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Compile Data Set for Download or QSAR

Found 65 hits of ki data for polymerid = 50000024,50000454   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367049
PNG
(CHEMBL604399)
Show SMILES CCSc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2OC([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C22H33N10O22P5S/c1-2-60-22-30-11-17(24)26-6-28-19(11)32(22)21-15(36)13(34)9(50-21)4-48-56(39,40)52-58(43,44)54-59(45,46)53-57(41,42)51-55(37,38)47-3-8-12(33)14(35)20(49-8)31-7-29-10-16(23)25-5-27-18(10)31/h5-9,12-15,20-21,33-36H,2-4H2,1H3,(H,37,38)(H,39,40)(H,41,42)(H,43,44)(H,45,46)(H2,23,25,27)(H2,24,26,28)/t8-,9-,12-,13-,14-,15-,20?,21?/m1/s1
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60n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat adenylate kinase II was determined in the presence of AMP, competitive inhibition


J Med Chem 25: 1179-84 (1983)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367049
PNG
(CHEMBL604399)
Show SMILES CCSc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2OC([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C22H33N10O22P5S/c1-2-60-22-30-11-17(24)26-6-28-19(11)32(22)21-15(36)13(34)9(50-21)4-48-56(39,40)52-58(43,44)54-59(45,46)53-57(41,42)51-55(37,38)47-3-8-12(33)14(35)20(49-8)31-7-29-10-16(23)25-5-27-18(10)31/h5-9,12-15,20-21,33-36H,2-4H2,1H3,(H,37,38)(H,39,40)(H,41,42)(H,43,44)(H,45,46)(H2,23,25,27)(H2,24,26,28)/t8-,9-,12-,13-,14-,15-,20?,21?/m1/s1
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60n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to inhibit the rat muscle adenylate kinase(AK II) isozyme in competition with the AMP varied


J Med Chem 25: 638-44 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367049
PNG
(CHEMBL604399)
Show SMILES CCSc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2OC([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C22H33N10O22P5S/c1-2-60-22-30-11-17(24)26-6-28-19(11)32(22)21-15(36)13(34)9(50-21)4-48-56(39,40)52-58(43,44)54-59(45,46)53-57(41,42)51-55(37,38)47-3-8-12(33)14(35)20(49-8)31-7-29-10-16(23)25-5-27-18(10)31/h5-9,12-15,20-21,33-36H,2-4H2,1H3,(H,37,38)(H,39,40)(H,41,42)(H,43,44)(H,45,46)(H2,23,25,27)(H2,24,26,28)/t8-,9-,12-,13-,14-,15-,20?,21?/m1/s1
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60n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat adenylate kinase II was determined in the presence of AMP, competitive inhibition


J Med Chem 25: 1179-84 (1983)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367049
PNG
(CHEMBL604399)
Show SMILES CCSc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2OC([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C22H33N10O22P5S/c1-2-60-22-30-11-17(24)26-6-28-19(11)32(22)21-15(36)13(34)9(50-21)4-48-56(39,40)52-58(43,44)54-59(45,46)53-57(41,42)51-55(37,38)47-3-8-12(33)14(35)20(49-8)31-7-29-10-16(23)25-5-27-18(10)31/h5-9,12-15,20-21,33-36H,2-4H2,1H3,(H,37,38)(H,39,40)(H,41,42)(H,43,44)(H,45,46)(H2,23,25,27)(H2,24,26,28)/t8-,9-,12-,13-,14-,15-,20?,21?/m1/s1
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80n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to inhibit the rat muscle adenylate kinase(AK II) isozyme in competition with the ATP varied


J Med Chem 25: 638-44 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50404859
PNG
(CHEMBL609832)
Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@@H]2OC([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C20H29N10O22P5/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(47-19)1-45-53(35,36)49-55(39,40)51-57(43,44)52-56(41,42)50-54(37,38)46-2-8-12(32)14(34)20(48-8)30-6-28-10-16(22)24-4-26-18(10)30/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H,41,42)(H,43,44)(H2,21,23,25)(H2,22,24,26)/t7-,8+,11-,12-,13-,14-,19?,20?/m1/s1
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280n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to inhibit the rat muscle adenylate kinase (AK II) isozyme in competition with the AMP varied


