BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 728 hits of affinity data for UniProtKB/TrEMBL: P35557    Zinc 0: unavailable per Zinc DB. Zinc 1: purchasable, 2 weeks to supply. Zinc 2: made on demand. Zinc 4: potentially available
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucokinase


(Homo sapiens (Human))
CHEMBL584052
PNG
(10-(4-hydroxyphenyl)-8,13,15-triazatetracyclo[9.6....)
Show SMILES Oc1ccc(cc1)C1c2c[nH]c3nccc(-c4ccccc4NC1=O)c23
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
ZINC 0

Patents

AffyNet 
Article
PubMed
340.0n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of GCK


Citation and Details
corrected by BindingDB staff
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3113985
PNG
Show SMILES CC(O)(c1ccc(cc1)N1CCN(C[C@@H]1CN1C2CCC1COC2)S(=O)(=O)c1cccs1)C(F)(F)F
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 2.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3114185
PNG
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 4.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3114183
PNG
Show SMILES CC#CC1CN(CCN1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 6.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3114186
PNG
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[C@](C)(O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 6.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3113980
PNG
Show SMILES C[C@H]1COCCN1C[C@H]1CN(CCN1c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1cccs1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 7.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3114187
PNG
Show SMILES CC#C[C@H]1CN(CCN1c1ccc(cc1)[C@@](C)(O)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 9.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3113988
PNG
Show SMILES C[C@@](O)(c1ccc(cc1)N1CCN(C[C@@H]1CN1[C@@H]2C[C@@H](O)[C@H]1COC2)S(=O)(=O)c1cccs1)C(F)(F)F
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 14.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3113989
PNG
Show SMILES C[C@](O)(c1ccc(cc1)N1CCN(C[C@@H]1CN1[C@@H]2C[C@@H](O)[C@H]1COC2)S(=O)(=O)c1cccs1)C(F)(F)F
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 16.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3113990
PNG
Show SMILES C[C@@](O)(c1ccc(cc1)N1CCN(C[C@@H]1CN1[C@H]2C[C@H](O)[C@@H]1COC2)S(=O)(=O)c1cccs1)C(F)(F)F
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 25.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3113987
PNG
Show SMILES CC(O)(c1ccc(cc1)N1CCN(C[C@@H]1CN1[C@@H]2C[C@H](O)[C@@H]1COC2)S(=O)(=O)c1cccs1)C(F)(F)F
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 26.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3113986
PNG
Show SMILES CC(O)(c1ccc(cc1)N1CCN(C[C@@H]1CN1[C@@H]2C[C@@H](O)[C@@H]1COC2)S(=O)(=O)c1cccs1)C(F)(F)F
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 44.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3114188
PNG
Show SMILES CCC#CC1CN(CCN1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 56.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3113991
PNG
Show SMILES C[C@](O)(c1ccc(cc1)N1CCN(C[C@@H]1CN1[C@H]2C[C@H](O)[C@@H]1COC2)S(=O)(=O)c1cccs1)C(F)(F)F
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 56.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens)
CHEMBL2064666
PNG
Show SMILES COc1c(Nc2ncc(Cl)c(N[C@@H]3[C@@H]4C[C@@H](C=C4)[C@@H]3C(N)=O)n2)ccc2CC[C@@H](CCc12)N1CCOCC1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/a 60.0n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GCK


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3114000
PNG
Show SMILES Nc1ccc(cn1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 87.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3113983
PNG
Show SMILES CC1CS(=O)(=O)CCN1C[C@H]1CN(CCN1c1ccc(cc1)C(C)(O)C(F)(F)F)S(=O)(=O)c1cccs1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 90.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3113994
PNG
Show SMILES Nc1ccc(s1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 252.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3114001
PNG
Show SMILES Nc1ncc(cn1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 316.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3113995
PNG
Show SMILES Nc1csc(c1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 324.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3113982
PNG
Show SMILES CC(O)(c1ccc(cc1)N1CCN(C[C@@H]1CN1CCS(=O)(=O)CC1)S(=O)(=O)c1cccs1)C(F)(F)F
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 343.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3113981
PNG
Show SMILES CC(O)(c1ccc(cc1)N1CCN(C[C@@H]1CN1CCC(F)(F)CC1)S(=O)(=O)c1cccs1)C(F)(F)F
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 439.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3113996
PNG
Show SMILES Nc1ccccc1S(=O)(=O)N1CCN(CC1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 445.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3113998
PNG
Show SMILES Nc1ccc(cc1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 484.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3114184
PNG
Show SMILES CC#C[C@@H]1CN(CCN1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 484.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3113984
PNG
Show SMILES CC(O)(c1ccc(cc1)N1CCN(C[C@@H]1CN1CC2(COC2)C1)S(=O)(=O)c1cccs1)C(F)(F)F
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 524.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3113997
PNG
Show SMILES Nc1cccc(c1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 645.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3114189
PNG
Show SMILES Nc1ccc(cn1)S(=O)(=O)N1CCN(C(C1)C#CC1CC1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 779.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3113993
PNG
Show SMILES OC(c1ccc(cc1)N1CCN(CC1)S(=O)(=O)c1ccccc1)(C(F)(F)F)C(F)(F)F
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 1010.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens)
CHEMBL1080994
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1cccc(\C=C\c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)c1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/a 1300.0n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of GCK


