BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 704 hits for UniProtKB: P32297   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuronal acetylcholine receptor protein alpha-3/beta-2 subunit


(Homo sapiens (Human))
BDBM50049757
PNG
(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Show SMILES Clc1ccc(cn1)C1CC2CCC1N2
Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
0.0350n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2


J Med Chem 48: 1721-4 (2005)


Article DOI: 10.1021/jm0492406
BindingDB Entry DOI: 10.7270/Q2BZ65JW
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50049757
PNG
(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Show SMILES Clc1ccc(cn1)C1CC2CCC1N2
Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
0.150n/an/an/an/an/an/an/an/a



Istituto di Chimica Biomolecolare

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranes


Eur J Med Chem 152: 401-416 (2018)


Article DOI: 10.1016/j.ejmech.2018.04.026
BindingDB Entry DOI: 10.7270/Q2930WQM
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50143314
PNG
((+)-Epibatidine | (-)-epibatidine | (1R,2R,4S)-2-(...)
Show SMILES Clc1ccc(cn1)[C@H]1C[C@@H]2CC[C@H]1N2
Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2/t8-,9+,10+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
Purchase

CHEMBL
DrugBank
MMDB
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
0.150n/an/an/an/an/an/an/an/a



Universit£ di Sassari

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK243 cell membrane


Eur J Med Chem 180: 51-61 (2019)


Article DOI: 10.1016/j.ejmech.2019.06.079
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50049757
PNG
(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Show SMILES Clc1ccc(cn1)C1CC2CCC1N2
Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
0.220n/an/an/an/an/an/an/an/a



Indiana State University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from alpha3beta4 nAChR (unknown origin) expressed in HEK cell membranes after 4 hrs by liquid scintillation counting ...


J Nat Prod 81: 1029-1035 (2018)


Article DOI: 10.1021/acs.jnatprod.8b00062
BindingDB Entry DOI: 10.7270/Q2R49TF0
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-2 subunit


(Homo sapiens (Human))
BDBM50162983
PNG
(6-[5-(7-Aza-bicyclo[2.2.1]hept-2-yl)-pyridin-3-yl]...)
Show SMILES OCCCCC#Cc1cncc(c1)C1CC2CCC1N2
Show InChI InChI=1S/C17H22N2O/c20-8-4-2-1-3-5-13-9-14(12-18-11-13)16-10-15-6-7-17(16)19-15/h9,11-12,15-17,19-20H,1-2,4,6-8,10H2
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
0.230n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2


J Med Chem 48: 1721-4 (2005)


Article DOI: 10.1021/jm0492406
BindingDB Entry DOI: 10.7270/Q2BZ65JW
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50049757
PNG
(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Show SMILES Clc1ccc(cn1)C1CC2CCC1N2
Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

PubMed
0.230n/an/an/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Binding affinity to human alpha3beta4 nAChR


Bioorg Med Chem 28: (2020)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50049757
PNG
(()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...)
Show SMILES Clc1ccc(cn1)C1CC2CCC1N2
Show InChI InChI=1S/C11H13ClN2/c12-11-4-1-7(6-13-11)9-5-8-2-3-10(9)14-8/h1,4,6,8-10,14H,2-3,5H2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
0.457n/an/an/an/an/an/an/an/a



University of Wollongong

Curated by ChEMBL


Assay Description
Binding affinity of the compound was determined against Nicotinic acetylcholine receptor using [3H]-(-)-nicotine radioligand


Bioorg Med Chem Lett 14: 271-3 (2003)


Article DOI: 10.1016/j.bmcl.2003.09.081
BindingDB Entry DOI: 10.7270/Q2MC8ZD0
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50406472
PNG
(CHEMBL4163848)
Show SMILES [O-][N+](=O)c1ccc(Nc2cncc(c2)N2CC3CC(C2)N3)cc1
Show InChI InChI=1S/C20H24N6O6/c21-20-25-16-13(18(30)26-20)7-12(9-23-16)22-8-10-1-3-11(4-2-10)17(29)24-14(19(31)32)5-6-15(27)28/h1-4,12,14,22H,5-9H2,(H,24,29)(H,27,28)(H,31,32)(H4,21,23,25,26,30)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.684n/an/an/an/an/an/an/an/a