J Med Chem 25: 638-44 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50404859
PNG
(CHEMBL609832)
Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@@H]2OC([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C20H29N10O22P5/c21-15-9-17(25-3-23-15)29(5-27-9)19-13(33)11(31)7(47-19)1-45-53(35,36)49-55(39,40)51-57(43,44)52-56(41,42)50-54(37,38)46-2-8-12(32)14(34)20(48-8)30-6-28-10-16(22)24-4-26-18(10)30/h3-8,11-14,19-20,31-34H,1-2H2,(H,35,36)(H,37,38)(H,39,40)(H,41,42)(H,43,44)(H2,21,23,25)(H2,22,24,26)/t7-,8+,11-,12-,13-,14-,19?,20?/m1/s1
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280n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to inhibit the rat muscle adenylate kinase (AK II) isozyme in competition with the AMP varied


J Med Chem 25: 638-44 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367044
PNG
(CHEMBL605639)
Show SMILES CCSc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)O[C@H](C)[C@H]2OC([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C23H35N10O22P5S/c1-3-61-23-31-11-18(25)27-6-29-20(11)33(23)22-14(36)12(34)9(49-22)4-48-56(38,39)52-58(42,43)54-60(46,47)55-59(44,45)53-57(40,41)51-8(2)16-13(35)15(37)21(50-16)32-7-30-10-17(24)26-5-28-19(10)32/h5-9,12-16,21-22,34-37H,3-4H2,1-2H3,(H,38,39)(H,40,41)(H,42,43)(H,44,45)(H,46,47)(H2,24,26,28)(H2,25,27,29)/t8-,9-,12-,13+,14-,15-,16-,21?,22?/m1/s1
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1.50E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat adenylate kinase II was determined in the presence of AMP, competitive inhibition


J Med Chem 25: 1179-84 (1983)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367044
PNG
(CHEMBL605639)
Show SMILES CCSc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)O[C@H](C)[C@H]2OC([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C23H35N10O22P5S/c1-3-61-23-31-11-18(25)27-6-29-20(11)33(23)22-14(36)12(34)9(49-22)4-48-56(38,39)52-58(42,43)54-60(46,47)55-59(44,45)53-57(40,41)51-8(2)16-13(35)15(37)21(50-16)32-7-30-10-17(24)26-5-28-19(10)32/h5-9,12-16,21-22,34-37H,3-4H2,1-2H3,(H,38,39)(H,40,41)(H,42,43)(H,44,45)(H,46,47)(H2,24,26,28)(H2,25,27,29)/t8-,9-,12-,13+,14-,15-,16-,21?,22?/m1/s1
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2.80E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat adenylate kinase II was determined in the presence of AMP, non competitive inhibition


J Med Chem 25: 1179-84 (1983)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367040
PNG
(CHEMBL606017)
Show SMILES CCSc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2OC([C@H](O)[C@@H]2O)n2c(SCC)nc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C24H37N10O22P5S2/c1-3-62-23-31-11-17(25)27-7-29-19(11)33(23)21-15(37)13(35)9(51-21)5-49-57(39,40)53-59(43,44)55-61(47,48)56-60(45,46)54-58(41,42)50-6-10-14(36)16(38)22(52-10)34-20-12(18(26)28-8-30-20)32-24(34)63-4-2/h7-10,13-16,21-22,35-38H,3-6H2,1-2H3,(H,39,40)(H,41,42)(H,43,44)(H,45,46)(H,47,48)(H2,25,27,29)(H2,26,28,30)/t9-,10-,13-,14-,15-,16-,21?,22?/m1/s1
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1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat adenylate kinase II was determined in the presence of AMP, competitive inhibition


J Med Chem 25: 1179-84 (1983)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367040
PNG
(CHEMBL606017)
Show SMILES CCSc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]2OC([C@H](O)[C@@H]2O)n2c(SCC)nc3c(N)ncnc23)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C24H37N10O22P5S2/c1-3-62-23-31-11-17(25)27-7-29-19(11)33(23)21-15(37)13(35)9(51-21)5-49-57(39,40)53-59(43,44)55-61(47,48)56-60(45,46)54-58(41,42)50-6-10-14(36)16(38)22(52-10)34-20-12(18(26)28-8-30-20)32-24(34)63-4-2/h7-10,13-16,21-22,35-38H,3-6H2,1-2H3,(H,39,40)(H,41,42)(H,43,44)(H,45,46)(H,47,48)(H2,25,27,29)(H2,26,28,30)/t9-,10-,13-,14-,15-,16-,21?,22?/m1/s1
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1.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat adenylate kinase II was determined in the presence of AMP, competitive inhibition


