=C\c5ccc(CN6C[C@H](C)O[C@H](C)C6)cc5)n[nH]c4c3)c2c1 Show InChI	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	84	n/a	n/a	n/a	n/a
Zhengzhou University Curated by ChEMBL					Assay Description Inhibition of TRKA (unknown origin)				Eur J Med Chem 95: 35-40 (2015) Article DOI: 10.1016/j.ejmech.2015.03.020 BindingDB Entry DOI: 10.7270/Q2NG4SBV
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM191138 (US9181261, 15) Show SMILES CC(C)N(Cc1cccc(c1)-c1nccs1)C(=O)Nc1cnc(nc1)C(C)(C)C Show InChI InChI=1S/C22H27N5OS/c1-15(2)27(14-16-7-6-8-17(11-16)19-23-9-10-29-19)21(28)26-18-12-24-20(25-13-18)22(3,4)5/h6-13,15H,14H2,1-5H3,(H,26,28)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	102	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp US Patent					Assay Description TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...				US Patent US9181261 (2015) BindingDB Entry DOI: 10.7270/Q24F1PJ5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50022677 (CHEMBL3298270 | US9181261, 17) Show SMILES CC(C)N(Cc1cccc(c1)-c1nccs1)C(=O)Nc1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C21H20F3N3O2S/c1-14(2)27(13-15-4-3-5-16(12-15)19-25-10-11-30-19)20(28)26-17-6-8-18(9-7-17)29-21(22,23)24/h3-12,14H,13H2,1-2H3,(H,26,28)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	119	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp US Patent					Assay Description TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...				US Patent US9181261 (2015) BindingDB Entry DOI: 10.7270/Q24F1PJ5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM191139 (US9181261, 20) Show SMILES CC(C)N(Cc1n[nH]c2ncccc12)C(=O)Nc1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C18H18F3N5O2/c1-11(2)26(10-15-14-4-3-9-22-16(14)25-24-15)17(27)23-12-5-7-13(8-6-12)28-18(19,20)21/h3-9,11H,10H2,1-2H3,(H,23,27)(H,22,24,25)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	141	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp US Patent					Assay Description TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...				US Patent US9181261 (2015) BindingDB Entry DOI: 10.7270/Q24F1PJ5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505017 (CHEMBL4462161) Show SMILES COCCOc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2cccc(C)c2)c1=O Show InChI InChI=1S/C25H23N3O6/c1-17-7-6-8-18(15-17)27-23(29)26-24(30)28(25(27)31)19-11-12-21(22(16-19)33-14-13-32-2)34-20-9-4-3-5-10-20/h3-12,15-16H,13-14H2,1-2H3,(H,26,29,30)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	UniChem	PubMed	n/a	n/a	n/a	n/a	180	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505010 (CHEMBL4455143) Show SMILES COCCOc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2cccc(Cl)c2)c1=O Show InChI InChI=1S/C24H20ClN3O6/c1-32-12-13-33-21-15-18(10-11-20(21)34-19-8-3-2-4-9-19)28-23(30)26-22(29)27(24(28)31)17-7-5-6-16(25)14-17/h2-11,14-15H,12-13H2,1H3,(H,26,29,30)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	UniChem	PubMed	n/a	n/a	n/a	n/a	220	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505015 (CHEMBL4538772) Show SMILES Brc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C21H14BrN3O4/c22-17-13-15(11-12-18(17)29-16-9-5-2-6-10-16)25-20(27)23-19(26)24(21(25)28)14-7-3-1-4-8-14/h1-13H,(H,23,26,27)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	UniChem	PubMed	n/a	n/a	n/a	n/a	220	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505006 (CHEMBL4483402) Show SMILES COc1cc(Oc2ccccc2)ccc1-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C22H17N3O5/c1-29-19-14-17(30-16-10-6-3-7-11-16)12-13-18(19)25-21(27)23-20(26)24(22(25)28)15-8-4-2-5-9-15/h2-14H,1H3,(H,23,26,27)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	UniChem	PubMed	n/a	n/a	n/a	n/a	230	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505011 (CHEMBL4529332) Show SMILES COCCOc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccc(C)cc2)c1=O Show InChI InChI=1S/C25H23N3O6/c1-17-8-10-18(11-9-17)27-23(29)26-24(30)28(25(27)31)19-12-13-21(22(16-19)33-15-14-32-2)34-20-6-4-3-5-7-20/h3-13,16H,14-15H2,1-2H3,(H,26,29,30)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	