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Compile Data Set for Download or QSAR

Found 162 hits of affinity data for UniProtKB/TrEMBL: P09038   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM142256
PNG
(US8933099, 22 | US9951047, Compound (I))
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CCO)CC4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C32H37N5O6/c1-33-32(40)37-14-10-25-19-29(28(21-27(25)37)42-18-17-41-2)43-26-7-11-34-30(20-26)35-31(39)24-5-3-22(4-6-24)23-8-12-36(13-9-23)15-16-38/h3-7,10-11,14,19-21,23,38H,8-9,12-13,15-18H2,1-2H3,(H,33,40)(H,34,35,39)
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US Patent
n/an/a 4.5n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR2 protein is measured.To each well of a flat b...


US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM142255
PNG
(US8933099, 21)
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(C)CC4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C31H35N5O5/c1-32-31(38)36-15-11-24-18-28(27(20-26(24)36)40-17-16-39-3)41-25-8-12-33-29(19-25)34-30(37)23-6-4-21(5-7-23)22-9-13-35(2)14-10-22/h4-8,11-12,15,18-20,22H,9-10,13-14,16-17H2,1-3H3,(H,32,38)(H,33,34,37)
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US Patent
n/an/a 5.10n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR2 protein is measured.To each well of a flat b...


US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM142236
PNG
(US8933099, 2)
Show SMILES CCN1CCC(CC1)c1ccc(cc1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OC)ccn1
Show InChI InChI=1S/C30H33N5O4/c1-4-34-14-10-21(11-15-34)20-5-7-22(8-6-20)29(36)33-28-18-24(9-13-32-28)39-27-17-23-12-16-35(30(37)31-2)25(23)19-26(27)38-3/h5-9,12-13,16-19,21H,4,10-11,14-15H2,1-3H3,(H,31,37)(H,32,33,36)
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US Patent
n/an/a 6.40n/an/an/an/an/a25



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR2 protein is measured.To each well of a flat b...


US Patent US8933099 (2015)


BindingDB Entry DOI: 10.7270/Q28S4NMG
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50000130
PNG
(CHEMBL320550)
Show SMILES OC1C(O)C(NC(=O)COc2ccc(Cl)cc2Cl)OC(C1O)C(O)=O
Show InChI InChI=1S/C14H15Cl2NO8/c15-5-1-2-7(6(16)3-5)24-4-8(18)17-13-11(21)9(19)10(20)12(25-13)14(22)23/h1-3,9-13,19-21H,4H2,(H,17,18)(H,22,23)
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n/an/a 10n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
24% inhibition of FGF-2 binding to heparin-albumin by ELISA


Bioorg Med Chem Lett 12: 3287-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00700-x
BindingDB Entry DOI: 10.7270/Q2ZP45G2
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50000128
PNG
(CHEMBL113091)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)NC1OC(C(O)C(O)C1O)C(O)=O
Show InChI InChI=1S/C16H21NO10/c1-24-7-4-6(5-8(25-2)12(7)26-3)14(21)17-15-11(20)9(18)10(19)13(27-15)16(22)23/h4-5,9-11,13,15,18-20H,1-3H3,(H,17,21)(H,22,23)
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n/an/a 58n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
23% inhibition of FGF-2 binding to heparin-albumin by ELISA


Bioorg Med Chem Lett 12: 3287-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00700-x
BindingDB Entry DOI: 10.7270/Q2ZP45G2
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50421574
PNG
(CHEMBL2303729)
Show SMILES O[C@@H]1[C@H](O)[C@H](OCCN2C(=O)CCC2=O)O[C@H]([C@H]1O)C(O)=O
Show InChI InChI=1S/C12H17NO9/c14-5-1-2-6(15)13(5)3-4-21-12-9(18)7(16)8(17)10(22-12)11(19)20/h7-10,12,16-18H,1-4H2,(H,19,20)/t7-,8-,9-,10+,12+/m0/s1
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n/an/a<100n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
25% inhibition of FGF-2 binding to heparin-albumin by ELISA


Bioorg Med Chem Lett 12: 3287-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00700-x
BindingDB Entry DOI: 10.7270/Q2ZP45G2
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167952
PNG
(1-(4-(3-Methoxyphenyl)piperazin-1-yl)-3-(quinazoli...)
Show SMILES COc1cccc(c1)N1CCN(CC(O)COc2ncnc3ccccc23)CC1
Show InChI InChI=1S/C22H26N4O3/c1-28-19-6-4-5-17(13-19)26-11-9-25(10-12-26)14-18(27)15-29-22-20-7-2-3-8-21(20)23-16-24-22/h2-8,13,16,18,27H,9-12,14-15H2,1H3
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n/an/a 103n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50331095
PNG
(CHEMBL1289494 | Tivozanib)
Show SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4cc(C)on4)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C22H19ClN4O5/c1-12-8-21(27-32-12)26-22(28)25-16-5-4-13(9-15(16)23)31-18-6-7-24-17-11-20(30-3)19(29-2)10-14(17)18/h4-11H,1-3H3,(H2,25,26,27,28)
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n/an/a 114n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167953
PNG
(1-(4-(4-Methoxyphenyl)piperazin-1-yl)-3-(quinazoli...)
Show SMILES COc1ccc(cc1)N1CCN(CC(O)COc2ncnc3ccccc23)CC1
Show InChI InChI=1S/C22H26N4O3/c1-28-19-8-6-17(7-9-19)26-12-10-25(11-13-26)14-18(27)15-29-22-20-4-2-3-5-21(20)23-16-24-22/h2-9,16,18,27H,10-15H2,1H3
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n/an/a 122n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167954
PNG
(1-(4-(3-(Trifluoromethyl)phenyl)piperazin-1-yl)-3-...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O2/c23-22(24,25)16-4-3-5-17(12-16)29-10-8-28(9-11-29)13-18(30)14-31-21-19-6-1-2-7-20(19)26-15-27-21/h1-7,12,15,18,30H,8-11,13-14H2
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n/an/a 145n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167956
PNG
(1-(4-(3,4-Dichlorophenyl)piperazin-1-yl)-3-(quinaz...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C21H22Cl2N4O2/c22-18-6-5-15(11-19(18)23)27-9-7-26(8-10-27)12-16(28)13-29-21-17-3-1-2-4-20(17)24-14-25-21/h1-6,11,14,16,28H,7-10,12-13H2
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n/an/a 178n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167951
PNG
(1-(4-(2-Methoxyphenyl)piperazin-1-yl)-3-(quinazoli...)
Show SMILES COc1ccccc1N1CCN(CC(O)COc2ncnc3ccccc23)CC1
Show InChI InChI=1S/C22H26N4O3/c1-28-21-9-5-4-8-20(21)26-12-10-25(11-13-26)14-17(27)15-29-22-18-6-2-3-7-19(18)23-16-24-22/h2-9,16-17,27H,10-15H2,1H3
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n/an/a 209n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167957
PNG
(1-(4-(2,4-Dimethylphenyl)piperazin-1-yl)-3-(quinaz...)
Show SMILES Cc1ccc(N2CCN(CC(O)COc3ncnc4ccccc34)CC2)c(C)c1
Show InChI InChI=1S/C23H28N4O2/c1-17-7-8-22(18(2)13-17)27-11-9-26(10-12-27)14-19(28)15-29-23-20-5-3-4-6-21(20)24-16-25-23/h3-8,13,16,19,28H,9-12,14-15H2,1-2H3
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n/an/a 222n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167950
PNG
(1-(4-(4-Nitrophenyl)piperazin-1-yl)-3-(quinazolin-...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccc(cc1)[N+]([O-])=O
Show InChI InChI=1S/C21H23N5O4/c27-18(14-30-21-19-3-1-2-4-20(19)22-15-23-21)13-24-9-11-25(12-10-24)16-5-7-17(8-6-16)26(28)29/h1-8,15,18,27H,9-14H2
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n/an/a 248n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167945
PNG
(1-(4-Phenylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C21H24N4O2/c26-18(15-27-21-19-8-4-5-9-20(19)22-16-23-21)14-24-10-12-25(13-11-24)17-6-2-1-3-7-17/h1-9,16,18,26H,10-15H2
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n/an/a 293n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167949
PNG
(1-(4-(4-Fluorophenyl)piperazin-1-yl)-3-(quinazolin...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C21H23FN4O2/c22-16-5-7-17(8-6-16)26-11-9-25(10-12-26)13-18(27)14-28-21-19-3-1-2-4-20(19)23-15-24-21/h1-8,15,18,27H,9-14H2
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n/an/a 300n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50421574
PNG
(CHEMBL2303729)
Show SMILES O[C@@H]1[C@H](O)[C@H](OCCN2C(=O)CCC2=O)O[C@H]([C@H]1O)C(O)=O
Show InChI InChI=1S/C12H17NO9/c14-5-1-2-6(15)13(5)3-4-21-12-9(18)7(16)8(17)10(22-12)11(19)20/h7-10,12,16-18H,1-4H2,(H,19,20)/t7-,8-,9-,10+,12+/m0/s1
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n/an/a 340n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
25% inhibition of FGF-2 binding to heparin-albumin by ELISA


Bioorg Med Chem Lett 12: 3287-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00700-x
BindingDB Entry DOI: 10.7270/Q2ZP45G2
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167948
PNG
(1-(4-(2-Fluorophenyl)piperazin-1-yl)-3-(quinazolin...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccccc1F
Show InChI InChI=1S/C21H23FN4O2/c22-18-6-2-4-8-20(18)26-11-9-25(10-12-26)13-16(27)14-28-21-17-5-1-3-7-19(17)23-15-24-21/h1-8,15-16,27H,9-14H2
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n/an/a 372n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167955
PNG
(1-(4-(2,3-Dichlorophenyl)piperazin-1-yl)-3-(quinaz...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1cccc(Cl)c1Cl
Show InChI InChI=1S/C21H22Cl2N4O2/c22-17-5-3-7-19(20(17)23)27-10-8-26(9-11-27)12-15(28)13-29-21-16-4-1-2-6-18(16)24-14-25-21/h1-7,14-15,28H,8-13H2
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n/an/a 398n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167947
PNG
(1-(4-(3-Chlorophenyl)piperazin-1-yl)-3-(quinazolin...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1cccc(Cl)c1
Show InChI InChI=1S/C21H23ClN4O2/c22-16-4-3-5-17(12-16)26-10-8-25(9-11-26)13-18(27)14-28-21-19-6-1-2-7-20(19)23-15-24-21/h1-7,12,15,18,27H,8-11,13-14H2
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n/an/a 402n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167959
PNG
(1-(4-Methylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...)
Show SMILES CN1CCN(CC(O)COc2ncnc3ccccc23)CC1
Show InChI InChI=1S/C16H22N4O2/c1-19-6-8-20(9-7-19)10-13(21)11-22-16-14-4-2-3-5-15(14)17-12-18-16/h2-5,12-13,21H,6-11H2,1H3
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n/an/a 419n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167958
PNG
(1-(4-Benzylpiperazin-1-yl)-3-(quinazolin-4-yloxy)p...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C22H26N4O2/c27-19(16-28-22-20-8-4-5-9-21(20)23-17-24-22)15-26-12-10-25(11-13-26)14-18-6-2-1-3-7-18/h1-9,17,19,27H,10-16H2
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n/an/a 444n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167946
PNG
(1-(4-(2-Chlorophenyl)piperazin-1-yl)-3-(quinazolin...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCN(CC1)c1ccccc1Cl
Show InChI InChI=1S/C21H23ClN4O2/c22-18-6-2-4-8-20(18)26-11-9-25(10-12-26)13-16(27)14-28-21-17-5-1-3-7-19(17)23-15-24-21/h1-8,15-16,27H,9-14H2
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n/an/a 506n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167960
PNG
(1-(4-Ethylpiperazin-1-yl)-3-(quinazolin-4-yloxy)pr...)
Show SMILES CCN1CCN(CC(O)COc2ncnc3ccccc23)CC1
Show InChI InChI=1S/C17H24N4O2/c1-2-20-7-9-21(10-8-20)11-14(22)12-23-17-15-5-3-4-6-16(15)18-13-19-17/h3-6,13-14,22H,2,7-12H2,1H3
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n/an/a 519n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167961
PNG
(1-(Dimethylamino)-3-(quinazolin-4-yloxy)propan-2-o...)
Show SMILES CN(C)CC(O)COc1ncnc2ccccc12
Show InChI InChI=1S/C13H17N3O2/c1-16(2)7-10(17)8-18-13-11-5-3-4-6-12(11)14-9-15-13/h3-6,9-10,17H,7-8H2,1-2H3
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n/an/a 582n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167965
PNG
(1-(2-Methyl-1H-imidazol-1-yl)-3-(quinazolin-4-ylox...)
Show SMILES Cc1nccn1CC(O)COc1ncnc2ccccc12
Show InChI InChI=1S/C15H16N4O2/c1-11-16-6-7-19(11)8-12(20)9-21-15-13-4-2-3-5-14(13)17-10-18-15/h2-7,10,12,20H,8-9H2,1H3
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n/an/a 586n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167966
PNG
(1-(4-Methyl-1H-imidazol-1-yl)-3-(quinazolin-4-ylox...)
Show SMILES Cc1cn(CC(O)COc2ncnc3ccccc23)cn1
Show InChI InChI=1S/C15H16N4O2/c1-11-6-19(10-18-11)7-12(20)8-21-15-13-4-2-3-5-14(13)16-9-17-15/h2-6,9-10,12,20H,7-8H2,1H3
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n/an/a 592n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167963
PNG
(1-(Piperidin-1-yl)-3-(quinazolin-4-yloxy)propan-2-...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCCCC1
Show InChI InChI=1S/C16H21N3O2/c20-13(10-19-8-4-1-5-9-19)11-21-16-14-6-2-3-7-15(14)17-12-18-16/h2-3,6-7,12-13,20H,1,4-5,8-11H2
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n/an/a 593n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167962
PNG
(1-Morpholino-3-(quinazolin-4-yloxy)propan-2-ol (3r...)
Show SMILES OC(COc1ncnc2ccccc12)CN1CCOCC1
Show InChI InChI=1S/C15H19N3O3/c19-12(9-18-5-7-20-8-6-18)10-21-15-13-3-1-2-4-14(13)16-11-17-15/h1-4,11-12,19H,5-10H2
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n/an/a 602n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM167964
PNG
(1-(1H-Imidazol-1-yl)-3-(quinazolin-4-yloxy)propan-...)
Show SMILES OC(COc1ncnc2ccccc12)Cn1ccnc1
Show InChI InChI=1S/C14H14N4O2/c19-11(7-18-6-5-15-10-18)8-20-14-12-3-1-2-4-13(12)16-9-17-14/h1-6,9-11,19H,7-8H2
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n/an/a 609n/an/an/an/a7.225



Nanjing University



Assay Description
VEGFR kinase assays were set up to assess the level of autophosphorylation based on DELFIA/Time-Resolved Fluorometry. 96-well plates were coated at r...


Chem Biol Drug Des 86: 1323-9 (2015)


Article DOI: 10.1111/cbdd.12596
BindingDB Entry DOI: 10.7270/Q2GB22TR
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50182285
PNG
(CHEMBL3819473)
Show SMILES C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@]34C)[C@@H]1CC[C@@H]2[C@@H](O)CC(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C24H34F6O3/c1-20-9-7-14(31)11-13(20)3-4-15-16-5-6-18(21(16,2)10-8-17(15)20)19(32)12-22(33,23(25,26)27)24(28,29)30/h3,14-19,31-33H,4-12H2,1-2H3/t14-,15-,16-,17-,18+,19-,20-,21-/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FGF2 assessed as reduction in HSPG/FGF2/FGDR interaction by measuring FGF2 mediated A475-CHO-flg-1A-luc cell to CHO-K...


J Med Chem 59: 4651-63 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02021
BindingDB Entry DOI: 10.7270/Q26Q205Q
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50182286
PNG
(CHEMBL3819333)
Show SMILES C[C@]12CC[C@H]3[C@@H](CC=C4C[C@@H](O)CC[C@]34C)[C@@H]1CC[C@@H]2C(O)CC(O)(C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C24H34F6O3/c1-20-9-7-14(31)11-13(20)3-4-15-16-5-6-18(21(16,2)10-8-17(15)20)19(32)12-22(33,23(25,26)27)24(28,29)30/h3,14-19,31-33H,4-12H2,1-2H3/t14-,15-,16-,17-,18+,19?,20-,21-/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Universit£ degli Studi di Parma

Curated by ChEMBL


Assay Description
Inhibition of human recombinant FGF2 assessed as reduction in HSPG/FGF2/FGDR interaction by measuring FGF2 mediated A475-CHO-flg-1A-luc cell to CHO-K...


J Med Chem 59: 4651-63 (2016)


Article DOI: 10.1021/acs.jmedchem.5b02021
BindingDB Entry DOI: 10.7270/Q26Q205Q
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50000129
PNG
(CHEMBL112763)
Show SMILES OC1C(O)C(NC(=O)c2ccc(F)c(F)c2)OC(C1O)C(O)=O
Show InChI InChI=1S/C13H13F2NO7/c14-5-2-1-4(3-6(5)15)11(20)16-12-9(19)7(17)8(18)10(23-12)13(21)22/h1-3,7-10,12,17-19H,(H,16,20)(H,21,22)
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n/an/a 1.10E+4n/an/an/an/an/an/a



University College Dublin

Curated by ChEMBL


Assay Description
25% inhibition of FGF-2 binding to heparin-albumin by ELISA


Bioorg Med Chem Lett 12: 3287-90 (2002)


Article DOI: 10.1016/s0960-894x(02)00700-x
BindingDB Entry DOI: 10.7270/Q2ZP45G2
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50260260
PNG
(Biotin-Ala-(Arg)9 | CID44576236 | [amino({[(1R,2S,...)
Show SMILES NC(=[NH2+])NCC1OC(OC2C(CO)OC(OC3C(O)C(CC([NH+]=C(N)N)C3OC3OC(CNC(N)=[NH2+])C(O)C(O)C3[NH+]=C(N)N)[NH+]=C(N)N)C2O)C(NC(N)=[NH2+])C(O)C1O
Show InChI InChI=1S/C29H58N18O13/c30-24(31)42-2-7-13(50)15(52)10(46-28(38)39)21(55-7)58-18-6(45-27(36)37)1-5(44-26(34)35)12(49)20(18)60-23-17(54)19(9(4-48)57-23)59-22-11(47-29(40)41)16(53)14(51)8(56-22)3-43-25(32)33/h5-23,48-54H,1-4H2,(H4,30,31,42)(H4,32,33,43)(H4,34,35,44)(H4,36,37,45)(H4,38,39,46)(H4,40,41,47)/p+6
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n/an/a 2.00E+4n/an/an/an/an/an/a



University of California

Curated by ChEMBL


Assay Description
Binding affinity to biotinylated FGF2 in CHO cells by flow cytometry


J Biol Chem 282: 13585-91 (2007)


Article DOI: 10.1074/jbc.M700463200
BindingDB Entry DOI: 10.7270/Q2NS0VTJ
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84561
PNG
(Linked sulfated tetracyclitol, 2)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C26H40N2O48S12/c29-77(30,31)65-15-5-1-11(19(69-81(41,42)43)23(15)73-85(53,54)55)27(12-2-6-16(66-78(32,33)34)24(74-86(56,57)58)20(12)70-82(44,45)46)9-10-28(13-3-7-17(67-79(35,36)37)25(75-87(59,60)61)21(13)71-83(47,48)49)14-4-8-18(68-80(38,39)40)26(76-88(62,63)64)22(14)72-84(50,51)52/h1-8,11-26H,9-10H2,(H,29,30,31)(H,32,33,34)(H,35,36,37)(H,38,39,40)(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)/p-12/t11-,12-,13-,14-,15+,16+,17+,18+,19+,20+,21+,22+,23+,24+,25+,26+/m0/s1
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n/an/an/a 1.10E+3n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84562
PNG
(Linked sulfated tetracyclitol, 3)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C27H42N2O48S12/c30-78(31,32)66-16-6-2-12(20(70-82(42,43)44)24(16)74-86(54,55)56)28(13-3-7-17(67-79(33,34)35)25(75-87(57,58)59)21(13)71-83(45,46)47)10-1-11-29(14-4-8-18(68-80(36,37)38)26(76-88(60,61)62)22(14)72-84(48,49)50)15-5-9-19(69-81(39,40)41)27(77-89(63,64)65)23(15)73-85(51,52)53/h2-9,12-27H,1,10-11H2,(H,30,31,32)(H,33,34,35)(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)/p-12/t12-,13-,14-,15-,16+,17+,18+,19+,20+,21+,22+,23+,24+,25+,26+,27+/m0/s1
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n/an/an/a 248n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84563
PNG
(Linked sulfated tetracyclitol, 4)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C28H44N2O48S12/c31-79(32,33)67-17-7-3-13(21(71-83(43,44)45)25(17)75-87(55,56)57)29(14-4-8-18(68-80(34,35)36)26(76-88(58,59)60)22(14)72-84(46,47)48)11-1-2-12-30(15-5-9-19(69-81(37,38)39)27(77-89(61,62)63)23(15)73-85(49,50)51)16-6-10-20(70-82(40,41)42)28(78-90(64,65)66)24(16)74-86(52,53)54/h3-10,13-28H,1-2,11-12H2,(H,31,32,33)(H,34,35,36)(H,37,38,39)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)(H,55,56,57)(H,58,59,60)(H,61,62,63)(H,64,65,66)/p-12/t13-,14-,15-,16-,17+,18+,19+,20+,21+,22+,23+,24+,25+,26+,27+,28+/m0/s1
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n/an/an/a 161n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84564
PNG
(Linked sulfated tetracyclitol, 5)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C29H46N2O48S12/c32-80(33,34)68-18-8-4-14(22(72-84(44,45)46)26(18)76-88(56,57)58)30(15-5-9-19(69-81(35,36)37)27(77-89(59,60)61)23(15)73-85(47,48)49)12-2-1-3-13-31(16-6-10-20(70-82(38,39)40)28(78-90(62,63)64)24(16)74-86(50,51)52)17-7-11-21(71-83(41,42)43)29(79-91(65,66)67)25(17)75-87(53,54)55/h4-11,14-29H,1-3,12-13H2,(H,32,33,34)(H,35,36,37)(H,38,39,40)(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)/p-12/t14-,15-,16-,17-,18+,19+,20+,21+,22+,23+,24+,25+,26+,27+,28+,29+/m0/s1
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n/an/an/a 148n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84565
PNG
(Linked sulfated tetracyclitol, 6)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCCCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C30H48N2O48S12/c33-81(34,35)69-19-9-5-15(23(73-85(45,46)47)27(19)77-89(57,58)59)31(16-6-10-20(70-82(36,37)38)28(78-90(60,61)62)24(16)74-86(48,49)50)13-3-1-2-4-14-32(17-7-11-21(71-83(39,40)41)29(79-91(63,64)65)25(17)75-87(51,52)53)18-8-12-22(72-84(42,43)44)30(80-92(66,67)68)26(18)76-88(54,55)56/h5-12,15-30H,1-4,13-14H2,(H,33,34,35)(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)/p-12/t15-,16-,17-,18-,19+,20+,21+,22+,23+,24+,25+,26+,27+,28+,29+,30+/m0/s1
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n/an/an/a 135n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84566
PNG
(Linked sulfated tetracyclitol, 7)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCCCCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C31H50N2O48S12/c34-82(35,36)70-20-10-6-16(24(74-86(46,47)48)28(20)78-90(58,59)60)32(17-7-11-21(71-83(37,38)39)29(79-91(61,62)63)25(17)75-87(49,50)51)14-4-2-1-3-5-15-33(18-8-12-22(72-84(40,41)42)30(80-92(64,65)66)26(18)76-88(52,53)54)19-9-13-23(73-85(43,44)45)31(81-93(67,68)69)27(19)77-89(55,56)57/h6-13,16-31H,1-5,14-15H2,(H,34,35,36)(H,37,38,39)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)(H,55,56,57)(H,58,59,60)(H,61,62,63)(H,64,65,66)(H,67,68,69)/p-12/t16-,17-,18-,19-,20+,21+,22+,23+,24+,25+,26+,27+,28+,29+,30+,31+/m0/s1
