Compile Data Set for Download or QSAR
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Found 108 of ic50 for UniProtKB: P22002
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50336640((nifedipine) 2,6-Dimethyl-4-(2-nitro-phenyl)-1,4-d...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of rat Cav1.2 channel in rat mesenteric artery assessed as relaxation of 70 mM K+ induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50052311(Acetic acid (4R,5R)-7-chloro-1-dimethylaminomethyl...)
Affinity DataIC50:  12nMAssay Description:Ability to inhibit [3H]nitrendipine binding to the L-type calcium channel receptor(CCR) in rat heart homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50029417(CHEMBL277363 | [4-(4-Methoxy-phenyl)-4H-benzo[b]py...)
Affinity DataIC50:  17nMAssay Description:Ability to inhibit [3H]nitrendipine binding to the L-type calcium channel receptor(CCR) in rat heart homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50101905(Fantofarone | SR-33557)
Affinity DataIC50:  22nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM81939(CAS_52-53-9 | NSC_62969 | VERAPAMIL)
Affinity DataIC50:  39nMAssay Description:Ability to inhibit [3H]nitrendipine binding to the L-type calcium channel receptor(CCR) in rat heart homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50004704((+)-cis-Diltiazem | (2S,3S)-5-(2-(dimethylamino)et...)
Affinity DataIC50:  54nMAssay Description:Ability to inhibit [3H]nitrendipine binding to the L-type calcium channel receptor(CCR) in rat heart homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50067631(3-(3-{[2-(Benzo[1,3]dioxol-5-yloxy)-ethyl]-methyl-...)
Affinity DataIC50:  62nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Vietnam Academy Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM81939(CAS_52-53-9 | NSC_62969 | VERAPAMIL)
Affinity DataIC50:  79nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of 60 mM K+-induced contractionMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50067622(2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3-(3-{[2-(3...)
Affinity DataIC50:  93nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50004704((+)-cis-Diltiazem | (2S,3S)-5-(2-(dimethylamino)et...)
Affinity DataIC50:  100nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50067624(2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3-{3-[(3,4-...)
Affinity DataIC50:  120nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50017376((+/-)1-(4-tert-butylphenyl)-4-(4-(hydroxydiphenylm...)
Affinity DataIC50:  142nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50041496(Butyric acid 5-(4-methoxy-phenyl)-6-thia-10b-aza-b...)
Affinity DataIC50:  150nMAssay Description:Ability to inhibit [3H]nitrendipine binding to the L-type calcium channel receptor(CCR) in rat heart homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50101964(CHEMBL3436047)
Affinity DataIC50:  170nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50067630(2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3-(3-{[2-(3...)
Affinity DataIC50:  180nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50067629(2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3-[3-(6,7-d...)
Affinity DataIC50:  200nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50067638(3-[3-(4-Benzyl-piperidin-1-yl)-propyl]-2-(3,5-di-t...)
Affinity DataIC50:  210nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50041493(Acetic acid 5-phenyl-6-thia-10b-aza-benzo[e]azulen...)
Affinity DataIC50:  220nMAssay Description:Ability to inhibit [3H]nitrendipine binding to the L-type calcium channel receptor(CCR) in rat heart homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50067637(2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3-(3-{[2-(4...)
Affinity DataIC50:  230nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50067632(3-{3-[4-(Benzothiazol-2-yl-methyl-amino)-piperidin...)
Affinity DataIC50:  230nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50067626(3-[3-(Benzo[1,3]dioxol-5-ylmethyl-methyl-amino)-pr...)
Affinity DataIC50:  250nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50067620(2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3-(3-{methy...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50041502(Acetic acid 5-(4-methoxy-phenyl)-6-thia-10b-aza-be...)
Affinity DataIC50:  340nMAssay Description:Ability to inhibit [3H]nitrendipine binding to the L-type calcium channel receptor(CCR) in rat heart homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50014335(CHEMBL1164066)
Affinity DataIC50:  340nMAssay Description:Inhibition of rat Cav1.2 channel in rat mesenteric artery assessed as relaxation of 70 mM K+ induced contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Vietnam Academy Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM81939(CAS_52-53-9 | NSC_62969 | VERAPAMIL)
Affinity DataIC50:  398nMAssay Description:Inhibition of L-type calcium channel in endothelium-denuded Wistar rat aorta rings assessed as relaxation of phenylephrine-induced contractionMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50067639(2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3-{3-[(2-hy...)
Affinity DataIC50:  420nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50067636(3-(3-{[3-(Benzo[1,3]dioxol-5-yloxy)-2-hydroxy-prop...)
Affinity DataIC50:  430nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Vietnam Academy Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM81939(CAS_52-53-9 | NSC_62969 | VERAPAMIL)
Affinity DataIC50:  481nMAssay Description:Inhibition of L-type calcium channel in Wistar rat aorta rings assessed as reduction in L-type Ba(2+) current at Vh of -50 mVMore data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Vietnam Academy Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50280989(2,6-dimethyl-5-methyloxycarbonyl-4-(3-nitrophenyl)...)
Affinity DataIC50:  592nMAssay Description:Inhibition of [3H]PN-200-110 binding to L-type calcium channels in rat cortex membranes.More data for this Ligand-Target Pair
In DepthDetails Article
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50067621(3-[3-(Benzyl-methyl-amino)-propyl]-2-(3,5-di-tert-...)
Affinity DataIC50:  600nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50041508(CHEMBL416040 | Pentanoic acid 5-phenyl-6-thia-10b-...)
Affinity DataIC50:  610nMAssay Description:Ability to inhibit [3H]nitrendipine binding to the L-type calcium channel receptor(CCR) in rat heart homogenate.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50067625(Benzothiazol-2-yl-{1-[4-(4-fluoro-phenoxy)-butyl]-...)
Affinity DataIC50:  760nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50067635(2-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-3-{3-[(2-et...)
Affinity DataIC50:  840nMAssay Description:In vitro inhibition of K+ induced contractions of the isolated rat aorta.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S(Rattus norvegicus)
Vietnam Academy Of Science And Technology

Curated by ChEMBL
LigandPNGBDBM50080302(2-(1-azepanylmethyl)-4-{1-[3-(1-azepanylmethyl)-4-...)
Affinity DataIC50:  900nMAssay Description:Inhibition of L-type calcium channels in GH-3 rat pituitary cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50283421(((E)-Azacyclotridec-1-en-2-yl)-(2,2-diphenyl-penty...)
Affinity DataIC50: >1.00E+3nMAssay Description:Binding of [3H]nitrendipine to calcium channel in rat heart membranes was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50283436((4,5-Dihydro-1H-imidazol-2-yl)-(2,2-diphenyl-ethyl...)
Affinity DataIC50: >1.00E+3nMAssay Description:Binding of [3H]-nitrendipine to calcium channel in rat heart membranes was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50283435((4,5-Dihydro-1H-imidazol-2-yl)-(3,3-diphenyl-propy...)
Affinity DataIC50: >1.00E+3nMAssay Description:Binding of [3H]-nitrendipine to calcium channel in rat heart membranes was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50283434((2,5-Dihydro-1H-benzo[e][1,3]diazepin-3-yl)-(3,3-d...)
Affinity DataIC50: >1.00E+3nMAssay Description:Binding of [3H]-nitrendipine to calcium channel in rat heart membranes was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50283433((2,2-Diphenyl-ethyl)-(1-methyl-4,5-dihydro-1H-imid...)
Affinity DataIC50: >1.00E+3nMAssay Description:Binding of [3H]-nitrendipine to calcium channel in rat heart membranes was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50283432(Benzhydryl-(4,5-dihydro-1H-imidazol-2-yl)-amine | ...)
Affinity DataIC50: >1.00E+3nMAssay Description:Binding of [3H]-nitrendipine to calcium channel in rat heart membranes was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50283431((2,2-Diphenyl-ethyl)-(3aS,7aS)-3a,4,5,6,7,7a-hexah...)
Affinity DataIC50: >1.00E+3nMAssay Description:Binding of [3H]-nitrendipine to calcium channel in rat heart membranes was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50283430((3,3-Diphenyl-propyl)-(3aS,7aS)-3a,4,5,6,7,7a-hexa...)
Affinity DataIC50: >1.00E+3nMAssay Description:Binding of [3H]-nitrendipine to calcium channel in rat heart membranes was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50283429((3,3-Diphenyl-propyl)-(1-methyl-4,5-dihydro-1H-imi...)
Affinity DataIC50: >1.00E+3nMAssay Description:Binding of [3H]-nitrendipine to calcium channel in rat heart membranes was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50283428((3,3-Diphenyl-propyl)-(4,5,6,7-tetrahydro-1H-[1,3]...)
Affinity DataIC50: >1.00E+3nMAssay Description:Binding of [3H]-nitrendipine to calcium channel in rat heart membranes was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50283427((2,2-Diphenyl-ethyl)-(1,4,5,6-tetrahydro-pyrimidin...)
Affinity DataIC50: >1.00E+3nMAssay Description:Binding of [3H]-nitrendipine to calcium channel in rat heart membranes was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50283426((4,4-Diphenyl-butyl)-(1-methyl-4,5-dihydro-1H-imid...)
Affinity DataIC50: >1.00E+3nMAssay Description:Binding of [3H]-nitrendipine to calcium channel in rat heart membranes was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50283417((3,3-Diphenyl-propyl)-(1-methyl-1,4,5,6-tetrahydro...)
Affinity DataIC50: >1.00E+3nMAssay Description:Binding of [3H]-nitrendipine to calcium channel in rat heart membranes was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50283418((3,3-Diphenyl-propyl)-((E)-1,4,5,6,7,8-hexahydro-[...)
Affinity DataIC50: >1.00E+3nMAssay Description:Binding of [3H]-nitrendipine to calcium channel in rat heart membranes was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50283419((2,5-Dihydro-1H-benzo[e][1,3]diazepin-3-yl)-(2,2-d...)
Affinity DataIC50: >1.00E+3nMAssay Description:Binding of [3H]-nitrendipine to calcium channel in rat heart membranes was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Universidad Complutense

Curated by ChEMBL
LigandPNGBDBM50283422((3,3-Diphenyl-propyl)-(1,4,5,6-tetrahydro-pyrimidi...)
Affinity DataIC50: >1.00E+3nMAssay Description:Binding of [3H]-nitrendipine to calcium channel in rat heart membranes was determinedMore data for this Ligand-Target Pair
In DepthDetails Article
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