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Compile Data Set for Download or QSAR

Found 334 hits of ic50 data for polymerid = 49000277   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II receptor


(HUMAN)
BDBM50030711
PNG
(CHEMBL338027 | L-163958 | Pentanoic acid {4-bromo-...)
Show SMILES CCCCC(=O)Nc1ccc(Br)c(c1)-n1nc(CC)n(Cc2ccc(cc2F)-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)c1=O
Show InChI InChI=1S/C33H37BrFN5O6S/c1-6-8-13-30(41)36-23-16-17-25(34)27(19-23)40-32(43)39(29(7-2)37-40)20-22-15-14-21(18-26(22)35)24-11-9-10-12-28(24)47(44,45)38-31(42)46-33(3,4)5/h9-12,14-19H,6-8,13,20H2,1-5H3,(H,36,41)(H,38,42)
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n/an/a 0.120n/an/an/an/an/an/a



DuPont Merck Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibition of Angiotensin II receptor, type 2


J Med Chem 39: 625-56 (1996)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50009718
PNG
(2-Ethyl-5,7-dimethyl-3-[2'-(1H-tetrazol-5-yl)-biph...)
Show SMILES CCc1nc2c(C)cc(C)nc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C24H23N7/c1-4-21-26-22-15(2)13-16(3)25-24(22)31(21)14-17-9-11-18(12-10-17)19-7-5-6-8-20(19)23-27-29-30-28-23/h5-13H,4,14H2,1-3H3,(H,27,28,29,30)
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n/an/a 0.200n/an/an/an/an/an/a



The M. S. University of Baroda

Curated by ChEMBL


Assay Description
Binding affinity to angiotensin AT2 receptor


Bioorg Med Chem 18: 8418-56 (2010)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50043280
PNG
(4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidaz...)
Show SMILES CCCc1nc2c(C)cc(cc2n1Cc1ccc(cc1)-c1ccccc1C(O)=O)-c1nc2ccccc2n1C
Show InChI InChI=1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)
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n/an/a 0.330n/an/an/an/an/an/a



Beijing Institute of Technology

Curated by ChEMBL


Assay Description
Displacement of [125I]Sar1 Ile8-Ang 2 from angiotensin 2 AT2 receptor after 180 mins by gamma counting


Eur J Med Chem 49: 183-90 (2012)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50048114
PNG
(CHEMBL384352 | c[Sar1-Arg2-Mpt3-Tyr4-Hcy5-His6-Pro...)
Show SMILES CNCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1C[C@H]2C[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCSS2)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C47H63N13O10S2/c1-50-24-39(62)54-33(9-5-16-52-47(48)49)44(67)60-25-31-22-38(60)43(66)56-34(19-28-11-13-30(61)14-12-28)41(64)55-32(15-18-71-72-31)40(63)57-35(21-29-23-51-26-53-29)45(68)59-17-6-10-37(59)42(65)58-36(46(69)70)20-27-7-3-2-4-8-27/h2-4,7-8,11-14,23,26,31-38,50,61H,5-6,9-10,15-22,24-25H2,1H3,(H,51,53)(H,54,62)(H,55,64)(H,56,66)(H,57,63)(H,58,65)(H,69,70)(H4,48,49,52)/t31-,32+,33+,34+,35+,36+,37+,38+/m1/s1
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n/an/a 0.470n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50283763
PNG
(CHEMBL321531 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Show SMILES CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(cc1F)-c1cc(CCC)ccc1S(=O)(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C37H36Cl2FN5O5S/c1-4-6-12-35-42-45(33-21-27(41-23(3)46)16-17-31(33)39)37(48)44(35)22-26-15-14-25(20-32(26)40)29-19-24(9-5-2)13-18-34(29)51(49,50)43-36(47)28-10-7-8-11-30(28)38/h7-8,10-11,13-21H,4-6,9,12,22H2,1-3H3,(H,41,46)(H,43,47)
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n/an/a 0.480n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound against cloned human AT1 receptor


Bioorg Med Chem Lett 4: 2787-2792 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50009338
PNG
((S)-2-((S)-1-((S)-2-((S)-2-((S)-2-((S)-2-((S)-5-(d...)
Show SMILES CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(O)=O
Show InChI InChI=1S/C42H65N13O10/c1-22(2)33(53-35(58)28(50-32(57)20-45-6)9-7-15-47-42(43)44)38(61)51-29(17-25-11-13-27(56)14-12-25)36(59)54-34(23(3)4)39(62)52-30(18-26-19-46-21-48-26)40(63)55-16-8-10-31(55)37(60)49-24(5)41(64)65/h11-14,19,21-24,28-31,33-34,45,56H,7-10,15-18,20H2,1-6H3,(H,46,48)(H,49,60)(H,50,57)(H,51,61)(H,52,62)(H,53,58)(H,54,59)(H,64,65)(H4,43,44,47)/t24-,28-,29-,30-,31-,33-,34-/m0/s1
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n/an/a 0.530n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of human angiotensin II AT2 receptor