Istituto di Chimica Biomolecolare

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranes


Eur J Med Chem 152: 401-416 (2018)


Article DOI: 10.1016/j.ejmech.2018.04.026
BindingDB Entry DOI: 10.7270/Q2930WQM
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50406641
PNG
(CHEMBL4170527)
Show SMILES C1C2CN(CC1N2)c1cncc(Nc2ccccc2)c1
Show InChI InChI=1S/C26H33I2N7O2/c27-22-15-20(16-23(28)24(22)30)25(36)31-9-10-33-26(34-18-29)32-8-5-13-37-21-7-4-6-19(14-21)17-35-11-2-1-3-12-35/h4,6-7,14-16H,1-3,5,8-13,17,30H2,(H,31,36)(H2,32,33,34)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.799n/an/an/an/an/an/an/an/a



Istituto di Chimica Biomolecolare

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranes


Eur J Med Chem 152: 401-416 (2018)


Article DOI: 10.1016/j.ejmech.2018.04.026
BindingDB Entry DOI: 10.7270/Q2930WQM
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50406541
PNG
(CHEMBL4163257)
Show SMILES FC(F)(F)c1ccc(Nc2ccc(cn2)N2CC3CC(C2)N3)cc1
Show InChI InChI=1S/C17H17F3N4/c18-17(19,20)11-1-3-12(4-2-11)23-16-6-5-15(8-21-16)24-9-13-7-14(10-24)22-13/h1-6,8,13-14,22H,7,9-10H2,(H,21,23)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.818n/an/an/an/an/an/an/an/a



Istituto di Chimica Biomolecolare

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranes


Eur J Med Chem 152: 401-416 (2018)


Article DOI: 10.1016/j.ejmech.2018.04.026
BindingDB Entry DOI: 10.7270/Q2930WQM
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50406792
PNG
(CHEMBL4174509)
Show SMILES Oc1ccc(Nc2cncc(c2)N2CC3CC(C2)N3)cc1
Show InChI InChI=1S/C48H58N6O6/c1-3-4-5-6-13-22-43(56)53-31-35(37-20-14-15-21-41(37)53)28-38(49-42(55)29-40-48(60)54-36-25-23-34(24-26-36)44(54)46(58)51-40)45(57)50-39(27-32-16-9-7-10-17-32)47(59)52(2)30-33-18-11-8-12-19-33/h7-12,14-21,31,34,36,38-40,44H,3-6,13,22-30H2,1-2H3,(H,49,55)(H,50,57)(H,51,58)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
0.988n/an/an/an/an/an/an/an/a



Istituto di Chimica Biomolecolare

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranes


Eur J Med Chem 152: 401-416 (2018)


Article DOI: 10.1016/j.ejmech.2018.04.026
BindingDB Entry DOI: 10.7270/Q2930WQM
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50406686
PNG
(CHEMBL4167298)
Show SMILES FC(F)(F)c1ccc(Nc2cncc(c2)N2CC3CC(C2)N3)cc1
Show InChI InChI=1S/C24H25N7O2/c1-3-4-9-21-25-14-20(24(32)33)23(26-21)31(2)15-16-10-12-17(13-11-16)18-7-5-6-8-19(18)22-27-29-30-28-22/h5-8,10-14H,3-4,9,15H2,1-2H3,(H,32,33)(H,27,28,29,30)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
1n/an/an/an/an/an/an/an/a



Istituto di Chimica Biomolecolare

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranes


Eur J Med Chem 152: 401-416 (2018)


Article DOI: 10.1016/j.ejmech.2018.04.026
BindingDB Entry DOI: 10.7270/Q2930WQM
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50406544
PNG
(CHEMBL4174940)
Show SMILES Clc1ccc(Nc2cncc(c2)N2CC3CC(C2)N3)cc1
Show InChI InChI=1S/C16H17ClN4/c17-11-1-3-12(4-2-11)19-13-6-16(8-18-7-13)21-9-14-5-15(10-21)20-14/h1-4,6-8,14-15,19-20H,5,9-10H2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
1.20n/an/an/an/an/an/an/an/a



Istituto di Chimica Biomolecolare

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranes


Eur J Med Chem 152: 401-416 (2018)


Article DOI: 10.1016/j.ejmech.2018.04.026
BindingDB Entry DOI: 10.7270/Q2930WQM
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50406500
PNG
(CHEMBL4166573)
Show SMILES Fc1ccc(Nc2cncc(c2)N2CC3CC(C2)N3)cc1
Show InChI InChI=1S/C16H17FN4/c17-11-1-3-12(4-2-11)19-13-6-16(8-18-7-13)21-9-14-5-15(10-21)20-14/h1-4,6-8,14-15,19-20H,5,9-10H2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.30n/an/an/an/an/an/an/an/a



Istituto di Chimica Biomolecolare

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranes


Eur J Med Chem 152: 401-416 (2018)


Article DOI: 10.1016/j.ejmech.2018.04.026
BindingDB Entry DOI: 10.7270/Q2930WQM
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50406685
PNG
(CHEMBL4164252)
Show SMILES Cc1ccc(Nc2cncc(c2)N2CC3CC(C2)N3)cc1
Show InChI InChI=1S/C19H15N7O2/c27-19(28)16-10-20-11-22-17(16)21-9-12-5-7-13(8-6-12)14-3-1-2-4-15(14)18-23-25-26-24-18/h1-8,10-11H,9H2,(H,27,28)(H,20,21,22)(H,23,24,25,26)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
1.40n/an/an/an/an/an/an/an/a



Istituto di Chimica Biomolecolare

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranes


Eur J Med Chem 152: 401-416 (2018)


Article DOI: 10.1016/j.ejmech.2018.04.026
BindingDB Entry DOI: 10.7270/Q2930WQM
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50406539
PNG
(CHEMBL4175573)
Show SMILES COc1ccc(Nc2cncc(c2)N2CC3CC(C2)N3)cc1
Show InChI InChI=1S/C17H20N4O/c1-22-17-4-2-12(3-5-17)19-13-7-16(9-18-8-13)21-10-14-6-15(11-21)20-14/h2-5,7-9,14-15,19-20H,6,10-11H2,1H3
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
2.20n/an/an/an/an/an/an/an/a



Istituto di Chimica Biomolecolare

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranes


Eur J Med Chem 152: 401-416 (2018)


Article DOI: 10.1016/j.ejmech.2018.04.026
BindingDB Entry DOI: 10.7270/Q2930WQM
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50534298
PNG
(CHEMBL4438684)
Show SMILES Fc1cccc(c1)-c1cn(nn1)[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C15H17FN4/c16-13-3-1-2-12(8-13)14-9-20(18-17-14)15-10-19-6-4-11(15)5-7-19/h1-3,8-9,11,15H,4-7,10H2/t15-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
2.30n/an/an/an/an/an/an/an/a



Mahidol University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK293 cell membranes after 120 mins by liquid scintillation counting


ACS Med Chem Lett 7: 890-895 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00146
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50534286
PNG
(CHEMBL4453542)
Show SMILES Oc1ccc(cc1)-c1cn(nn1)[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C15H18N4O/c20-13-3-1-11(2-4-13)14-9-19(17-16-14)15-10-18-7-5-12(15)6-8-18/h1-4,9,12,15,20H,5-8,10H2/t15-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
2.5n/an/an/an/an/an/an/an/a



Mahidol University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK293 cell membranes after 120 mins by liquid scintillation counting


ACS Med Chem Lett 7: 890-895 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00146
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50534287
PNG
(CHEMBL4519018)
Show SMILES CN1C2CCCC1CC(C2)Nc1ccccc1Br
Show InChI InChI=1S/C15H21BrN2/c1-18-12-5-4-6-13(18)10-11(9-12)17-15-8-3-2-7-14(15)16/h2-3,7-8,11-13,17H,4-6,9-10H2,1H3
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
Purchase

PC cid
PC sid
PDB
UniChem
Article
PubMed
2.60n/an/an/an/an/an/an/an/a



Mahidol University

Curated by ChEMBL


Assay Description
Binding affinity to alpha3beta4 nAChR (unknown origin)


ACS Med Chem Lett 7: 890-895 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00146
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50500410
PNG
(CHEMBL3745799)
Show SMILES Fc1ccc(cc1)-c1cn(nn1)[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C15H17FN4/c16-13-3-1-11(2-4-13)14-9-20(18-17-14)15-10-19-7-5-12(15)6-8-19/h1-4,9,12,15H,5-8,10H2/t15-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
3.10n/an/an/an/an/an/an/an/a



Mahidol University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK293 cell membranes after 120 mins by liquid scintillation counting


ACS Med Chem Lett 7: 890-895 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00146
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50534288
PNG
(CHEMBL4472617)
Show SMILES Oc1ccc(cc1)-c1cn(nn1)C1CN2CCC1CC2
Show InChI InChI=1S/C15H18N4O/c20-13-3-1-11(2-4-13)14-9-19(17-16-14)15-10-18-7-5-12(15)6-8-18/h1-4,9,12,15,20H,5-8,10H2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
3.40n/an/an/an/an/an/an/an/a



Mahidol University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK293 cell membranes after 120 mins by liquid scintillation counting


ACS Med Chem Lett 7: 890-895 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00146
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50140291
PNG
(CHEMBL3758455)
Show SMILES Ic1cccc(c1)C1=NCCCC1
Show InChI InChI=1S/C11H12IN/c12-10-5-3-4-9(8-10)11-6-1-2-7-13-11/h3-5,8H,1-2,6-7H2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
4.70n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from human alpha3beta4 nACh receptor expressed in HEK293 cells preincubated for 5 mins followed by radioligand addit...


Eur J Med Chem 108: 392-405 (2016)


Article DOI: 10.1016/j.ejmech.2015.11.045
BindingDB Entry DOI: 10.7270/Q2ZS2ZCH
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50406704
PNG
(CHEMBL4160411)
Show SMILES Clc1cccc(Nc2ccc(cn2)N2CC3CC(C2)N3)c1
Show InChI InChI=1S/C16H17ClN4/c17-11-2-1-3-12(6-11)20-16-5-4-15(8-18-16)21-9-13-7-14(10-21)19-13/h1-6,8,13-14,19H,7,9-10H2,(H,18,20)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
4.80n/an/an/an/an/an/an/an/a



Istituto di Chimica Biomolecolare

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranes


Eur J Med Chem 152: 401-416 (2018)


Article DOI: 10.1016/j.ejmech.2018.04.026
BindingDB Entry DOI: 10.7270/Q2930WQM
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50004108
PNG
((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)
Show SMILES CN1CCCC1c1cccnc1
Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

PubMed
5n/an/an/an/an/an/an/an/a



University of Auckland

Curated by ChEMBL


Assay Description
Binding affinity to human alpha3beta4 nAChR


Bioorg Med Chem 28: (2020)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50534291
PNG
(CHEMBL4559236)
Show SMILES Fc1cccc(c1)-c1cn(nn1)C1CN2CCC1CC2
Show InChI InChI=1S/C15H17FN4/c16-13-3-1-2-12(8-13)14-9-20(18-17-14)15-10-19-6-4-11(15)5-7-19/h1-3,8-9,11,15H,4-7,10H2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
5.20n/an/an/an/an/an/an/an/a



Mahidol University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK293 cell membranes after 120 mins by liquid scintillation counting


ACS Med Chem Lett 7: 890-895 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00146
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-2 subunit


(Homo sapiens (Human))
BDBM50135594
PNG
((+/-)-2-(6-chloropyridin-3-yl)-9-aza-bicyclo[4.2.1...)
Show SMILES Clc1ccc(cn1)C1=CCCC2CCC1N2
Show InChI InChI=1S/C13H15ClN2/c14-13-7-4-9(8-15-13)11-3-1-2-10-5-6-12(11)16-10/h3-4,7-8,10,12,16H,1-2,5-6H2
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
Purchase

CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
6.5n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity towards alpha3-beta4 subtype of neuronal nicotinic acetylcholine receptor (nAChR) using [3H]-epibatidine as radioligand


Bioorg Med Chem Lett 13: 2825-8 (2003)


