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Compile Data Set for Download or QSAR

Found 319 hits of kd data for polymerid = 49000244,49000246   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404774
PNG
(CHEMBL31857)
Show SMILES CCOC(=O)CCCNCC(O)COc1ccccc1C
Show InChI InChI=1S/C16H25NO4/c1-3-20-16(19)9-6-10-17-11-14(18)12-21-15-8-5-4-7-13(15)2/h4-5,7-8,14,17-18H,3,6,9-12H2,1-2H3
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n/an/an/a 0.00000100n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vivo inihibition of Beta-1 adrenergic receptor in guinea pig right atria after 40 min


J Med Chem 25: 1402-7 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404791
PNG
(CHEMBL31025)
Show SMILES COC(=O)CCc1ccc(OCC(O)CNC(C)(C)C)cc1
Show InChI InChI=1S/C17H27NO4/c1-17(2,3)18-11-14(19)12-22-15-8-5-13(6-9-15)7-10-16(20)21-4/h5-6,8-9,14,18-19H,7,10-12H2,1-4H3
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TBA

Curated by ChEMBL


Assay Description
Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3h


J Med Chem 25: 1408-12 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404790
PNG
(CHEMBL13284)
Show SMILES COC(=O)c1ccccc1OCC(O)CNC(C)C
Show InChI InChI=1S/C14H21NO4/c1-10(2)15-8-11(16)9-19-13-7-5-4-6-12(13)14(17)18-3/h4-7,10-11,15-16H,8-9H2,1-3H3
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TBA

Curated by ChEMBL


Assay Description
Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 40 min


J Med Chem 25: 1408-12 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404790
PNG
(CHEMBL13284)
Show SMILES COC(=O)c1ccccc1OCC(O)CNC(C)C
Show InChI InChI=1S/C14H21NO4/c1-10(2)15-8-11(16)9-19-13-7-5-4-6-12(13)14(17)18-3/h4-7,10-11,15-16H,8-9H2,1-3H3
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TBA

Curated by ChEMBL


Assay Description
Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3h


J Med Chem 25: 1408-12 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404763
PNG
(CHEMBL283289)
Show SMILES CCOC(=O)CCNCC(O)COc1ccccc1C
Show InChI InChI=1S/C15H23NO4/c1-3-19-15(18)8-9-16-10-13(17)11-20-14-7-5-4-6-12(14)2/h4-7,13,16-17H,3,8-11H2,1-2H3
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TBA

Curated by ChEMBL


Assay Description
In vivo inihibition of Beta-1 adrenergic receptor in guinea pig right atria after 40 min


J Med Chem 25: 1402-7 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404793
PNG
(CHEMBL31638)
Show SMILES COC(=O)CCc1ccc(OCC(O)CNCCc2ccc(OC)c(OC)c2)cc1
Show InChI InChI=1S/C23H31NO6/c1-27-21-10-6-18(14-22(21)28-2)12-13-24-15-19(25)16-30-20-8-4-17(5-9-20)7-11-23(26)29-3/h4-6,8-10,14,19,24-25H,7,11-13,15-16H2,1-3H3
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TBA

Curated by ChEMBL


Assay Description
Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3h


J Med Chem 25: 1408-12 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404796
PNG
(Brevibloc | ESMOLOL)
Show SMILES COC(=O)CCc1ccc(OCC(O)CNC(C)C)cc1
Show InChI InChI=1S/C16H25NO4/c1-12(2)17-10-14(18)11-21-15-7-4-13(5-8-15)6-9-16(19)20-3/h4-5,7-8,12,14,17-18H,6,9-11H2,1-3H3
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TBA

Curated by ChEMBL


Assay Description
Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 40 min


J Med Chem 25: 1408-12 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404804
PNG
(CHEMBL13365)
Show SMILES COC(=O)c1ccccc1OCC(O)CNC(C)(C)C
Show InChI InChI=1S/C15H23NO4/c1-15(2,3)16-9-11(17)10-20-13-8-6-5-7-12(13)14(18)19-4/h5-8,11,16-17H,9-10H2,1-4H3
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TBA

Curated by ChEMBL


Assay Description
Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 40 min


J Med Chem 25: 1408-12 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404796
PNG
(Brevibloc | ESMOLOL)
Show SMILES COC(=O)CCc1ccc(OCC(O)CNC(C)C)cc1
Show InChI InChI=1S/C16H25NO4/c1-12(2)17-10-14(18)11-21-15-7-4-13(5-8-15)6-9-16(19)20-3/h4-5,7-8,12,14,17-18H,6,9-11H2,1-3H3
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TBA

