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Compile Data Set for Download or QSAR

Found 825 hits of ic50 data for polymerid = 49000267,5550   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50049199
PNG
(4'-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-y...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C37H34N4O3S/c1-4-33-39-35-25(2)23-26(3)38-36(35)41(33)24-27-19-21-28(22-20-27)31-17-11-12-18-32(31)45(43,44)40-37(42)34(29-13-7-5-8-14-29)30-15-9-6-10-16-30/h5-23,34H,4,24H2,1-3H3,(H,40,42)
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n/an/a 0.0500n/an/an/an/an/an/a



DuPont Merck Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibition of Angiotensin II receptor, type 1


J Med Chem 39: 625-56 (1996)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50030692
PNG
(CHEMBL339672 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C35H32Cl2FN5O5S/c1-3-5-14-32-40-43(30-20-24(17-18-28(30)37)39-33(44)4-2)35(46)42(32)21-23-16-15-22(19-29(23)38)25-10-7-9-13-31(25)49(47,48)41-34(45)26-11-6-8-12-27(26)36/h6-13,15-20H,3-5,14,21H2,1-2H3,(H,39,44)(H,41,45)
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n/an/a 0.0720n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283201
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL305238)
Show SMILES CCCc1nc(CC)c(C(=O)OCCC(=O)Nc2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C37H43FN4O7S/c1-5-12-33-40-31(6-2)35(36(44)48-22-20-34(43)39-28-13-8-7-9-14-28)42(33)24-27-18-17-26(23-30(27)38)29-15-10-11-16-32(29)50(46,47)41-37(45)49-21-19-25(3)4/h7-11,13-18,23,25H,5-6,12,19-22,24H2,1-4H3,(H,39,43)(H,41,45)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283235
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL305017)
Show SMILES CCCc1nc(CC)c(C(=O)OCCN(C(=O)c2ccccc2)c2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C43H47FN4O7S/c1-5-15-39-45-37(6-2)40(42(50)54-27-25-47(34-18-11-8-12-19-34)41(49)31-16-9-7-10-17-31)48(39)29-33-23-22-32(28-36(33)44)35-20-13-14-21-38(35)56(52,53)46-43(51)55-26-24-30(3)4/h7-14,16-23,28,30H,5-6,15,24-27,29H2,1-4H3,(H,46,51)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283194
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL69721)
Show SMILES CCCc1nc(CC)c(C(=O)OCCCOc2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C37H44FN3O7S/c1-5-13-34-39-32(6-2)35(36(42)47-22-12-21-46-29-14-8-7-9-15-29)41(34)25-28-19-18-27(24-31(28)38)30-16-10-11-17-33(30)49(44,45)40-37(43)48-23-20-26(3)4/h7-11,14-19,24,26H,5-6,12-13,20-23,25H2,1-4H3,(H,40,43)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283237
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL70161)
Show SMILES CCCc1nc(CC)c(C(=O)OCCCC(=O)c2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C38H44FN3O7S/c1-5-13-35-40-32(6-2)36(37(44)48-22-12-17-33(43)27-14-8-7-9-15-27)42(35)25-29-20-19-28(24-31(29)39)30-16-10-11-18-34(30)50(46,47)41-38(45)49-23-21-26(3)4/h7-11,14-16,18-20,24,26H,5-6,12-13,17,21-23,25H2,1-4H3,(H,41,45)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283213
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL307318)
Show SMILES CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1
Show InChI InChI=1S/C37H43FN4O7S/c1-4-7-13-22-49-37(45)41-50(46,47)32-18-12-11-17-29(32)26-19-20-27(30(38)24-26)25-42-33(14-5-2)40-31(6-3)35(42)36(44)48-23-21-34(43)39-28-15-9-8-10-16-28/h8-12,15-20,24H,4-7,13-14,21-23,25H2,1-3H3,(H,39,43)(H,41,45)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283231
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL70935)
Show SMILES CCCc1nc(CC)c(C(=O)OCC(=O)c2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C36H40FN3O7S/c1-5-12-33-38-30(6-2)34(35(42)47-23-31(41)25-13-8-7-9-14-25)40(33)22-27-18-17-26(21-29(27)37)28-15-10-11-16-32(28)48(44,45)39-36(43)46-20-19-24(3)4/h7-11,13-18,21,24H,5-6,12,19-20,22-23H2,1-4H3,(H,39,43)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50041969
PNG
(3-{2-Butyl-4-oxo-3-[2'-(1H-tetrazol-5-yl)-biphenyl...)
Show SMILES CCCCc1nc2ccc(NC(=O)N(C)C(C)C)cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C31H34N8O2/c1-5-6-11-28-33-27-17-16-23(32-31(41)38(4)20(2)3)18-26(27)30(40)39(28)19-21-12-14-22(15-13-21)24-9-7-8-10-25(24)29-34-36-37-35-29/h7-10,12-18,20H,5-6,11,19H2,1-4H3,(H,32,41)(H,34,35,36,37)
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n/an/a 0.100n/an/an/an/an/an/a



Organon Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against angiotensin II receptor, type 1


J Med Chem 48: 6523-43 (2005)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283219
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL70843)
Show SMILES CCCc1nc(CC)c(C(=O)OCCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C39H43FN4O8S/c1-5-12-34-41-32(6-2)35(38(47)51-21-11-20-43-36(45)29-14-7-8-15-30(29)37(43)46)44(34)24-27-18-17-26(23-31(27)40)28-13-9-10-16-33(28)53(49,50)42-39(48)52-22-19-25(3)4/h7-10,13-18,23,25H,5-6,11-12,19-22,24H2,1-4H3,(H,42,48)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50030684
PNG
(CHEMBL339722 | N-{3-[3-Butyl-4-(3-fluoro-2-(N-t-bu...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C34H39ClFN5O7S/c1-6-8-13-30-38-41(28-19-24(16-17-26(28)35)37-31(42)21-47-7-2)33(44)40(30)20-23-15-14-22(18-27(23)36)25-11-9-10-12-29(25)49(45,46)39-32(43)48-34(3,4)5/h9-12,14-19H,6-8,13,20-21H2,1-5H3,(H,37,42)(H,39,43)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283245
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL70789)
Show SMILES CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C36H42FN3O7S/c1-6-12-33-38-30(7-2)34(35(41)47-23-27-13-8-10-15-31(27)45-5)40(33)22-26-18-17-25(21-29(26)37)28-14-9-11-16-32(28)48(43,44)39-36(42)46-20-19-24(3)4/h8-11,13-18,21,24H,6-7,12,19-20,22-23H2,1-5H3,(H,39,42)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283223
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL70370)
Show SMILES CCCc1nc(CC)c(C(=O)OCCCOCc2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C38H46FN3O7S/c1-5-13-35-40-33(6-2)36(37(43)48-22-12-21-47-26-28-14-8-7-9-15-28)42(35)25-30-19-18-29(24-32(30)39)31-16-10-11-17-34(31)50(45,46)41-38(44)49-23-20-27(3)4/h7-11,14-19,24,27H,5-6,12-13,20-23,25-26H2,1-4H3,(H,41,44)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50030710
PNG
(CHEMBL332909 | N-{3-[4-(2'-Benzoylsulfamoyl-3-fluo...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C36H33F4N5O5S/c1-3-5-15-32-42-45(30-21-26(41-33(46)4-2)18-19-28(30)36(38,39)40)35(48)44(32)22-25-17-16-24(20-29(25)37)27-13-9-10-14-31(27)51(49,50)43-34(47)23-11-7-6-8-12-23/h6-14,16-21H,3-5,15,22H2,1-2H3,(H,41,46)(H,43,47)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50030698
PNG
(CHEMBL435811 | N-{3-[3-Butyl-4-(3-fluoro-2'-(N-t-b...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C34H39ClFN5O7S/c1-6-7-12-30-38-41(28-20-24(15-16-26(28)35)37-31(42)17-18-47-5)33(44)40(30)21-23-14-13-22(19-27(23)36)25-10-8-9-11-29(25)49(45,46)39-32(43)48-34(2,3)4/h8-11,13-16,19-20H,6-7,12,17-18,21H2,1-5H3,(H,37,42)(H,39,43)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50030697
PNG
(CHEMBL339004 | N-Butyl-3-{3-butyl-4-[2'-(2-chloro-...)
Show SMILES CCCCNC(=O)c1ccc(Cl)c(c1)-n1nc(CCCC)n(Cc2ccc(cc2F)-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2Cl)c1=O
Show InChI InChI=1S/C37H36Cl2FN5O5S/c1-3-5-15-34-42-45(32-22-25(18-19-30(32)39)35(46)41-20-6-4-2)37(48)44(34)23-26-17-16-24(21-31(26)40)27-11-8-10-14-33(27)51(49,50)43-36(47)28-12-7-9-13-29(28)38/h7-14,16-19,21-22H,3-6,15,20,23H2,1-2H3,(H,41,46)(H,43,47)
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n/an/a 0.160n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50067536
PNG
(5-Hydroxy-2,4-dimethyl-8-[2'-(1H-tetrazol-5-yl)-bi...)
Show SMILES Cc1nc(C)c2c(O)cc(=O)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c2n1
Show InChI InChI=1S/C23H19N7O2/c1-13-21-19(31)11-20(32)30(23(21)25-14(2)24-13)12-15-7-9-16(10-8-15)17-5-3-4-6-18(17)22-26-28-29-27-22/h3-11,31H,12H2,1-2H3,(H,26,27,28,29)
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n/an/a 0.170n/an/an/an/an/an/a



