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Compile Data Set for Download or QSAR

Found 554 hits of ki for UniProtKB: P09958   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Furin


(Homo sapiens (Human))
BDBM50264892
PNG
(CHEMBL4065072)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C51H91N15O8/c1-29(2)25-39(64-49(73)41(27-31(5)6)65-48(72)40(26-30(3)4)63-45(69)37(60-33(9)67)16-11-13-23-53)47(71)61-38(17-14-24-58-51(56)57)46(70)66-42(32(7)8)50(74)62-36(15-10-12-22-52)44(68)59-28-34-18-20-35(21-19-34)43(54)55/h18-21,29-32,36-42H,10-17,22-28,52-53H2,1-9H3,(H3,54,55)(H,59,68)(H,60,67)(H,61,71)(H,62,74)(H,63,69)(H,64,73)(H,65,72)(H,66,70)(H4,56,57,58)/t36-,37-,38-,39-,40-,41-,42-/m0/s1
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0.400n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Furin


(Homo sapiens (Human))
BDBM50265344
PNG
(CHEMBL4070237)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C51H91N17O8/c1-28(2)24-38(62-32(9)69)46(73)67-40(26-30(5)6)48(75)63-36(15-12-22-59-50(55)56)44(71)66-39(25-29(3)4)47(74)64-37(16-13-23-60-51(57)58)45(72)68-41(31(7)8)49(76)65-35(14-10-11-21-52)43(70)61-27-33-17-19-34(20-18-33)42(53)54/h17-20,28-31,35-41H,10-16,21-27,52H2,1-9H3,(H3,53,54)(H,61,70)(H,62,69)(H,63,75)(H,64,74)(H,65,76)(H,66,71)(H,67,73)(H,68,72)(H4,55,56,59)(H4,57,58,60)/t35-,36-,37-,38-,39-,40-,41-/m0/s1
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0.5n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50265119
PNG
(CHEMBL4091099)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C51H91N17O8/c1-28(2)24-38(62-32(9)69)46(73)63-36(15-12-22-59-50(55)56)44(71)66-40(26-30(5)6)48(75)67-39(25-29(3)4)47(74)64-37(16-13-23-60-51(57)58)45(72)68-41(31(7)8)49(76)65-35(14-10-11-21-52)43(70)61-27-33-17-19-34(20-18-33)42(53)54/h17-20,28-31,35-41H,10-16,21-27,52H2,1-9H3,(H3,53,54)(H,61,70)(H,62,69)(H,63,73)(H,64,74)(H,65,76)(H,66,71)(H,67,75)(H,68,72)(H4,55,56,59)(H4,57,58,60)/t35-,36-,37-,38-,39-,40-,41-/m0/s1
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0.5n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50265083
PNG
(CHEMBL4100996)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C51H91N15O8/c1-29(2)25-39(60-33(9)67)47(71)61-37(16-11-13-23-53)45(69)64-41(27-31(5)6)49(73)65-40(26-30(3)4)48(72)62-38(17-14-24-58-51(56)57)46(70)66-42(32(7)8)50(74)63-36(15-10-12-22-52)44(68)59-28-34-18-20-35(21-19-34)43(54)55/h18-21,29-32,36-42H,10-17,22-28,52-53H2,1-9H3,(H3,54,55)(H,59,68)(H,60,67)(H,61,71)(H,62,72)(H,63,74)(H,64,69)(H,65,73)(H,66,70)(H4,56,57,58)/t36-,37-,38-,39-,40-,41-,42-/m0/s1
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0.600n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Furin


(Homo sapiens (Human))
BDBM50264960
PNG
(CHEMBL4089819)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C51H91N17O8/c1-28(2)24-38(62-32(9)69)46(73)66-40(26-30(5)6)48(75)67-39(25-29(3)4)47(74)64-36(15-12-22-59-50(55)56)44(71)63-37(16-13-23-60-51(57)58)45(72)68-41(31(7)8)49(76)65-35(14-10-11-21-52)43(70)61-27-33-17-19-34(20-18-33)42(53)54/h17-20,28-31,35-41H,10-16,21-27,52H2,1-9H3,(H3,53,54)(H,61,70)(H,62,69)(H,63,71)(H,64,74)(H,65,76)(H,66,73)(H,67,75)(H,68,72)(H4,55,56,59)(H4,57,58,60)/t35-,36-,37-,38-,39-,40-,41-/m0/s1
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0.700n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50303774
PNG
(CHEMBL566340 | phenylacetyl-Arg-Val-Arg-4-amidinob...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C33H50N12O4/c1-20(2)27(45-30(48)25(11-7-17-41-33(38)39)43-26(46)18-21-8-4-3-5-9-21)31(49)44-24(10-6-16-40-32(36)37)29(47)42-19-22-12-14-23(15-13-22)28(34)35/h3-5,8-9,12-15,20,24-25,27H,6-7,10-11,16-19H2,1-2H3,(H3,34,35)(H,42,47)(H,43,46)(H,44,49)(H,45,48)(H4,36,37,40)(H4,38,39,41)/t24-,25-,27-/m0/s1
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0.810n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human furin by fluorescence assay


J Med Chem 53: 1067-75 (2010)