J Med Chem 25: 1179-84 (1983)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367048
PNG
(CHEMBL605430)
Show SMILES CCC[C@@H](OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]1OC([C@H](O)[C@@H]1O)n1c(SCC)nc2c(N)ncnc12)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C25H39N10O22P5S/c1-3-5-10(18-15(37)17(39)23(52-18)34-9-32-12-19(26)28-7-30-21(12)34)53-59(42,43)55-61(46,47)57-62(48,49)56-60(44,45)54-58(40,41)50-6-11-14(36)16(38)24(51-11)35-22-13(20(27)29-8-31-22)33-25(35)63-4-2/h7-11,14-18,23-24,36-39H,3-6H2,1-2H3,(H,40,41)(H,42,43)(H,44,45)(H,46,47)(H,48,49)(H2,26,28,30)(H2,27,29,31)/t10-,11-,14-,15+,16-,17-,18-,23?,24?/m1/s1
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5.20E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat adenylate kinase II was determined in the presence of AMP, competitive inhibition


J Med Chem 25: 1179-84 (1983)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50010310
PNG
(CHEMBL3251359)
Show SMILES CCCSc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C13H22N5O13P3S/c1-2-3-35-13-17-7-10(14)15-5-16-11(7)18(13)12-9(20)8(19)6(29-12)4-28-33(24,25)31-34(26,27)30-32(21,22)23/h5-6,8-9,12,19-20H,2-4H2,1H3,(H,24,25)(H,26,27)(H2,14,15,16)(H2,21,22,23)/t6-,8-,9-,12-/m1/s1
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5.50E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibition of Sprague-Dawley rat liver adenylate kinase 2 by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367087
PNG
(CHEMBL610146)
Show SMILES CCCSc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C13H22N5O13P3S/c1-2-3-35-13-17-7-10(14)15-5-16-11(7)18(13)12-9(20)8(19)6(29-12)4-28-33(24,25)31-34(26,27)30-32(21,22)23/h5-6,8-9,12,19-20H,2-4H2,1H3,(H,24,25)(H,26,27)(H2,14,15,16)(H2,21,22,23)/t6-,8-,9-,12?/m1/s1
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6.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive binding inhibition constant(Ki) of rat adenylate kinase (AK II) isozymes was determined


J Med Chem 25: 638-44 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367048
PNG
(CHEMBL605430)
Show SMILES CCC[C@@H](OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(=O)OC[C@H]1OC([C@H](O)[C@@H]1O)n1c(SCC)nc2c(N)ncnc12)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C25H39N10O22P5S/c1-3-5-10(18-15(37)17(39)23(52-18)34-9-32-12-19(26)28-7-30-21(12)34)53-59(42,43)55-61(46,47)57-62(48,49)56-60(44,45)54-58(40,41)50-6-11-14(36)16(38)24(51-11)35-22-13(20(27)29-8-31-22)33-25(35)63-4-2/h7-11,14-18,23-24,36-39H,3-6H2,1-2H3,(H,40,41)(H,42,43)(H,44,45)(H,46,47)(H,48,49)(H2,26,28,30)(H2,27,29,31)/t10-,11-,14-,15+,16-,17-,18-,23?,24?/m1/s1
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6.30E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat adenylate kinase II was determined in the presence of AMP,competitive and non competitive inhibition


J Med Chem 25: 1179-84 (1983)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50010311
PNG
(CHEMBL2364580)
Show SMILES CCCCSc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C14H24N5O13P3S/c1-2-3-4-36-14-18-8-11(15)16-6-17-12(8)19(14)13-10(21)9(20)7(30-13)5-29-34(25,26)32-35(27,28)31-33(22,23)24/h6-7,9-10,13,20-21H,2-5H2,1H3,(H,25,26)(H,27,28)(H2,15,16,17)(H2,22,23,24)/t7-,9-,10-,13-/m1/s1
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7.50E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibition of Sprague-Dawley rat liver adenylate kinase 2 by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367043
PNG
(CHEMBL604394)
Show SMILES CCSc1nc2c(N)ncnc2n1C1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C12H20N5O13P3S/c1-2-34-12-16-6-9(13)14-4-15-10(6)17(12)11-8(19)7(18)5(28-11)3-27-32(23,24)30-33(25,26)29-31(20,21)22/h4-5,7-8,11,18-19H,2-3H2,1H3,(H,23,24)(H,25,26)(H2,13,14,15)(H2,20,21,22)/t5-,7-,8-,11?/m1/s1
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8.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat adenylate kinase II was determined in the presence of ATP


J Med Chem 25: 1179-84 (1983)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50010312
PNG
(CHEMBL3251360)
Show SMILES CCCCCSc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C15H26N5O13P3S/c1-2-3-4-5-37-15-19-9-12(16)17-7-18-13(9)20(15)14-11(22)10(21)8(31-14)6-30-35(26,27)33-36(28,29)32-34(23,24)25/h7-8,10-11,14,21-22H,2-6H2,1H3,(H,26,27)(H,28,29)(H2,16,17,18)(H2,23,24,25)/t8-,10-,11-,14-/m1/s1
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8.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibition of Sprague-Dawley rat liver adenylate kinase 2 by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50010309
PNG
(CHEMBL3251358)
Show SMILES CCSc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C12H20N5O13P3S/c1-2-34-12-16-6-9(13)14-4-15-10(6)17(12)11-8(19)7(18)5(28-11)3-27-32(23,24)30-33(25,26)29-31(20,21)22/h4-5,7-8,11,18-19H,2-3H2,1H3,(H,23,24)(H,25,26)(H2,13,14,15)(H2,20,21,22)/t5-,7-,8-,11-/m1/s1
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8.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibition of Sprague-Dawley rat liver adenylate kinase 2 by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM18137
PNG
(AMP | CHEMBL752 | [(2R,3S,4R,5R)-5-adenin-9-yl-3,4...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C10H14N5O7P/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(22-10)1-21-23(18,19)20/h2-4,6-7,10,16-17H,1H2,(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
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8.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat adenylate kinase II was determined in the presence of AMP


J Med Chem 25: 1179-84 (1983)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50366480
PNG
(ADENOSINE TRIPHOSPHATE | ATP)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
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9.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat adenylate kinase II was determined in the presence of ATP, non competitive inhibition


J Med Chem 25: 1179-84 (1983)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50010314
PNG
(CHEMBL3251362)
Show SMILES Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c(SCCCCO)nc12
Show InChI InChI=1S/C14H24N5O14P3S/c15-11-8-12(17-6-16-11)19(14(18-8)37-4-2-1-3-20)13-10(22)9(21)7(31-13)5-30-35(26,27)33-36(28,29)32-34(23,24)25/h6-7,9-10,13,20-22H,1-5H2,(H,26,27)(H,28,29)(H2,15,16,17)(H2,23,24,25)/t7-,9-,10-,13-/m1/s1
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1.45E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibition of Sprague-Dawley rat liver adenylate kinase 2 by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50010313
PNG
(CHEMBL3251361)
Show SMILES Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c(SCCO)nc12
Show InChI InChI=1S/C12H20N5O14P3S/c13-9-6-10(15-4-14-9)17(12(16-6)35-2-1-18)11-8(20)7(19)5(29-11)3-28-33(24,25)31-34(26,27)30-32(21,22)23/h4-5,7-8,11,18-20H,1-3H2,(H,24,25)(H,26,27)(H2,13,14,15)(H2,21,22,23)/t5-,7-,8-,11-/m1/s1
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2.50E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibition of Sprague-Dawley rat liver adenylate kinase 2 by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367068
PNG
(CHEMBL609795)
Show SMILES Nc1ncnc2n(C3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c(NCCCCCCNC(=O)CI)nc12
Show InChI InChI=1S/C18H31IN7O14P3/c19-7-11(27)21-5-3-1-2-4-6-22-18-25-12-15(20)23-9-24-16(12)26(18)17-14(29)13(28)10(38-17)8-37-42(33,34)40-43(35,36)39-41(30,31)32/h9-10,13-14,17,28-29H,1-8H2,(H,21,27)(H,22,25)(H,33,34)(H,35,36)(H2,20,23,24)(H2,30,31,32)/t10-,13-,14-,17?/m1/s1
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3.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to inhibit rat adenylate kinase II, activity expressed as Inhibition constant


J Med Chem 25: 382-6 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50010308
PNG
(CHEMBL3251357)
Show SMILES CSc1nc2c(N)ncnc2n1[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H18N5O13P3S/c1-33-11-15-5-8(12)13-3-14-9(5)16(11)10-7(18)6(17)4(27-10)2-26-31(22,23)29-32(24,25)28-30(19,20)21/h3-4,6-7,10,17-18H,2H2,1H3,(H,22,23)(H,24,25)(H2,12,13,14)(H2,19,20,21)/t4-,6-,7-,10-/m1/s1
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3.20E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibition of Sprague-Dawley rat liver adenylate kinase 2 by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367090
PNG
(CHEMBL609545)
Show SMILES Nc1ncnc2n(C3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c(Sc3ccccc3)nc12
Show InChI InChI=1S/C16H20N5O13P3S/c17-13-10-14(19-7-18-13)21(16(20-10)38-8-4-2-1-3-5-8)15-12(23)11(22)9(32-15)6-31-36(27,28)34-37(29,30)33-35(24,25)26/h1-5,7,9,11-12,15,22-23H,6H2,(H,27,28)(H,29,30)(H2,17,18,19)(H2,24,25,26)/t9-,11-,12-,15?/m1/s1
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3.20E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive binding inhibition constant (Ki) of rat adenylate kinase (AK II) isozymes was determined


J Med Chem 25: 638-44 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50010315
PNG
(CHEMBL3251363)
Show SMILES Nc1ncnc2n([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]3O)c(Sc3ccccc3)nc12
Show InChI InChI=1S/C16H20N5O13P3S/c17-13-10-14(19-7-18-13)21(16(20-10)38-8-4-2-1-3-5-8)15-12(23)11(22)9(32-15)6-31-36(27,28)34-37(29,30)33-35(24,25)26/h1-5,7,9,11-12,15,22-23H,6H2,(H,27,28)(H,29,30)(H2,17,18,19)(H2,24,25,26)/t9-,11-,12-,15-/m1/s1
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3.20E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibition of Sprague-Dawley rat liver adenylate kinase 2 by Lineweaver-Burk plot analysis


Citation and Details
More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367104
PNG
(CHEMBL607646)
Show SMILES Nc1ncnc2n(cnc12)C1O[C@@](COP(O)(O)=O)(CC=C)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C13H18N5O7P/c1-2-3-13(4-24-26(21,22)23)9(20)8(19)12(25-13)18-6-17-7-10(14)15-5-16-11(7)18/h2,5-6,8-9,12,19-20H,1,3-4H2,(H2,14,15,16)(H2,21,22,23)/t8-,9+,12?,13-/m1/s1
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3.80E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibitory constant with Rat adenylate kinase II isozyme


J Med Chem 25: 806-12 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367038
PNG
(CHEMBL604815)
Show SMILES CCC[C@H](OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C13H22N5O13P3/c1-2-3-6(29-33(24,25)31-34(26,27)30-32(21,22)23)10-8(19)9(20)13(28-10)18-5-17-7-11(14)15-4-16-12(7)18/h4-6,8-10,13,19-20H,2-3H2,1H3,(H,24,25)(H,26,27)(H2,14,15,16)(H2,21,22,23)/t6-,8-,9+,10+,13?/m0/s1
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4.50E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat adenylate kinase II was determined in the presence of ATP,competitive inhibition


J Med Chem 25: 1179-84 (1983)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367046
PNG
(CHEMBL604395)
Show SMILES CCC[C@@H](OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C13H22N5O13P3/c1-2-3-6(29-33(24,25)31-34(26,27)30-32(21,22)23)10-8(19)9(20)13(28-10)18-5-17-7-11(14)15-4-16-12(7)18/h4-6,8-10,13,19-20H,2-3H2,1H3,(H,24,25)(H,26,27)(H2,14,15,16)(H2,21,22,23)/t6-,8+,9-,10-,13?/m1/s1
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4.50E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat adenylate kinase II was determined in the presence of AMP, competitive inhibition


J Med Chem 25: 1179-84 (1983)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367042
PNG
(CHEMBL606221)
Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](CCOP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H18N5O13P3/c12-9-6-10(14-3-13-9)16(4-15-6)11-8(18)7(17)5(27-11)1-2-26-31(22,23)29-32(24,25)28-30(19,20)21/h3-5,7-8,11,17-18H,1-2H2,(H,22,23)(H,24,25)(H2,12,13,14)(H2,19,20,21)/t5-,7-,8-,11?/m1/s1
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5.40E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat adenylate kinase II was determined in the presence of AMP, competitive inhibition


J Med Chem 25: 1179-84 (1983)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50027422
PNG
(1N-{4-[9-(3,4-dihydroxy-5-hydroxymethyltetrahydro-...)
Show SMILES CN(CCCCN(C)c1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O)C(C)=O
Show InChI InChI=1S/C18H31N6O14P3/c1-11(25)22(2)6-4-5-7-23(3)16-13-17(20-9-19-16)24(10-21-13)18-15(27)14(26)12(36-18)8-35-40(31,32)38-41(33,34)37-39(28,29)30/h9-10,12,14-15,18,26-27H,4-8H2,1-3H3,(H,31,32)(H,33,34)(H2,28,29,30)/t12-,14-,15-,18-/m1/s1
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9.00E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibition of adenylate kinase III in rat liver with respect to ATP


J Med Chem 25: 373-81 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50027451
PNG
(CHEMBL166430 | Phosphoric acid mono-[5-(6-amino-pu...)
Show SMILES COC1C(COP(O)(O)=O)OC(C1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C11H16N5O7P/c1-21-8-5(2-22-24(18,19)20)23-11(7(8)17)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17H,2H2,1H3,(H2,12,13,14)(H2,18,19,20)
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9.40E+5n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibitory constant with Rat adenylate kinase II isozyme


J Med Chem 25: 806-12 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50027422
PNG
(1N-{4-[9-(3,4-dihydroxy-5-hydroxymethyltetrahydro-...)
Show SMILES CN(CCCCN(C)c1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O)C(C)=O
Show InChI InChI=1S/C18H31N6O14P3/c1-11(25)22(2)6-4-5-7-23(3)16-13-17(20-9-19-16)24(10-21-13)18-15(27)14(26)12(36-18)8-35-40(31,32)38-41(33,34)37-39(28,29)30/h9-10,12,14-15,18,26-27H,4-8H2,1-3H3,(H,31,32)(H,33,34)(H2,28,29,30)/t12-,14-,15-,18-/m1/s1
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1.10E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibition of adenylate kinase II in rat liver with respect to ATP


J Med Chem 25: 373-81 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367067
PNG
(CHEMBL612174)
Show SMILES CN(CCCCN(C)c1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O)C(=O)CCCCCCNC(=O)CI
Show InChI InChI=1S/C25H43IN7O15P3/c1-31(19(35)9-5-3-4-6-10-27-18(34)13-26)11-7-8-12-32(2)23-20-24(29-15-28-23)33(16-30-20)25-22(37)21(36)17(46-25)14-45-50(41,42)48-51(43,44)47-49(38,39)40/h15-17,21-22,25,36-37H,3-14H2,1-2H3,(H,27,34)(H,41,42)(H,43,44)(H2,38,39,40)/t17-,21-,22-,25?/m1/s1
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1.60E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to inhibit rat adenylate kinase II, activity expressed as Inhibition constant


J Med Chem 25: 382-6 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367066
PNG
(CHEMBL610373)
Show SMILES CN(CCCCCCN(C)c1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O)C(=O)CCCCCCNC(=O)CI
Show InChI InChI=1S/C27H47IN7O15P3/c1-33(21(37)11-7-3-4-8-12-29-20(36)15-28)13-9-5-6-10-14-34(2)25-22-26(31-17-30-25)35(18-32-22)27-24(39)23(38)19(48-27)16-47-52(43,44)50-53(45,46)49-51(40,41)42/h17-19,23-24,27,38-39H,3-16H2,1-2H3,(H,29,36)(H,43,44)(H,45,46)(H2,40,41,42)/t19-,23-,24-,27?/m1/s1
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1.80E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to inhibit rat adenylate kinase II, activity expressed as Inhibition constant


J Med Chem 25: 382-6 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367073
PNG
(CHEMBL609819)
Show SMILES CN(CCCCCCN(C)c1ncnc2n(cnc12)C1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O)C(=O)CCCCCNC(=O)CI
Show InChI InChI=1S/C26H45IN7O15P3/c1-32(20(36)10-6-5-7-11-28-19(35)14-27)12-8-3-4-9-13-33(2)24-21-25(30-16-29-24)34(17-31-21)26-23(38)22(37)18(47-26)15-46-51(42,43)49-52(44,45)48-50(39,40)41/h16-18,22-23,26,37-38H,3-15H2,1-2H3,(H,28,35)(H,42,43)(H,44,45)(H2,39,40,41)/t18-,22-,23-,26?/m1/s1
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1.90E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to inhibit rat adenylate kinase II, activity expressed as Inhibition constant


J Med Chem 25: 382-6 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367037
PNG
(CHEMBL606008)
Show SMILES C[C@H](OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C11H18N5O13P3/c1-4(27-31(22,23)29-32(24,25)28-30(19,20)21)8-6(17)7(18)11(26-8)16-3-15-5-9(12)13-2-14-10(5)16/h2-4,6-8,11,17-18H,1H3,(H,22,23)(H,24,25)(H2,12,13,14)(H2,19,20,21)/t4-,6-,7+,8+,11?/m0/s1
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2.00E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat adenylate kinase II was determined in the presence of ATP,competitive inhibition


J Med Chem 25: 1179-84 (1983)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367098
PNG
(CHEMBL607630)
Show SMILES CCC[C@H](OP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C13H20N5O7P/c1-2-3-6(25-26(21,22)23)10-8(19)9(20)13(24-10)18-5-17-7-11(14)15-4-16-12(7)18/h4-6,8-10,13,19-20H,2-3H2,1H3,(H2,14,15,16)(H2,21,22,23)/t6-,8-,9+,10+,13?/m0/s1
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2.10E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Non-competitive inhibitory constant of compound with Rat adenylate kinase II isozyme


J Med Chem 25: 806-12 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50027448
PNG
(CHEMBL167355 | Phosphoric acid mono-[6-(6-amino-pu...)
Show SMILES CC1(C)OC2C(COP(O)(O)=O)OC(C2O1)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C13H18N5O7P/c1-13(2)24-8-6(3-22-26(19,20)21)23-12(9(8)25-13)18-5-17-7-10(14)15-4-16-11(7)18/h4-6,8-9,12H,3H2,1-2H3,(H2,14,15,16)(H2,19,20,21)
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2.10E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibitory constant with Rat adenylate kinase II isozyme


J Med Chem 25: 806-12 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367039
PNG
(CHEMBL604398)
Show SMILES C[C@@H](OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C11H18N5O13P3/c1-4(27-31(22,23)29-32(24,25)28-30(19,20)21)8-6(17)7(18)11(26-8)16-3-15-5-9(12)13-2-14-10(5)16/h2-4,6-8,11,17-18H,1H3,(H,22,23)(H,24,25)(H2,12,13,14)(H2,19,20,21)/t4-,6+,7-,8-,11?/m1/s1
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2.20E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat adenylate kinase II was determined in the presence of ATP


J Med Chem 25: 1179-84 (1983)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367103
PNG
(CHEMBL608483)
Show SMILES CC[C@H](OP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C12H18N5O7P/c1-2-5(24-25(20,21)22)9-7(18)8(19)12(23-9)17-4-16-6-10(13)14-3-15-11(6)17/h3-5,7-9,12,18-19H,2H2,1H3,(H2,13,14,15)(H2,20,21,22)/t5-,7-,8+,9+,12?/m0/s1
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2.40E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Non-competitive/Competitive inhibitory constant of compound with Rat adenylate kinase II isozyme


J Med Chem 25: 806-12 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50027455
PNG
(CHEMBL353011 | Phosphoric acid mono-[6-(6-amino-pu...)
Show SMILES CCC1OC2C(COP(O)(O)=O)OC(C2O1)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C13H18N5O7P/c1-2-7-24-9-6(3-22-26(19,20)21)23-13(10(9)25-7)18-5-17-8-11(14)15-4-16-12(8)18/h4-7,9-10,13H,2-3H2,1H3,(H2,14,15,16)(H2,19,20,21)
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2.70E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibitory constant with Rat adenylate kinase II isozyme


J Med Chem 25: 806-12 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50027446
PNG
(CHEMBL355659 | Phosphoric acid mono-[6-(6-amino-pu...)
Show SMILES CC1OC2C(COP(O)(O)=O)OC(C2O1)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C12H16N5O7P/c1-5-22-8-6(2-21-25(18,19)20)24-12(9(8)23-5)17-4-16-7-10(13)14-3-15-11(7)17/h3-6,8-9,12H,2H2,1H3,(H2,13,14,15)(H2,18,19,20)
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2.70E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibitory constant with Rat adenylate kinase II isozyme