Curated by ChEMBL


Assay Description
Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3h


J Med Chem 25: 1408-12 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404789
PNG
(CHEMBL30622)
Show SMILES CCOC(=O)CCNCC(O)COc1ccccc1C(=O)OC
Show InChI InChI=1S/C16H23NO6/c1-3-22-15(19)8-9-17-10-12(18)11-23-14-7-5-4-6-13(14)16(20)21-2/h4-7,12,17-18H,3,8-11H2,1-2H3
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TBA

Curated by ChEMBL


Assay Description
Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation at a duration of 3h


J Med Chem 25: 1408-12 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50405625
PNG
(CHEMBL304344)
Show SMILES O[C@H](COc1cccc2ccccc12)[C@@H]1CCCCN1
Show InChI InChI=1S/C17H21NO2/c19-16(15-9-3-4-11-18-15)12-20-17-10-5-7-13-6-1-2-8-14(13)17/h1-2,5-8,10,15-16,18-19H,3-4,9,11-12H2/t15-,16+/m0/s1
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n/an/an/a 0.151n/an/an/an/an/a



Universidad de Barcelona

Curated by ChEMBL


Assay Description
Beta-1 adrenergic receptor activitation measured by isoprenaline-induced positive inotropic effect in guinea pig left atrium


J Med Chem 31: 2122-6 (1988)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50292219
PNG
((-)-3-morpholino-4-(3-tert-butylamino-2-hydroxypro...)
Show SMILES CC(C)(C)NC[C@H](O)COc1nsnc1N1CCOCC1
Show InChI InChI=1S/C13H24N4O3S/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17/h10,14,18H,4-9H2,1-3H3/t10-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated...


J Med Chem 29: 1065-80 (1986)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50292219
PNG
((-)-3-morpholino-4-(3-tert-butylamino-2-hydroxypro...)
Show SMILES CC(C)(C)NC[C@H](O)COc1nsnc1N1CCOCC1
Show InChI InChI=1S/C13H24N4O3S/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17/h10,14,18H,4-9H2,1-3H3/t10-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea p...


J Med Chem 26: 950-7 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50292219
PNG
((-)-3-morpholino-4-(3-tert-butylamino-2-hydroxypro...)
Show SMILES CC(C)(C)NC[C@H](O)COc1nsnc1N1CCOCC1
Show InChI InChI=1S/C13H24N4O3S/c1-13(2,3)14-8-10(18)9-20-12-11(15-21-16-12)17-4-6-19-7-5-17/h10,14,18H,4-9H2,1-3H3/t10-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
Compound was tested for its Beta-1 adrenergic receptor antagonistic activity on guinea pig atria


J Med Chem 25: 931-6 (1982)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404978
PNG
(CHEMBL173424)
Show SMILES OC(CNC1CC1)COc1ccc(cc1)-c1ncc([nH]1)C(F)(F)F
Show InChI InChI=1S/C16H18F3N3O2/c17-16(18,19)14-8-21-15(22-14)10-1-5-13(6-2-10)24-9-12(23)7-20-11-3-4-11/h1-2,5-6,8,11-12,20,23H,3-4,7,9H2,(H,21,22)
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TBA

Curated by ChEMBL


Assay Description
In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea p...


J Med Chem 26: 950-7 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404980
PNG
(CHEMBL1788320)
Show SMILES COc1ccc(CCNC[C@H](O)COc2ccc(cc2)-c2nc(c[nH]2)-c2cccs2)cc1OC
Show InChI InChI=1S/C26H29N3O4S/c1-31-23-10-5-18(14-24(23)32-2)11-12-27-15-20(30)17-33-21-8-6-19(7-9-21)26-28-16-22(29-26)25-4-3-13-34-25/h3-10,13-14,16,20,27,30H,11-12,15,17H2,1-2H3,(H,28,29)/t20-/m0/s1
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TBA

Curated by ChEMBL


Assay Description
In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea p...


J Med Chem 26: 950-7 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404977
PNG
(CHEMBL11671)
Show SMILES COc1ccc(CCNCC(O)COc2ccc(cc2)-c2nc(c[nH]2)-c2cccs2)cc1OC
Show InChI InChI=1S/C26H29N3O4S/c1-31-23-10-5-18(14-24(23)32-2)11-12-27-15-20(30)17-33-21-8-6-19(7-9-21)26-28-16-22(29-26)25-4-3-13-34-25/h3-10,13-14,16,20,27,30H,11-12,15,17H2,1-2H3,(H,28,29)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated...


J Med Chem 29: 1065-80 (1986)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404987
PNG
(CHEMBL3085291)
Show SMILES CC(C)(C)NC[C@H](O)COc1ccc(cc1)-c1nc(c[nH]1)C(F)(F)F
Show InChI InChI=1S/C17H22F3N3O2/c1-16(2,3)22-8-12(24)10-25-13-6-4-11(5-7-13)15-21-9-14(23-15)17(18,19)20/h4-7,9,12,22,24H,8,10H2,1-3H3,(H,21,23)/t12-/m0/s1
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n/an/an/a 0.891n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea p...


J Med Chem 26: 950-7 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM25748
PNG
(3-(2-{[3-(2-cyanophenoxy)-2-hydroxypropyl]amino}et...)
Show SMILES OC(CNCCNC(=O)Nc1ccccc1)COc1ccccc1C#N
Show InChI InChI=1S/C19H22N4O3/c20-12-15-6-4-5-9-18(15)26-14-17(24)13-21-10-11-22-19(25)23-16-7-2-1-3-8-16/h1-9,17,21,24H,10-11,13-14H2,(H2,22,23,25)
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n/an/an/a 0.933n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated...


J Med Chem 29: 1065-80 (1986)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404988
PNG
(CHEMBL11171)
Show SMILES CC(C)NCC(O)COc1ccc(cc1)-c1nc(c[nH]1)-c1cccs1
Show InChI InChI=1S/C19H23N3O2S/c1-13(2)20-10-15(23)12-24-16-7-5-14(6-8-16)19-21-11-17(22-19)18-4-3-9-25-18/h3-9,11,13,15,20,23H,10,12H2,1-2H3,(H,21,22)
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TBA

Curated by ChEMBL


Assay Description
In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea p...


J Med Chem 26: 950-7 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404988
PNG
(CHEMBL11171)
Show SMILES CC(C)NCC(O)COc1ccc(cc1)-c1nc(c[nH]1)-c1cccs1
Show InChI InChI=1S/C19H23N3O2S/c1-13(2)20-10-15(23)12-24-16-7-5-14(6-8-16)19-21-11-17(22-19)18-4-3-9-25-18/h3-9,11,13,15,20,23H,10,12H2,1-2H3,(H,21,22)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated...


J Med Chem 29: 1065-80 (1986)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404988
PNG
(CHEMBL11171)
Show SMILES CC(C)NCC(O)COc1ccc(cc1)-c1nc(c[nH]1)-c1cccs1
Show InChI InChI=1S/C19H23N3O2S/c1-13(2)20-10-15(23)12-24-16-7-5-14(6-8-16)19-21-11-17(22-19)18-4-3-9-25-18/h3-9,11,13,15,20,23H,10,12H2,1-2H3,(H,21,22)
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n/an/an/a 1.30n/an/an/an/an/a



University of Melbourne

Curated by ChEMBL


Assay Description
Activity at beta-1 adrenergic receptor


J Med Chem 35: 4676-82 (1993)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50405441
PNG
(CHEMBL11145)
Show SMILES COc1ccc(CCNCC(O)COc2ccc(cc2)-c2nc(c[nH]2)C(C)C)cc1OC
Show InChI InChI=1S/C25H33N3O4/c1-17(2)22-15-27-25(28-22)19-6-8-21(9-7-19)32-16-20(29)14-26-12-11-18-5-10-23(30-3)24(13-18)31-4/h5-10,13,15,17,20,26,29H,11-12,14,16H2,1-4H3,(H,27,28)
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n/an/an/a 1.5n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated...