Article DOI: 10.1021/jm9012455
BindingDB Entry DOI: 10.7270/Q2DN455Q
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50303774
PNG
(CHEMBL566340 | phenylacetyl-Arg-Val-Arg-4-amidinob...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C33H50N12O4/c1-20(2)27(45-30(48)25(11-7-17-41-33(38)39)43-26(46)18-21-8-4-3-5-9-21)31(49)44-24(10-6-16-40-32(36)37)29(47)42-19-22-12-14-23(15-13-22)28(34)35/h3-5,8-9,12-15,20,24-25,27H,6-7,10-11,16-19H2,1-2H3,(H3,34,35)(H,42,47)(H,43,46)(H,44,49)(H,45,48)(H4,36,37,40)(H4,38,39,41)/t24-,25-,27-/m0/s1
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0.810n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Bioorg Med Chem Lett 21: 4695-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.091
BindingDB Entry DOI: 10.7270/Q27W6CJR
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50386999
PNG
(CHEMBL2049152)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NCC(=O)Oc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)Nc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C32H48N12O5/c1-19(2)26(44-28(46)23(10-6-16-39-31(35)36)41-18-25(45)49-22-8-4-3-5-9-22)30(48)43-24(11-7-17-40-32(37)38)29(47)42-21-14-12-20(13-15-21)27(33)34/h3-5,8-9,12-15,19,23-24,26,41H,6-7,10-11,16-18H2,1-2H3,(H3,33,34)(H,42,47)(H,43,48)(H,44,46)(H4,35,36,39)(H4,37,38,40)/t23-,24-,26-/m0/s1
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0.810n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Inhibition of furin


Bioorg Med Chem 20: 4462-71 (2012)


Article DOI: 10.1016/j.bmc.2012.05.029
BindingDB Entry DOI: 10.7270/Q2514075
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50349574
PNG
(CHEMBL1808902)
Show SMILES NC(N)=NCCC[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](CNC(N)=N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C32H49N15O4/c33-26(34)21-12-10-20(11-13-21)17-43-27(49)22(8-4-14-41-30(35)36)46-29(51)24(18-44-32(39)40)47-28(50)23(9-5-15-42-31(37)38)45-25(48)16-19-6-2-1-3-7-19/h1-3,6-7,10-13,22-24H,4-5,8-9,14-18H2,(H3,33,34)(H,43,49)(H,45,48)(H,46,51)(H,47,50)(H4,35,36,41)(H4,37,38,42)(H4,39,40,44)/t22-,23-,24-/m0/s1
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0.830n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Bioorg Med Chem Lett 21: 4695-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.091
BindingDB Entry DOI: 10.7270/Q27W6CJR
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50349575
PNG
(CHEMBL1808903)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C34H52N12O4/c1-3-21(2)28(46-31(49)26(12-8-18-42-34(39)40)44-27(47)19-22-9-5-4-6-10-22)32(50)45-25(11-7-17-41-33(37)38)30(48)43-20-23-13-15-24(16-14-23)29(35)36/h4-6,9-10,13-16,21,25-26,28H,3,7-8,11-12,17-20H2,1-2H3,(H3,35,36)(H,43,48)(H,44,47)(H,45,50)(H,46,49)(H4,37,38,41)(H4,39,40,42)/t21-,25-,26-,28-/m0/s1
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0.840n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Bioorg Med Chem Lett 21: 4695-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.091
BindingDB Entry DOI: 10.7270/Q27W6CJR
More data for this
Ligand-Target Pair
Furin


(Homo sapiens (Human))
BDBM50264931
PNG
(CHEMBL4084457)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C51H86N16O8/c1-28(2)21-38(61-32(9)68)46(71)64-39(22-29(3)4)47(72)65-40(23-30(5)6)48(73)66-41(24-35-26-57-27-60-35)49(74)62-37(14-12-20-58-51(55)56)45(70)67-42(31(7)8)50(75)63-36(13-10-11-19-52)44(69)59-25-33-15-17-34(18-16-33)43(53)54/h15-18,26-31,36-42H,10-14,19-25,52H2,1-9H3,(H3,53,54)(H,57,60)(H,59,69)(H,61,68)(H,62,74)(H,63,75)(H,64,71)(H,65,72)(H,66,73)(H,67,70)(H4,55,56,58)/t36-,37-,38-,39-,40-,41-,42-/m0/s1
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0.900n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50264941
PNG
(CHEMBL4063327)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C51H91N15O8/c1-29(2)25-39(60-33(9)67)47(71)64-41(27-31(5)6)49(73)65-40(26-30(3)4)48(72)62-37(16-11-13-23-53)45(69)61-38(17-14-24-58-51(56)57)46(70)66-42(32(7)8)50(74)63-36(15-10-12-22-52)44(68)59-28-34-18-20-35(21-19-34)43(54)55/h18-21,29-32,36-42H,10-17,22-28,52-53H2,1-9H3,(H3,54,55)(H,59,68)(H,60,67)(H,61,69)(H,62,72)(H,63,74)(H,64,71)(H,65,73)(H,66,70)(H4,56,57,58)/t36-,37-,38-,39-,40-,41-,42-/m0/s1
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0.900n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50303775
PNG
((S)-2-acetamido-N-((S)-1-((S)-1-(4-carbamimidoylbe...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C27H46N12O4/c1-15(2)21(39-24(42)20(37-16(3)40)7-5-13-35-27(32)33)25(43)38-19(6-4-12-34-26(30)31)23(41)36-14-17-8-10-18(11-9-17)22(28)29/h8-11,15,19-21H,4-7,12-14H2,1-3H3,(H3,28,29)(H,36,41)(H,37,40)(H,38,43)(H,39,42)(H4,30,31,34)(H4,32,33,35)/t19-,20-,21-/m0/s1
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PubMed
1n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human furin by fluorescence assay