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3113992
PNG
Show SMILES OC(c1ccc(cc1)N1CCN(CC1)S(=O)(=O)c1cccs1)(C(F)(F)F)C(F)(F)F
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
AffyNet 
Article
PubMed
n/an/a 1420.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3114190
PNG
Show SMILES CC(C)(C)C#CC1CN(CCN1c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F)S(=O)(=O)c1ccc(N)nc1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 1430.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase (GCK)


(Homo sapiens (Human))
Kinase inhibitor, A2
PNG
Show SMILES Nc1cnc2c(cccn2c1=O)-c1c(F)cccc1F
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
ZINC 0
AffyNet 
Article
PubMed
n/an/a 4000.0n/an/an/an/an/an/a



University of Dundee



Assay Description
Selected compounds were screened against a panel of mammalian kinases. Compounds were supplied in DMSO and screened in duplicates at 100 uM concentr...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens)
CHEMBL1087650
PNG
(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Show SMILES CN1C[C@@H]2C[C@H]1CN2c1ccc(cc1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc(O)c1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/a 4100.0n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of GCK


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase (GCK)


(Homo sapiens (Human))
Kinase inhibitor, B1
PNG
Show SMILES Nc1nc2cnc(cn2n1)-c1ccccc1
PDB
MMDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
PDB
ZINC 0
AffyNet 
Article
PubMed
n/an/a 6000.0n/an/an/an/an/an/a



University of Dundee



Assay Description
Selected compounds were screened against a panel of mammalian kinases. Compounds were supplied in DMSO and screened in duplicates at 100 uM concentr...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
CHEMBL3113999
PNG
Show SMILES Nc1cc(ccn1)S(=O)(=O)N1CCN(CC1)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
AffyNet 
Article
PubMed
n/an/a 8630.0n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of fluorescein-labeled human GK interaction with biotin-labeled human GKRP incubated for 20 mins prior to addition of fluorescein-labeled ...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens)
CHEMBL1095626
PNG
(methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazo...)
Show SMILES COC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(N)cc1)N1CCOCC1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/a>50000.0n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of GCK


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens)
CHEMBL1095627
PNG
(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(N)cc1)N1CCOCC1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/a>50000.0n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of GCK


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens)
CHEMBL1080995
PNG
(6-methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-m...)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1cccc(\C=C\c2c(C)ncc(C#N)c2Nc2ccc3[nH]ccc3c2C)c1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/a>50000.0n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of GCK


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens)
CHEMBL1089082
PNG
(N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1ccncc1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/a>50000.0n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of GCK


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens)
CHEMBL1092754
PNG
(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Show SMILES Cn1cc(\C=C2/Oc3cccc(O)c3C2=O)c2c(ccnc12)-c1ccc(cc1)C(=O)NCCO
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/a 50000.0n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of GCK


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13m
PNG
Show SMILES Nc1cc(F)c(Sc2nccs2)cc1C(=O)Nc1cccc(c1)C#N
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13n
PNG
Show SMILES Cc1csc(Sc2cc(C(=O)Nc3cccc(c3)C#N)c(N)cc2F)n1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13v
PNG
Show SMILES COc1ccc(NC(=O)c2cc(Sc3nccn3C)c(F)cc2N)cc1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/an/an/a 1360n/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13w
PNG
Show SMILES COc1cccc(NC(=O)c2cc(Sc3nccn3C)c(F)cc2N)c1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13x
PNG
Show SMILES COc1ccc(NC(=O)c2cc(Sc3nccn3C)c(F)cc2N)cc1OC
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 14a
PNG
Show SMILES Nc1cccc(NC(=O)CN2CCN(CC2)c2ccccc2F)c1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 14b
PNG
Show SMILES Fc1ccccc1N1CCN(CC(=O)Nc2cccc(c2)C(F)(F)F)CC1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 14c
PNG
Show SMILES Fc1cccc(NC(=O)CN2CCN(CC2)c2ccccc2F)c1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 14d
PNG
Show SMILES Fc1ccccc1N1CCN(CC(=O)Nc2cccc(c2)C#N)CC1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
ZINC 0
AffyNet 
Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 728 total )  |  Next  |  Last  >>
Jump to: