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Compile Data Set for Download or QSAR

Found 6498 hits of affinity data for UniProtKB/TrEMBL: P00533    Zinc 0: unavailable per Zinc DB. Zinc 1: purchasable, 2 weeks to supply. Zinc 2: made on demand. Zinc 4: potentially available
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
EGFR(L747-S752del P753S)


(Homo sapiens)
PD153035
PNG
(CHEMBL29197 | N-(3-bromophenyl)-6,7-dimethoxyquina...)
Show SMILES COc1cc2ncnc(Nc3cccc(Br)c3)c2cc1OC
PDB
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Article
PubMed
0.006n/an/an/an/an/an/an/an/a



University of Oxford

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL939
PNG
((3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(2-morphol...)
Show SMILES COc1cc2[nH]cn\c(=N/c3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
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Article
PubMed
0.4n/an/an/an/an/an/an/an/a



University of California-San Francisco

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL257411
PNG
((R)-1-morpholino-2-(4-(1-(thiazol-2-ylmethyl)-1H-i...)
Show SMILES C[C@@H](Oc1cccc2ncnc(Nc3ccc4n(Cc5nccs5)ncc4c3)c12)C(=O)N1CCOCC1
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1.6n/an/an/an/an/an/an/an/a



Centre de Recherches

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL248393
PNG
(6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)-4-...)
Show SMILES COc1cc2c(N[C@@H]3C[C@H]3c3ccccc3)c(cnc2cc1OCCCN1CCN(C)CC1)C#N
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3.0n/an/an/an/an/an/an/an/a



Tanabe Research Laboratories USA, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EGFR by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL1682560
PNG
(5-(1-(1-benzylpyrrolidin-3-yl)-4-(4-fluorophenyl)-...)
Show SMILES Fc1ccc(cc1)-c1ncn(C2CCN(Cc3ccccc3)C2)c1-c1ccc2[nH]ncc2c1
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8.0n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL248392
PNG
(6-methoxy-7-(3-morpholinopropoxy)-4-((1R,2S)-2-phe...)
Show SMILES COc1cc2c(N[C@@H]3C[C@H]3c3ccccc3)c(cnc2cc1OCCCN1CCOCC1)C#N
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8.4n/an/an/an/an/an/an/an/a



Tanabe Research Laboratories USA, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EGFR by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL1682558
PNG
(4-(2-(4-(4-fluorophenyl)-5-(1H-indazol-5-yl)-1H-im...)
Show SMILES Fc1ccc(cc1)-c1ncn(CCN2CCOCC2)c1-c1ccc2[nH]ncc2c1
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17.0n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL248044
PNG
(6,7-dimethoxy-4-((1R,2S)-2-phenylcyclopropylamino)...)
Show SMILES COc1cc2ncc(C#N)c(N[C@@H]3C[C@H]3c3ccccc3)c2cc1OC
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24.0n/an/an/an/an/an/an/an/a



Tanabe Research Laboratories USA, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EGFR by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL1682559
PNG
(4-(3-(4-(4-fluorophenyl)-5-(1H-indazol-5-yl)-1H-im...)
Show SMILES Fc1ccc(cc1)-c1ncn(CCCN2CCOCC2)c1-c1ccc2[nH]ncc2c1
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27.0n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL1090356
PNG
(N-(3-(5-(2-(4-morpholinophenylamino)pyrimidin-4-yl...)
Show SMILES O=C(Cc1ccccc1)Nc1cccc(c1)-c1nc2sccn2c1-c1ccnc(Nc2ccc(cc2)N2CCOCC2)n1
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PDB
31.62n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of EGFR


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL2170582
PNG
Show SMILES CNC(=O)COc1cccc(Nc2ncc(F)c(Nc3ccc4OC(F)(F)C(=O)Nc4c3)n2)c1
PDB
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35.0n/an/an/an/an/an/an/an/a



Rigel, Inc.

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL246419
PNG
(4-((1R,2S)-2-(2-fluorophenyl)cyclopropylamino)-6,7...)
Show SMILES COc1cc2ncc(C#N)c(N[C@@H]3C[C@H]3c3ccccc3F)c2cc1OC
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36.0n/an/an/an/an/an/an/an/a



Tanabe Research Laboratories USA, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EGFR by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL245800
PNG
(6-(4-(aminomethyl)phenyl)-4-((1R,2S)-2-phenylcyclo...)
Show SMILES NCc1ccc(cc1)-c1ccc2ncc(C#N)c(N[C@@H]3C[C@H]3c3ccccc3)c2c1
PDB
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40.0n/an/an/an/an/an/an/an/a



Tanabe Research Laboratories USA, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EGFR by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL247196
PNG
(6,7-diethyl-2-ethynyl-1-(((1S,2R)-2-p-tolylcyclopr...)
Show SMILES COc1cc2ncc(C#N)c(N[C@@H]3C[C@H]3c3ccc(Cl)cc3)c2cc1OC
PDB
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44.0n/an/an/an/an/an/an/an/a



Tanabe Research Laboratories USA, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EGFR by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL248425
PNG
(4-((1R,2S)-2-(3-bromophenyl)cyclopropylamino)-6,7-...)
Show SMILES COc1cc2ncc(C#N)c(N[C@@H]3C[C@H]3c3cccc(Br)c3)c2cc1OC
PDB
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52.0n/an/an/an/an/an/an/an/a



Tanabe Research Laboratories USA, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EGFR by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL248221
PNG
(7-methoxy-6-(3-morpholinopropoxy)-4-((1R,2S)-2-phe...)
Show SMILES COc1cc2ncc(C#N)c(N[C@@H]3C[C@H]3c3ccccc3)c2cc1OCCCN1CCOCC1
PDB
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52.0n/an/an/an/an/an/an/an/a



Tanabe Research Laboratories USA, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EGFR by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL401251
PNG
(6-methoxy-7-(2-methoxyethoxy)-4-((1R,2S)-2-phenylc...)
Show SMILES COCCOc1cc2ncc(C#N)c(N[C@@H]3C[C@H]3c3ccccc3)c2cc1OC
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60.0n/an/an/an/an/an/an/an/a



Tanabe Research Laboratories USA, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EGFR by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL401054
PNG
(7-methoxy-6-(2-morpholinoethoxy)-4-((1R,2S)-2-phen...)
Show SMILES COc1cc2ncc(C#N)c(N[C@@H]3C[C@H]3c3ccccc3)c2cc1OCCN1CCOCC1
PDB
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64.0n/an/an/an/an/an/an/an/a



Tanabe Research Laboratories USA, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EGFR by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL1682557
PNG
(2-(4-(4-fluorophenyl)-5-(1H-indazol-5-yl)-1H-imida...)
Show SMILES CN(C)CCn1cnc(c1-c1ccc2[nH]ncc2c1)-c1ccc(F)cc1
PDB
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67.0n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL248222
PNG
(7-methoxy-4-((1R,2S)-2-phenylcyclopropylamino)-6-(...)
Show SMILES COc1cc2ncc(C#N)c(N[C@@H]3C[C@H]3c3ccccc3)c2cc1OCCCc1cccnc1
PDB
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68.0n/an/an/an/an/an/an/an/a



Tanabe Research Laboratories USA, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EGFR by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL399438
PNG
(7-(4-(morpholinomethyl)phenyl)-4-((1R,2S)-2-phenyl...)
Show SMILES N#Cc1cnc2cc(ccc2c1N[C@@H]1C[C@H]1c1ccccc1)-c1ccc(CN2CCOCC2)cc1
PDB
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80.0n/an/an/an/an/an/an/an/a



Tanabe Research Laboratories USA, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EGFR by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL245996
PNG
(6,7-dimethoxy-4-((1R,2S)-2-(4-phenoxyphenyl)cyclop...)
Show SMILES COc1cc2ncc(C#N)c(N[C@@H]3C[C@H]3c3ccc(Oc4ccccc4)cc3)c2cc1OC
PDB
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80.0n/an/an/an/an/an/an/an/a



Tanabe Research Laboratories USA, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EGFR by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL248220
PNG
(6-(benzyloxy)-7-methoxy-4-((1R,2S)-2-phenylcyclopr...)
Show SMILES COc1cc2ncc(C#N)c(N[C@@H]3C[C@H]3c3ccccc3)c2cc1OCc1ccccc1
PDB
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120.0n/an/an/an/an/an/an/an/a



Tanabe Research Laboratories USA, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EGFR by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL268868
PNG
(4,5-dianilinophthalimide | 5,6-bis(phenylamino)-1H...)
Show SMILES O=C1NC(=O)c2cc(Nc3ccccc3)c(Nc3ccccc3)cc12
PDB
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160.0n/an/an/an/an/an/an/an/a



Ciba-Geigy Limited

Curated by ChEMBL


Assay Description
Competitive inhibition of ATP binding to EGF-R


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL248045
PNG
(7-methoxy-4-((1R,2S)-2-phenylcyclopropylamino)quin...)
Show SMILES COc1ccc2c(N[C@@H]3C[C@H]3c3ccccc3)c(cnc2c1)C#N
PDB
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180.0n/an/an/an/an/an/an/an/a



Tanabe Research Laboratories USA, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EGFR by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
PP1
PNG
(1-tert-butyl-3-(4-methylphenyl)-1H-pyrazolo[3,4-d]...)
Show SMILES Cc1ccc(cc1)-c1nn(c2ncnc(N)c12)C(C)(C)C
PDB
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200.0n/an/an/an/an/an/an/an/a


TBA

Assay Description
Inhibition of EGFR


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL400742
PNG
(4-((1R,2S)-2-(4-bromophenyl)cyclopropylamino)-6,7-...)
Show SMILES COc1cc2ncc(C#N)c(N[C@@H]3C[C@H]3c3ccc(Br)cc3)c2cc1OC
PDB
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PubMed
220.0n/an/an/an/an/an/an/an/a



Tanabe Research Laboratories USA, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EGFR by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL248391
PNG
(6-methoxy-4-((1R,2S)-2-phenylcyclopropylamino)-7-(...)
Show SMILES COc1cc2c(N[C@@H]3C[C@H]3c3ccccc3)c(cnc2cc1OCCCc1cccnc1)C#N
PDB
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220.0n/an/an/an/an/an/an/an/a



Tanabe Research Laboratories USA, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EGFR by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL245799
PNG
(6-(3-(morpholinomethyl)phenyl)-4-((1R,2S)-2-phenyl...)
Show SMILES N#Cc1cnc2ccc(cc2c1N[C@@H]1C[C@H]1c1ccccc1)-c1cccc(CN2CCOCC2)c1
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340.0n/an/an/an/an/an/an/an/a



Tanabe Research Laboratories USA, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EGFR by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL401644
PNG
(6-methoxy-4-((1R,2S)-2-phenylcyclopropylamino)quin...)
Show SMILES COc1ccc2ncc(C#N)c(N[C@@H]3C[C@H]3c3ccccc3)c2c1
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360.0n/an/an/an/an/an/an/an/a



Tanabe Research Laboratories USA, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EGFR by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL245798
PNG
(6-methoxy-7-(1-methylpiperidin-4-yloxy)-4-((1R,2S)...)
Show SMILES COc1cc2c(N[C@@H]3C[C@H]3c3ccccc3)c(cnc2cc1OC1CCN(C)CC1)C#N
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360.0n/an/an/an/an/an/an/an/a



Tanabe Research Laboratories USA, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EGFR by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL1290072
PNG
(N-(4-methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine)
Show SMILES COc1ccc(CNc2ccnc3oc4ccccc4c23)cc1
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400.0n/an/an/an/an/an/an/an/a



Martin Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL247024
PNG
(6-(4-(morpholinomethyl)phenyl)-4-((1R,2S)-2-phenyl...)
Show SMILES N#Cc1cnc2ccc(cc2c1N[C@@H]1C[C@H]1c1ccccc1)-c1ccc(CN2CCOCC2)cc1
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400.0n/an/an/an/an/an/an/an/a



Tanabe Research Laboratories USA, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human recombinant EGFR by fluorescence polarization assay


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL1290177
PNG
(N-(4-chlorobenzyl)benzofuro[2,3-b]pyridin-4-amine)
Show SMILES Clc1ccc(CNc2ccnc3oc4ccccc4c23)cc1
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500.0n/an/an/an/an/an/an/an/a



Martin Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL1289976
PNG
(N-benzylbenzofuro[2,3-b]pyridin-4-amine)
Show SMILES C(Nc1ccnc2oc3ccccc3c12)c1ccccc1
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590.0n/an/an/an/an/an/an/an/a



Martin Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL1290071
PNG
(N-(naphthalen-1-ylmethyl)benzofuro[2,3-b]pyridin-4...)
Show SMILES C(Nc1ccnc2oc3ccccc3c12)c1cccc2ccccc12
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680.0n/an/an/an/an/an/an/an/a



Martin Luther University Halle-Wittenberg

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Citation and Details
More data for this
Ligand-Target Pair
EGF-R Tyrosine Kinase


(Homo sapiens (human))
AG 213
PNG
((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)
Show SMILES NC(=S)C(=C\c1ccc(O)c(O)c1)\C#N
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850.0 -34.3 2400.0n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Citation and Details
More data for this
Ligand-Target Pair
EGF-R Tyrosine Kinase


(Homo sapiens (human))
benzylidenemalononitrile (BMN) deriv. 25
PNG
(2-[(3,4,5-trihydroxyphenyl)methylidene]propanedini...)
Show SMILES Oc1cc(C=C(C#N)C#N)cc(O)c1O
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1000.0 -33.9 3000.0n/an/an/an/a7.622



Hebrew University of Jerusalem



Assay Description
The activity of EGFR, preactivated with EGF, is measured by its ability to transfer terminal phosphate from [gamma-32P]ATP to poly(GAT) substrate.


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL1765781
PNG
((S)-3-(4-(2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl...)
Show SMILES CNc1cncc(n1)-c1c[nH]c(=O)c(NC(=O)c2ccc(cc2)N2CCC[C@H]2CN2CCCC2)c1
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>1000.0n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals (Europe) Ltd.

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL1682335
PNG
(5-(4-propyl-1H-1,2,3-triazol-1-yl)-1H-indazole)
Show SMILES CCCc1cn(nn1)-c1ccc2[nH]ncc2c1
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>1800.0n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of EGFR after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL1682336
PNG
(5-(4-(methoxymethyl)-1H-1,2,3-triazol-1-yl)-1H-ind...)
Show SMILES COCc1cn(nn1)-c1ccc2[nH]ncc2c1
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>1800.0n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of EGFR after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL1682337
PNG
(3-(1-(1H-indazol-5-yl)-1H-1,2,3-triazol-4-yl)propa...)
Show SMILES OCCCc1cn(nn1)-c1ccc2[nH]ncc2c1
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>1800.0n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of EGFR after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL1682338
PNG
(5-(4-cyclopropyl-1H-1,2,3-triazol-1-yl)-1H-indazol...)
Show SMILES C1CC1c1cn(nn1)-c1ccc2[nH]ncc2c1
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>1800.0n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of EGFR after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL1682339
PNG
(5-(4-cyclopentyl-1H-1,2,3-triazol-1-yl)-1H-indazol...)
Show SMILES C1CCC(C1)c1cn(nn1)-c1ccc2[nH]ncc2c1
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>1800.0n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of EGFR after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL1682340
PNG
(5-(4-(cyclohexylmethyl)-1H-1,2,3-triazol-1-yl)-1H-...)
Show SMILES C(C1CCCCC1)c1cn(nn1)-c1ccc2[nH]ncc2c1
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>1800.0n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of EGFR after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL1682341
PNG
(5-(4-benzyl-1H-1,2,3-triazol-1-yl)-1H-indazole)
Show SMILES C(c1cn(nn1)-c1ccc2[nH]ncc2c1)c1ccccc1
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>1800.0n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of EGFR after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL1682540
PNG
(2-(1H-indazol-5-yl)imidazo[1,2-a]pyrimidine)
Show SMILES c1n[nH]c2ccc(cc12)-c1cn2cccnc2n1
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>1800.0n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL1682359
PNG
(5-(1H-indazol-5-yl)-3-propylisoxazole)
Show SMILES CCCc1cc(on1)-c1ccc2[nH]ncc2c1
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>1800.0n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of EGFR after 1 hr


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL2205426
PNG
Show SMILES CC(C)(C)Nc1c(Nc2ccnc(Nc3ccc(cc3)-c3ccncc3)n2)c(=O)c1=O
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>1800.0n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of recombinant EGFR after 1 hr by scintillation counter analysis in presence of gamma-[33P]ATP


Citation and Details
More data for this
Ligand-Target Pair
EGFR(L747-S752del P753S)


(Homo sapiens)
CHEMBL1682553
PNG
(2-(1H-indazol-5-yl)-N-isopropylimidazo[1,2-a]pyrim...)
Show SMILES CC(C)Nc1c(nc2ncccn12)-c1ccc2[nH]ncc2c1
PDB
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>1800.0n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of EGFR


Citation and Details
More data for this
Ligand-Target Pair
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