Compile Data Set for Download or QSAR
maximum 50k data
Found 293 of ec50 data for polymerid = 49000611
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50457616(CHEMBL4218628)
Affinity DataEC50:  1.26nMAssay Description:Positive allosteric modulation of GluA2Q flop isoform (unknown origin) expressed in HEK293 cells assessed as increase in L-glutamate induced calcium ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50457616(CHEMBL4218628)
Affinity DataEC50:  1.30nMAssay Description:Positive allosteric modulation of GluA2Q flop isoform (unknown origin) expressed in HEK293 cells assessed as increase in L-glutamate induced calcium ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50251236(CHEMBL4091984)
Affinity DataEC50:  2nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50251236(CHEMBL4091984)
Affinity DataEC50:  2nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50457614(CHEMBL4202524)
Affinity DataEC50:  14nMAssay Description:Positive allosteric modulation of GluA2Q flop isoform (unknown origin) expressed in HEK293 cells assessed as increase in L-glutamate induced calcium ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50457614(CHEMBL4202524)
Affinity DataEC50:  14.5nMAssay Description:Positive allosteric modulation of GluA2Q flop isoform (unknown origin) expressed in HEK293 cells assessed as increase in L-glutamate induced calcium ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50191961(4-cyano-5-ethyl-1-methyl-3-(2'-methylsulfanyl-biph...)
Affinity DataEC50:  32nMAssay Description:Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50191957(4-cyano-3-(2'-ethoxy-biphenyl-4-yl)-5-ethyl-1-meth...)
Affinity DataEC50:  36nMAssay Description:Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50191954(3-(2'-chloro-biphenyl-4-yl)-4-cyano-5-ethyl-1-meth...)
Affinity DataEC50:  42nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50251237(CHEMBL4062524)
Affinity DataEC50:  46nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50192216(3-(4-tert-butylphenyl)-4-cyano-5-ethylthiophene-2-...)
Affinity DataEC50:  47nMAssay Description:Activity against human GLUR2 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50164477(CHEMBL3800556)
Affinity DataEC50:  48nMAssay Description:Positive allosteric modulation of human GluA2 AMPAR flop isomer expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50251237(CHEMBL4062524)
Affinity DataEC50:  50nMAssay Description:Positive allosteric modulation of GluA2 (Q) flop isoform (unknown origin) expressed in HEK293 cells assessed as potentiation of glutamate-evoked calc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50191954(3-(2'-chloro-biphenyl-4-yl)-4-cyano-5-ethyl-1-meth...)
Affinity DataEC50:  55nMAssay Description:Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50191961(4-cyano-5-ethyl-1-methyl-3-(2'-methylsulfanyl-biph...)
Affinity DataEC50:  57nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50164380(CHEMBL3799878)
Affinity DataEC50:  73nMAssay Description:Positive allosteric modulation of human GluA2 receptor flop isoform assessed as increase in glutamate-induced calcium flux measured at time interval ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50164380(CHEMBL3799878)
Affinity DataEC50:  73nMAssay Description:Positive allosteric modulation of human GluA2 AMPAR flop isomer expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50191952(4-cyano-3-(2'-cyano-biphenyl-4-yl)-5-ethyl-1-methy...)
Affinity DataEC50:  73nMAssay Description:Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50192221(3-(4-tert-butylphenyl)-4-cyano-5-(trifluoromethyl)...)
Affinity DataEC50:  78nMAssay Description:Activity against human GLUR2 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50191952(4-cyano-3-(2'-cyano-biphenyl-4-yl)-5-ethyl-1-methy...)
Affinity DataEC50:  82nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50191957(4-cyano-3-(2'-ethoxy-biphenyl-4-yl)-5-ethyl-1-meth...)
Affinity DataEC50:  83nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50191959(3-(4-tert-butylphenyl)-4-cyano-5-(methylthio)thiop...)
Affinity DataEC50:  97nMAssay Description:Activity against human GLUR2 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50191959(3-(4-tert-butylphenyl)-4-cyano-5-(methylthio)thiop...)
Affinity DataEC50:  97nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50417564(CHEMBL1642168)
Affinity DataEC50:  100nMAssay Description:Modulatory activity at GluA2 receptor LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50417574(CHEMBL1642155)
Affinity DataEC50:  100nMAssay Description:Modulatory activity at GluA2 receptor LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50331386(CHEMBL1289293 | N-((3S,4S)-4-(3'-acetylbiphenyl-4-...)
Affinity DataEC50:  100nMAssay Description:Positive modulation of human GluA2 flip receptor by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50191955(3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrol...)
Affinity DataEC50:  103nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50191948(4-cyano-5-ethyl-3-(2'-fluoro-biphenyl-4-yl)-1-meth...)
Affinity DataEC50:  111nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50191956(3-(4'-chloro-biphenyl-4-yl)-4-cyano-5-ethyl-1-meth...)
Affinity DataEC50:  142nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50191948(4-cyano-5-ethyl-3-(2'-fluoro-biphenyl-4-yl)-1-meth...)
Affinity DataEC50:  143nMAssay Description:Activity at human recombinant iGluR2 flop expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50316375(CHEMBL1097939 | LY-404187 | N-[2-(4'-cyanobiphenyl...)
Affinity DataEC50:  150nMAssay Description:Activity at human recombinant GluA2 receptor flip isoform expressed in HEK293 cells assessed as effect on glutamate-induced calcium flux by Fluo-4/AM...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50094024((+/-) Propane-2-sulfonic acid [2-(4'-cyano-bipheny...)
Affinity DataEC50:  150nMAssay Description:Agonist activity at GluR2 receptorMore data for this Ligand-Target Pair
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50164477(CHEMBL3800556)
Affinity DataEC50:  150nMAssay Description:Positive allosteric modulation of human GluA2 AMPAR flip isomer expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50417565(CHEMBL1642169)
Affinity DataEC50:  158nMAssay Description:Modulatory activity at GluA2 receptor LBDMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50191962(3-biphenyl-4-yl-4-cyano-1-methyl-5-methylsulfanyl-...)
Affinity DataEC50:  174nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50191962(3-biphenyl-4-yl-4-cyano-1-methyl-5-methylsulfanyl-...)
Affinity DataEC50:  174nMAssay Description:Activity against human GLUR2 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50192222(3-(4-tert-butylphenyl)-4-cyano-5-(dimethylamino)th...)
Affinity DataEC50:  176nMAssay Description:Activity against human GLUR2 flip expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50191964(3-(3'-chloro-biphenyl-4-yl)-4-cyano-5-ethyl-1-meth...)
Affinity DataEC50:  186nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50164485(CHEMBL3799657)
Affinity DataEC50:  204nMAssay Description:Positive allosteric modulation of human GluA2 AMPAR flop isomer expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50205852(CHEMBL3976578 | US10280165, Example 38)
Affinity DataEC50:  210nMAssay Description:Positive allosteric modulation of human GluA2 receptor flop isoform assessed as increase in glutamate-induced calcium flux measured at time interval ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50205852(CHEMBL3976578 | US10280165, Example 38)
Affinity DataEC50:  210nMAssay Description:Positive allosteric modulation of human GluA2 receptor flop isoform assessed as increase in glutamate-induced calcium flux measured at time interval ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50192216(3-(4-tert-butylphenyl)-4-cyano-5-ethylthiophene-2-...)
Affinity DataEC50:  216nMAssay Description:Activity against human GLUR2 flop expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50192221(3-(4-tert-butylphenyl)-4-cyano-5-(trifluoromethyl)...)
Affinity DataEC50:  231nMAssay Description:Activity against human GLUR2 flop expressed in HEK293 cells assesed as glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50164476(CHEMBL3799732)
Affinity DataEC50:  245nMAssay Description:Positive allosteric modulation of human GluA2 AMPAR flop isomer expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50164476(CHEMBL3799732)
Affinity DataEC50:  252nMAssay Description:Positive allosteric modulation of human GluA2 AMPAR flip isomer expressed in Dox-inducible cells measured every 5 mins by BD calcium indicator dye ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50191965(4-cyano-5-ethyl-1-methyl-3-(2'-methyl-biphenyl-4-y...)
Affinity DataEC50:  270nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50191958(4-cyano-5-ethyl-3-(2'-methoxy-biphenyl-4-yl)-1-met...)
Affinity DataEC50:  280nMAssay Description:Activity at human recombinant iGluR2 flip expressed in HEK293 cells measured as change in intracellular calcium ion concentration in presence of glut...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50331389(CHEMBL1289409 | N-((3S,4S)-4-(4-(5-fluoropyridin-2...)
Affinity DataEC50:  300nMAssay Description:Positive modulation of human GluA2 flip receptor by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50331387(CHEMBL1289294 | N-((3S,4S)-4-(4-(6-fluoropyridin-3...)
Affinity DataEC50:  300nMAssay Description:Positive modulation of human GluA2 flip receptor by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate receptor 2(Homo sapiens (Human))
University Of Liege

Curated by ChEMBL
LigandPNGBDBM50331388(CHEMBL1289408 | N-((3S,4S)-4-(4-(5-fluoropyridin-3...)
Affinity DataEC50:  300nMAssay Description:Positive modulation of human GluA2 flip receptor by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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