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Compile Data Set for Download or QSAR

Found 100 hits of ec50 data for polymerid = 49000208   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50000195
PNG
(CHEMBL142784)
Show SMILES C(Oc1ccccc1-c1ccoc1)C1=NCCN1
Show InChI InChI=1S/C14H14N2O2/c1-2-4-13(18-10-14-15-6-7-16-14)12(3-1)11-5-8-17-9-11/h1-5,8-9H,6-7,10H2,(H,15,16)
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n/an/an/an/a 5n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC ...


Bioorg Med Chem Lett 12: 471-5 (2002)

Checked by Author
More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50421593
PNG
(CHEMBL357129)
Show SMILES C(Oc1ccccc1-c1ccc[nH]1)C1=NCCN1
Show InChI InChI=1S/C14H15N3O/c1-2-6-13(18-10-14-16-8-9-17-14)11(4-1)12-5-3-7-15-12/h1-7,15H,8-10H2,(H,16,17)
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n/an/an/an/a 6.30n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC ...


Bioorg Med Chem Lett 12: 471-5 (2002)

Checked by Author
More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50000210
PNG
(CHEMBL422477)
Show SMILES C(Oc1ccccc1-c1ccsc1)C1=NCCN1
Show InChI InChI=1S/C14H14N2OS/c1-2-4-13(17-9-14-15-6-7-16-14)12(3-1)11-5-8-18-10-11/h1-5,8,10H,6-7,9H2,(H,15,16)
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n/an/an/an/a 13n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC ...


Bioorg Med Chem Lett 12: 471-5 (2002)

Checked by Author
More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50000216
PNG
(CHEMBL143801)
Show SMILES C(Oc1ccccc1-c1cccs1)C1=NCCN1
Show InChI InChI=1S/C14H14N2OS/c1-2-5-12(17-10-14-15-7-8-16-14)11(4-1)13-6-3-9-18-13/h1-6,9H,7-8,10H2,(H,15,16)
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n/an/an/an/a 16n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC ...


Bioorg Med Chem Lett 12: 471-5 (2002)

Checked by Author
More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50000207
PNG
(CHEMBL142387)
Show SMILES C(Oc1ccccc1-c1ccns1)C1=NCCN1
Show InChI InChI=1S/C13H13N3OS/c1-2-4-11(17-9-13-14-7-8-15-13)10(3-1)12-5-6-16-18-12/h1-6H,7-9H2,(H,14,15)
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n/an/an/an/a 25n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC ...


Bioorg Med Chem Lett 12: 471-5 (2002)

Checked by Author
More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50000208
PNG
(CHEMBL142871)
Show SMILES C(Oc1ccccc1-c1nccs1)C1=NCCN1
Show InChI InChI=1S/C13H13N3OS/c1-2-4-11(17-9-12-14-5-6-15-12)10(3-1)13-16-7-8-18-13/h1-4,7-8H,5-6,9H2,(H,14,15)
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n/an/an/an/a 32n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC ...


Bioorg Med Chem Lett 12: 471-5 (2002)

Checked by Author
More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50258563
PNG
((S)-6-(2-(pyridin-3-yl)phenyl)-6,7-dihydro-5H-pyrr...)
Show SMILES C1[C@H](Cn2ccnc12)c1ccccc1-c1cccnc1
Show InChI InChI=1S/C17H15N3/c1-2-6-16(14-10-17-19-8-9-20(17)12-14)15(5-1)13-4-3-7-18-11-13/h1-9,11,14H,10,12H2/t14-/m1/s1
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n/an/an/an/a 119n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3113-7 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50419680
PNG
(CHEMBL1945039)
Show SMILES COc1ccccc1CNCc1cccc(CCNC[C@H](O)c2ccc(O)c3[nH]c(=O)sc23)c1
Show InChI InChI=1S/C26H29N3O4S/c1-33-23-8-3-2-7-19(23)15-28-14-18-6-4-5-17(13-18)11-12-27-16-22(31)20-9-10-21(30)24-25(20)34-26(32)29-24/h2-10,13,22,27-28,30-31H,11-12,14-16H2,1H3,(H,29,32)/t22-/m0/s1
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n/an/an/an/a 126n/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Binding affinity to Alpha-1D adrenoreceptor expressed in HEK cells by calcium flux assay


Bioorg Med Chem Lett 22: 689-95 (2011)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50027060
PNG
(2-(2-Cyclopropyl-phenoxymethyl)-4,5-dihydro-1H-imi...)
Show SMILES C(Oc1ccccc1C1CC1)C1=NCCN1
Show InChI InChI=1S/C13H16N2O/c1-2-4-12(11(3-1)10-5-6-10)16-9-13-14-7-8-15-13/h1-4,10H,5-9H2,(H,14,15)
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n/an/an/an/a 126n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC ...


Bioorg Med Chem Lett 12: 471-5 (2002)

Checked by Author
More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50258560
PNG
((S)-2-(2-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-6-...)
Show SMILES C1[C@H](Cn2ccnc12)c1ccccc1-c1ncco1
Show InChI InChI=1S/C15H13N3O/c1-2-4-13(15-17-6-8-19-15)12(3-1)11-9-14-16-5-7-18(14)10-11/h1-8,11H,9-10H2/t11-/m1/s1
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n/an/an/an/a 146n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3113-7 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50421594
PNG
(CHEMBL356605)
Show SMILES C(Oc1ccccc1-c1cccnc1)C1=NCCN1
Show InChI InChI=1S/C15H15N3O/c1-2-6-14(19-11-15-17-8-9-18-15)13(5-1)12-4-3-7-16-10-12/h1-7,10H,8-9,11H2,(H,17,18)
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n/an/an/an/a 158n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC ...


Bioorg Med Chem Lett 12: 471-5 (2002)

Checked by Author
More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50258640
PNG
(2-(2-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-6-yl)-...)
Show SMILES Fc1ccc(-c2ncco2)c(c1)C1Cc2nccn2C1
Show InChI InChI=1S/C15H12FN3O/c16-11-1-2-12(15-18-4-6-20-15)13(8-11)10-7-14-17-3-5-19(14)9-10/h1-6,8,10H,7,9H2
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n/an/an/an/a 276n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3113-7 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50258641
PNG
(6-(4-fluoro-2-(1H-pyrazol-5-yl)phenyl)-6,7-dihydro...)
Show SMILES Fc1ccc(C2Cc3nccn3C2)c(c1)-c1cc[nH]n1
Show InChI InChI=1S/C15H13FN4/c16-11-1-2-12(13(8-11)14-3-4-18-19-14)10-7-15-17-5-6-20(15)9-10/h1-6,8,10H,7,9H2,(H,18,19)
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n/an/an/an/a 276n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3113-7 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50259534
PNG
(6-(2-fluorophenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]im...)
Show SMILES Fc1ccccc1C1Cc2nccn2C1
Show InChI InChI=1S/C12H11FN2/c13-11-4-2-1-3-10(11)9-7-12-14-5-6-15(12)8-9/h1-6,9H,7-8H2
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n/an/an/an/a 301n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human cloned adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3118-21 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50377388
PNG
(CHEMBL406316)
Show SMILES C1Cc2c(cccc2-c2cn[nH]c2)C1c1ncc[nH]1
Show InChI InChI=1S/C15H14N4/c1-2-11(10-8-18-19-9-10)13-4-5-14(12(13)3-1)15-16-6-7-17-15/h1-3,6-9,14H,4-5H2,(H,16,17)(H,18,19)
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n/an/an/an/a 319n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 18: 2930-4 (2008)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50377389
PNG
(CHEMBL256983)
Show SMILES C1Cc2c(cccc2-c2cc[nH]n2)C1c1ncc[nH]1
Show InChI InChI=1S/C15H14N4/c1-2-10-11(12(3-1)14-6-7-18-19-14)4-5-13(10)15-16-8-9-17-15/h1-3,6-9,13H,4-5H2,(H,16,17)(H,18,19)
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n/an/an/an/a 336n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 18: 2930-4 (2008)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50259486
PNG
(6-(2-chlorophenyl)-6,7-dihydro-5H-pyrrolo[1,2-a]im...)
Show SMILES Clc1ccccc1C1Cc2nccn2C1
Show InChI InChI=1S/C12H11ClN2/c13-11-4-2-1-3-10(11)9-7-12-14-5-6-15(12)8-9/h1-6,9H,7-8H2
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n/an/an/an/a 364n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human cloned adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3118-21 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50377396
PNG
(CHEMBL258007)
Show SMILES C1CC(c2ncc[nH]2)c2ccccc2C1
Show InChI InChI=1S/C13H14N2/c1-2-6-11-10(4-1)5-3-7-12(11)13-14-8-9-15-13/h1-2,4,6,8-9,12H,3,5,7H2,(H,14,15)
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n/an/an/an/a 364n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 18: 2930-4 (2008)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50258559
PNG
((S)-6-(2-(pyrimidin-5-yl)phenyl)-6,7-dihydro-5H-py...)
Show SMILES C1[C@H](Cn2ccnc12)c1ccccc1-c1cncnc1
Show InChI InChI=1S/C16H14N4/c1-2-4-15(13-8-17-11-18-9-13)14(3-1)12-7-16-19-5-6-20(16)10-12/h1-6,8-9,11-12H,7,10H2/t12-/m1/s1
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n/an/an/an/a 391n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3113-7 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50377387
PNG
(CHEMBL260720)
Show SMILES Cc1[nH]ncc1-c1cccc2C(CCc12)c1ncc[nH]1
Show InChI InChI=1S/C16H16N4/c1-10-15(9-19-20-10)12-4-2-3-11-13(12)5-6-14(11)16-17-7-8-18-16/h2-4,7-9,14H,5-6H2,1H3,(H,17,18)(H,19,20)
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n/an/an/an/a 634n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 18: 2930-4 (2008)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50258564
PNG
((S)-6-(2-(pyridin-4-yl)phenyl)-6,7-dihydro-5H-pyrr...)
Show SMILES C1[C@H](Cn2ccnc12)c1ccccc1-c1ccncc1
Show InChI InChI=1S/C17H15N3/c1-2-4-16(14-11-17-19-9-10-20(17)12-14)15(3-1)13-5-7-18-8-6-13/h1-10,14H,11-12H2/t14-/m1/s1
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n/an/an/an/a 656n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3113-7 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50258518
PNG
((S)-6-(biphenyl-2-yl)-6,7-dihydro-5H-pyrrolo[1,2-a...)
Show SMILES C1[C@H](Cn2ccnc12)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C18H16N2/c1-2-6-14(7-3-1)16-8-4-5-9-17(16)15-12-18-19-10-11-20(18)13-15/h1-11,15H,12-13H2/t15-/m1/s1
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n/an/an/an/a 729n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3113-7 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50000214
PNG
(CHEMBL337862)
Show SMILES C(Nc1ccccc1-c1ccccc1)C1=NCCN1
Show InChI InChI=1S/C16H17N3/c1-2-6-13(7-3-1)14-8-4-5-9-15(14)19-12-16-17-10-11-18-16/h1-9,19H,10-12H2,(H,17,18)
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n/an/an/an/a 794n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC ...


Bioorg Med Chem Lett 12: 471-5 (2002)

Checked by Author
More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50377401
PNG
(CHEMBL407308)
Show SMILES C1Cc2c(cccc2-c2ncco2)C1c1ncc[nH]1
Show InChI InChI=1S/C15H13N3O/c1-2-10-11(13(3-1)15-18-8-9-19-15)4-5-12(10)14-16-6-7-17-14/h1-3,6-9,12H,4-5H2,(H,16,17)
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n/an/an/an/a 1.39E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 18: 2930-4 (2008)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50258594
PNG
(6-(5-fluoro-2-(pyrimidin-5-yl)phenyl)-6,7-dihydro-...)
Show SMILES Fc1ccc(-c2cncnc2)c(c1)C1Cc2nccn2C1
Show InChI InChI=1S/C16H13FN4/c17-13-1-2-14(12-7-18-10-19-8-12)15(6-13)11-5-16-20-3-4-21(16)9-11/h1-4,6-8,10-11H,5,9H2
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n/an/an/an/a>2.60E+3n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3113-7 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50377400
PNG
(CHEMBL260116)
Show SMILES C1Cc2c(cccc2-c2nccs2)C1c1ncc[nH]1
Show InChI InChI=1S/C15H13N3S/c1-2-10-11(13(3-1)15-18-8-9-19-15)4-5-12(10)14-16-6-7-17-14/h1-3,6-9,12H,4-5H2,(H,16,17)
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n/an/an/an/a 3.19E+3n/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Agonist activity at human cloned adrenergic Alpha-1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 18: 2930-4 (2008)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50258593
PNG
(6-(4-fluoro-2-(pyrimidin-5-yl)phenyl)-6,7-dihydro-...)
Show SMILES Fc1ccc(C2Cc3nccn3C2)c(c1)-c1cncnc1
Show InChI InChI=1S/C16H13FN4/c17-13-1-2-14(11-5-16-20-3-4-21(16)9-11)15(6-13)12-7-18-10-19-8-12/h1-4,6-8,10-11H,5,9H2
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n/an/an/an/a>3.40E+3n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3113-7 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50259386
PNG
(6-(2-methoxyphenyl)-4,5,6,7-tetrahydro-1H-benzo[d]...)
Show SMILES COc1ccccc1C1CCc2nc[nH]c2C1
Show InChI InChI=1S/C14H16N2O/c1-17-14-5-3-2-4-11(14)10-6-7-12-13(8-10)16-9-15-12/h2-5,9-10H,6-8H2,1H3,(H,15,16)
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n/an/an/an/a 3.50E+3n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human cloned adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3118-21 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50258561
PNG
((R)-2-(2-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-6-...)
Show SMILES C1[C@@H](Cn2ccnc12)c1ccccc1-c1ncco1
Show InChI InChI=1S/C15H13N3O/c1-2-4-13(15-17-6-8-19-15)12(3-1)11-9-14-16-5-7-18(14)10-11/h1-8,11H,9-10H2/t11-/m0/s1
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n/an/an/an/a>3.57E+3n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3113-7 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50258644
PNG
(6-(4-fluoro-2-(1H-pyrazol-1-yl)phenyl)-6,7-dihydro...)
Show SMILES Fc1ccc(C2Cc3nccn3C2)c(c1)-n1cccn1
Show InChI InChI=1S/C15H13FN4/c16-12-2-3-13(14(9-12)20-6-1-4-18-20)11-8-15-17-5-7-19(15)10-11/h1-7,9,11H,8,10H2
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n/an/an/an/a>4.10E+3n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3113-7 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50421513
PNG
(CHEMBL421011)
Show SMILES CCN(CC)C(=O)c1ccccc1NCC1=NCCN1
Show InChI InChI=1S/C15H22N4O/c1-3-19(4-2)15(20)12-7-5-6-8-13(12)18-11-14-16-9-10-17-14/h5-8,18H,3-4,9-11H2,1-2H3,(H,16,17)
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n/an/an/an/a<5.01E+3n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC ...


Bioorg Med Chem Lett 12: 471-5 (2002)

Checked by Author
More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50000200
PNG
(CHEMBL117914)
Show SMILES CCN(CC)C(=O)c1ccccc1OCC1=NCCN1
Show InChI InChI=1S/C15H21N3O2/c1-3-18(4-2)15(19)12-7-5-6-8-13(12)20-11-14-16-9-10-17-14/h5-8H,3-4,9-11H2,1-2H3,(H,16,17)
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n/an/an/an/a<5.01E+3n/an/an/an/a



GlaxoSmithKline Research and Development

Curated by ChEMBL


Assay Description
Activation of recombinant human adrenergic, alpha-1D receptor expressed in rat-1 fibroblasts assayed via calcium mobilization through Gq coupled PLC ...


Bioorg Med Chem Lett 12: 471-5 (2002)

Checked by Author
More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50256563
PNG
((R)-2-(5-chloro-4-(methoxymethyl)-2,3-dihydro-1H-i...)
Show SMILES COCc1c2CC[C@@H](c3ncc[nH]3)c2ccc1Cl
Show InChI InChI=1S/C14H15ClN2O/c1-18-8-12-10-2-3-11(14-16-6-7-17-14)9(10)4-5-13(12)15/h4-7,11H,2-3,8H2,1H3,(H,16,17)/t11-/m1/s1
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n/an/an/an/a>7.00E+3n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3113-7 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50259381
PNG
(6-phenyl-6,7-di hydro-5H-pyrrolo[1,2-a]imidazole |...)
Show SMILES C1C(Cn2ccnc12)c1ccccc1
Show InChI InChI=1S/C12H12N2/c1-2-4-10(5-3-1)11-8-12-13-6-7-14(12)9-11/h1-7,11H,8-9H2
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n/an/an/an/a 7.36E+3n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human cloned adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3118-21 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50258592
PNG
((S)-2'-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-6-yl...)
Show SMILES CNC(=O)c1cccc(c1)-c1ccccc1[C@@H]1Cc2nccn2C1
Show InChI InChI=1S/C20H19N3O/c1-21-20(24)15-6-4-5-14(11-15)17-7-2-3-8-18(17)16-12-19-22-9-10-23(19)13-16/h2-11,16H,12-13H2,1H3,(H,21,24)/t16-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3113-7 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50258638
PNG
(6-(2-fluoro-6-(pyrimidin-5-yl)phenyl)-6,7-dihydro-...)
Show SMILES Fc1cccc(-c2cncnc2)c1C1Cc2nccn2C1
Show InChI InChI=1S/C16H13FN4/c17-14-3-1-2-13(12-7-18-10-19-8-12)16(14)11-6-15-20-4-5-21(15)9-11/h1-5,7-8,10-11H,6,9H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3113-7 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50258639
PNG
(2-(2-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-6-yl)-...)
Show SMILES Fc1ccc(C2Cc3nccn3C2)c(c1)-c1ncco1
Show InChI InChI=1S/C15H12FN3O/c16-11-1-2-12(13(8-11)15-18-4-6-20-15)10-7-14-17-3-5-19(14)9-10/h1-6,8,10H,7,9H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3113-7 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50258643
PNG
(6-(5-fluoro-2-(1H-pyrazol-1-yl)phenyl)-6,7-dihydro...)
Show SMILES Fc1ccc(c(c1)C1Cc2nccn2C1)-n1cccn1
Show InChI InChI=1S/C15H13FN4/c16-12-2-3-14(20-6-1-4-18-20)13(9-12)11-8-15-17-5-7-19(15)10-11/h1-7,9,11H,8,10H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3113-7 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50258589
PNG
((S)-6-(2-(1H-pyrazol-1-yl)phenyl)-6,7-dihydro-5H-p...)
Show SMILES C1[C@H](Cn2ccnc12)c1ccccc1-n1cccn1
Show InChI InChI=1S/C15H14N4/c1-2-5-14(19-8-3-6-17-19)13(4-1)12-10-15-16-7-9-18(15)11-12/h1-9,12H,10-11H2/t12-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3113-7 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50258590
PNG
((S)-N-(2'-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-6...)
Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1ccccc1[C@@H]1Cc2nccn2C1
Show InChI InChI=1S/C19H19N3O2S/c1-25(23,24)21-16-6-4-5-14(11-16)17-7-2-3-8-18(17)15-12-19-20-9-10-22(19)13-15/h2-11,15,21H,12-13H2,1H3/t15-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3113-7 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50258591
PNG
((S)-2-(2-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-6-...)
Show SMILES CNS(=O)(=O)CCc1ccccc1[C@@H]1Cc2nccn2C1
Show InChI InChI=1S/C15H19N3O2S/c1-16-21(19,20)9-6-12-4-2-3-5-14(12)13-10-15-17-7-8-18(15)11-13/h2-5,7-8,13,16H,6,9-11H2,1H3/t13-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3113-7 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50258517
PNG
((S)-2-(6,7-dihydro-5H-pyrrolo[1,2-a]imidazol-6-yl)...)
Show SMILES N#Cc1ccccc1[C@@H]1Cc2nccn2C1
Show InChI InChI=1S/C13H11N3/c14-8-10-3-1-2-4-12(10)11-7-13-15-5-6-16(13)9-11/h1-6,11H,7,9H2/t11-/m1/s1
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3113-7 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50259381
PNG
(6-phenyl-6,7-di hydro-5H-pyrrolo[1,2-a]imidazole |...)
Show SMILES C1C(Cn2ccnc12)c1ccccc1
Show InChI InChI=1S/C12H12N2/c1-2-4-10(5-3-1)11-8-12-13-6-7-14(12)9-11/h1-7,11H,8-9H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human cloned adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3118-21 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50259382
PNG
(6-phenyl-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine ...)
Show SMILES C1Cc2nccn2CC1c1ccccc1
Show InChI InChI=1S/C13H14N2/c1-2-4-11(5-3-1)12-6-7-13-14-8-9-15(13)10-12/h1-5,8-9,12H,6-7,10H2
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human cloned adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3118-21 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50259383
PNG
(6-(2-chlorophenyl)-4,5,6,7-tetrahydro-1H-benzo[d]i...)
Show SMILES Clc1ccccc1C1CCc2nc[nH]c2C1
Show InChI InChI=1S/C13H13ClN2/c14-11-4-2-1-3-10(11)9-5-6-12-13(7-9)16-8-15-12/h1-4,8-9H,5-7H2,(H,15,16)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human cloned adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3118-21 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50259384
PNG
(6-(3-chlorophenyl)-4,5,6,7-tetrahydro-1H-benzo[d]i...)
Show SMILES Clc1cccc(c1)C1CCc2nc[nH]c2C1
Show InChI InChI=1S/C13H13ClN2/c14-11-3-1-2-9(6-11)10-4-5-12-13(7-10)16-8-15-12/h1-3,6,8,10H,4-5,7H2,(H,15,16)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human cloned adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3118-21 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50259385
PNG
(6-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-benzo[d]i...)
Show SMILES Clc1ccc(cc1)C1CCc2nc[nH]c2C1
Show InChI InChI=1S/C13H13ClN2/c14-11-4-1-9(2-5-11)10-3-6-12-13(7-10)16-8-15-12/h1-2,4-5,8,10H,3,6-7H2,(H,15,16)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human cloned adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3118-21 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50259387
PNG
(6-(3-methoxyphenyl)-4,5,6,7-tetrahydro-1H-benzo[d]...)
Show SMILES COc1cccc(c1)C1CCc2nc[nH]c2C1
Show InChI InChI=1S/C14H16N2O/c1-17-12-4-2-3-10(7-12)11-5-6-13-14(8-11)16-9-15-13/h2-4,7,9,11H,5-6,8H2,1H3,(H,15,16)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human cloned adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3118-21 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50259484
PNG
(6-(4-methoxyphenyl)-4,5,6,7-tetrahydro-1H-benzo[d]...)
Show SMILES COc1ccc(cc1)C1CCc2nc[nH]c2C1
Show InChI InChI=1S/C14H16N2O/c1-17-12-5-2-10(3-6-12)11-4-7-13-14(8-11)16-9-15-13/h2-3,5-6,9,11H,4,7-8H2,1H3,(H,15,16)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human cloned adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3118-21 (2009)

More data for this
Ligand-Target Pair
Alpha adrenergic receptor (1a and 1d)


(HUMAN)
BDBM50259485
PNG
(6-(2-(methoxy methyl)phenyl)-4,5,6,7-tetrahydro-1H...)
Show SMILES COCc1ccccc1C1CCc2nc[nH]c2C1
Show InChI InChI=1S/C15H18N2O/c1-18-9-12-4-2-3-5-13(12)11-6-7-14-15(8-11)17-10-16-14/h2-5,10-11H,6-9H2,1H3,(H,16,17)
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PubMed
n/an/an/an/a>1.00E+4n/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Agonist activity at human cloned adrenergic alpha1D receptor expressed in CHO cells assessed as calcium mobilization by FLIPR


Bioorg Med Chem Lett 19: 3118-21 (2009)

More data for this
Ligand-Target Pair
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