Article DOI: 10.1016/s0960-894x(03)00594-8
BindingDB Entry DOI: 10.7270/Q2Z31Z26
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50534299
PNG
(CHEMBL4450133)
Show SMILES C(Oc1cccc(c1)-c1cn(nn1)[C@@H]1CN2CCC1CC2)c1ccccc1
Show InChI InChI=1S/C22H24N4O/c1-2-5-17(6-3-1)16-27-20-8-4-7-19(13-20)21-14-26(24-23-21)22-15-25-11-9-18(22)10-12-25/h1-8,13-14,18,22H,9-12,15-16H2/t22-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
6.70n/an/an/an/an/an/an/an/a



Mahidol University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK293 cell membranes after 120 mins by liquid scintillation counting


ACS Med Chem Lett 7: 890-895 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00146
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-2 subunit


(Homo sapiens (Human))
BDBM50162988
PNG
(3-[5-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridin...)
Show SMILES CN1CCC[C@H]1COc1cncc(c1)C#CCO
Show InChI InChI=1S/C14H18N2O2/c1-16-6-2-5-13(16)11-18-14-8-12(4-3-7-17)9-15-10-14/h8-10,13,17H,2,5-7,11H2,1H3/t13-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
7.10n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2


J Med Chem 48: 1721-4 (2005)


Article DOI: 10.1021/jm0492406
BindingDB Entry DOI: 10.7270/Q2BZ65JW
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50534300
PNG
(CHEMBL4442125)
Show SMILES Fc1ccc(COc2cccc(c2)-c2cn(nn2)[C@@H]2CN3CCC2CC3)cc1
Show InChI InChI=1S/C22H23FN4O/c23-19-6-4-16(5-7-19)15-28-20-3-1-2-18(12-20)21-13-27(25-24-21)22-14-26-10-8-17(22)9-11-26/h1-7,12-13,17,22H,8-11,14-15H2/t22-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
7.20n/an/an/an/an/an/an/an/a



Mahidol University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK293 cell membranes after 120 mins by liquid scintillation counting


ACS Med Chem Lett 7: 890-895 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00146
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50534284
PNG
(CHEMBL4468804)
Show SMILES C(Oc1cccc(c1)-c1cn(nn1)C1CN2CCC1CC2)c1ccccc1
Show InChI InChI=1S/C22H24N4O/c1-2-5-17(6-3-1)16-27-20-8-4-7-19(13-20)21-14-26(24-23-21)22-15-25-11-9-18(22)10-12-25/h1-8,13-14,18,22H,9-12,15-16H2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
7.60n/an/an/an/an/an/an/an/a



Mahidol University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK293 cell membranes after 120 mins by liquid scintillation counting


ACS Med Chem Lett 7: 890-895 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00146
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-2 subunit


(Homo sapiens (Human))
BDBM50049756
PNG
(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridine |...)
Show SMILES CN1CCC[C@H]1COc1cccnc1
Show InChI InChI=1S/C11H16N2O/c1-13-7-3-4-10(13)9-14-11-5-2-6-12-8-11/h2,5-6,8,10H,3-4,7,9H2,1H3/t10-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
7.70n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2


J Med Chem 48: 1721-4 (2005)


Article DOI: 10.1021/jm0492406
BindingDB Entry DOI: 10.7270/Q2BZ65JW
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-2 subunit


(Homo sapiens (Human))
BDBM50162986
PNG
(3-Ethynyl-5-((S)-1-methyl-pyrrolidin-2-ylmethoxy)-...)
Show SMILES CN1CCC[C@H]1COc1cncc(c1)C#C
Show InChI InChI=1S/C13H16N2O/c1-3-11-7-13(9-14-8-11)16-10-12-5-4-6-15(12)2/h1,7-9,12H,4-6,10H2,2H3/t12-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
8.20n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2


J Med Chem 48: 1721-4 (2005)


Article DOI: 10.1021/jm0492406
BindingDB Entry DOI: 10.7270/Q2BZ65JW
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50538046
PNG
(CHEMBL4647198)
Show SMILES Cl.Clc1cncc(OC[C@H]2NC[C@@H]3C[C@H]23)c1
Show InChI InChI=1S/C11H13ClN2O.ClH/c12-8-2-9(5-13-4-8)15-6-11-10-1-7(10)3-14-11;/h2,4-5,7,10-11,14H,1,3,6H2;1H/t7-,10-,11+;/m0./s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
8.20n/an/an/an/an/an/an/an/a



Suven Life Sciences Ltd.

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in IMR32 cell membrane by microbeta scintillation counting method


J Med Chem 63: 2833-2853 (2020)


Article DOI: 10.1021/acs.jmedchem.9b00790
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50534292
PNG
(CHEMBL4437323)
Show SMILES Fc1ccc(cc1)-c1cn(nn1)C1CN2CCC1CC2
Show InChI InChI=1S/C15H17FN4/c16-13-3-1-11(2-4-13)14-9-20(18-17-14)15-10-19-7-5-12(15)6-8-19/h1-4,9,12,15H,5-8,10H2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
8.5n/an/an/an/an/an/an/an/a



Mahidol University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK293 cell membranes after 120 mins by liquid scintillation counting


ACS Med Chem Lett 7: 890-895 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00146
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-2 subunit


(Homo sapiens (Human))
BDBM50097613
PNG
(3-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-5-phenylet...)
Show SMILES CN1CCC[C@H]1COc1cncc(c1)C#Cc1ccccc1
Show InChI InChI=1S/C19H20N2O/c1-21-11-5-8-18(21)15-22-19-12-17(13-20-14-19)10-9-16-6-3-2-4-7-16/h2-4,6-7,12-14,18H,5,8,11,15H2,1H3/t18-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
8.60n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2


J Med Chem 48: 1721-4 (2005)


Article DOI: 10.1021/jm0492406
BindingDB Entry DOI: 10.7270/Q2BZ65JW
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50406687
PNG
(CHEMBL4164706)
Show SMILES COc1ccc(Nc2ccc(cn2)N2CC3CC(C2)N3)cc1
Show InChI InChI=1S/C24H24N6O2/c1-2-3-15-30(23-21(24(31)32)9-6-14-25-23)16-17-10-12-18(13-11-17)19-7-4-5-8-20(19)22-26-28-29-27-22/h4-14H,2-3,15-16H2,1H3,(H,31,32)(H,26,27,28,29)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
9n/an/an/an/an/an/an/an/a



Istituto di Chimica Biomolecolare

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranes


Eur J Med Chem 152: 401-416 (2018)


Article DOI: 10.1016/j.ejmech.2018.04.026
BindingDB Entry DOI: 10.7270/Q2930WQM
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50465459
PNG
(CHEMBL4290888)
Show SMILES Clc1ccc2[C@H]3CN[C@@H]4CC[C@]34Oc2n1
Show InChI InChI=1S/C11H11ClN2O/c12-9-2-1-6-7-5-13-8-3-4-11(7,8)15-10(6)14-9/h1-2,7-8,13H,3-5H2/t7-,8-,11+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
9.10n/an/an/an/an/an/an/an/a



Indiana State University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from alpha3beta4 nAChR (unknown origin) expressed in HEK cell membranes after 4 hrs by liquid scintillation counting ...


J Nat Prod 81: 1029-1035 (2018)


Article DOI: 10.1021/acs.jnatprod.8b00062
BindingDB Entry DOI: 10.7270/Q2R49TF0
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50465456
PNG
(CHEMBL4283703)
Show SMILES Clc1ccc2C3CNC4CCC34Oc2n1
Show InChI InChI=1S/C11H11ClN2O/c12-9-2-1-6-7-5-13-8-3-4-11(7,8)15-10(6)14-9/h1-2,7-8,13H,3-5H2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
11n/an/an/an/an/an/an/an/a



Indiana State University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from alpha3beta4 nAChR (unknown origin) expressed in HEK cell membranes after 4 hrs by liquid scintillation counting ...


J Nat Prod 81: 1029-1035 (2018)


Article DOI: 10.1021/acs.jnatprod.8b00062
BindingDB Entry DOI: 10.7270/Q2R49TF0
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50534297
PNG
(CHEMBL4443082)
Show SMILES FCCOc1cccc(c1)-c1cn(nn1)[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C17H21FN4O/c18-6-9-23-15-3-1-2-14(10-15)16-11-22(20-19-16)17-12-21-7-4-13(17)5-8-21/h1-3,10-11,13,17H,4-9,12H2/t17-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
12n/an/an/an/an/an/an/an/a



Mahidol University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK293 cell membranes after 120 mins by liquid scintillation counting


ACS Med Chem Lett 7: 890-895 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00146
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-2 subunit