J Med Chem 53: 1067-75 (2010)


Article DOI: 10.1021/jm9012455
BindingDB Entry DOI: 10.7270/Q2DN455Q
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50265090
PNG
(CHEMBL4101304)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C49H85N15O9/c1-26(2)21-35(58-30(9)65)44(69)63-38(24-39(51)66)47(72)62-37(23-28(5)6)46(71)61-36(22-27(3)4)45(70)59-34(14-12-20-56-49(54)55)43(68)64-40(29(7)8)48(73)60-33(13-10-11-19-50)42(67)57-25-31-15-17-32(18-16-31)41(52)53/h15-18,26-29,33-38,40H,10-14,19-25,50H2,1-9H3,(H2,51,66)(H3,52,53)(H,57,67)(H,58,65)(H,59,70)(H,60,73)(H,61,71)(H,62,72)(H,63,69)(H,64,68)(H4,54,55,56)/t33-,34-,35-,36-,37-,38-,40-/m0/s1
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1n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50387001
PNG
(CHEMBL2049154)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)Nc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C26H44N12O4/c1-14(2)20(38-23(41)18(35-15(3)39)6-4-12-33-25(29)30)24(42)37-19(7-5-13-34-26(31)32)22(40)36-17-10-8-16(9-11-17)21(27)28/h8-11,14,18-20H,4-7,12-13H2,1-3H3,(H3,27,28)(H,35,39)(H,36,40)(H,37,42)(H,38,41)(H4,29,30,33)(H4,31,32,34)/t18-,19-,20-/m0/s1
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1n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Inhibition of furin


Bioorg Med Chem 20: 4462-71 (2012)


Article DOI: 10.1016/j.bmc.2012.05.029
BindingDB Entry DOI: 10.7270/Q2514075
More data for this
Ligand-Target Pair
Furin


(Homo sapiens (Human))
BDBM50265384
PNG
(CHEMBL4104777)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C51H91N17O8/c1-28(2)24-38(66-48(75)40(26-30(5)6)67-47(74)39(25-29(3)4)65-44(71)36(62-32(9)69)15-12-22-59-50(55)56)46(73)63-37(16-13-23-60-51(57)58)45(72)68-41(31(7)8)49(76)64-35(14-10-11-21-52)43(70)61-27-33-17-19-34(20-18-33)42(53)54/h17-20,28-31,35-41H,10-16,21-27,52H2,1-9H3,(H3,53,54)(H,61,70)(H,62,69)(H,63,73)(H,64,76)(H,65,71)(H,66,75)(H,67,74)(H,68,72)(H4,55,56,59)(H4,57,58,60)/t35-,36-,37-,38-,39-,40-,41-/m0/s1
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1.10n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Furin


(Homo sapiens (Human))
BDBM50264971
PNG
(CHEMBL4089913)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C50H86N14O8/c1-28(2)24-37(60-46(69)38(25-29(3)4)61-47(70)39(26-30(5)6)62-48(71)40-16-13-23-64(40)32(9)65)45(68)58-36(15-12-22-56-50(54)55)44(67)63-41(31(7)8)49(72)59-35(14-10-11-21-51)43(66)57-27-33-17-19-34(20-18-33)42(52)53/h17-20,28-31,35-41H,10-16,21-27,51H2,1-9H3,(H3,52,53)(H,57,66)(H,58,68)(H,59,72)(H,60,69)(H,61,70)(H,62,71)(H,63,67)(H4,54,55,56)/t35-,36-,37-,38-,39-,40-,41-/m0/s1
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1.10n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50265185
PNG
(CHEMBL4092088)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C50H86N14O8/c1-28(2)24-37(58-32(9)65)45(68)62-39(26-30(5)6)49(72)64-23-13-16-40(64)47(70)61-38(25-29(3)4)46(69)59-36(15-12-22-56-50(54)55)44(67)63-41(31(7)8)48(71)60-35(14-10-11-21-51)43(66)57-27-33-17-19-34(20-18-33)42(52)53/h17-20,28-31,35-41H,10-16,21-27,51H2,1-9H3,(H3,52,53)(H,57,66)(H,58,65)(H,59,69)(H,60,71)(H,61,70)(H,62,68)(H,63,67)(H4,54,55,56)/t35-,36-,37-,38-,39-,40-,41-/m0/s1
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1.40n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50349576
PNG
(CHEMBL1808904)
Show SMILES NC(N)=NCCC[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C37H50N12O4/c38-32(39)27-17-15-26(16-18-27)23-46-33(51)28(13-7-19-44-36(40)41)48-35(53)30(21-24-9-3-1-4-10-24)49-34(52)29(14-8-20-45-37(42)43)47-31(50)22-25-11-5-2-6-12-25/h1-6,9-12,15-18,28-30H,7-8,13-14,19-23H2,(H3,38,39)(H,46,51)(H,47,50)(H,48,53)(H,49,52)(H4,40,41,44)(H4,42,43,45)/t28-,29-,30-/m0/s1
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1.40n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Bioorg Med Chem Lett 21: 4695-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.091
BindingDB Entry DOI: 10.7270/Q27W6CJR
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50399754
PNG
(CHEMBL2179836)
Show SMILES NCCCC[C@H](NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C37H69N15O13/c38-15-3-1-7-21(47-29(58)20(40)11-13-27(54)55)30(59)50-24(12-14-28(56)57)33(62)48-23(9-5-17-45-36(41)42)32(61)52-26(19-53)34(63)49-22(8-2-4-16-39)31(60)51-25(35(64)65)10-6-18-46-37(43)44/h20-26,53H,1-19,38-40H2,(H,47,58)(H,48,62)(H,49,63)(H,50,59)(H,51,60)(H,52,61)(H,54,55)(H,56,57)(H,64,65)(H4,41,42,45)(H4,43,44,46)/t20-,21-,22-,23-,24-,25-,26-/m0/s1
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1.40n/an/an/an/an/an/a7.5n/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


J Med Chem 55: 10501-11 (2012)


Article DOI: 10.1021/jm3011178
BindingDB Entry DOI: 10.7270/Q2NV9KDZ
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50349603
PNG
(CHEMBL1808933)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C33H50N10O4/c1-21(2)28(43-31(46)26(12-8-18-39-33(37)38)41-27(44)19-22-9-4-3-5-10-22)32(47)42-25(11-6-7-17-34)30(45)40-20-23-13-15-24(16-14-23)29(35)36/h3-5,9-10,13-16,21,25-26,28H,6-8,11-12,17-20,34H2,1-2H3,(H3,35,36)(H,40,45)(H,41,44)(H,42,47)(H,43,46)(H4,37,38,39)/t25-,26-,28-/m0/s1
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1.5n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Bioorg Med Chem Lett 21: 4695-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.091
BindingDB Entry DOI: 10.7270/Q27W6CJR
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50265091
PNG
(CHEMBL4083310)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C50H86N14O8/c1-28(2)24-37(61-46(69)38(25-29(3)4)62-47(70)40-16-13-23-64(40)49(72)39(26-30(5)6)58-32(9)65)45(68)59-36(15-12-22-56-50(54)55)44(67)63-41(31(7)8)48(71)60-35(14-10-11-21-51)43(66)57-27-33-17-19-34(20-18-33)42(52)53/h17-20,28-31,35-41H,10-16,21-27,51H2,1-9H3,(H3,52,53)(H,57,66)(H,58,65)(H,59,68)(H,60,71)(H,61,69)(H,62,70)(H,63,67)(H4,54,55,56)/t35-,36-,37-,38-,39-,40-,41-/m0/s1
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1.5n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50265328
PNG
(CHEMBL4087970)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C48H84N14O8/c1-26(2)22-36(57-31(10)63)44(67)56-30(9)41(64)60-37(23-27(3)4)46(69)61-38(24-28(5)6)45(68)58-35(15-13-21-54-48(52)53)43(66)62-39(29(7)8)47(70)59-34(14-11-12-20-49)42(65)55-25-32-16-18-33(19-17-32)40(50)51/h16-19,26-30,34-39H,11-15,20-25,49H2,1-10H3,(H3,50,51)(H,55,65)(H,56,67)(H,57,63)(H,58,68)(H,59,70)(H,60,64)(H,61,69)(H,62,66)(H4,52,53,54)/t30-,34-,35-,36-,37-,38-,39-/m0/s1
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1.5n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50387000
PNG
(CHEMBL2049153)
Show SMILES CCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)Nc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C34H60N12O4/c1-4-5-6-7-8-9-10-15-27(47)44-25(13-11-20-41-33(37)38)31(49)46-28(22(2)3)32(50)45-26(14-12-21-42-34(39)40)30(48)43-24-18-16-23(17-19-24)29(35)36/h16-19,22,25-26,28H,4-15,20-21H2,1-3H3,(H3,35,36)(H,43,48)(H,44,47)(H,45,50)(H,46,49)(H4,37,38,41)(H4,39,40,42)/t25-,26-,28-/m0/s1
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1.60n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Inhibition of furin


Bioorg Med Chem 20: 4462-71 (2012)


Article DOI: 10.1016/j.bmc.2012.05.029
BindingDB Entry DOI: 10.7270/Q2514075
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50303776
PNG
(CHEMBL568525 | N-((6S,9S,12S)-1,17-diamino-6-(4-ca...)
Show SMILES CCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C35H62N12O4/c1-4-5-6-7-8-9-10-15-28(48)45-27(14-12-21-43-35(40)41)32(50)47-29(23(2)3)33(51)46-26(13-11-20-42-34(38)39)31(49)44-22-24-16-18-25(19-17-24)30(36)37/h16-19,23,26-27,29H,4-15,20-22H2,1-3H3,(H3,36,37)(H,44,49)(H,45,48)(H,46,51)(H,47,50)(H4,38,39,42)(H4,40,41,43)/t26-,27-,29-/m0/s1
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1.60n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human furin by fluorescence assay


J Med Chem 53: 1067-75 (2010)


Article DOI: 10.1021/jm9012455
BindingDB Entry DOI: 10.7270/Q2DN455Q
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50399753
PNG
(CHEMBL2179835)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C37H74N18O9/c1-20(40)28(57)50-22(10-3-5-15-38)29(58)51-24(12-7-17-47-35(41)42)30(59)52-25(13-8-18-48-36(43)44)32(61)55-27(21(2)56)33(62)53-23(11-4-6-16-39)31(60)54-26(34(63)64)14-9-19-49-37(45)46/h20-27,56H,3-19,38-40H2,1-2H3,(H,50,57)(H,51,58)(H,52,59)(H,53,62)(H,54,60)(H,55,61)(H,63,64)(H4,41,42,47)(H4,43,44,48)(H4,45,46,49)/t20-,21+,22-,23-,24-,25-,26-,27-/m0/s1
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1.70n/an/an/an/an/an/a7.5n/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


J Med Chem 55: 10501-11 (2012)


