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Compile Data Set for Download or QSAR

Found 10 hits of ic50 data for polymerid = 49000611   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GRIA2


(HUMAN)
BDBM50253632
PNG
(6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione |...)
Show SMILES [O-][N+](=O)c1cc2[nH]c(=O)c(=O)[nH]c2cc1[N-][N+]#N
Show InChI InChI=1S/C8H4N6O4/c9-13-12-5-1-3-4(2-6(5)14(17)18)11-8(16)7(15)10-3/h1-2H,(H,10,15)(H,11,16)
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of California San Francisco

Curated by ChEMBL


Assay Description
Inhibition of GluR2 receptor (unknown origin)


J Med Chem 51: 5856-60 (2008)

More data for this
Ligand-Target Pair
GRIA2


(HUMAN)
BDBM50207594
PNG
(2,3-Dihydroxy-6-nitro-benzo[f]quinoxaline-7-sulfon...)
Show SMILES NS(=O)(=O)c1cccc2c1c(cc1[nH]c(=O)c(=O)[nH]c21)[N+]([O-])=O
Show InChI InChI=1S/C12H8N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22)
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KEGG
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PubMed
n/an/a 2.50E+3n/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx ...


J Med Chem 50: 1558-70 (2007)

More data for this
Ligand-Target Pair
GRIA2


(HUMAN)
BDBM50207594
PNG
(2,3-Dihydroxy-6-nitro-benzo[f]quinoxaline-7-sulfon...)
Show SMILES NS(=O)(=O)c1cccc2c1c(cc1[nH]c(=O)c(=O)[nH]c21)[N+]([O-])=O
Show InChI InChI=1S/C12H8N4O6S/c13-23(21,22)8-3-1-2-5-9(8)7(16(19)20)4-6-10(5)15-12(18)11(17)14-6/h1-4H,(H,14,17)(H,15,18)(H2,13,21,22)
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n/an/a 2.50E+3n/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Inhibition of glutamate-induced calcium influx in HEK293 cells expressing human GLUA2


J Med Chem 49: 2579-92 (2006)

More data for this
Ligand-Target Pair
GRIA2


(HUMAN)
BDBM50253650
PNG
(CHEMBL462490 | [1,2,5]oxadiazolo[3,4-g]quinoxaline...)
Show SMILES [O-][n+]1onc2cc3[nH]c(=O)c(=O)[nH]c3cc12
Show InChI InChI=1S/C8H4N4O4/c13-7-8(14)10-4-2-6-5(1-3(4)9-7)11-16-12(6)15/h1-2H,(H,9,13)(H,10,14)
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n/an/a 7.60E+3n/an/an/an/an/an/a



University of California San Francisco

Curated by ChEMBL


Assay Description
Inhibition of GluR2 receptor (unknown origin)


J Med Chem 51: 5856-60 (2008)

More data for this
Ligand-Target Pair
GRIA2


(HUMAN)
BDBM50185318
PNG
((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxythiophe...)
Show SMILES N[C@@H](Cn1ccc(=O)n(Cc2ccsc2C(O)=O)c1=O)C(O)=O
Show InChI InChI=1S/C13H13N3O6S/c14-8(11(18)19)6-15-3-1-9(17)16(13(15)22)5-7-2-4-23-10(7)12(20)21/h1-4,8H,5-6,14H2,(H,18,19)(H,20,21)/t8-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx ...


J Med Chem 50: 1558-70 (2007)

More data for this
Ligand-Target Pair
GRIA2


(HUMAN)
BDBM50137124
PNG
(4-Chloro-2-(3-naphthalen-2-yl-ureido)-benzoic acid...)
Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)Nc1ccc2ccccc2c1
Show InChI InChI=1S/C18H13ClN2O3/c19-13-6-8-15(17(22)23)16(10-13)21-18(24)20-14-7-5-11-3-1-2-4-12(11)9-14/h1-10H,(H,22,23)(H2,20,21,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
In vitro inhibitory activity of the compound against Ionotropic glutamate receptor AMPA 2 of HEK293 cells in FLIPR assay


J Med Chem 46: 5834-43 (2003)

More data for this
Ligand-Target Pair
GRIA2


(HUMAN)
BDBM50207591
PNG
((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxy-5-phen...)
Show SMILES Cc1cn(C[C@H](N)C(O)=O)c(=O)n(Cc2cc(sc2C(O)=O)-c2ccccc2)c1=O
Show InChI InChI=1S/C20H19N3O6S/c1-11-8-22(10-14(21)18(25)26)20(29)23(17(11)24)9-13-7-15(30-16(13)19(27)28)12-5-3-2-4-6-12/h2-8,14H,9-10,21H2,1H3,(H,25,26)(H,27,28)/t14-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx ...


J Med Chem 50: 1558-70 (2007)

More data for this
Ligand-Target Pair
GRIA2


(HUMAN)
BDBM50207593
PNG
((S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHEN...)
Show SMILES Cc1cn(C[C@H](N)C(O)=O)c(=O)n(Cc2ccsc2C(O)=O)c1=O
Show InChI InChI=1S/C14H15N3O6S/c1-7-4-16(6-9(15)12(19)20)14(23)17(11(7)18)5-8-2-3-24-10(8)13(21)22/h2-4,9H,5-6,15H2,1H3,(H,19,20)(H,21,22)/t9-/m0/s1
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n/an/a>1.00E+5n/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx ...


J Med Chem 50: 1558-70 (2007)

More data for this
Ligand-Target Pair
GRIA2


(HUMAN)
BDBM50137125
PNG
(2-(3-(3-bromophenyl)ureido)-4-chlorobenzoic acid |...)
Show SMILES OC(=O)c1ccc(Cl)cc1NC(=O)Nc1cccc(Br)c1
Show InChI InChI=1S/C14H10BrClN2O3/c15-8-2-1-3-10(6-8)17-14(21)18-12-7-9(16)4-5-11(12)13(19)20/h1-7H,(H,19,20)(H2,17,18,21)
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n/an/a>1.00E+5n/an/an/an/an/an/a



The Danish University of Pharmaceutical Sciences

Curated by ChEMBL


Assay Description
In vitro inhibitory activity of the compound against Ionotropic glutamate receptor AMPA 2 of HEK293 cells in FLIPR assay


J Med Chem 46: 5834-43 (2003)

More data for this
Ligand-Target Pair
GRIA2


(HUMAN)
BDBM50178136
PNG
((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl)...)
Show SMILES N[C@@H](Cn1ccc(=O)n(Cc2ccccc2C(O)=O)c1=O)C(O)=O
Show InChI InChI=1S/C15H15N3O6/c16-11(14(22)23)8-17-6-5-12(19)18(15(17)24)7-9-3-1-2-4-10(9)13(20)21/h1-6,11H,7-8,16H2,(H,20,21)(H,22,23)/t11-/m0/s1
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n/an/a>3.00E+5n/an/an/an/an/an/a



University Walk

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx ...


J Med Chem 50: 1558-70 (2007)

More data for this
Ligand-Target Pair