J Med Chem 25: 806-12 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367045
PNG
(CHEMBL605010)
Show SMILES CCC[C@@H](OP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C13H20N5O7P/c1-2-3-6(25-26(21,22)23)10-8(19)9(20)13(24-10)18-5-17-7-11(14)15-4-16-12(7)18/h4-6,8-10,13,19-20H,2-3H2,1H3,(H2,14,15,16)(H2,21,22,23)/t6-,8+,9-,10-,13?/m1/s1
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3.20E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibitory constant with Rat adenylate kinase II isozyme


J Med Chem 25: 806-12 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367045
PNG
(CHEMBL605010)
Show SMILES CCC[C@@H](OP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C13H20N5O7P/c1-2-3-6(25-26(21,22)23)10-8(19)9(20)13(24-10)18-5-17-7-11(14)15-4-16-12(7)18/h4-6,8-10,13,19-20H,2-3H2,1H3,(H2,14,15,16)(H2,21,22,23)/t6-,8+,9-,10-,13?/m1/s1
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3.20E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory activity against rat adenylate kinase II was determined in the presence of AMP, non competitive inhibition


J Med Chem 25: 1179-84 (1983)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50027447
PNG
(CHEMBL167729 | Phosphoric acid mono-[5-(6-amino-pu...)
Show SMILES COC1C(O)C(COP(O)(O)=O)OC1n1cnc2c(N)ncnc12
Show InChI InChI=1S/C11H16N5O7P/c1-21-8-7(17)5(2-22-24(18,19)20)23-11(8)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17H,2H2,1H3,(H2,12,13,14)(H2,18,19,20)
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3.60E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibitory constant with Rat adenylate kinase II isozyme


J Med Chem 25: 806-12 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367106
PNG
(CHEMBL609083)
Show SMILES CNc1ncnc2n(cnc12)C1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H16N5O7P/c1-12-9-6-10(14-3-13-9)16(4-15-6)11-8(18)7(17)5(23-11)2-22-24(19,20)21/h3-5,7-8,11,17-18H,2H2,1H3,(H,12,13,14)(H2,19,20,21)/t5-,7-,8-,11?/m1/s1
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4.20E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Non-competitive inhibitory constant of compound with Rat adenylate kinase II isozyme


J Med Chem 25: 806-12 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Homo sapiens)
BDBM50367071
PNG
(CHEMBL607736)
Show SMILES O[C@@H]1[C@@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)OC([C@@H]1O)n1cnc2c(NCCCCCNC(=O)OCc3ccccc3)ncnc12
Show InChI InChI=1S/C23H33N6O15P3/c30-18-16(12-41-46(36,37)44-47(38,39)43-45(33,34)35)42-22(19(18)31)29-14-28-17-20(26-13-27-21(17)29)24-9-5-2-6-10-25-23(32)40-11-15-7-3-1-4-8-15/h1,3-4,7-8,13-14,16,18-19,22,30-31H,2,5-6,9-12H2,(H,25,32)(H,36,37)(H,38,39)(H,24,26,27)(H2,33,34,35)/t16-,18-,19-,22?/m1/s1
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4.70E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Ability to inhibit Escherichia coli adenylate kinase II, activity expressed as Inhibition constant


J Med Chem 25: 382-6 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367100
PNG
(CHEMBL607942)
Show SMILES CC[C@@H](OP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C12H18N5O7P/c1-2-5(24-25(20,21)22)9-7(18)8(19)12(23-9)17-4-16-6-10(13)14-3-15-11(6)17/h3-5,7-9,12,18-19H,2H2,1H3,(H2,13,14,15)(H2,20,21,22)/t5-,7+,8-,9-,12?/m1/s1
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5.40E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibitory constant with Rat adenylate kinase II isozyme


J Med Chem 25: 806-12 (1982)

More data for this
Ligand-Target Pair
Adenylate kinase 2


(Rattus norvegicus)
BDBM50367110
PNG
(CHEMBL609073)
Show SMILES CN(C)c1nc(N)c2ncn(C3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)c2n1
Show InChI InChI=1S/C12H19N6O7P/c1-17(2)12-15-9(13)6-10(16-12)18(4-14-6)11-8(20)7(19)5(25-11)3-24-26(21,22)23/h4-5,7-8,11,19-20H,3H2,1-2H3,(H2,13,15,16)(H2,21,22,23)/t5-,7-,8-,11?/m1/s1
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5.80E+6n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Competitive inhibitory constant with Rat adenylate kinase II isozyme


J Med Chem 25: 806-12 (1982)

More data for this
Ligand-Target Pair
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