Article DOI: 10.1021/jm3011178
BindingDB Entry DOI: 10.7270/Q2NV9KDZ
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50265130
PNG
(CHEMBL4064275)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C49H86N14O9/c1-26(2)22-36(57-31(10)65)46(70)63-40(30(9)64)48(72)61-38(24-28(5)6)45(69)60-37(23-27(3)4)44(68)58-35(15-13-21-55-49(53)54)43(67)62-39(29(7)8)47(71)59-34(14-11-12-20-50)42(66)56-25-32-16-18-33(19-17-32)41(51)52/h16-19,26-30,34-40,64H,11-15,20-25,50H2,1-10H3,(H3,51,52)(H,56,66)(H,57,65)(H,58,68)(H,59,71)(H,60,69)(H,61,72)(H,62,67)(H,63,70)(H4,53,54,55)/t30-,34+,35+,36+,37+,38+,39+,40+/m1/s1
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1.70n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Furin


(Homo sapiens (Human))
BDBM50265145
PNG
(CHEMBL4073661)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1cnc[nH]1)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C51H86N16O8/c1-28(2)21-38(64-47(72)39(22-29(3)4)65-48(73)40(23-30(5)6)66-49(74)41(61-32(9)68)24-35-26-57-27-60-35)46(71)62-37(14-12-20-58-51(55)56)45(70)67-42(31(7)8)50(75)63-36(13-10-11-19-52)44(69)59-25-33-15-17-34(18-16-33)43(53)54/h15-18,26-31,36-42H,10-14,19-25,52H2,1-9H3,(H3,53,54)(H,57,60)(H,59,69)(H,61,68)(H,62,71)(H,63,75)(H,64,72)(H,65,73)(H,66,74)(H,67,70)(H4,55,56,58)/t36-,37-,38-,39-,40-,41-,42-/m0/s1
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1.80n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50448473
PNG
(CHEMBL3126399)
Show SMILES C[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(C)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C49H90N24O8/c1-28(67-41(77)33(68-29(2)74)13-7-23-62-46(54)55)39(75)69-35(14-8-24-63-47(56)57)43(79)72-37(16-10-26-65-49(60)61)45(81)73-36(15-9-25-64-48(58)59)44(80)71-34(12-4-6-22-51)42(78)70-32(11-3-5-21-50)40(76)66-27-30-17-19-31(20-18-30)38(52)53/h17-20,28,32-37H,3-16,21-27,50-51H2,1-2H3,(H3,52,53)(H,66,76)(H,67,77)(H,68,74)(H,69,75)(H,70,78)(H,71,80)(H,72,79)(H,73,81)(H4,54,55,62)(H4,56,57,63)(H4,58,59,64)(H4,60,61,65)/t28-,32-,33-,34-,35-,36-,37-/m0/s1
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1.90n/an/an/an/an/an/an/an/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of recombinant furin (unknown origin) using as substrate after 60 mins


J Med Chem 57: 29-41 (2014)


Article DOI: 10.1021/jm400633d
BindingDB Entry DOI: 10.7270/Q27M09FJ
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50349577
PNG
(CHEMBL1808905)
Show SMILES NC(N)=NCCC[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C37H50N12O5/c38-32(39)26-14-10-25(11-15-26)22-46-33(52)28(8-4-18-44-36(40)41)48-35(54)30(20-24-12-16-27(50)17-13-24)49-34(53)29(9-5-19-45-37(42)43)47-31(51)21-23-6-2-1-3-7-23/h1-3,6-7,10-17,28-30,50H,4-5,8-9,18-22H2,(H3,38,39)(H,46,52)(H,47,51)(H,48,54)(H,49,53)(H4,40,41,44)(H4,42,43,45)/t28-,29-,30-/m0/s1
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1.90n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Bioorg Med Chem Lett 21: 4695-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.091
BindingDB Entry DOI: 10.7270/Q27W6CJR
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50265131
PNG
(CHEMBL4093570)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C50H88N14O8/c1-27(2)23-37(58-32(11)65)47(70)64-41(31(9)10)49(72)62-39(25-29(5)6)46(69)61-38(24-28(3)4)45(68)59-36(16-14-22-56-50(54)55)44(67)63-40(30(7)8)48(71)60-35(15-12-13-21-51)43(66)57-26-33-17-19-34(20-18-33)42(52)53/h17-20,27-31,35-41H,12-16,21-26,51H2,1-11H3,(H3,52,53)(H,57,66)(H,58,65)(H,59,68)(H,60,71)(H,61,69)(H,62,72)(H,63,67)(H,64,70)(H4,54,55,56)/t35-,36-,37-,38-,39-,40-,41-/m0/s1
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2n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50265048
PNG
(CHEMBL4065627)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C51H90N14O8/c1-12-32(10)42(65-48(71)38(24-28(2)3)59-33(11)66)50(73)63-40(26-30(6)7)47(70)62-39(25-29(4)5)46(69)60-37(17-15-23-57-51(55)56)45(68)64-41(31(8)9)49(72)61-36(16-13-14-22-52)44(67)58-27-34-18-20-35(21-19-34)43(53)54/h18-21,28-32,36-42H,12-17,22-27,52H2,1-11H3,(H3,53,54)(H,58,67)(H,59,66)(H,60,69)(H,61,72)(H,62,70)(H,63,73)(H,64,68)(H,65,71)(H4,55,56,57)/t32-,36-,37-,38-,39-,40-,41-,42-/m0/s1
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2n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50265092
PNG
(CHEMBL4063219)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C50H87N15O9/c1-27(2)23-37(59-31(9)66)46(71)61-36(19-20-40(52)67)44(69)63-39(25-29(5)6)48(73)64-38(24-28(3)4)47(72)60-35(14-12-22-57-50(55)56)45(70)65-41(30(7)8)49(74)62-34(13-10-11-21-51)43(68)58-26-32-15-17-33(18-16-32)42(53)54/h15-18,27-30,34-39,41H,10-14,19-26,51H2,1-9H3,(H2,52,67)(H3,53,54)(H,58,68)(H,59,66)(H,60,72)(H,61,71)(H,62,74)(H,63,69)(H,64,73)(H,65,70)(H4,55,56,57)/t34-,35-,36-,37-,38-,39-,41-/m0/s1
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2.30n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Furin