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n/an/an/a 90n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84567
PNG
(Linked sulfated tetracyclitol, 8)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCCCCCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C32H52N2O48S12/c35-83(36,37)71-21-11-7-17(25(75-87(47,48)49)29(21)79-91(59,60)61)33(18-8-12-22(72-84(38,39)40)30(80-92(62,63)64)26(18)76-88(50,51)52)15-5-3-1-2-4-6-16-34(19-9-13-23(73-85(41,42)43)31(81-93(65,66)67)27(19)77-89(53,54)55)20-10-14-24(74-86(44,45)46)32(82-94(68,69)70)28(20)78-90(56,57)58/h7-14,17-32H,1-6,15-16H2,(H,35,36,37)(H,38,39,40)(H,41,42,43)(H,44,45,46)(H,47,48,49)(H,50,51,52)(H,53,54,55)(H,56,57,58)(H,59,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)/p-12/t17-,18-,19-,20-,21+,22+,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+/m0/s1
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n/an/an/a 108n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84568
PNG
(Linked sulfated tetracyclitol, 9)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCCCCCCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C33H54N2O48S12/c36-84(37,38)72-22-12-8-18(26(76-88(48,49)50)30(22)80-92(60,61)62)34(19-9-13-23(73-85(39,40)41)31(81-93(63,64)65)27(19)77-89(51,52)53)16-6-4-2-1-3-5-7-17-35(20-10-14-24(74-86(42,43)44)32(82-94(66,67)68)28(20)78-90(54,55)56)21-11-15-25(75-87(45,46)47)33(83-95(69,70)71)29(21)79-91(57,58)59/h8-15,18-33H,1-7,16-17H2,(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)/p-12/t18-,19-,20-,21-,22+,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+/m0/s1
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n/an/an/a 194n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84569
PNG
(Linked sulfated tetracyclitol, 10)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CCCCCCCCCCN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C34H56N2O48S12/c37-85(38,39)73-23-13-9-19(27(77-89(49,50)51)31(23)81-93(61,62)63)35(20-10-14-24(74-86(40,41)42)32(82-94(64,65)66)28(20)78-90(52,53)54)17-7-5-3-1-2-4-6-8-18-36(21-11-15-25(75-87(43,44)45)33(83-95(67,68)69)29(21)79-91(55,56)57)22-12-16-26(76-88(46,47)48)34(84-96(70,71)72)30(22)80-92(58,59)60/h9-16,19-34H,1-8,17-18H2,(H,37,38,39)(H,40,41,42)(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54)(H,55,56,57)(H,58,59,60)(H,61,62,63)(H,64,65,66)(H,67,68,69)(H,70,71,72)/p-12/t19-,20-,21-,22-,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+,33+,34+/m0/s1
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n/an/an/a 448n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84570
PNG
(Linked sulfated tetracyclitol, 11)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=C[C@@H]([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)c1ccc(cc1)N([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C30H40N2O48S12/c33-81(34,35)69-19-9-5-15(23(73-85(45,46)47)27(19)77-89(57,58)59)31(16-6-10-20(70-82(36,37)38)28(78-90(60,61)62)24(16)74-86(48,49)50)13-1-2-14(4-3-13)32(17-7-11-21(71-83(39,40)41)29(79-91(63,64)65)25(17)75-87(51,52)53)18-8-12-22(72-84(42,43)44)30(80-92(66,67)68)26(18)76-88(54,55)56/h1-12,15-30H,(H,33,34,35)(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)/p-12/t15-,16-,17-,18-,19+,20+,21+,22+,23+,24+,25+,26+,27+,28+,29+,30+/m0/s1
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n/an/an/a 332n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM84571
PNG
(Linked sulfated tetracyclitol, 12)
Show SMILES [O-]S(=O)(=O)O[C@@H]1C=CC([C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)N(CN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)CN([C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O)[C@H]1C=C[C@@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C32H51N3O60S15/c36-96(37,38)81-18-6-1-13(23(86-101(51,52)53)28(18)91-106(66,67)68)33(11-34(14-2-7-19(82-97(39,40)41)29(92-107(69,70)71)24(14)87-102(54,55)56)15-3-8-20(83-98(42,43)44)30(93-108(72,73)74)25(15)88-103(57,58)59)12-35(16-4-9-21(84-99(45,46)47)31(94-109(75,76)77)26(16)89-104(60,61)62)17-5-10-22(85-100(48,49)50)32(95-110(78,79)80)27(17)90-105(63,64)65/h1-10,13-32,102H,11-12H2,(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)(H2,54,55,56)(H,57,58,59)(H,60,61,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80)/p-15/t13?,14-,15-,16-,17-,18+,19+,20+,21+,22+,23+,24+,25+,26+,27+,28+,29+,30+,31+,32+/m0/s1
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n/an/an/a 85n/an/an/a7.4n/a



Progen Industries Ltd.



Assay Description
Human FGF-1 and FGF-2 were purchased from R&D Systems, Inc. and supplied as protein (ug) dissolved in bovine serum albumin (BSA, 50ug). Surface plas...


Chembiochem 6: 1882-90 (2005)

Checked by Author
Article DOI: 10.1002/cbic.200500089
BindingDB Entry DOI: 10.7270/Q22N50S0
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50017346
PNG
(CHEMBL3288258)
Show SMILES [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CCCCCO[C@H]1O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]2O[C@H]([C@@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]4O[C@H]([C@@H](O[C@H]5O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]6O[C@H]([C@@H](O)[C@H](O)[C@H]6OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]5NC(C)=O)[C@H](O)[C@H]4OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]3NC(C)=O)[C@H](O)[C@H]2OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]1NC(C)=O
Show InChI InChI=1S/C47H75N3O52S6.9Na/c1-5-6-7-8-85-42-18(48-12(2)51)21(54)28(15(89-42)9-86-103(67,68)69)93-46-35(101-107(79,80)81)26(59)31(37(98-46)40(63)64)96-44-20(50-14(4)53)23(56)30(17(91-44)11-88-105(73,74)75)94-47-36(102-108(82,83)84)27(60)32(38(99-47)41(65)66)95-43-19(49-13(3)52)22(55)29(16(90-43)10-87-104(70,71)72)92-45-34(100-106(76,77)78)25(58)24(57)33(97-45)39(61)62;;;;;;;;;/h15-38,42-47,54-60H,5-11H2,1-4H3,(H,48,51)(H,49,52)(H,50,53)(H,61,62)(H,63,64)(H,65,66)(H,67,68,69)(H,70,71,72)(H,73,74,75)(H,76,77,78)(H,79,80,81)(H,82,83,84);;;;;;;;;/q;9*+1/p-9/t15-,16-,17-,18-,19-,20-,21-,22-,23-,24+,25+,26+,27+,28-,29-,30-,31+,32+,33-,34-,35-,36-,37-,38-,42+,43-,44-,45-,46-,47-;;;;;;;;;/m1........./s1
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n/an/an/a 2.50E+7n/an/an/an/an/a



Momenta Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant FGF2 by surface plasmon resonance assay


J Med Chem 57: 4511-20 (2014)


Article DOI: 10.1021/jm4016069
BindingDB Entry DOI: 10.7270/Q2ZG6TSN
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50017347
PNG
(CHEMBL3288259)
Show SMILES [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].NCCCCCO[C@H]1O[C@H](CO)[C@@H](O[C@@H]2O[C@H]([C@@H](O[C@H]3O[C@H](CO)[C@@H](O[C@@H]4O[C@H]([C@@H](O[C@H]5O[C@H](CO)[C@@H](O[C@@H]6O[C@H]([C@@H](O)[C@H](O)[C@H]6OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]5NS([O-])(=O)=O)[C@H](O)[C@H]4OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]3NS([O-])(=O)=O)[C@H](O)[C@H]2OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]1NS([O-])(=O)=O
Show InChI InChI=1S/C41H70N4O49S6.9Na/c42-4-2-1-3-5-80-36-12(43-95(62,63)64)15(49)22(9(6-46)81-36)85-40-29(93-99(74,75)76)20(54)25(31(90-40)34(58)59)88-38-14(45-97(68,69)70)17(51)24(11(8-48)83-38)86-41-30(94-100(77,78)79)21(55)26(32(91-41)35(60)61)87-37-13(44-96(65,66)67)16(50)23(10(7-47)82-37)84-39-28(92-98(71,72)73)19(53)18(52)27(89-39)33(56)57;;;;;;;;;/h9-32,36-41,43-55H,1-8,42H2,(H,56,57)(H,58,59)(H,60,61)(H,62,63,64)(H,65,66,67)(H,68,69,70)(H,71,72,73)(H,74,75,76)(H,77,78,79);;;;;;;;;/q;9*+1/p-9/t9-,10-,11-,12-,13-,14-,15-,16-,17-,18+,19+,20+,21+,22-,23-,24-,25+,26+,27-,28-,29-,30-,31-,32-,36+,37-,38-,39-,40-,41-;;;;;;;;;/m1........./s1
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n/an/an/a 1.00E+3n/an/an/an/an/a



Momenta Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant FGF2 by surface plasmon resonance assay


J Med Chem 57: 4511-20 (2014)


Article DOI: 10.1021/jm4016069
BindingDB Entry DOI: 10.7270/Q2ZG6TSN
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50017345
PNG
(CHEMBL3288260)
Show SMILES [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].CCCCCO[C@H]1O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]2O[C@H]([C@@H](O[C@H]3O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]4O[C@H]([C@@H](O[C@H]5O[C@H](COS([O-])(=O)=O)[C@@H](O[C@@H]6O[C@H]([C@@H](O)[C@H](O)[C@H]6OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]5NC(C)=O)[C@H](O)[C@H]4OS([O-])(=O)=O)C([O-])=O)[C@H](O)[C@H]3NS([O-])(=O)=O)[C@H](O)[C@H]2O)C([O-])=O)[C@H](O)[C@H]1NC(C)=O
Show InChI InChI=1S/C45H73N3O51S6.9Na/c1-4-5-6-7-83-40-16(46-11(2)49)19(51)27(13(87-40)8-84-101(68,69)70)90-43-25(57)24(56)30(35(96-43)38(61)62)93-42-18(48-100(65,66)67)21(53)29(15(89-42)10-86-103(74,75)76)92-45-34(99-105(80,81)82)26(58)31(36(97-45)39(63)64)94-41-17(47-12(3)50)20(52)28(14(88-41)9-85-102(71,72)73)91-44-33(98-104(77,78)79)23(55)22(54)32(95-44)37(59)60;;;;;;;;;/h13-36,40-45,48,51-58H,4-10H2,1-3H3,(H,46,49)(H,47,50)(H,59,60)(H,61,62)(H,63,64)(H,65,66,67)(H,68,69,70)(H,71,72,73)(H,74,75,76)(H,77,78,79)(H,80,81,82);;;;;;;;;/q;9*+1/p-9/t13-,14-,15-,16-,17-,18-,19-,20-,21-,22+,23+,24-,25-,26+,27-,28-,29-,30+,31+,32-,33-,34-,35-,36-,40+,41-,42-,43-,44-,45-;;;;;;;;;/m1........./s1
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n/an/an/a 2.50E+7n/an/an/an/an/a



Momenta Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Binding affinity to human recombinant FGF2 by surface plasmon resonance assay


J Med Chem 57: 4511-20 (2014)


Article DOI: 10.1021/jm4016069
BindingDB Entry DOI: 10.7270/Q2ZG6TSN
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144519
PNG
(CHEMBL3215309 | CHEMBL385967 | Sodium sulfated gly...)
Show SMILES [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[O-]S(=O)(=O)OC[C@@H]1O[C@H](OCCNC(=O)CN(Cc2ccccc2)C(=O)CO[C@@H]2[C@H](OS([O-])(=O)=O)O[C@H](COS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@H]2OS([O-])(=O)=O)[C@H](OS([O-])(=O)=O)[C@@H](OS([O-])(=O)=O)[C@@H]1OS([O-])(=O)=O
Show InChI InChI=1S/C25H38N2O38S8/c28-16(26-6-7-54-24-23(64-72(48,49)50)21(63-71(45,46)47)19(61-69(39,40)41)14(58-24)10-56-66(30,31)32)9-27(8-13-4-2-1-3-5-13)17(29)12-55-22-20(62-70(42,43)44)18(60-68(36,37)38)15(11-57-67(33,34)35)59-25(22)65-73(51,52)53/h1-5,14-15,18-25H,6-12H2,(H,26,28)(H,30,31,32)(H,33,34,35)(H,36,37,38)(H,39,40,41)(H,42,43,44)(H,45,46,47)(H,48,49,50)(H,51,52,53)/p-8
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n/an/an/a 8.50E+4n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 2 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.017
BindingDB Entry DOI: 10.7270/Q2M9084D
More data for this
Ligand-Target Pair
Basic fibroblast growth factor


(Homo sapiens (Human))
BDBM50144523
PNG
(CHEMBL305519 | Sodium sulfated glycoconjugate deri...)
Show SMILES [O-]S(=O)(=O)OCCN(CC(=O)NC1CCCCC1)C(=O)C1OC(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C(OS([O-])(=O)=O)C1OS([O-])(=O)=O
Show InChI InChI=1S/C16H28N2O23S5/c19-10(17-9-4-2-1-3-5-9)8-18(6-7-36-42(21,22)23)15(20)13-11(38-43(24,25)26)12(39-44(27,28)29)14(40-45(30,31)32)16(37-13)41-46(33,34)35/h9,11-14,16H,1-8H2,(H,17,19)(H,21,22,23)(H,24,25,26)(H,27,28,29)(H,30,31,32)(H,33,34,35)/p-5
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n/an/an/a>8.00E+5n/an/an/an/an/a



Progen Industries Ltd

Curated by ChEMBL


Assay Description
Binding affinity for human fibroblast growth factor 2 in surface plasmon resonance (SPR) assay


Bioorg Med Chem Lett 14: 2221-6 (2004)


Article DOI: 10.1016/j.bmcl.2004.02.017
BindingDB Entry DOI: 10.7270/Q2M9084D
More data for this
Ligand-Target Pair
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