Technische Universit£t Darmstadt

Curated by ChEMBL


Assay Description
Compound was tested for inhibition against Angiotensin II receptor, type 1


J Med Chem 46: 2261-70 (2003)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50030695
PNG
(CHEMBL340632 | N-Butyl-3-[3-butyl-4-(3-fluoro-2'-(...)
Show SMILES CCCCNC(=O)c1ccc(Cl)c(c1)-n1nc(CCCC)n(Cc2ccc(cc2F)-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)c1=O
Show InChI InChI=1S/C35H41ClFN5O6S/c1-6-8-14-31-39-42(29-21-24(17-18-27(29)36)32(43)38-19-9-7-2)34(45)41(31)22-25-16-15-23(20-28(25)37)26-12-10-11-13-30(26)49(46,47)40-33(44)48-35(3,4)5/h10-13,15-18,20-21H,6-9,14,19,22H2,1-5H3,(H,38,43)(H,40,44)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50030689
PNG
(CHEMBL125008 | N-{4-Bromo-3-[3-butyl-4-(3-fluoro-2...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)c3ccccc3)ccc2Br)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C37H37BrFN5O6S/c1-5-6-16-33-41-44(31-22-27(19-20-29(31)38)40-34(45)24-12-8-7-9-13-24)36(47)43(33)23-26-18-17-25(21-30(26)39)28-14-10-11-15-32(28)51(48,49)42-35(46)50-37(2,3)4/h7-15,17-22H,5-6,16,23H2,1-4H3,(H,40,45)(H,42,46)
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n/an/a 0.190n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50038189
PNG
(4'-(2-Ethyl-5,7-dimethyl-imidazo[4,5-b]pyridin-3-y...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C30H28N4O3S/c1-4-27-32-28-20(2)18-21(3)31-29(28)34(27)19-22-14-16-23(17-15-22)25-12-8-9-13-26(25)38(36,37)33-30(35)24-10-6-5-7-11-24/h5-18H,4,19H2,1-3H3,(H,33,35)
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n/an/a 0.200n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at angiotensin 1 receptor


J Med Chem 54: 2529-91 (2011)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50030711
PNG
(CHEMBL338027 | L-163958 | Pentanoic acid {4-bromo-...)
Show SMILES CCCCC(=O)Nc1ccc(Br)c(c1)-n1nc(CC)n(Cc2ccc(cc2F)-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)c1=O
Show InChI InChI=1S/C33H37BrFN5O6S/c1-6-8-13-30(41)36-23-16-17-25(34)27(19-23)40-32(43)39(29(7-2)37-40)20-22-15-14-21(18-26(22)35)24-11-9-10-12-28(24)47(44,45)38-31(42)46-33(3,4)5/h9-12,14-19H,6-8,13,20H2,1-5H3,(H,36,41)(H,38,42)
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n/an/a 0.200n/an/an/an/an/an/a



DuPont Merck Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibition of Angiotensin II receptor, type 1


J Med Chem 39: 625-56 (1996)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283225
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL302964)
Show SMILES CCCc1nc(CC)c(C(=O)OCCCCOc2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C38H46FN3O7S/c1-5-14-35-40-33(6-2)36(37(43)48-23-13-12-22-47-30-15-8-7-9-16-30)42(35)26-29-20-19-28(25-32(29)39)31-17-10-11-18-34(31)50(45,46)41-38(44)49-24-21-27(3)4/h7-11,15-20,25,27H,5-6,12-14,21-24,26H2,1-4H3,(H,41,44)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283228
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL430792)
Show SMILES CCCc1nc(CC)c(C(=O)OCCCC(=O)Nc2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C38H45FN4O7S/c1-5-13-34-41-32(6-2)36(37(45)49-22-12-18-35(44)40-29-14-8-7-9-15-29)43(34)25-28-20-19-27(24-31(28)39)30-16-10-11-17-33(30)51(47,48)42-38(46)50-23-21-26(3)4/h7-11,14-17,19-20,24,26H,5-6,12-13,18,21-23,25H2,1-4H3,(H,40,44)(H,42,46)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283209
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL303427)
Show SMILES CCCc1nc(CC)c(C(=O)OCCN(C(=O)OCCC(C)C)c2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C42H53FN4O8S/c1-7-14-38-44-36(8-2)39(40(48)53-26-23-46(33-15-10-9-11-16-33)42(50)55-25-22-30(5)6)47(38)28-32-20-19-31(27-35(32)43)34-17-12-13-18-37(34)56(51,52)45-41(49)54-24-21-29(3)4/h9-13,15-20,27,29-30H,7-8,14,21-26,28H2,1-6H3,(H,45,49)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283215
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL311253)
Show SMILES CCCc1nc(CC)c(C(=O)OCCN2C(=O)c3ccccc3C2=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C38H41FN4O8S/c1-5-11-33-40-31(6-2)34(37(46)50-21-19-42-35(44)28-13-7-8-14-29(28)36(42)45)43(33)23-26-17-16-25(22-30(26)39)27-12-9-10-15-32(27)52(48,49)41-38(47)51-20-18-24(3)4/h7-10,12-17,22,24H,5-6,11,18-21,23H2,1-4H3,(H,41,47)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283200
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL71172)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1
Show InChI InChI=1S/C41H42FN3O7S/c1-4-7-24-51-41(48)44-53(49,50)36-21-14-13-19-32(36)29-22-23-30(34(42)25-29)26-45-37(15-5-2)43-35(6-3)38(45)40(47)52-27-31-18-11-12-20-33(31)39(46)28-16-9-8-10-17-28/h8-14,16-23,25H,4-7,15,24,26-27H2,1-3H3,(H,44,48)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283214
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL71639)
Show SMILES CCCc1nc(CC)c(C(=O)OCCCSc2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C37H44FN3O6S2/c1-5-13-34-39-32(6-2)35(36(42)46-21-12-23-48-29-14-8-7-9-15-29)41(34)25-28-19-18-27(24-31(28)38)30-16-10-11-17-33(30)49(44,45)40-37(43)47-22-20-26(3)4/h7-11,14-19,24,26H,5-6,12-13,20-23,25H2,1-4H3,(H,40,43)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50030688
PNG
(CHEMBL122917 | N-(3-{3-Butyl-4-[2'-(3,3-dimethyl-b...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)CC(C)(C)C
Show InChI InChI=1S/C35H39F4N5O5S/c1-6-8-13-30-41-44(28-19-24(40-31(45)7-2)16-17-26(28)35(37,38)39)33(47)43(30)21-23-15-14-22(18-27(23)36)25-11-9-10-12-29(25)50(48,49)42-32(46)20-34(3,4)5/h9-12,14-19H,6-8,13,20-21H2,1-5H3,(H,40,45)(H,42,46)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283249
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL308323)
Show SMILES CCCc1nc(CC)c(C(=O)OCCCS(=O)(=O)c2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C37H44FN3O8S2/c1-5-13-34-39-32(6-2)35(36(42)48-21-12-23-50(44,45)29-14-8-7-9-15-29)41(34)25-28-19-18-27(24-31(28)38)30-16-10-11-17-33(30)51(46,47)40-37(43)49-22-20-26(3)4/h7-11,14-19,24,26H,5-6,12-13,20-23,25H2,1-4H3,(H,40,43)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283203
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL70868)
Show SMILES CCCCN(Cc1ccccc1)C(=O)CCCOC(=O)c1c(CC)nc(CCC)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C43H55FN4O7S/c1-6-9-25-47(29-32-17-11-10-12-18-32)40(49)21-15-26-54-42(50)41-37(8-3)45-39(16-7-2)48(41)30-34-23-22-33(28-36(34)44)35-19-13-14-20-38(35)56(52,53)46-43(51)55-27-24-31(4)5/h10-14,17-20,22-23,28,31H,6-9,15-16,21,24-27,29-30H2,1-5H3,(H,46,51)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283207
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL73283)
Show SMILES CCCc1nc(CC)c(C(=O)OCc2ccccc2S(=O)c2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C41H44FN3O7S2/c1-5-14-38-43-35(6-2)39(40(46)52-27-31-15-10-12-19-36(31)53(48)32-16-8-7-9-17-32)45(38)26-30-22-21-29(25-34(30)42)33-18-11-13-20-37(33)54(49,50)44-41(47)51-24-23-28(3)4/h7-13,15-22,25,28H,5-6,14,23-24,26-27H2,1-4H3,(H,44,47)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50030712
PNG
(2-Ethoxy-N-{3-[4-(3-fluoro-2'-(N-t-butyloxycarbony...)
Show SMILES CCCc1nn(-c2cc(NC(=O)COCC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C34H37F4N5O7S/c1-6-10-29-40-43(27-18-23(39-30(44)20-49-7-2)15-16-25(27)34(36,37)38)32(46)42(29)19-22-14-13-21(17-26(22)35)24-11-8-9-12-28(24)51(47,48)41-31(45)50-33(3,4)5/h8-9,11-18H,6-7,10,19-20H2,1-5H3,(H,39,44)(H,41,45)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283204
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL311625)
Show SMILES CCCc1nc(CC)c(C(=O)OCCCS(=O)c2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C37H44FN3O7S2/c1-5-13-34-39-32(6-2)35(36(42)47-21-12-23-49(44)29-14-8-7-9-15-29)41(34)25-28-19-18-27(24-31(28)38)30-16-10-11-17-33(30)50(45,46)40-37(43)48-22-20-26(3)4/h7-11,14-19,24,26H,5-6,12-13,20-23,25H2,1-4H3,(H,40,43)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50030713
PNG
(5-n-Butyl-4-[[2'-[N-(tert-butoxycarbonyl)sulfamoyl...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)CC)ccc2Cl)c(=O)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C33H38ClN5O6S/c1-6-8-13-29-36-39(27-20-24(18-19-26(27)34)35-30(40)7-2)32(42)38(29)21-22-14-16-23(17-15-22)25-11-9-10-12-28(25)46(43,44)37-31(41)45-33(3,4)5/h9-12,14-20H,6-8,13,21H2,1-5H3,(H,35,40)(H,37,41)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50030707
PNG
(CHEMBL122273 | Pentanoic acid (4-bromo-3-{3-ethyl-...)
Show SMILES CCCCC(=O)Nc1ccc(Br)c(c1)-n1nc(CC)n(Cc2ccc(cc2F)-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)c1=O
Show InChI InChI=1S/C35H32BrF2N5O5S/c1-3-5-14-33(44)39-24-17-18-27(36)30(20-24)43-35(46)42(32(4-2)40-43)21-23-16-15-22(19-29(23)38)25-10-7-9-13-31(25)49(47,48)41-34(45)26-11-6-8-12-28(26)37/h6-13,15-20H,3-5,14,21H2,1-2H3,(H,39,44)(H,41,45)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50030691
PNG
(CHEMBL122380 | Pentanoic acid (4-bromo-3-{4-[2'-(2...)
Show SMILES CCCCC(=O)Nc1ccc(Br)c(c1)-n1nc(CC)n(Cc2ccc(cc2F)-c2ccccc2S(=O)(=O)NC(=O)c2cc(F)ccc2F)c1=O
Show InChI InChI=1S/C35H31BrF3N5O5S/c1-3-5-10-33(45)40-24-14-15-27(36)30(19-24)44-35(47)43(32(4-2)41-44)20-22-12-11-21(17-29(22)39)25-8-6-7-9-31(25)50(48,49)42-34(46)26-18-23(37)13-16-28(26)38/h6-9,11-19H,3-5,10,20H2,1-2H3,(H,40,45)(H,42,46)
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Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50030687
PNG
(CHEMBL339256 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C36H32ClF4N5O5S/c1-3-5-14-32-43-46(30-20-24(42-33(47)4-2)17-18-27(30)36(39,40)41)35(49)45(32)21-23-16-15-22(19-29(23)38)25-10-7-9-13-31(25)52(50,51)44-34(48)26-11-6-8-12-28(26)37/h6-13,15-20H,3-5,14,21H2,1-2H3,(H,42,47)(H,44,48)
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n/an/a 0.25n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 in human adrenal membrane preparations. For this assay, only 0.02%BSA was presen...


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50030722
PNG
(3-[3-Butyl-4-(3-fluoro-2'-(N-t-butyloxycarbonyl)-S...)
Show SMILES CCCCc1nn(-c2cc(ccc2Cl)C(=O)NCCOC)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C34H39ClFN5O7S/c1-6-7-12-30-38-41(28-20-23(15-16-26(28)35)31(42)37-17-18-47-5)33(44)40(30)21-24-14-13-22(19-27(24)36)25-10-8-9-11-29(25)49(45,46)39-32(43)48-34(2,3)4/h8-11,13-16,19-20H,6-7,12,17-18,21H2,1-5H3,(H,37,42)(H,39,43)
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n/an/a 0.260n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50030702
PNG
(3-[3-Butyl-4-(3-fluoro-2'-(N-t-butyloxycarbonyl)-S...)
Show SMILES CCCCc1nn(-c2cc(ccc2Cl)C(=O)NCCC)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C34H39ClFN5O6S/c1-6-8-13-30-38-41(28-20-23(16-17-26(28)35)31(42)37-18-7-2)33(44)40(30)21-24-15-14-22(19-27(24)36)25-11-9-10-12-29(25)48(45,46)39-32(43)47-34(3,4)5/h9-12,14-17,19-20H,6-8,13,18,21H2,1-5H3,(H,37,42)(H,39,43)
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n/an/a 0.270n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283248
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL70726)
Show SMILES CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1
Show InChI InChI=1S/C40H40FN3O7S/c1-4-14-36-42-34(6-3)37(39(46)51-26-30-17-10-11-19-32(30)38(45)27-15-8-7-9-16-27)44(36)25-29-22-21-28(24-33(29)41)31-18-12-13-20-35(31)52(48,49)43-40(47)50-23-5-2/h7-13,15-22,24H,4-6,14,23,25-26H2,1-3H3,(H,43,47)
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n/an/a 0.280n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50030690
PNG
(CHEMBL339113 | N-{3-[3-Butyl-4-(3-fluoro-2'-(N-t-b...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C34H37F4N5O6S/c1-6-8-13-29-40-43(27-19-23(39-30(44)7-2)16-17-25(27)34(36,37)38)32(46)42(29)20-22-15-14-21(18-26(22)35)24-11-9-10-12-28(24)50(47,48)41-31(45)49-33(3,4)5/h9-12,14-19H,6-8,13,20H2,1-5H3,(H,39,44)(H,41,45)
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n/an/a 0.280n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 1 in rabbit aorta membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283238
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL70867)
Show SMILES CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C42H45FN4O7S/c1-5-14-38-45-36(6-2)39(41(49)54-27-31-15-10-11-19-34(31)40(48)44-32-16-8-7-9-17-32)47(38)26-30-22-21-29(25-35(30)43)33-18-12-13-20-37(33)55(51,52)46-42(50)53-24-23-28(3)4/h7-13,15-22,25,28H,5-6,14,23-24,26-27H2,1-4H3,(H,44,48)(H,46,50)
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n/an/a 0.300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283198
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL311018)
Show SMILES CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2cccc(c2)C(=O)c2ccccc2)c(F)c1
Show InChI InChI=1S/C40H40FN3O7S/c1-4-13-36-42-34(6-3)37(39(46)51-26-27-14-12-17-30(23-27)38(45)28-15-8-7-9-16-28)44(36)25-31-21-20-29(24-33(31)41)32-18-10-11-19-35(32)52(48,49)43-40(47)50-22-5-2/h7-12,14-21,23-24H,4-6,13,22,25-26H2,1-3H3,(H,43,47)
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n/an/a 0.300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283220
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL302579)
Show SMILES CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C42H45FN4O7S/c1-5-14-38-44-35(6-2)39(41(49)54-27-32-17-10-12-19-36(32)45-40(48)29-15-8-7-9-16-29)47(38)26-31-22-21-30(25-34(31)43)33-18-11-13-20-37(33)55(51,52)46-42(50)53-24-23-28(3)4/h7-13,15-22,25,28H,5-6,14,23-24,26-27H2,1-4H3,(H,45,48)(H,46,50)
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n/an/a 0.300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50031491
PNG
(2-propyl-4-(methythio)-1-[[[2'-[(propylamino)carbo...)
Show SMILES CCCNC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(SC)c2C(O)=O)cc1
Show InChI InChI=1S/C25H30N4O5S2/c1-4-8-21-27-23(35-3)22(24(30)31)29(21)16-17-11-13-18(14-12-17)19-9-6-7-10-20(19)36(33,34)28-25(32)26-15-5-2/h6-7,9-14H,4-5,8,15-16H2,1-3H3,(H,30,31)(H2,26,28,32)
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n/an/a 0.300n/an/an/an/an/an/a