Bioorg Med Chem 18: 7675-99 (2010)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50282401
PNG
(CHEMBL157510 | PD-126055 | Potassium; (S)-5-benzyl...)
Show SMILES COc1ccc2CN([C@@H](Cc2c1OCc1ccccc1)C([O-])=O)C(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C32H29NO5/c1-37-28-18-17-25-20-33(31(34)29(23-13-7-3-8-14-23)24-15-9-4-10-16-24)27(32(35)36)19-26(25)30(28)38-21-22-11-5-2-6-12-22/h2-18,27,29H,19-21H2,1H3,(H,35,36)/p-1/t27-/m0/s1
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n/an/a 0.580n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.


Bioorg Med Chem Lett 4: 57-62 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50049182
PNG
((S)-5-Benzyloxy-2-diphenylacetyl-6-methoxy-1,2,3,4...)
Show SMILES COc1ccc2CN([C@@H](Cc2c1OCc1ccccc1)C(O)=O)C(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C32H29NO5/c1-37-28-18-17-25-20-33(31(34)29(23-13-7-3-8-14-23)24-15-9-4-10-16-24)27(32(35)36)19-26(25)30(28)38-21-22-11-5-2-6-12-22/h2-18,27,29H,19-21H2,1H3,(H,35,36)/t27-/m0/s1
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n/an/a 0.580n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity of compound was measured against angiotensin II (AT2) receptor


Bioorg Med Chem Lett 4: 1479-1484 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50049182
PNG
((S)-5-Benzyloxy-2-diphenylacetyl-6-methoxy-1,2,3,4...)
Show SMILES COc1ccc2CN([C@@H](Cc2c1OCc1ccccc1)C(O)=O)C(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C32H29NO5/c1-37-28-18-17-25-20-33(31(34)29(23-13-7-3-8-14-23)24-15-9-4-10-16-24)27(32(35)36)19-26(25)30(28)38-21-22-11-5-2-6-12-22/h2-18,27,29H,19-21H2,1H3,(H,35,36)/t27-/m0/s1
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n/an/a 0.600n/an/an/an/an/an/a



DuPont Merck Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibitory activity was evaluated against Angiotensin II receptor, type 2


J Med Chem 39: 625-56 (1996)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50030707
PNG
(CHEMBL122273 | Pentanoic acid (4-bromo-3-{3-ethyl-...)
Show SMILES CCCCC(=O)Nc1ccc(Br)c(c1)-n1nc(CC)n(Cc2ccc(cc2F)-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2F)c1=O
Show InChI InChI=1S/C35H32BrF2N5O5S/c1-3-5-14-33(44)39-24-17-18-27(36)30(20-24)43-35(46)42(32(4-2)40-43)21-23-16-15-22(19-29(23)38)25-10-7-9-13-31(25)49(47,48)41-34(45)26-11-6-8-12-28(26)37/h6-13,15-20H,3-5,14,21H2,1-2H3,(H,39,44)(H,41,45)
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n/an/a 0.640n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50048119
PNG
(CHEMBL385283 | c[Sar1-Arg2-Hcy3-Tyr4-MPt5-His6-Pro...)
Show SMILES CNCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCSS[C@@H]2C[C@H](N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C47H63N13O10S2/c1-50-24-39(62)54-32(9-5-16-52-47(48)49)40(63)55-33-15-18-71-72-31-22-38(60(25-31)45(68)34(56-41(33)64)19-28-11-13-30(61)14-12-28)43(66)57-35(21-29-23-51-26-53-29)44(67)59-17-6-10-37(59)42(65)58-36(46(69)70)20-27-7-3-2-4-8-27/h2-4,7-8,11-14,23,26,31-38,50,61H,5-6,9-10,15-22,24-25H2,1H3,(H,51,53)(H,54,62)(H,55,63)(H,56,64)(H,57,66)(H,58,65)(H,69,70)(H4,48,49,52)/t31-,32+,33+,34+,35+,36+,37+,38+/m1/s1
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n/an/a 0.650n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50049206
PNG
(5-Ethyl-3-(3-fluoro-2'-isopentyloxycarbaronylsulfa...)
Show SMILES CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C42H44FN3O7S/c1-5-14-38-44-36(6-2)39(41(48)53-27-32-17-10-11-19-34(32)40(47)29-15-8-7-9-16-29)46(38)26-31-22-21-30(25-35(31)43)33-18-12-13-20-37(33)54(50,51)45-42(49)52-24-23-28(3)4/h7-13,15-22,25,28H,5-6,14,23-24,26-27H2,1-4H3,(H,45,49)
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n/an/a 0.690n/an/an/an/an/an/a



DuPont Merck Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibition of Angiotensin II receptor, type 2


J Med Chem 39: 625-56 (1996)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50283244
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL71125)
Show SMILES CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCc1ccccc1
Show InChI InChI=1S/C45H42FN3O7S/c1-3-15-41-47-39(4-2)42(44(51)56-30-35-20-11-12-22-37(35)43(50)32-18-9-6-10-19-32)49(41)29-34-25-24-33(28-38(34)46)36-21-13-14-23-40(36)57(53,54)48-45(52)55-27-26-31-16-7-5-8-17-31/h5-14,16-25,28H,3-4,15,26-27,29-30H2,1-2H3,(H,48,52)
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n/an/a 0.690n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for angiotensin II AT-2 receptor


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50049206
PNG
(5-Ethyl-3-(3-fluoro-2'-isopentyloxycarbaronylsulfa...)
Show SMILES CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C42H44FN3O7S/c1-5-14-38-44-36(6-2)39(41(48)53-27-32-17-10-11-19-34(32)40(47)29-15-8-7-9-16-29)46(38)26-31-22-21-30(25-35(31)43)33-18-12-13-20-37(33)54(50,51)45-42(49)52-24-23-28(3)4/h7-13,15-22,25,28H,5-6,14,23-24,26-27H2,1-4H3,(H,45,49)
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n/an/a 0.700n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for angiotensin II AT-2 receptor


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50141059
PNG
(CHEMBL289614 | L-162782 | N-Butyloxycarbonyl-4'-(2...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc23)cc1
Show InChI InChI=1S/C32H40N4O4S/c1-7-9-16-40-32(37)35-41(38,39)28-15-12-25(17-21(3)4)19-27(28)26-13-10-24(11-14-26)20-36-29(8-2)34-30-22(5)18-23(6)33-31(30)36/h10-15,18-19,21H,7-9,16-17,20H2,1-6H3,(H,35,37)
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n/an/a 0.700n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity to type-2 angiotensin-2 receptor (unknown origin)


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50141059
PNG
(CHEMBL289614 | L-162782 | N-Butyloxycarbonyl-4'-(2...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc23)cc1
Show InChI InChI=1S/C32H40N4O4S/c1-7-9-16-40-32(37)35-41(38,39)28-15-12-25(17-21(3)4)19-27(28)26-13-10-24(11-14-26)20-36-29(8-2)34-30-22(5)18-23(6)33-31(30)36/h10-15,18-19,21H,7-9,16-17,20H2,1-6H3,(H,35,37)
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n/an/a 0.700n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity to AT2 receptor (unknown origin)


ACS Med Chem Lett 6: 178-82 (2015)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50141059
PNG
(CHEMBL289614 | L-162782 | N-Butyloxycarbonyl-4'-(2...)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2c(CC)nc3c(C)cc(C)nc23)cc1
Show InChI InChI=1S/C32H40N4O4S/c1-7-9-16-40-32(37)35-41(38,39)28-15-12-25(17-21(3)4)19-27(28)26-13-10-24(11-14-26)20-36-29(8-2)34-30-22(5)18-23(6)33-31(30)36/h10-15,18-19,21H,7-9,16-17,20H2,1-6H3,(H,35,37)
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n/an/a 0.700n/an/an/an/an/an/a



Uppsala University

Curated by ChEMBL


Assay Description
Binding affinity of the compound towards Angiotensin II receptor, type 2 was measured through displacement of [125I]-Ang II in pig uterus myometrial ...


J Med Chem 47: 1536-46 (2004)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM82433
PNG
(CHEMBL302102 | L-159,689 | L-159689 | N-Pentyl-N-[...)
Show SMILES CCCCCN(C(=O)c1ccccc1)c1ccc2nc(CCC)n(Cc3ccc(cc3)-c3ccccc3-c3nnn[nH]3)c(=O)c2c1
Show InChI InChI=1S/C37H37N7O2/c1-3-5-11-23-43(36(45)28-13-7-6-8-14-28)29-21-22-33-32(24-29)37(46)44(34(38-33)12-4-2)25-26-17-19-27(20-18-26)30-15-9-10-16-31(30)35-39-41-42-40-35/h6-10,13-22,24H,3-5,11-12,23,25H2,1-2H3,(H,39,40,41,42)
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n/an/a 0.700n/an/an/an/an/an/a



Organon Laboratories

Curated by ChEMBL


Assay Description
Inhibitory concentration against angiotensin II receptor, type 2