(Homo sapiens (Human))
BDBM50264994
PNG
(CHEMBL4097058)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(C)=O)[C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C49H86N14O9/c1-26(2)22-36(60-45(69)37(23-27(3)4)61-46(70)38(24-28(5)6)62-48(72)40(30(9)64)57-31(10)65)44(68)58-35(15-13-21-55-49(53)54)43(67)63-39(29(7)8)47(71)59-34(14-11-12-20-50)42(66)56-25-32-16-18-33(19-17-32)41(51)52/h16-19,26-30,34-40,64H,11-15,20-25,50H2,1-10H3,(H3,51,52)(H,56,66)(H,57,65)(H,58,68)(H,59,71)(H,60,69)(H,61,70)(H,62,72)(H,63,67)(H4,53,54,55)/t30-,34+,35+,36+,37+,38+,39+,40+/m1/s1
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2.40n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50265129
PNG
(CHEMBL4085824)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C48H84N14O9/c1-26(2)21-35(56-30(9)64)43(67)61-38(25-63)46(70)60-37(23-28(5)6)45(69)59-36(22-27(3)4)44(68)57-34(14-12-20-54-48(52)53)42(66)62-39(29(7)8)47(71)58-33(13-10-11-19-49)41(65)55-24-31-15-17-32(18-16-31)40(50)51/h15-18,26-29,33-39,63H,10-14,19-25,49H2,1-9H3,(H3,50,51)(H,55,65)(H,56,64)(H,57,68)(H,58,71)(H,59,69)(H,60,70)(H,61,67)(H,62,66)(H4,52,53,54)/t33-,34-,35-,36-,37-,38-,39-/m0/s1
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2.60n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50399752
PNG
(CHEMBL2179429)
Show SMILES CC(C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(O)=O
Show InChI InChI=1S/C39H78N16O9/c1-22(2)29(43)35(61)52-25(13-5-8-18-41)32(58)50-24(12-4-7-17-40)31(57)51-27(15-10-20-48-38(44)45)34(60)55-30(23(3)56)36(62)53-26(14-6-9-19-42)33(59)54-28(37(63)64)16-11-21-49-39(46)47/h22-30,56H,4-21,40-43H2,1-3H3,(H,50,58)(H,51,57)(H,52,61)(H,53,62)(H,54,59)(H,55,60)(H,63,64)(H4,44,45,48)(H4,46,47,49)/t23-,24+,25+,26+,27+,28+,29+,30+/m1/s1
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2.90n/an/an/an/an/an/a7.5n/a



Universit£ de Sherbrooke

Curated by ChEMBL


Assay Description
Competitive inhibition of human recombinant furin expressed in Drosophila S2 cells using pyroGlu-Arg-Val-Lys-Arg-methyl-coumaryl-7-amide as substrate...


J Med Chem 55: 10501-11 (2012)


Article DOI: 10.1021/jm3011178
BindingDB Entry DOI: 10.7270/Q2NV9KDZ
More data for this
Ligand-Target Pair
Furin