UniChem	PubMed	n/a	n/a	n/a	n/a	290	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505018 (CHEMBL4464173) Show SMILES COc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C22H17N3O5/c1-29-19-14-16(12-13-18(19)30-17-10-6-3-7-11-17)25-21(27)23-20(26)24(22(25)28)15-8-4-2-5-9-15/h2-14H,1H3,(H,23,26,27)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	UniChem	PubMed	n/a	n/a	n/a	n/a	320	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505007 (CHEMBL4464037) Show SMILES Cc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C22H17N3O4/c1-15-14-17(12-13-19(15)29-18-10-6-3-7-11-18)25-21(27)23-20(26)24(22(25)28)16-8-4-2-5-9-16/h2-14H,1H3,(H,23,26,27)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	UniChem	PubMed	n/a	n/a	n/a	n/a	340	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505012 (CHEMBL4472787) Show SMILES CC(C)Oc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C24H21N3O5/c1-16(2)31-21-15-18(13-14-20(21)32-19-11-7-4-8-12-19)27-23(29)25-22(28)26(24(27)30)17-9-5-3-6-10-17/h3-16H,1-2H3,(H,25,28,29)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	UniChem	PubMed	n/a	n/a	n/a	n/a	360	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505016 (CHEMBL4527488) Show SMILES CCOc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccccc2)c1=O Show InChI InChI=1S/C23H19N3O5/c1-2-30-20-15-17(13-14-19(20)31-18-11-7-4-8-12-18)26-22(28)24-21(27)25(23(26)29)16-9-5-3-6-10-16/h3-15H,2H2,1H3,(H,24,27,28)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	UniChem	PubMed	n/a	n/a	n/a	n/a	390	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505005 (CHEMBL4455810) Show SMILES COCCOc1cc(ccc1Oc1ccccc1)-n1c(=O)[nH]c(=O)n(-c2ccc(Cl)cc2)c1=O Show InChI InChI=1S/C24H20ClN3O6/c1-32-13-14-33-21-15-18(11-12-20(21)34-19-5-3-2-4-6-19)28-23(30)26-22(29)27(24(28)31)17-9-7-16(25)8-10-17/h2-12,15H,13-14H2,1H3,(H,26,29,30)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	UniChem	PubMed	n/a	n/a	n/a	n/a	480	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505013 (CHEMBL4574315) Show SMILES Cn1c(=O)[nH]c(=O)n(-c2ccc(Oc3ccccc3)c(OCC3COC3)c2)c1=O Show InChI InChI=1S/C20H19N3O6/c1-22-18(24)21-19(25)23(20(22)26)14-7-8-16(29-15-5-3-2-4-6-15)17(9-14)28-12-13-10-27-11-13/h2-9,13H,10-12H2,1H3,(H,21,24,25)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	UniChem	PubMed	n/a	n/a	n/a	n/a	500	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505019 (CHEMBL4465865) Show SMILES O=c1[nH]c(=O)n(-c2ccc(Oc3ccccc3)c(OCC3COC3)c2)c(=O)n1-c1ccccc1 Show InChI InChI=1S/C25H21N3O6/c29-23-26-24(30)28(25(31)27(23)18-7-3-1-4-8-18)19-11-12-21(34-20-9-5-2-6-10-20)22(13-19)33-16-17-14-32-15-17/h1-13,17H,14-16H2,(H,26,29,30)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	UniChem	PubMed	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50508282 (CHEMBL4471556) Show SMILES COc1ccc(cc1)-c1cc2cccc(O)c2c(=O)o1 Show InChI InChI=1S/C16H12O4/c1-19-12-7-5-10(6-8-12)14-9-11-3-2-4-13(17)15(11)16(18)20-14/h2-9,17H,1H3	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	UniChem	PubMed	n/a	n/a	n/a	n/a	667	n/a	n/a	n/a	n/a
Indian Institute of Technology Madras Curated by ChEMBL					Assay Description Agonist activity at RFP-fused TrkA receptor (unknown origin) expressed in HEK293T cells after 6 hrs by luciferase reporter gene assay				Bioorg Med Chem Lett 29: 585-590 (2019)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505014 (CHEMBL4467829) Show SMILES O=c1[nH]c(=O)n(-c2ccc(Oc3ccccc3)c(OC3CCOC3)c2)c(=O)n1-c1ccccc1 Show InChI	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	UniChem	PubMed	n/a	n/a	n/a	n/a	780	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505008 (CHEMBL4518577) Show SMILES COc1cccc(c1)-n1c(=O)[nH]c(=O)n(-c2ccc(Oc3ccccc3)cc2)c1=O Show InChI InChI=1S/C22H17N3O5/c1-29-19-9-5-6-16(14-19)25-21(27)23-20(26)24(22(25)28)15-10-12-18(13-11-15)30-17-7-3-2-4-8-17/h2-14H,1H3,(H,23,26,27)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	UniChem	PubMed	n/a	n/a	n/a	n/a	830	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50446393 (CHEMBL3109644 | US9181261, 74) Show SMILES CC1(C)CN(C(=O)N1Cc1cccc(c1)-c1nccs1)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C22H20F3N3O2S/c1-21(2)14-27(17-6-8-18(9-7-17)30-22(23,24)25)20(29)28(21)13-15-4-3-5-16(12-15)19-26-10-11-31-19/h3-12H,13-14H2,1-2H3	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.01E+3	n/a	n/a	n/a	n/a