J Med Chem 29: 1065-80 (1986)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404804
PNG
(CHEMBL13365)
Show SMILES COC(=O)c1ccccc1OCC(O)CNC(C)(C)C
Show InChI InChI=1S/C15H23NO4/c1-15(2,3)16-9-11(17)10-20-13-8-6-5-7-12(13)14(18)19-4/h5-8,11,16-17H,9-10H2,1-4H3
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n/an/an/a 1.60n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation


J Med Chem 25: 1408-12 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404982
PNG
(CHEMBL366769)
Show SMILES CC(C)(C)NCC(O)COc1ccc(cc1)-c1nc(c[nH]1)-c1cccs1
Show InChI InChI=1S/C20H25N3O2S/c1-20(2,3)22-11-15(24)13-25-16-8-6-14(7-9-16)19-21-12-17(23-19)18-5-4-10-26-18/h4-10,12,15,22,24H,11,13H2,1-3H3,(H,21,23)
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TBA

Curated by ChEMBL


Assay Description
In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea p...


J Med Chem 26: 950-7 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50405521
PNG
(ALO 1401-02 | ALO-1401-02 | BETAXOLOL HYDROCHLORID...)
Show SMILES CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1
Show InChI InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3
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n/an/an/a 1.70n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated...


J Med Chem 29: 1065-80 (1986)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50169785
PNG
((2-Hydroxy-3-phenoxy-propyl)-isopropyl-ammonium | ...)
Show SMILES CC(C)NCC(O)COc1ccccc1
Show InChI InChI=1S/C12H19NO2/c1-10(2)13-8-11(14)9-15-12-6-4-3-5-7-12/h3-7,10-11,13-14H,8-9H2,1-2H3
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n/an/an/a 1.70n/an/an/an/an/a



Universidad de Barcelona

Curated by ChEMBL


Assay Description
Beta-1 adrenergic receptor activitation measured by isoprenaline-induced positive inotropic effect in guinea pig left atrium


J Med Chem 31: 2122-6 (1988)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50405521
PNG
(ALO 1401-02 | ALO-1401-02 | BETAXOLOL HYDROCHLORID...)
Show SMILES CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1
Show InChI InChI=1S/C18H29NO3/c1-14(2)19-11-17(20)13-22-18-7-5-15(6-8-18)9-10-21-12-16-3-4-16/h5-8,14,16-17,19-20H,3-4,9-13H2,1-2H3
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n/an/an/a 1.70n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea p...


J Med Chem 26: 950-7 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM25761
PNG
(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)
Show SMILES CC(C)NCC(O)COc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
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n/an/an/a 1.70n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated...


J Med Chem 29: 1065-80 (1986)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM25761
PNG
(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)
Show SMILES CC(C)NCC(O)COc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
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n/an/an/a 1.70n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea p...


J Med Chem 26: 950-7 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50241366
PNG
((S)-1-(isopropylamino)-3-(m-tolyloxy)propan-2-ol |...)
Show SMILES CC(C)NC[C@H](O)COc1cccc(C)c1
Show InChI InChI=1S/C13H21NO2/c1-10(2)14-8-12(15)9-16-13-6-4-5-11(3)7-13/h4-7,10,12,14-15H,8-9H2,1-3H3/t12-/m0/s1
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n/an/an/a 1.80n/an/an/an/an/a



Universidad de Barcelona

Curated by ChEMBL


Assay Description
Beta-1 adrenergic receptor activitation measured by isoprenaline-induced positive inotropic effect in guinea pig left atrium


J Med Chem 31: 2122-6 (1988)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50405626
PNG
(CHEMBL69635)
Show SMILES O[C@H](COc1cccc2ccccc12)[C@H]1CCCCN1
Show InChI InChI=1S/C17H21NO2/c19-16(15-9-3-4-11-18-15)12-20-17-10-5-7-13-6-1-2-8-14(13)17/h1-2,5-8,10,15-16,18-19H,3-4,9,11-12H2/t15-,16-/m1/s1
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Universidad de Barcelona

Curated by ChEMBL


Assay Description
Beta-1 adrenergic receptor activitation measured by isoprenaline-induced positive inotropic effect in guinea pig left atrium


J Med Chem 31: 2122-6 (1988)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404994
PNG
(CHEMBL2096752)
Show SMILES O[C@@H](CNC1CC1)COc1ccc(cc1)-c1ncc([nH]1)C(F)(F)F
Show InChI InChI=1S/C16H18F3N3O2/c17-16(18,19)14-8-21-15(22-14)10-1-5-13(6-2-10)24-9-12(23)7-20-11-3-4-11/h1-2,5-6,8,11-12,20,23H,3-4,7,9H2,(H,21,22)/t12-/m0/s1
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n/an/an/a 1.90n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro beta-1 adrenergic receptor activity was determined via inhibition of the positive chronotropic actions of isoproterenol in isolated guinea p...