(Homo sapiens (Human))
BDBM50162987
PNG
(6-[5-((S)-1-Methyl-pyrrolidin-2-ylmethoxy)-pyridin...)
Show SMILES CN1CCC[C@H]1COc1cncc(c1)C#CCCCCO
Show InChI InChI=1S/C17H24N2O2/c1-19-9-6-8-16(19)14-21-17-11-15(12-18-13-17)7-4-2-3-5-10-20/h11-13,16,20H,2-3,5-6,8-10,14H2,1H3/t16-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
13n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2


J Med Chem 48: 1721-4 (2005)


Article DOI: 10.1021/jm0492406
BindingDB Entry DOI: 10.7270/Q2BZ65JW
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50406540
PNG
(CHEMBL4177240)
Show SMILES Fc1ccc(Nc2ccc(cn2)N2CC3CC(C2)N3)cc1
Show InChI InChI=1S/C16H17FN4/c17-11-1-3-12(4-2-11)20-16-6-5-15(8-18-16)21-9-13-7-14(10-21)19-13/h1-6,8,13-14,19H,7,9-10H2,(H,18,20)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Similars

Article
PubMed
13n/an/an/an/an/an/an/an/a



Istituto di Chimica Biomolecolare

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR expressed in HEK293 cell membranes


Eur J Med Chem 152: 401-416 (2018)


Article DOI: 10.1016/j.ejmech.2018.04.026
BindingDB Entry DOI: 10.7270/Q2930WQM
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein beta-2 subunit/protein beta-3 subunit/subunit alpha-3/subunit alpha-6


(Homo sapiens (Human))
BDBM50498034
PNG
(CHEMBL3329543)
Show SMILES C[C@@H]1C[C@H]1C(=O)N1CC2CC(C1)N2
Show InChI InChI=1S/C10H16N2O/c1-6-2-9(6)10(13)12-4-7-3-8(5-12)11-7/h6-9,11H,2-5H2,1H3/t6-,7?,8?,9-/m1/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
14n/an/an/an/an/an/an/an/a



Targacept, Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha6/alpha3beta2beta3 nAChR transfected in CHO cells by liquid scintillation counting


Eur J Med Chem 86: 60-74 (2014)


Article DOI: 10.1016/j.ejmech.2014.08.019
BindingDB Entry DOI: 10.7270/Q2PK0K4H
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50534296
PNG
(CHEMBL4557590)
Show SMILES Fc1ccc(COc2cccc(c2)-c2cn(nn2)C2CN3CCC2CC3)cc1
Show InChI InChI=1S/C22H23FN4O/c23-19-6-4-16(5-7-19)15-28-20-3-1-2-18(12-20)21-13-27(25-24-21)22-14-26-10-8-17(22)9-11-26/h1-7,12-13,17,22H,8-11,14-15H2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
14n/an/an/an/an/an/an/an/a



Mahidol University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK293 cell membranes after 120 mins by liquid scintillation counting


ACS Med Chem Lett 7: 890-895 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00146
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3


(Homo sapiens (Human))
BDBM50004108
PNG
((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)
Show SMILES CN1CCCC1c1cccnc1
Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
Purchase

CHEBI
CHEMBL
DrugBank
KEGG
PC cid
PC sid
PDB
UniChem

Patents


Similars

Article
PubMed
14n/an/an/an/an/an/an/an/a



Sanofi-Synthelabo Research

Curated by PDSP Ki Database




J Pharmacol Exp Ther 306: 407-20 (2003)


Article DOI: 10.1124/jpet.103.049262
BindingDB Entry DOI: 10.7270/Q2GM85WX
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-2 subunit


(Homo sapiens (Human))
BDBM50162984
PNG
(3-(6-Fluoro-hex-1-ynyl)-5-((S)-1-methyl-pyrrolidin...)
Show SMILES CN1CCC[C@H]1COc1cncc(c1)C#CCCCCF
Show InChI InChI=1S/C17H23FN2O/c1-20-10-6-8-16(20)14-21-17-11-15(12-19-13-17)7-4-2-3-5-9-18/h11-13,16H,2-3,5-6,8-10,14H2,1H3/t16-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
14n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2


J Med Chem 48: 1721-4 (2005)