J Med Chem 48: 6523-43 (2005)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50048113
PNG
(CHEMBL414533 | c[Sar1-Arg2-Cys3-Tyr4-MPt5-His6-Pro...)
Show SMILES CNCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSS[C@@H]2C[C@H](N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C46H61N13O10S2/c1-49-22-38(61)53-31(9-5-15-51-46(47)48)39(62)57-35-24-70-71-30-20-37(59(23-30)44(67)32(54-40(35)63)17-27-11-13-29(60)14-12-27)42(65)55-33(19-28-21-50-25-52-28)43(66)58-16-6-10-36(58)41(64)56-34(45(68)69)18-26-7-3-2-4-8-26/h2-4,7-8,11-14,21,25,30-37,49,60H,5-6,9-10,15-20,22-24H2,1H3,(H,50,52)(H,53,61)(H,54,63)(H,55,65)(H,56,64)(H,57,62)(H,68,69)(H4,47,48,51)/t30-,31+,32+,33+,34+,35+,36+,37+/m1/s1
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n/an/a 0.820n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50030732
PNG
(CHEMBL323506 | N-{3-[3-Butyl-4-(3-fluoro-2'(tert-b...)
Show SMILES CCCCc1nn(-c2cc(NC(C)=O)ccc2Cl)c(=O)n1Cc1ccc(cc1F)-c1cc(CCC)ccc1S(=O)(=O)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C35H41ClFN5O6S/c1-7-9-11-32-39-42(30-20-26(38-22(3)43)15-16-28(30)36)34(45)41(32)21-25-14-13-24(19-29(25)37)27-18-23(10-8-2)12-17-31(27)49(46,47)40-33(44)48-35(4,5)6/h12-20H,7-11,21H2,1-6H3,(H,38,43)(H,40,44)
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n/an/a 0.820n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound against cloned human AT1 receptor


Bioorg Med Chem Lett 4: 2787-2792 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50049182
PNG
((S)-5-Benzyloxy-2-diphenylacetyl-6-methoxy-1,2,3,4...)
Show SMILES COc1ccc2CN([C@@H](Cc2c1OCc1ccccc1)C(O)=O)C(=O)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C32H29NO5/c1-37-28-18-17-25-20-33(31(34)29(23-13-7-3-8-14-23)24-15-9-4-10-16-24)27(32(35)36)19-26(25)30(28)38-21-22-11-5-2-6-12-22/h2-18,27,29H,19-21H2,1H3,(H,35,36)/t27-/m0/s1
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n/an/a 0.840n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.


Bioorg Med Chem Lett 4: 57-62 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50030709
PNG
(CHEMBL338434 | Pentanoic acid {3-[3-butyl-4-(3-flu...)
Show SMILES CCCCC(=O)Nc1ccc(c(c1)-n1nc(CCCC)n(Cc2ccc(cc2F)-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)c1=O)C(F)(F)F
Show InChI InChI=1S/C36H41F4N5O6S/c1-6-8-14-31-42-45(29-21-25(41-32(46)15-9-7-2)18-19-27(29)36(38,39)40)34(48)44(31)22-24-17-16-23(20-28(24)37)26-12-10-11-13-30(26)52(49,50)43-33(47)51-35(3,4)5/h10-13,16-21H,6-9,14-15,22H2,1-5H3,(H,41,46)(H,43,47)
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n/an/a 0.880n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was presen...


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50280907
PNG
((S)-1,4-Bis-diphenylcarbamoyl-piperazine-2-carboxy...)
Show SMILES OC(=O)[C@@H]1CN(CCN1C(=O)N(c1ccccc1)c1ccccc1)C(=O)N(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C31H28N4O4/c36-29(37)28-23-32(30(38)34(24-13-5-1-6-14-24)25-15-7-2-8-16-25)21-22-33(28)31(39)35(26-17-9-3-10-18-26)27-19-11-4-12-20-27/h1-20,28H,21-23H2,(H,36,37)/t28-/m0/s1
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n/an/a 0.890n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.


Bioorg Med Chem Lett 4: 57-62 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50283199
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL71220)
Show SMILES CCCc1nc(CC)c(C(=O)OCc2cccc(c2)C(=O)c2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C42H44FN3O7S/c1-5-13-38-44-36(6-2)39(41(48)53-27-29-14-12-17-32(24-29)40(47)30-15-8-7-9-16-30)46(38)26-33-21-20-31(25-35(33)43)34-18-10-11-19-37(34)54(50,51)45-42(49)52-23-22-28(3)4/h7-12,14-21,24-25,28H,5-6,13,22-23,26-27H2,1-4H3,(H,45,49)
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n/an/a 0.900n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for angiotensin II AT-2 receptor


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50285762
PNG
(5-alpha-hydroxyacid imidazolyl biphenyl sulfonyl u...)
Show SMILES CCCCC(O)(C(O)=O)c1c(SC)nc(CCC)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C34H40N4O6S2/c1-4-6-21-34(42,32(39)40)30-31(45-3)36-29(12-5-2)38(30)23-25-17-19-26(20-18-25)27-15-10-11-16-28(27)46(43,44)37-33(41)35-22-24-13-8-7-9-14-24/h7-11,13-20,42H,4-6,12,21-23H2,1-3H3,(H,39,40)(H2,35,37,41)
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n/an/a 0.900n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]-AII displacement.


Bioorg Med Chem Lett 5: 2611-2616 (1995)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50283200
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL71172)
Show SMILES CCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1
Show InChI InChI=1S/C41H42FN3O7S/c1-4-7-24-51-41(48)44-53(49,50)36-21-14-13-19-32(36)29-22-23-30(34(42)25-29)26-45-37(15-5-2)43-35(6-3)38(45)40(47)52-27-31-18-11-12-20-33(31)39(46)28-16-9-8-10-17-28/h8-14,16-23,25H,4-7,15,24,26-27H2,1-3H3,(H,44,48)
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n/an/a 0.900n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for angiotensin II AT-2 receptor


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50283238
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL70867)
Show SMILES CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)Nc2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C42H45FN4O7S/c1-5-14-38-45-36(6-2)39(41(49)54-27-31-15-10-11-19-34(31)40(48)44-32-16-8-7-9-17-32)47(38)26-30-22-21-29(25-35(30)43)33-18-12-13-20-37(33)55(51,52)46-42(50)53-24-23-28(3)4/h7-13,15-22,25,28H,5-6,14,23-24,26-27H2,1-4H3,(H,44,48)(H,46,50)
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n/an/a 1n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for angiotensin II AT-2 receptor


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50032362
PNG
(3-(2'-Isopentyloxycarbonylsulfamoyl-3-fluoro-biphe...)
Show SMILES CCCc1nc(CC)c(C(=O)OC)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C29H36FN3O6S/c1-6-10-26-31-24(7-2)27(28(34)38-5)33(26)18-21-14-13-20(17-23(21)30)22-11-8-9-12-25(22)40(36,37)32-29(35)39-16-15-19(3)4/h8-9,11-14,17,19H,6-7,10,15-16,18H2,1-5H3,(H,32,35)
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n/an/a 1n/an/an/an/an/an/a



DuPont Merck Pharmaceutical Company

Curated by ChEMBL


Assay Description
Inhibition of Angiotensin II receptor, type 2


J Med Chem 39: 625-56 (1996)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50283204
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL311625)
Show SMILES CCCc1nc(CC)c(C(=O)OCCCS(=O)c2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C37H44FN3O7S2/c1-5-13-34-39-32(6-2)35(36(42)47-21-12-23-49(44)29-14-8-7-9-15-29)41(34)25-28-19-18-27(24-31(28)38)30-16-10-11-17-33(30)50(45,46)40-37(43)48-22-20-26(3)4/h7-11,14-19,24,26H,5-6,12-13,20-23,25H2,1-4H3,(H,40,43)
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n/an/a 1n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for angiotensin II AT-2 receptor


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50283234
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL72595)
Show SMILES CCCc1nc(CC)c(C(=O)OCc2ccccc2C(=O)c2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCC(C)C
Show InChI InChI=1S/C41H42FN3O7S/c1-5-14-37-43-35(6-2)38(40(47)51-26-31-17-10-11-19-33(31)39(46)28-15-8-7-9-16-28)45(37)24-30-22-21-29(23-34(30)42)32-18-12-13-20-36(32)53(49,50)44-41(48)52-25-27(3)4/h7-13,15-23,27H,5-6,14,24-26H2,1-4H3,(H,44,48)
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n/an/a 1n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for angiotensin II AT-2 receptor


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50283213
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL307318)
Show SMILES CCCCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCCC(=O)Nc2ccccc2)c(F)c1
Show InChI InChI=1S/C37H43FN4O7S/c1-4-7-13-22-49-37(45)41-50(46,47)32-18-12-11-17-29(32)26-19-20-27(30(38)24-26)25-42-33(14-5-2)40-31(6-3)35(42)36(44)48-23-21-34(43)39-28-15-9-8-10-16-28/h8-12,15-20,24H,4-7,13-14,21-23,25H2,1-3H3,(H,39,43)(H,41,45)
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n/an/a 1n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for angiotensin II AT-2 receptor


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50283220
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL302579)
Show SMILES CCCc1nc(CC)c(C(=O)OCc2ccccc2NC(=O)c2ccccc2)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C42H45FN4O7S/c1-5-14-38-44-35(6-2)39(41(49)54-27-32-17-10-12-19-36(32)45-40(48)29-15-8-7-9-16-29)47(38)26-31-22-21-30(25-34(31)43)33-18-11-13-20-37(33)55(51,52)46-42(50)53-24-23-28(3)4/h7-13,15-22,25,28H,5-6,14,23-24,26-27H2,1-4H3,(H,45,48)(H,46,50)
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n/an/a 1n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for angiotensin II AT-2 receptor


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50283245
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL70789)
Show SMILES CCCc1nc(CC)c(C(=O)OCc2ccccc2OC)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OCCC(C)C
Show InChI InChI=1S/C36H42FN3O7S/c1-6-12-33-38-30(7-2)34(35(41)47-23-27-13-8-10-15-31(27)45-5)40(33)22-26-18-17-25(21-29(26)37)28-14-9-11-16-32(28)48(43,44)39-36(42)46-20-19-24(3)4/h8-11,13-18,21,24H,6-7,12,19-20,22-23H2,1-5H3,(H,39,42)
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n/an/a 1n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for angiotensin II AT-2 receptor


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50282404
PNG
(5-Benzyloxy-2-(2-cyclopentyl-2-phenyl-acetyl)-6-me...)
Show SMILES COc1ccc2CN(C(Cc2c1OCc1ccccc1)C(O)=O)C(=O)C(C1CCCC1)c1ccccc1
Show InChI InChI=1S/C31H33NO5/c1-36-27-17-16-24-19-32(30(33)28(23-14-8-9-15-23)22-12-6-3-7-13-22)26(31(34)35)18-25(24)29(27)37-20-21-10-4-2-5-11-21/h2-7,10-13,16-17,23,26,28H,8-9,14-15,18-20H2,1H3,(H,34,35)
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n/an/a 1.10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against angiotensin II type 2 (AT2) receptor in rabbit uterine membranes.


Bioorg Med Chem Lett 4: 57-62 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50285763
PNG
(5-alpha-hydroxyacid imidazolyl biphenyl sulfonyl u...)
Show SMILES CCCc1nc(SC)c(n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1)C(O)(Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C37H38N4O6S2/c1-3-12-32-39-34(48-2)33(37(45,35(42)43)23-26-13-6-4-7-14-26)41(32)25-28-19-21-29(22-20-28)30-17-10-11-18-31(30)49(46,47)40-36(44)38-24-27-15-8-5-9-16-27/h4-11,13-22,45H,3,12,23-25H2,1-2H3,(H,42,43)(H2,38,40,44)
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TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]-AII displacement.


Bioorg Med Chem Lett 5: 2611-2616 (1995)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50285757
PNG
(5-alpha-hydroxyacid imidazolyl biphenyl sulfonyl u...)
Show SMILES CCCc1nc(SC)c(n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1)C(O)(C(C)C)C(O)=O
Show InChI InChI=1S/C33H38N4O6S2/c1-5-11-28-35-30(44-4)29(33(41,22(2)3)31(38)39)37(28)21-24-16-18-25(19-17-24)26-14-9-10-15-27(26)45(42,43)36-32(40)34-20-23-12-7-6-8-13-23/h6-10,12-19,22,41H,5,11,20-21H2,1-4H3,(H,38,39)(H2,34,36,40)
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n/an/a 1.10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]-AII displacement.


Bioorg Med Chem Lett 5: 2611-2616 (1995)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50030693
PNG
(CHEMBL338687 | Pentanoic acid {4-bromo-3-[3-ethyl-...)
Show SMILES CCCCC(=O)Nc1ccc(Br)c(c1)-n1nc(CC)n(Cc2ccc(cc2F)-c2ccccc2S(=O)(=O)NC(=O)OC(C)C)c1=O
Show InChI InChI=1S/C32H35BrFN5O6S/c1-5-7-12-30(40)35-23-15-16-25(33)27(18-23)39-32(42)38(29(6-2)36-39)19-22-14-13-21(17-26(22)34)24-10-8-9-11-28(24)46(43,44)37-31(41)45-20(3)4/h8-11,13-18,20H,5-7,12,19H2,1-4H3,(H,35,40)(H,37,41)
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n/an/a 1.10n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50285752
PNG
(5-alpha-hydroxyacid imidazolyl biphenyl sulfonyl u...)
Show SMILES CCCCCCC(O)(C(O)=O)c1c(SC)nc(CCC)n1Cc1ccc(cc1)-c1ccccc1S(=O)(=O)NC(=O)NCc1ccccc1
Show InChI InChI=1S/C36H44N4O6S2/c1-4-6-7-13-23-36(44,34(41)42)32-33(47-3)38-31(14-5-2)40(32)25-27-19-21-28(22-20-27)29-17-11-12-18-30(29)48(45,46)39-35(43)37-24-26-15-9-8-10-16-26/h8-12,15-22,44H,4-7,13-14,23-25H2,1-3H3,(H,41,42)(H2,37,39,43)
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n/an/a 1.10n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity at Angiotensin II Type 2 receptor in rabbit uterus membrane by [125I]-AII displacement.


Bioorg Med Chem Lett 5: 2611-2616 (1995)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50030684
PNG
(CHEMBL339722 | N-{3-[3-Butyl-4-(3-fluoro-2-(N-t-bu...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)COCC)ccc2Cl)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C34H39ClFN5O7S/c1-6-8-13-30-38-41(28-19-24(16-17-26(28)35)37-31(42)21-47-7-2)33(44)40(30)20-23-15-14-22(18-27(23)36)25-11-9-10-12-29(25)49(45,46)39-32(43)48-34(3,4)5/h9-12,14-19H,6-8,13,20-21H2,1-5H3,(H,37,42)(H,39,43)
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n/an/a 1.20n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was presen...


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50030687
PNG
(CHEMBL339256 | N-(3-{3-Butyl-4-[2'-(2-chloro-benzo...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)CC)ccc2C(F)(F)F)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)c1ccccc1Cl
Show InChI InChI=1S/C36H32ClF4N5O5S/c1-3-5-14-32-43-46(30-20-24(42-33(47)4-2)17-18-27(30)36(39,40)41)35(49)45(32)21-23-16-15-22(19-29(23)38)25-10-7-9-13-31(25)52(50,51)44-34(48)26-11-6-8-12-28(26)37/h6-13,15-20H,3-5,14,21H2,1-2H3,(H,42,47)(H,44,48)
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n/an/a 1.30n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor, type 2 in human adrenal membrane preparations. For this assay, only 0.02%BSA was presen...


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50009338
PNG
((S)-2-((S)-1-((S)-2-((S)-2-((S)-2-((S)-2-((S)-5-(d...)
Show SMILES CNCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(O)=O
Show InChI InChI=1S/C42H65N13O10/c1-22(2)33(53-35(58)28(50-32(57)20-45-6)9-7-15-47-42(43)44)38(61)51-29(17-25-11-13-27(56)14-12-25)36(59)54-34(23(3)4)39(62)52-30(18-26-19-46-21-48-26)40(63)55-16-8-10-31(55)37(60)49-24(5)41(64)65/h11-14,19,21-24,28-31,33-34,45,56H,7-10,15-18,20H2,1-6H3,(H,46,48)(H,49,60)(H,50,57)(H,51,61)(H,52,62)(H,53,58)(H,54,59)(H,64,65)(H4,43,44,47)/t24-,28-,29-,30-,31-,33-,34-/m0/s1
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n/an/a 1.32n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50030700
PNG
(CHEMBL436396 | N-{4-Bromo-3-[4-(3-fluoro-2'-(N-t-b...)
Show SMILES CCCc1nn(-c2cc(NC(=O)CC)ccc2Br)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C32H35BrFN5O6S/c1-6-10-28-36-39(26-18-22(15-16-24(26)33)35-29(40)7-2)31(42)38(28)19-21-14-13-20(17-25(21)34)23-11-8-9-12-27(23)46(43,44)37-30(41)45-32(3,4)5/h8-9,11-18H,6-7,10,19H2,1-5H3,(H,35,40)(H,37,41)
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n/an/a 1.40n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50030691
PNG
(CHEMBL122380 | Pentanoic acid (4-bromo-3-{4-[2'-(2...)
Show SMILES CCCCC(=O)Nc1ccc(Br)c(c1)-n1nc(CC)n(Cc2ccc(cc2F)-c2ccccc2S(=O)(=O)NC(=O)c2cc(F)ccc2F)c1=O
Show InChI InChI=1S/C35H31BrF3N5O5S/c1-3-5-10-33(45)40-24-14-15-27(36)30(19-24)44-35(47)43(32(4-2)41-44)20-22-12-11-21(17-29(22)39)25-8-6-7-9-31(25)50(48,49)42-34(46)26-18-23(37)13-16-28(26)38/h6-9,11-19H,3-5,10,20H2,1-2H3,(H,40,45)(H,42,46)
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n/an/a 1.5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50030708
PNG
(CHEMBL125760 | N-{4-Chloro-3-[3-ethyl-4-(3-fluoro-...)
Show SMILES CCOCC(=O)Nc1ccc(Cl)c(c1)-n1nc(CC)n(Cc2ccc(cc2F)-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)c1=O
Show InChI InChI=1S/C32H35ClFN5O7S/c1-6-28-36-39(26-17-22(14-15-24(26)33)35-29(40)19-45-7-2)31(42)38(28)18-21-13-12-20(16-25(21)34)23-10-8-9-11-27(23)47(43,44)37-30(41)46-32(3,4)5/h8-17H,6-7,18-19H2,1-5H3,(H,35,40)(H,37,41)
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n/an/a 1.5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50280907
PNG
((S)-1,4-Bis-diphenylcarbamoyl-piperazine-2-carboxy...)
Show SMILES OC(=O)[C@@H]1CN(CCN1C(=O)N(c1ccccc1)c1ccccc1)C(=O)N(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C31H28N4O4/c36-29(37)28-23-32(30(38)34(24-13-5-1-6-14-24)25-15-7-2-8-16-25)21-22-33(28)31(39)35(26-17-9-3-10-18-26)27-19-11-4-12-20-27/h1-20,28H,21-23H2,(H,36,37)/t28-/m0/s1
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n/an/a 1.5n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
In vitro binding affinity of compound was measured against Angiotensin II receptor, type 2


Bioorg Med Chem Lett 4: 1479-1484 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50283248
PNG
(Biphenylsulfonylcarbamate compound | CHEMBL70726)
Show SMILES CCCOC(=O)NS(=O)(=O)c1ccccc1-c1ccc(Cn2c(CCC)nc(CC)c2C(=O)OCc2ccccc2C(=O)c2ccccc2)c(F)c1
Show InChI InChI=1S/C40H40FN3O7S/c1-4-14-36-42-34(6-3)37(39(46)51-26-30-17-10-11-19-32(30)38(45)27-15-8-7-9-16-27)44(36)25-29-22-21-28(24-33(29)41)31-18-12-13-20-35(31)52(48,49)43-40(47)50-23-5-2/h7-13,15-22,24H,4-6,14,23,25-26H2,1-3H3,(H,43,47)
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n/an/a 1.60n/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Binding affinity for angiotensin II AT-2 receptor


Bioorg Med Chem Lett 4: 2235-2240 (1994)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50030726
PNG
(3-[4-(2'-Benzoylsulfamoyl-3-fluoro-biphenyl-4-ylme...)
Show SMILES CCCNC(=O)c1ccc(c(c1)-n1nc(CCC)n(Cc2ccc(cc2F)-c2ccccc2S(=O)(=O)NC(=O)c2ccccc2)c1=O)C(F)(F)F
Show InChI InChI=1S/C36H33F4N5O5S/c1-3-10-32-42-45(30-21-25(33(46)41-19-4-2)17-18-28(30)36(38,39)40)35(48)44(32)22-26-16-15-24(20-29(26)37)27-13-8-9-14-31(27)51(49,50)43-34(47)23-11-6-5-7-12-23/h5-9,11-18,20-21H,3-4,10,19,22H2,1-2H3,(H,41,46)(H,43,47)
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n/an/a 1.70n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50030723
PNG
(CHEMBL122157 | N-{4-Bromo-3-[3-ethyl-4-(3-fluoro-2...)
Show SMILES CCC(=O)Nc1ccc(Br)c(c1)-n1nc(CC)n(Cc2ccc(cc2F)-c2ccccc2S(=O)(=O)NC(=O)OC(C)(C)C)c1=O
Show InChI InChI=1S/C31H33BrFN5O6S/c1-6-27-35-38(25-17-21(14-15-23(25)32)34-28(39)7-2)30(41)37(27)18-20-13-12-19(16-24(20)33)22-10-8-9-11-26(22)45(42,43)36-29(40)44-31(3,4)5/h8-17H,6-7,18H2,1-5H3,(H,34,39)(H,36,40)
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n/an/a 1.70n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50048127
PNG
(Angiotensin III | CHEMBL56448)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(O)=O
Show InChI InChI=1S/C40H60N12O11/c1-20(2)31(50-34(57)26(7-5-13-45-40(42)43)47-33(56)25(41)17-30(54)55)36(59)48-27(15-22-9-11-24(53)12-10-22)35(58)51-32(21(3)4)37(60)49-28(16-23-18-44-19-46-23)38(61)52-14-6-8-29(52)39(62)63/h9-12,18-21,25-29,31-32,53H,5-8,13-17,41H2,1-4H3,(H,44,46)(H,47,56)(H,48,59)(H,49,60)(H,50,57)(H,51,58)(H,54,55)(H,62,63)(H4,42,43,45)/t25-,26-,27-,28-,29-,31-,32-/m0/s1
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n/an/a 1.74n/an/an/an/an/an/a



Washington University School of Medicine

Curated by ChEMBL


Assay Description
In vitro binding affinity at angiotensin II (type 2) receptor in rabbit uterus.


Citation and Details
More data for this
Ligand-Target Pair
Angiotensin II receptor


(HUMAN)
BDBM50030698
PNG
(CHEMBL435811 | N-{3-[3-Butyl-4-(3-fluoro-2'-(N-t-b...)
Show SMILES CCCCc1nn(-c2cc(NC(=O)CCOC)ccc2Cl)c(=O)n1Cc1ccc(cc1F)-c1ccccc1S(=O)(=O)NC(=O)OC(C)(C)C
Show InChI InChI=1S/C34H39ClFN5O7S/c1-6-7-12-30-38-41(28-20-24(15-16-26(28)35)37-31(42)17-18-47-5)33(44)40(30)21-23-14-13-22(19-27(23)36)25-10-8-9-11-29(25)49(45,46)39-32(43)48-34(2,3)4/h8-11,13-16,19-20H,6-7,12,17-18,21H2,1-5H3,(H,37,42)(H,39,43)
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n/an/a 1.80n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against Angiotensin II receptor type 2 in human adrenal membrane preparations.


Citation and Details
More data for this
Ligand-Target Pair
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