(Homo sapiens (Human))
BDBM50264955
PNG
(CHEMBL4099961)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C49H85N15O9/c1-26(2)21-35(58-30(9)65)44(69)61-36(22-27(3)4)45(70)62-37(23-28(5)6)46(71)63-38(24-39(51)66)47(72)59-34(14-12-20-56-49(54)55)43(68)64-40(29(7)8)48(73)60-33(13-10-11-19-50)42(67)57-25-31-15-17-32(18-16-31)41(52)53/h15-18,26-29,33-38,40H,10-14,19-25,50H2,1-9H3,(H2,51,66)(H3,52,53)(H,57,67)(H,58,65)(H,59,72)(H,60,73)(H,61,69)(H,62,70)(H,63,71)(H,64,68)(H4,54,55,56)/t33-,34-,35-,36-,37-,38-,40-/m0/s1
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3n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50265331
PNG
(CHEMBL4103443)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C47H82N14O8/c1-26(2)21-35(56-30(9)62)42(65)55-25-38(63)57-36(22-27(3)4)44(67)60-37(23-28(5)6)45(68)58-34(14-12-20-53-47(51)52)43(66)61-39(29(7)8)46(69)59-33(13-10-11-19-48)41(64)54-24-31-15-17-32(18-16-31)40(49)50/h15-18,26-29,33-37,39H,10-14,19-25,48H2,1-9H3,(H3,49,50)(H,54,64)(H,55,65)(H,56,62)(H,57,63)(H,58,68)(H,59,69)(H,60,67)(H,61,66)(H4,51,52,53)/t33-,34-,35-,36-,37-,39-/m0/s1
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3n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50265302
PNG
(CHEMBL4060537)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C50H88N14O8/c1-27(2)23-37(58-32(11)65)45(68)61-39(25-29(5)6)47(70)64-41(31(9)10)49(72)62-38(24-28(3)4)46(69)59-36(16-14-22-56-50(54)55)44(67)63-40(30(7)8)48(71)60-35(15-12-13-21-51)43(66)57-26-33-17-19-34(20-18-33)42(52)53/h17-20,27-31,35-41H,12-16,21-26,51H2,1-11H3,(H3,52,53)(H,57,66)(H,58,65)(H,59,69)(H,60,71)(H,61,68)(H,62,72)(H,63,67)(H,64,70)(H4,54,55,56)/t35-,36-,37-,38-,39-,40-,41-/m0/s1
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3n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50265140
PNG
(CHEMBL4066994)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C54H88N14O9/c1-30(2)25-41(62-34(9)69)49(73)67-44(28-35-17-21-38(70)22-18-35)52(76)66-43(27-32(5)6)51(75)65-42(26-31(3)4)50(74)63-40(14-12-24-60-54(58)59)48(72)68-45(33(7)8)53(77)64-39(13-10-11-23-55)47(71)61-29-36-15-19-37(20-16-36)46(56)57/h15-22,30-33,39-45,70H,10-14,23-29,55H2,1-9H3,(H3,56,57)(H,61,71)(H,62,69)(H,63,74)(H,64,77)(H,65,75)(H,66,76)(H,67,73)(H,68,72)(H4,58,59,60)/t39-,40-,41-,42-,43-,44-,45-/m0/s1
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3n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50349578
PNG
(CHEMBL1808906)
Show SMILES NC(N)=NCCC[C@H](NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C34H53N15O4/c35-28(36)23-14-12-22(13-15-23)20-46-29(51)24(9-4-16-43-32(37)38)48-31(53)26(11-6-18-45-34(41)42)49-30(52)25(10-5-17-44-33(39)40)47-27(50)19-21-7-2-1-3-8-21/h1-3,7-8,12-15,24-26H,4-6,9-11,16-20H2,(H3,35,36)(H,46,51)(H,47,50)(H,48,53)(H,49,52)(H4,37,38,43)(H4,39,40,44)(H4,41,42,45)/t24-,25-,26-/m0/s1
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3n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Bioorg Med Chem Lett 21: 4695-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.091
BindingDB Entry DOI: 10.7270/Q27W6CJR
More data for this
Ligand-Target Pair
Furin


(Homo sapiens (Human))
BDBM50264972
PNG
(CHEMBL4080551)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C50H87N15O9/c1-27(2)23-37(63-48(73)39(25-29(5)6)64-47(72)38(24-28(3)4)62-44(69)36(59-31(9)66)19-20-40(52)67)46(71)60-35(14-12-22-57-50(55)56)45(70)65-41(30(7)8)49(74)61-34(13-10-11-21-51)43(68)58-26-32-15-17-33(18-16-32)42(53)54/h15-18,27-30,34-39,41H,10-14,19-26,51H2,1-9H3,(H2,52,67)(H3,53,54)(H,58,68)(H,59,66)(H,60,71)(H,61,74)(H,62,69)(H,63,73)(H,64,72)(H,65,70)(H4,55,56,57)/t34-,35-,36-,37-,38-,39-,41-/m0/s1
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3n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50265141
PNG
(CHEMBL4094478)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](C)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C48H84N14O8/c1-26(2)22-36(59-41(64)30(9)56-31(10)63)45(68)61-38(24-28(5)6)46(69)60-37(23-27(3)4)44(67)57-35(15-13-21-54-48(52)53)43(66)62-39(29(7)8)47(70)58-34(14-11-12-20-49)42(65)55-25-32-16-18-33(19-17-32)40(50)51/h16-19,26-30,34-39H,11-15,20-25,49H2,1-10H3,(H3,50,51)(H,55,65)(H,56,63)(H,57,67)(H,58,70)(H,59,64)(H,60,69)(H,61,68)(H,62,66)(H4,52,53,54)/t30-,34-,35-,36-,37-,38-,39-/m0/s1
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3n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Furin


(Homo sapiens (Human))
BDBM50265144
PNG
(CHEMBL4067772)
Show SMILES CC(C)C[C@H](NC(=O)CNC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C47H82N14O8/c1-26(2)21-35(56-38(63)25-54-30(9)62)43(66)59-37(23-28(5)6)45(68)60-36(22-27(3)4)44(67)57-34(14-12-20-53-47(51)52)42(65)61-39(29(7)8)46(69)58-33(13-10-11-19-48)41(64)55-24-31-15-17-32(18-16-31)40(49)50/h15-18,26-29,33-37,39H,10-14,19-25,48H2,1-9H3,(H3,49,50)(H,54,62)(H,55,64)(H,56,63)(H,57,67)(H,58,69)(H,59,66)(H,60,68)(H,61,65)(H4,51,52,53)/t33-,34-,35-,36-,37-,39-/m0/s1
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3n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50349579
PNG
(CHEMBL1808907)
Show SMILES NC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)Cc1ccccc1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C31H47N13O4/c32-17-24(44-28(47)23(9-5-15-40-31(37)38)42-25(45)16-19-6-2-1-3-7-19)29(48)43-22(8-4-14-39-30(35)36)27(46)41-18-20-10-12-21(13-11-20)26(33)34/h1-3,6-7,10-13,22-24H,4-5,8-9,14-18,32H2,(H3,33,34)(H,41,46)(H,42,45)(H,43,48)(H,44,47)(H4,35,36,39)(H4,37,38,40)/t22-,23-,24-/m0/s1
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3n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in CHO cells using pyroGlu- Arg-Thr-Lys-Arg-AMC as the substrate after 30 mins