Article DOI: 10.1021/jm0492406
BindingDB Entry DOI: 10.7270/Q2BZ65JW
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50549596
PNG
(CHEMBL4785648)
Show SMILES CN1CCC[C@H]1[C@@H]1COc2ccc(N)cc2O1
Show InChI InChI=1S/C13H18N2O2/c1-15-6-2-3-10(15)13-8-16-11-5-4-9(14)7-12(11)17-13/h4-5,7,10,13H,2-3,6,8,14H2,1H3/t10-,13-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
PubMed
19n/an/an/an/an/an/an/an/a



Universit£ degli Studi di Milano

Curated by ChEMBL


Assay Description
Displacement of [3H]-epibatidine from human alpha3beta4 transfected in HEK293 cell membranes preincubated for 5 mins followed by [3H]-epibatidine add...


J Med Chem 63: 15668-15692 (2020)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50534283
PNG
(CHEMBL4440403)
Show SMILES FCCCOc1cccc(c1)-c1cn(nn1)[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C18H23FN4O/c19-7-2-10-24-16-4-1-3-15(11-16)17-12-23(21-20-17)18-13-22-8-5-14(18)6-9-22/h1,3-4,11-12,14,18H,2,5-10,13H2/t18-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
20n/an/an/an/an/an/an/an/a



Mahidol University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK293 cell membranes after 120 mins by liquid scintillation counting


ACS Med Chem Lett 7: 890-895 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00146
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor protein alpha-3/beta-2 subunit


(Homo sapiens (Human))
BDBM50162982
PNG
(3-Hex-1-ynyl-5-((S)-1-methyl-pyrrolidin-2-ylmethox...)
Show SMILES CCCCC#Cc1cncc(OC[C@@H]2CCCN2C)c1
Show InChI InChI=1S/C17H24N2O/c1-3-4-5-6-8-15-11-17(13-18-12-15)20-14-16-9-7-10-19(16)2/h11-13,16H,3-5,7,9-10,14H2,1-2H3/t16-/m0/s1
PDB

Reactome pathway

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
antibodypedia
GoogleScholar
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
21n/an/an/an/an/an/an/an/a



University of Illinois at Chicago

Curated by ChEMBL


Assay Description
Inhibition of [3H]epibatidine binding to Nicotinic acetylcholine receptor alpha3-beta2


J Med Chem 48: 1721-4 (2005)


Article DOI: 10.1021/jm0492406
BindingDB Entry DOI: 10.7270/Q2BZ65JW
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50534282
PNG
(CHEMBL4437189)
Show SMILES FCCOc1cccc(c1)-c1cn(nn1)C1CN2CCC1CC2
Show InChI InChI=1S/C17H21FN4O/c18-6-9-23-15-3-1-2-14(10-15)16-11-22(20-19-16)17-12-21-7-4-13(17)5-8-21/h1-3,10-11,13,17H,4-9,12H2
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
Article
PubMed
21n/an/an/an/an/an/an/an/a



Mahidol University

Curated by ChEMBL


Assay Description
Displacement of [3H]epibatidine from human alpha3beta4 nAChR transfected in HEK293 cell membranes after 120 mins by liquid scintillation counting


ACS Med Chem Lett 7: 890-895 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00146
More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor; alpha3/beta4


(Homo sapiens (Human))
BDBM50534293
PNG
(CHEMBL3341966)
Show SMILES FC(F)(F)c1ccc2[C@@H]3C[C@@H](CNC3)c2c1
Show InChI InChI=1S/C12H12F3N/c13-12(14,15)9-1-2-10-7-3-8(6-16-5-7)11(10)4-9/h1-2,4,7-8,16H,3,5-6H2/t7-,8+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
antibodypedia
GoogleScholar
Purchase

PC cid
PC sid
UniChem
Article
PubMed
21n/an/an/an/an/an/an/an/a



Mahidol University

Curated by ChEMBL


Assay Description
Displacement of [3H] epibatidine from alpha3beta4 nAChR (unknown origin) expressed in HEK293 cells


ACS Med Chem Lett 7: 890-895 (2016)


Article DOI: 10.1021/acsmedchemlett.6b00146
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 704 total )  |  Next  |  Last  >>
Jump to: