Compile Data Set for Download or QSAR
maximum 50k data
Found 58 of ki for UniProtKB: P07382
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)
Affinity DataKi:  0.129nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291790(1-[3-(Biphenyl-3-yloxymethyl)-phenyl]-6,6-dimethyl...)
Affinity DataKi:  17.0nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291769(6,6-Dimethyl-1-(3-nonyl-phenyl)-1,6-dihydro-[1,3,5...)
Affinity DataKi:  20.9nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291791(6,6-Dimethyl-1-[3-(naphthalen-1-yloxymethyl)-pheny...)
Affinity DataKi:  39.8nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291772(6,6-Dimethyl-1-[3-(2,4,5-trichloro-phenoxymethyl)-...)
Affinity DataKi:  69.2nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291803(1-(3-Dodecyl-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3...)
Affinity DataKi:  72.4nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291778(CHEMBL20812 | N-{3-[3-(4,6-Diamino-2,2-dimethyl-2H...)
Affinity DataKi:  75.9nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291805(6,6-Dimethyl-1-{3-[4-(3-trifluoromethyl-phenoxy)-b...)
Affinity DataKi:  75.9nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM18771((2S)-2-[(4-{[(2-amino-4-oxo-1,4-dihydroquinazolin-...)
Affinity DataKi:  80nM ΔG°:  -9.51kcal/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291771(CHEMBL20528 | {3-[3-(4,6-Diamino-2,2-dimethyl-2H-[...)
Affinity DataKi:  91.2nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291807(1-[3-(4-Chloro-benzylsulfanyl)-phenyl]-6,6-dimethy...)
Affinity DataKi:  110nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM18069(5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-d...)
Affinity DataKi:  120nMAssay Description:Inhibition of Leishmania major DHFR assessed by NADPH oxidation measured by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291802(1-[3-(3-Ethyl-phenoxymethyl)-phenyl]-6,6-dimethyl-...)
Affinity DataKi:  126nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291783(1-[3-(3-Methoxy-phenoxymethyl)-phenyl]-6,6-dimethy...)
Affinity DataKi:  151nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291766(1-[3-(3-Isopropyl-phenoxymethyl)-phenyl]-6,6-dimet...)
Affinity DataKi:  174nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291782(3-[3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1...)
Affinity DataKi:  178nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291789(1-[3-(3-Chloro-phenoxymethyl)-phenyl]-6,6-dimethyl...)
Affinity DataKi:  224nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291804(1-(3-Benzylsulfanyl-phenyl)-6,6-dimethyl-1,6-dihyd...)
Affinity DataKi:  224nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291797(6,6-Dimethyl-1-{3-[2-(3-trifluoromethyl-phenoxy)-e...)
Affinity DataKi:  251nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291768(6,6-Dimethyl-1-(3-phenylselanylmethyl-phenyl)-1,6-...)
Affinity DataKi:  275nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291784(6,6-Dimethyl-1-(3-nonyloxy-phenyl)-1,6-dihydro-[1,...)
Affinity DataKi:  302nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291787(6,6-Dimethyl-1-[3-(4-pentyl-phenoxymethyl)-phenyl]...)
Affinity DataKi:  339nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291794(6,6-Dimethyl-1-(3-phenylsulfanylmethyl-phenyl)-1,6...)
Affinity DataKi:  407nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291785(6,6-Dimethyl-1-(3-m-tolyloxymethyl-phenyl)-1,6-dih...)
Affinity DataKi:  427nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291781(5-[3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1...)
Affinity DataKi:  513nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291795(CHEMBL441503 | {3-[3-(4,6-Diamino-2,2-dimethyl-2H-...)
Affinity DataKi:  646nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291765(1-{3-[(4-Chloro-phenylamino)-methyl]-phenyl}-6,6-d...)
Affinity DataKi:  661nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291792(4-[3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1...)
Affinity DataKi:  759nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291800(6,6-Dimethyl-1-(3-undecyloxy-phenyl)-1,6-dihydro-[...)
Affinity DataKi:  977nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50090054(1-(3-Chloro-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291780(1-(3-Benzyloxy-phenyl)-6,6-dimethyl-1,6-dihydro-[1...)
Affinity DataKi:  1.91E+3nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291767(1-(3-Ethyl-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,5...)
Affinity DataKi:  1.95E+3nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291793(6,6-Dimethyl-1-(3-trifluoromethyl-phenyl)-1,6-dihy...)
Affinity DataKi:  2.19E+3nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291806(1-[3-(Adamantan-1-ylmethoxy)-phenyl]-6,6-dimethyl-...)
Affinity DataKi:  3.09E+3nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291786(1-(3-Hexyloxy-phenyl)-6,6-dimethyl-1,6-dihydro-[1,...)
Affinity DataKi:  3.98E+3nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50398388(CHEMBL2178604)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of Leishmania major DHFR assessed by NADPH oxidation measured by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291798(1-(3-tert-Butyl-phenyl)-6,6-dimethyl-1,6-dihydro-[...)
Affinity DataKi:  5.75E+3nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291801(6,6-Dimethyl-1-(3-tetradecyloxy-phenyl)-1,6-dihydr...)
Affinity DataKi:  5.89E+3nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291779(3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1-yl...)
Affinity DataKi:  6.03E+3nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291774(6,6-Dimethyl-1-(3-nitro-phenyl)-1,6-dihydro-[1,3,5...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50090067(6,6-Dimethyl-1-phenyl-1,6-dihydro-[1,3,5]triazine-...)
Affinity DataKi:  1.26E+4nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50562452(CHEMBL4776197)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of Leishmania major DHFR assessed by NADPH oxidation measured by spectrophotometric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50291796(1-(3-Methoxy-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3...)
Affinity DataKi:  2.29E+4nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291788(1-(3-Ethoxy-phenyl)-6,6-dimethyl-1,6-dihydro-[1,3,...)
Affinity DataKi:  3.80E+4nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291799(1-[3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1...)
Affinity DataKi:  3.98E+4nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50562451(CHEMBL4763597)
Affinity DataKi:  4.00E+4nMAssay Description:Inhibition of Leishmania major DHFR assessed by NADPH oxidation measured by spectrophotometric methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM18759(1,2-naphthalein derivative, 5 | 3,3-bis(3,5-dibrom...)
Affinity DataKi:  4.10E+4nM ΔG°:  -5.88kcal/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291773(CHEMBL21051 | [3-(4,6-Diamino-2,2-dimethyl-2H-[1,3...)
Affinity DataKi:  4.27E+4nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50291775(3-(4,6-Diamino-2,2-dimethyl-2H-[1,3,5]triazin-1-yl...)
Affinity DataKi:  5.37E+4nMAssay Description:Inhibition of dihydrofolate reductase (DHFR) from Leishmania majorChecked by AuthorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM18758(1,2-naphthalein derivative, 4 | 3,3-bis(3-bromo-4-...)
Affinity DataKi:  6.30E+4nM ΔG°:  -5.63kcal/molepH: 7.0 T: 2°CAssay Description:The inhibition assay pattern for all of the compounds was determined by steady-state kinetic analysis of the dependence of the TS enzyme activity on ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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