J Med Chem 26: 950-7 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM25761
PNG
(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)
Show SMILES CC(C)NCC(O)COc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
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n/an/an/a 2n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation


J Med Chem 25: 1408-12 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM81886
PNG
(CAS_3506-09-0 | CHEMBL287651 | PROPRANOLOL, dl)
Show SMILES CC(C)CNCC(O)COc1cccc2ccccc12
Show InChI InChI=1S/C17H23NO2/c1-13(2)10-18-11-15(19)12-20-17-9-5-7-14-6-3-4-8-16(14)17/h3-9,13,15,18-19H,10-12H2,1-2H3
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n/an/an/a 2n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro ability to block beta-1 adrenergic receptor in guinea pig right atria.


J Med Chem 25: 1402-7 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404695
PNG
(CHEMBL174853)
Show SMILES COc1ccc(CCNCC(O)C2=COc3ccccc3O2)cc1OC
Show InChI InChI=1S/C20H23NO5/c1-23-16-8-7-14(11-19(16)24-2)9-10-21-12-15(22)20-13-25-17-5-3-4-6-18(17)26-20/h3-8,11,13,15,21-22H,9-10,12H2,1-2H3
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TBA

Curated by ChEMBL


Assay Description
Antagonist activity of compound against Beta-1 adrenergic receptor in isolated guinea pig left atria


J Med Chem 24: 994-8 (1982)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50405416
PNG
(CHEMBL11051)
Show SMILES COc1ccc(CCNCC(O)COc2ccc(cc2)-c2ncc(Br)[nH]2)cc1OC
Show InChI InChI=1S/C22H26BrN3O4/c1-28-19-8-3-15(11-20(19)29-2)9-10-24-12-17(27)14-30-18-6-4-16(5-7-18)22-25-13-21(23)26-22/h3-8,11,13,17,24,27H,9-10,12,14H2,1-2H3,(H,25,26)
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TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated...


J Med Chem 29: 1065-80 (1986)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50405434
PNG
(CHEMBL416150)
Show SMILES COc1ccc(CCNCC(O)COc2ccc(cc2)-c2ncc(Cl)[nH]2)cc1OC
Show InChI InChI=1S/C22H26ClN3O4/c1-28-19-8-3-15(11-20(19)29-2)9-10-24-12-17(27)14-30-18-6-4-16(5-7-18)22-25-13-21(23)26-22/h3-8,11,13,17,24,27H,9-10,12,14H2,1-2H3,(H,25,26)
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n/an/an/a 2n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated...


J Med Chem 29: 1065-80 (1986)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM25761
PNG
(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)
Show SMILES CC(C)NCC(O)COc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
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n/an/an/a 2.40n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against beta-1 adrenergic receptor determined as pA2 in guinea pig atria


J Med Chem 28: 896-900 (1985)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM25761
PNG
(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)
Show SMILES CC(C)NCC(O)COc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
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n/an/an/a 2.40n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Beta-1 adrenergic receptor blocking activity in atria of guinea pig.


J Med Chem 27: 1291-4 (1984)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM25761
PNG
(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)
Show SMILES CC(C)NCC(O)COc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
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n/an/an/a 2.40n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Antagonism of the isoprenaline-induced positive chronotropic effect on the atria of guinea pig


J Med Chem 23: 620-4 (1980)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404808
PNG
(CHEMBL281967)
Show SMILES COC(=O)CCc1ccccc1OCC(O)CNC(C)C
Show InChI InChI=1S/C16H25NO4/c1-12(2)17-10-14(18)11-21-15-7-5-4-6-13(15)8-9-16(19)20-3/h4-7,12,14,17-18H,8-11H2,1-3H3
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n/an/an/a 2.5n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation


J Med Chem 25: 1408-12 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404770
PNG
(CHEMBL31021)
Show SMILES CC(C)CNCC(O)COc1ccccc1C
Show InChI InChI=1S/C14H23NO2/c1-11(2)8-15-9-13(16)10-17-14-7-5-4-6-12(14)3/h4-7,11,13,15-16H,8-10H2,1-3H3
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n/an/an/a 2.5n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro ability to block beta-1 adrenergic receptor in guinea pig right atria.


J Med Chem 25: 1402-7 (1983)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM25761
PNG
(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)
Show SMILES CC(C)NCC(O)COc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
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n/an/an/a 2.5n/an/an/an/an/a



Universidad de Barcelona

Curated by ChEMBL


Assay Description
Beta-1 adrenergic receptor activitation measured by isoprenaline-induced positive inotropic effect in guinea pig left atrium


J Med Chem 31: 2122-6 (1988)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50405442
PNG
(CHEMBL11205)
Show SMILES COc1ccc(CCNCC(O)COc2ccc(Cc3nc(c[nH]3)-c3cccs3)cc2)cc1OC
Show InChI InChI=1S/C27H31N3O4S/c1-32-24-10-7-20(14-25(24)33-2)11-12-28-16-21(31)18-34-22-8-5-19(6-9-22)15-27-29-17-23(30-27)26-4-3-13-35-26/h3-10,13-14,17,21,28,31H,11-12,15-16,18H2,1-2H3,(H,29,30)
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n/an/an/a 2.90n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated...


J Med Chem 29: 1065-80 (1986)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50405413
PNG
(CHEMBL11112)
Show SMILES COc1ccc(CCNCC(O)COc2ccc(CCc3ncc(Br)[nH]3)cc2)cc1OC
Show InChI InChI=1S/C24H30BrN3O4/c1-30-21-9-5-18(13-22(21)31-2)11-12-26-14-19(29)16-32-20-7-3-17(4-8-20)6-10-24-27-15-23(25)28-24/h3-5,7-9,13,15,19,26,29H,6,10-12,14,16H2,1-2H3,(H,27,28)
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n/an/an/a 2.90n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated...


J Med Chem 29: 1065-80 (1986)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50405421
PNG
(CHEMBL415970)
Show SMILES COc1ccc(CCNCC(O)COc2ccc(CCc3nc(c[nH]3)-c3cccs3)cc2)cc1OC
Show InChI InChI=1S/C28H33N3O4S/c1-33-25-11-7-21(16-26(25)34-2)13-14-29-17-22(32)19-35-23-9-5-20(6-10-23)8-12-28-30-18-24(31-28)27-4-3-15-36-27/h3-7,9-11,15-16,18,22,29,32H,8,12-14,17,19H2,1-2H3,(H,30,31)
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n/an/an/a 3.10n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against beta-1 adrenergic receptor measured by inhibition of positive chronotropic effect of isoproterenolin in isolated...


J Med Chem 29: 1065-80 (1986)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM25761
PNG
(Anapriline | Avlocardyl | CHEMBL27 | PROPANOLOL(-)...)
Show SMILES CC(C)NCC(O)COc1cccc2ccccc12
Show InChI InChI=1S/C16H21NO2/c1-12(2)17-10-14(18)11-19-16-9-5-7-13-6-3-4-8-15(13)16/h3-9,12,14,17-18H,10-11H2,1-2H3
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n/an/an/a 3.10n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Compound was evaluated for competitive antagonism of beta-1 adrenergic receptor in guinea pig atria measured as pA2 (-log KB)


J Med Chem 27: 857-61 (1984)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50405403
PNG
(CHEMBL11125)
Show SMILES CC(C)NCC(O)COc1ccc(Cc2ncc(Br)[nH]2)cc1
Show InChI InChI=1S/C16H22BrN3O2/c1-11(2)18-8-13(21)10-22-14-5-3-12(4-6-14)7-16-19-9-15(17)20-16/h3-6,9,11,13,18,21H,7-8,10H2,1-2H3,(H,19,20)
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n/an/an/a 3.20n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against beta-1 adrenergic receptor was measured by the inhibition of the positive chronotropic effectof isoproterenolin ...


J Med Chem 29: 1065-80 (1986)

More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(GUINEA PIG)
BDBM50404805
PNG
(CHEMBL281294)
Show SMILES CCOC(=O)c1ccccc1OCC(O)CNC(C)(C)C
Show InChI InChI=1S/C16H25NO4/c1-5-20-15(19)13-8-6-7-9-14(13)21-11-12(18)10-17-16(2,3)4/h6-9,12,17-18H,5,10-11H2,1-4H3
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n/an/an/a 3.20n/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to block Beta-1 adrenergic receptor in guinea pig right atria preparation


J Med Chem 25: 1408-12 (1983)

More data for this
Ligand-Target Pair
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