DuPont Merck Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibition of Angiotensin II receptor, type 1


J Med Chem 39: 625-56 (1996)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283230
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL303647)
Show SMILES CCCc1nc(CC)c(C(=O)OCc2ccccc2-c2ccccn2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C40H43FN4O6S/c1-5-13-37-43-34(6-2)38(39(46)51-26-30-14-7-8-15-31(30)35-17-11-12-22-42-35)45(37)25-29-20-19-28(24-33(29)41)32-16-9-10-18-36(32)52(48,49)44-40(47)50-23-21-27(3)4/h7-12,14-20,22,24,27H,5-6,13,21,23,25-26H2,1-4H3,(H,44,47)
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n/an/a 0.300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283202
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL71286)
Show SMILES CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2-c2ccsc2)c(F)c1
Show InChI InChI=1S/C37H38FN3O6S2/c1-4-11-34-39-32(6-3)35(36(42)47-23-27-12-7-8-13-29(27)28-18-20-48-24-28)41(34)22-26-17-16-25(21-31(26)38)30-14-9-10-15-33(30)49(44,45)40-37(43)46-19-5-2/h7-10,12-18,20-21,24H,4-6,11,19,22-23H2,1-3H3,(H,40,43)
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n/an/a 0.300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283217
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL306340)
Show SMILES CCCc1nc(CC)c(C(=O)NCCCOc2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C37H45FN4O6S/c1-5-13-34-40-32(6-2)35(36(43)39-21-12-22-47-29-14-8-7-9-15-29)42(34)25-28-19-18-27(24-31(28)38)30-16-10-11-17-33(30)49(45,46)41-37(44)48-23-20-26(3)4/h7-11,14-19,24,26H,5-6,12-13,20-23,25H2,1-4H3,(H,39,43)(H,41,44)
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n/an/a 0.300n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50283222
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL309790)
Show SMILES CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)C(C)(C)C)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C40H48FN3O7S/c1-8-14-35-42-33(9-2)36(38(46)51-25-29-15-10-11-17-31(29)37(45)40(5,6)7)44(35)24-28-20-19-27(23-32(28)41)30-16-12-13-18-34(30)52(48,49)43-39(47)50-22-21-26(3)4/h10-13,15-20,23,26H,8-9,14,21-22,24-25H2,1-7H3,(H,43,47)
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TBA

Curated by ChEMBL


Assay Description
Binding affinity for Angiotensin II receptor, type 1


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50009718
PNG
(2-Ethyl-5,7-dimethyl-3-[2'-(1H-tetrazol-5-yl)-biph...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C24H23N7/c1-4-21-26-22-15(2)13-16(3)25-24(22)31(21)14-17-9-11-18(12-10-17)19-7-5-6-8-20(19)23-27-29-30-28-23/h5-13H,4,14H2,1-3H3,(H,27,28,29,30)
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n/an/a 0.300n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at angiotensin 1 receptor


J Med Chem 54: 2529-91 (2011)

More data for this
Ligand-Target Pair
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