Bioorg Med Chem Lett 21: 4695-7 (2011)


Article DOI: 10.1016/j.bmcl.2011.06.091
BindingDB Entry DOI: 10.7270/Q27W6CJR
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50265089
PNG
(CHEMBL4074250)
Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C50H88N14O8S/c1-28(2)24-38(58-32(9)65)46(69)60-37(20-23-73-10)44(67)62-40(26-30(5)6)48(71)63-39(25-29(3)4)47(70)59-36(15-13-22-56-50(54)55)45(68)64-41(31(7)8)49(72)61-35(14-11-12-21-51)43(66)57-27-33-16-18-34(19-17-33)42(52)53/h16-19,28-31,35-41H,11-15,20-27,51H2,1-10H3,(H3,52,53)(H,57,66)(H,58,65)(H,59,70)(H,60,69)(H,61,72)(H,62,67)(H,63,71)(H,64,68)(H4,54,55,56)/t35-,36-,37-,38-,39-,40-,41-/m0/s1
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3n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Furin


(Homo sapiens (Human))
BDBM50265341
PNG
(CHEMBL4068820)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C49H85N15O9/c1-26(2)21-35(61-45(70)36(22-27(3)4)62-46(71)37(23-28(5)6)63-47(72)38(24-39(51)66)58-30(9)65)44(69)59-34(14-12-20-56-49(54)55)43(68)64-40(29(7)8)48(73)60-33(13-10-11-19-50)42(67)57-25-31-15-17-32(18-16-31)41(52)53/h15-18,26-29,33-38,40H,10-14,19-25,50H2,1-9H3,(H2,51,66)(H3,52,53)(H,57,67)(H,58,65)(H,59,69)(H,60,73)(H,61,70)(H,62,71)(H,63,72)(H,64,68)(H4,54,55,56)/t33-,34-,35-,36-,37-,38-,40-/m0/s1
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3.10n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50265000
PNG
(CHEMBL4101342)
Show SMILES CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C54H88N14O9/c1-30(2)25-41(62-34(9)69)49(73)65-42(26-31(3)4)50(74)66-43(27-32(5)6)51(75)67-44(28-35-17-21-38(70)22-18-35)52(76)63-40(14-12-24-60-54(58)59)48(72)68-45(33(7)8)53(77)64-39(13-10-11-23-55)47(71)61-29-36-15-19-37(20-16-36)46(56)57/h15-22,30-33,39-45,70H,10-14,23-29,55H2,1-9H3,(H3,56,57)(H,61,71)(H,62,69)(H,63,76)(H,64,77)(H,65,73)(H,66,74)(H,67,75)(H,68,72)(H4,58,59,60)/t39-,40-,41-,42-,43-,44-,45-/m0/s1
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3.10n/an/an/an/an/an/an/an/a



University of Gdansk

Curated by ChEMBL


Assay Description
Inhibition of recombinant human furin expressed in drosophila S2 cells using pyrGlu-Arg-Thr-Lys-Arg-7-amido-4-methylcoumarin as substrate after 60 mi...


J Med Chem 60: 2732-2744 (2017)

More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50303781
PNG
(CHEMBL565931 | N-((4S,7S,10S)-15-amino-4-(4-aminob...)
Show SMILES CCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C35H62N10O4/c1-4-5-6-7-8-9-10-16-29(46)43-28(15-13-22-41-35(39)40)33(48)45-30(24(2)3)34(49)44-27(14-11-12-21-36)32(47)42-23-25-17-19-26(20-18-25)31(37)38/h17-20,24,27-28,30H,4-16,21-23,36H2,1-3H3,(H3,37,38)(H,42,47)(H,43,46)(H,44,49)(H,45,48)(H4,39,40,41)/t27-,28-,30-/m0/s1
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3.30n/an/an/an/an/an/an/an/a



Philipps University Marburg

Curated by ChEMBL


Assay Description
Inhibition of human furin by fluorescence assay


J Med Chem 53: 1067-75 (2010)


Article DOI: 10.1021/jm9012455
BindingDB Entry DOI: 10.7270/Q2DN455Q
More data for this
Ligand-Target Pair
Homo sapiens furin (paired basic amino acid cleaving enzyme) (FURIN), mRNA


(Homo sapiens (Human))
BDBM50387002
PNG
(CHEMBL2049155)
Show SMILES CCCCCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)Nc1ccc(cc1)C(N)=N
Show InChI InChI=1S/C34H60N10O4/c1-4-5-6-7-8-9-10-16-28(45)42-26(15-13-22-40-34(38)39)32(47)44-29(23(2)3)33(48)43-27(14-11-12-21-35)31(46)41-25-19-17-24(18-20-25)30(36)37/h17-20,23,26-27,29H,4-16,21-22,35H2,1-3H3,(H3,36,37)(H,41,46)(H,42,45)(H,43,48)(H,44,47)(H4,38,39,40)/t26-,27-,29-/m0/s1
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3.30n/an/an/an/an/an/an/an/a



Torrey Pines Institute for Molecular Studies

Curated by ChEMBL


Assay Description
Inhibition of furin


Bioorg Med Chem 20: 4462-71 (2012)


Article DOI: 10.1016/j.bmc.2012.05.029
BindingDB Entry DOI: 10.7270/Q2514075
More data for this
Ligand-Target Pair
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