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Compile Data Set for Download or QSAR

Found 31 hits of ic50 data for polymerid = 4019   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32522
PNG
(pyridine amide, 30)
Show SMILES Cc1ccc(cc1F)-c1cccc(n1)C(=O)N1CCCC(C)(C)C1
Show InChI InChI=1S/C20H23FN2O/c1-14-8-9-15(12-16(14)21)17-6-4-7-18(22-17)19(24)23-11-5-10-20(2,3)13-23/h4,6-9,12H,5,10-11,13H2,1-3H3
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n/an/a 0.100n/an/an/an/a6.523



Bristol-Myers Squibb Company



Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32521
PNG
(pyridine amide, 29)
Show SMILES CC1(C)CCCN(C1)C(=O)c1cccc(n1)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C20H21F3N2O2/c1-19(2)11-4-12-25(13-19)18(26)17-6-3-5-16(24-17)14-7-9-15(10-8-14)27-20(21,22)23/h3,5-10H,4,11-13H2,1-2H3
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n/an/a 1.10n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32520
PNG
(pyridine amide, 28)
Show SMILES CC1(C)CCCN(C1)C(=O)c1cccc(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C19H21ClN2O/c1-19(2)11-4-12-22(13-19)18(23)17-6-3-5-16(21-17)14-7-9-15(20)10-8-14/h3,5-10H,4,11-13H2,1-2H3
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32527
PNG
(pyridine amide, 35)
Show SMILES C[C@]12C[C@H](CC(C)(C)C1)N(C2)C(=O)c1cncc(COc2c(Cl)cccc2Cl)c1
Show InChI InChI=1S/C23H26Cl2N2O2/c1-22(2)8-17-9-23(3,13-22)14-27(17)21(28)16-7-15(10-26-11-16)12-29-20-18(24)5-4-6-19(20)25/h4-7,10-11,17H,8-9,12-14H2,1-3H3/t17-,23-/m0/s1
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32523
PNG
(pyridine amide, 31)
Show SMILES [O-][N+](=O)c1ccccc1-c1cccc(n1)C(=O)N1CCCC2CCCCC12
Show InChI InChI=1S/C21H23N3O3/c25-21(23-14-6-8-15-7-1-3-12-19(15)23)18-11-5-10-17(22-18)16-9-2-4-13-20(16)24(26)27/h2,4-5,9-11,13,15,19H,1,3,6-8,12,14H2
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32526
PNG
(pyridine amide, 34)
Show SMILES Clc1cccc(Cl)c1OCc1cncc(c1)C(=O)N1CCCCC1c1cccnc1
Show InChI InChI=1S/C23H21Cl2N3O2/c24-19-6-3-7-20(25)22(19)30-15-16-11-18(14-27-12-16)23(29)28-10-2-1-8-21(28)17-5-4-9-26-13-17/h3-7,9,11-14,21H,1-2,8,10,15H2
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32508
PNG
(pyridine amide, 23)
Show SMILES Clc1cccc(Cl)c1S(=O)(=O)Cc1cncc(c1)C(=O)N1CCCCCCCC1
Show InChI InChI=1S/C21H24Cl2N2O3S/c22-18-8-7-9-19(23)20(18)29(27,28)15-16-12-17(14-24-13-16)21(26)25-10-5-3-1-2-4-6-11-25/h7-9,12-14H,1-6,10-11,15H2
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32519
PNG
(pyridine amide, 27)
Show SMILES CC1(C)CCCN(C1)C(=O)c1cccc(n1)-c1ccccc1Cl
Show InChI InChI=1S/C19H21ClN2O/c1-19(2)11-6-12-22(13-19)18(23)17-10-5-9-16(21-17)14-7-3-4-8-15(14)20/h3-5,7-10H,6,11-13H2,1-2H3
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32524
PNG
(pyridine amide, 32)
Show SMILES FC(F)(F)c1ccc(cc1)-c1cccc(n1)C(=O)N1CCCC2CCCCC12
Show InChI InChI=1S/C22H23F3N2O/c23-22(24,25)17-12-10-15(11-13-17)18-7-3-8-19(26-18)21(28)27-14-4-6-16-5-1-2-9-20(16)27/h3,7-8,10-13,16,20H,1-2,4-6,9,14H2
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n/an/a 3.60n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32529
PNG
(pyridine amide, 37)
Show SMILES Clc1cccc(Cl)c1OCc1cccc(n1)C(=O)N1CCCC2CCCCC12
Show InChI InChI=1S/C22H24Cl2N2O2/c23-17-9-4-10-18(24)21(17)28-14-16-8-3-11-19(25-16)22(27)26-13-5-7-15-6-1-2-12-20(15)26/h3-4,8-11,15,20H,1-2,5-7,12-14H2
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32525
PNG
(pyridine amide, 33)
Show SMILES O=C(N1CCCC2CCCCC12)c1cccc(n1)-c1ccccc1-c1ccccc1
Show InChI InChI=1S/C27H28N2O/c30-27(29-19-9-13-21-12-4-7-18-26(21)29)25-17-8-16-24(28-25)23-15-6-5-14-22(23)20-10-2-1-3-11-20/h1-3,5-6,8,10-11,14-17,21,26H,4,7,9,12-13,18-19H2
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32528
PNG
(pyridine amide, 36)
Show SMILES CC1(C)CCCN(C1)C(=O)c1cccc(COc2c(Cl)cc(Cl)cc2Cl)n1
Show InChI InChI=1S/C20H21Cl3N2O2/c1-20(2)7-4-8-25(12-20)19(26)17-6-3-5-14(24-17)11-27-18-15(22)9-13(21)10-16(18)23/h3,5-6,9-10H,4,7-8,11-12H2,1-2H3
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32512
PNG
(pyridine amide, 6)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(CSc2c(Cl)cccc2Cl)n1
Show InChI InChI=1S/C19H20Cl2N2OS/c1-13-8-10-23(11-9-13)19(24)17-7-2-4-14(22-17)12-25-18-15(20)5-3-6-16(18)21/h2-7,13H,8-12H2,1H3
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32507
PNG
(pyridine amide, 22)
Show SMILES Clc1cccc(Cl)c1S(=O)(=O)Cc1cncc(c1)C(=O)N1CCCCCCC1
Show InChI InChI=1S/C20H22Cl2N2O3S/c21-17-7-6-8-18(22)19(17)28(26,27)14-15-11-16(13-23-12-15)20(25)24-9-4-2-1-3-5-10-24/h6-8,11-13H,1-5,9-10,14H2
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n/an/a 11n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32518
PNG
(pyridine amide, 9)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(n1)-c1ccccc1Cl
Show InChI InChI=1S/C18H19ClN2O/c1-13-9-11-21(12-10-13)18(22)17-8-4-7-16(20-17)14-5-2-3-6-15(14)19/h2-8,13H,9-12H2,1H3
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
3D
3D Structure (docked)
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32506
PNG
(pyridine amide, 21)
Show SMILES Clc1cccc(Cl)c1S(=O)(=O)Cc1cncc(c1)C(=O)N1CCCCCC1
Show InChI InChI=1S/C19H20Cl2N2O3S/c20-16-6-5-7-17(21)18(16)27(25,26)13-14-10-15(12-22-11-14)19(24)23-8-3-1-2-4-9-23/h5-7,10-12H,1-4,8-9,13H2
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32500
PNG
(pyridine amide, 15)
Show SMILES CC1CCN(CC1)C(=O)c1cncc(CS(=O)(=O)c2c(Cl)cccc2Cl)c1
Show InChI InChI=1S/C19H20Cl2N2O3S/c1-13-5-7-23(8-6-13)19(24)15-9-14(10-22-11-15)12-27(25,26)18-16(20)3-2-4-17(18)21/h2-4,9-11,13H,5-8,12H2,1H3
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32499
PNG
(pyridine amide, 8)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(CS(=O)(=O)c2c(Cl)cccc2Cl)n1
Show InChI InChI=1S/C19H20Cl2N2O3S/c1-13-8-10-23(11-9-13)19(24)17-7-2-4-14(22-17)12-27(25,26)18-15(20)5-3-6-16(18)21/h2-7,13H,8-12H2,1H3
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32513
PNG
(pyridine amide, 7)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(COc2c(Cl)cccc2Cl)n1
Show InChI InChI=1S/C19H20Cl2N2O2/c1-13-8-10-23(11-9-13)19(24)17-7-2-4-14(22-17)12-25-18-15(20)5-3-6-16(18)21/h2-7,13H,8-12H2,1H3
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32501
PNG
(pyridine amide, 16)
Show SMILES CC1CCN(CC1)C(=O)c1ccnc(CS(=O)(=O)c2c(Cl)cccc2Cl)c1
Show InChI InChI=1S/C19H20Cl2N2O3S/c1-13-6-9-23(10-7-13)19(24)14-5-8-22-15(11-14)12-27(25,26)18-16(20)3-2-4-17(18)21/h2-5,8,11,13H,6-7,9-10,12H2,1H3
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n/an/a 106n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32514
PNG
(pyridine amide, 11)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(Sc2ccccc2Cl)n1
Show InChI InChI=1S/C18H19ClN2OS/c1-13-9-11-21(12-10-13)18(22)15-6-4-8-17(20-15)23-16-7-3-2-5-14(16)19/h2-8,13H,9-12H2,1H3
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32509
PNG
(pyridine amide, 24)
Show SMILES Clc1cccc(Cl)c1S(=O)(=O)Cc1cncc(c1)C(=O)N1CCCCC1
Show InChI InChI=1S/C18H18Cl2N2O3S/c19-15-5-4-6-16(20)17(15)26(24,25)12-13-9-14(11-21-10-13)18(23)22-7-2-1-3-8-22/h4-6,9-11H,1-3,7-8,12H2
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n/an/a 220n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32515
PNG
(pyridine amide, 12)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(Oc2ccccc2Cl)n1
Show InChI InChI=1S/C18H19ClN2O2/c1-13-9-11-21(12-10-13)18(22)15-6-4-8-17(20-15)23-16-7-3-2-5-14(16)19/h2-8,13H,9-12H2,1H3
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n/an/a 282n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32502
PNG
(pyridine amide, 17)
Show SMILES CC1CCN(CC1)C(=O)c1cc(CS(=O)(=O)c2c(Cl)cccc2Cl)ccn1
Show InChI InChI=1S/C19H20Cl2N2O3S/c1-13-6-9-23(10-7-13)19(24)17-11-14(5-8-22-17)12-27(25,26)18-15(20)3-2-4-16(18)21/h2-5,8,11,13H,6-7,9-10,12H2,1H3
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32516
PNG
(pyridine amide, 13)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(Nc2ccccc2Cl)n1
Show InChI InChI=1S/C18H20ClN3O/c1-13-9-11-22(12-10-13)18(23)16-7-4-8-17(21-16)20-15-6-3-2-5-14(15)19/h2-8,13H,9-12H2,1H3,(H,20,21)
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n/an/a 381n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32503
PNG
(pyridine amide, 18)
Show SMILES CC1CCN(CC1)C(=O)c1ccc(CS(=O)(=O)c2c(Cl)cccc2Cl)nc1
Show InChI InChI=1S/C19H20Cl2N2O3S/c1-13-7-9-23(10-8-13)19(24)14-5-6-15(22-11-14)12-27(25,26)18-16(20)3-2-4-17(18)21/h2-6,11,13H,7-10,12H2,1H3
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n/an/a 2.05E+3n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32504
PNG
(pyridine amide, 19)
Show SMILES CC1CCN(CC1)C(=O)c1ccc(CS(=O)(=O)c2c(Cl)cccc2Cl)cn1
Show InChI InChI=1S/C19H20Cl2N2O3S/c1-13-7-9-23(10-8-13)19(24)17-6-5-14(11-22-17)12-27(25,26)18-15(20)3-2-4-16(18)21/h2-6,11,13H,7-10,12H2,1H3
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n/an/a 2.13E+3n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32505
PNG
(pyridine amide, 20)
Show SMILES Clc1cccc(Cl)c1S(=O)(=O)Cc1cncc(c1)C(=O)N1CCCC1
Show InChI InChI=1S/C17H16Cl2N2O3S/c18-14-4-3-5-15(19)16(14)25(23,24)11-12-8-13(10-20-9-12)17(22)21-6-1-2-7-21/h3-5,8-10H,1-2,6-7,11H2
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n/an/a 2.14E+3n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32510
PNG
(pyridine amide, 25)
Show SMILES NC(=O)C1CCN(CC1)C(=O)c1cncc(CS(=O)(=O)c2c(Cl)cccc2Cl)c1
Show InChI InChI=1S/C19H19Cl2N3O4S/c20-15-2-1-3-16(21)17(15)29(27,28)11-12-8-14(10-23-9-12)19(26)24-6-4-13(5-7-24)18(22)25/h1-3,8-10,13H,4-7,11H2,(H2,22,25)
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n/an/a 2.35E+3n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32517
PNG
(pyridine amide, 14)
Show SMILES CC1CCN(CC1)C(=O)c1cccc(n1)S(=O)(=O)c1ccccc1Cl
Show InChI InChI=1S/C18H19ClN2O3S/c1-13-9-11-21(12-10-13)18(22)15-6-4-8-17(20-15)25(23,24)16-7-3-2-5-14(16)19/h2-8,13H,9-12H2,1H3
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n/an/a 4.67E+3n/an/an/an/a6.523



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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair
11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1)


(Homo sapiens (Human))
BDBM32511
PNG
(pyridine amide, 26)
Show SMILES Clc1cccc(Cl)c1S(=O)(=O)Cc1cncc(c1)C(=O)N1CCOCC1
Show InChI InChI=1S/C17H16Cl2N2O4S/c18-14-2-1-3-15(19)16(14)26(23,24)11-12-8-13(10-20-9-12)17(22)21-4-6-25-7-5-21/h1-3,8-10H,4-7,11H2
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Assay Description
11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...


Bioorg Med Chem Lett 18: 3168-72 (2008)

More data for this
Ligand-Target Pair