Therachem Research Medilab (India) Pvt. Ltd. Curated by ChEMBL					Assay Description Inhibition of TrkA (unknown origin) using fluorescently labeled peptide substrate after 3 hrs				ACS Med Chem Lett 5: 8-9 (2014) Article DOI: 10.1021/ml4005073 BindingDB Entry DOI: 10.7270/Q2B56M6V
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50446393 (CHEMBL3109644 | US9181261, 74) Show SMILES CC1(C)CN(C(=O)N1Cc1cccc(c1)-c1nccs1)c1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C22H20F3N3O2S/c1-21(2)14-27(17-6-8-18(9-7-17)30-22(23,24)25)20(29)28(21)13-15-4-3-5-16(12-15)19-26-10-11-31-19/h3-12H,13-14H2,1-2H3	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	1.01E+3	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp US Patent					Assay Description TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...				US Patent US9181261 (2015) BindingDB Entry DOI: 10.7270/Q24F1PJ5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50505009 (CHEMBL4542212) Show SMILES O=c1[nH]c(=O)n(-c2ccc(Oc3ccccc3)cc2)c(=O)n1-c1ccccc1 Show InChI InChI=1S/C21H15N3O4/c25-19-22-20(26)24(21(27)23(19)15-7-3-1-4-8-15)16-11-13-18(14-12-16)28-17-9-5-2-6-10-17/h1-14H,(H,22,25,26)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	UniChem	PubMed	n/a	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a
Usona Institute Curated by ChEMBL					Assay Description Agonist activity at TrkA (unknown origin) in expressed in U2OS cells incubated for 3 hrs and measured after 60 hrs in presence of NGF by fluorescence...				ACS Med Chem Lett 10: 1590-1591 (2019)
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50242740 (CHEMBL459850 | N-(3-(7-Amino-1-methyl-2-oxo-1,2-di...) Show SMILES CN1C(=O)N(Cc2cnc(N)nc12)c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C Show InChI InChI=1S/C22H19F3N6O2/c1-12-6-7-16(28-19(32)13-4-3-5-15(8-13)22(23,24)25)9-17(12)31-11-14-10-27-20(26)29-18(14)30(2)21(31)33/h3-10H,11H2,1-2H3,(H,28,32)(H2,26,27,29)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a
Harvard Medical School Curated by ChEMBL					Assay Description Inhibition of NTRK1				Proc Natl Acad Sci U S A 104: 19936-41 (2007) Article DOI: 10.1073/pnas.0707498104 BindingDB Entry DOI: 10.7270/Q24X58QS
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM191140 (US9181261, 152) Show SMILES CC(C)N(Cc1cc(ccn1)-c1nccs1)C(=O)Nc1ccc(OC(F)(F)F)cc1 Show InChI InChI=1S/C20H19F3N4O2S/c1-13(2)27(12-16-11-14(7-8-24-16)18-25-9-10-30-18)19(28)26-15-3-5-17(6-4-15)29-20(21,22)23/h3-11,13H,12H2,1-2H3,(H,26,28)	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	8.08E+3	n/a	n/a	n/a	25
Merck Sharp & Dohme Corp US Patent					Assay Description TrkA kinase activity was measured as the ability of the enzyme to phosphorylate a fluorescently labeled peptide substrate. Buffer salts, reagents, an...				US Patent US9181261 (2015) BindingDB Entry DOI: 10.7270/Q24F1PJ5
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM50020712 (10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...) Show SMILES CN(C)CCC=C1c2ccccc2CCc2ccccc12 Show InChI InChI=1S/C20H23N/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20/h3-6,8-12H,7,13-15H2,1-2H3	PDB MMDB Reactome pathway UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar	Purchase CHEBI CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	8.60E+4	n/a	n/a	n/a	n/a
Southmead Hospital Curated by ChEMBL					Assay Description Antagonist activity at full length glycosylated human TrkA expressed in HEKN3S cells cells assessed as reduction in NGF-induced ERK 42/44 phosphoryla...				J Med Chem 58: 767-77 (2015) Article DOI: 10.1021/jm501307e BindingDB Entry DOI: 10.7270/Q25B045H
					More data for this Ligand-Target Pair