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Compile Data Set for Download or QSAR

Found 33 hits for UniProtKB: P01589    Zinc 0: unavailable per Zinc DB. Zinc 1: purchasable, 2 weeks to supply. Zinc 2: made on demand. Zinc 4: potentially available
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL429852
PNG
(5-[2,3-DICHLORO-4-(5-{1-[2-(2-GUANIDINO-4-METHYL-P...)
Show SMILES CC(C)CC([NH+]=C(N)N)C(=O)NCC(=O)N1CCC(CC1)c1cc(nn1C)-c1ccc(OCc2ccc(o2)C([O-])=O)c(Cl)c1Cl
Show InChI InChI=1/C30H37Cl2N7O6/c1-16(2)12-21(36-30(33)34)28(41)35-14-25(40)39-10-8-17(9-11-39)22-13-20(37-38(22)3)19-5-7-23(27(32)26(19)31)44-15-18-4-6-24(45-18)29(42)43/h4-7,13,16-17,21H,8-12,14-15H2,1-3H3,(H,35,41)(H,42,43)(H4,33,34,36)
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ChEBI
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PC cid
PC sid
ZINC 0

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Article
PubMed
n/an/a 60.0n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL182704
PNG
(5-[2,3-Dichloro-4-(1-methyl-5-{1-[3-(N-methyl-guan...)
Show SMILES CN(CCCNS(=O)(=O)N1CCC(CC1)c1cc(nn1C)-c1ccc(OCc2ccc(o2)C(O)=O)c(Cl)c1Cl)C(N)=N
Show InChI InChI=1S/C26H33Cl2N7O6S/c1-33(26(29)30)11-3-10-31-42(38,39)35-12-8-16(9-13-35)20-14-19(32-34(20)2)18-5-7-21(24(28)23(18)27)40-15-17-4-6-22(41-17)25(36)37/h4-7,14,16,31H,3,8-13,15H2,1-2H3,(H3,29,30)(H,36,37)
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PubMed
n/an/a 600.0n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL419362
PNG
((S)-2-[2-((R)-1-Carbamimidoyl-piperidin-3-yl)-acet...)
Show SMILES COC(=O)[C@H](Cc1ccc(cc1)C#Cc1ccccc1)NC(=O)C[C@H]1CCCN(C1)C(N)=N
Show InChI InChI=1S/C26H30N4O3/c1-33-25(32)23(29-24(31)17-22-8-5-15-30(18-22)26(27)28)16-21-13-11-20(12-14-21)10-9-19-6-3-2-4-7-19/h2-4,6-7,11-14,22-23H,5,8,15-18H2,1H3,(H3,27,28)(H,29,31)/t22-,23+/m1/s1
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n/an/a 3000.0n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL106187
PNG
((R)-2-Cyclohexyl-N-(2-{4-[5-(2,3-dichloro-phenyl)-...)
Show SMILES NC(N)=N[C@H](C1CCCCC1)C(=O)NCC(=O)N1CCC(CC1)c1cc(n[nH]1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C25H33Cl2N7O2/c26-18-8-4-7-17(22(18)27)20-13-19(32-33-20)15-9-11-34(12-10-15)21(35)14-30-24(36)23(31-25(28)29)16-5-2-1-3-6-16/h4,7-8,13,15-16,23H,1-3,5-6,9-12,14H2,(H,30,36)(H,32,33)(H4,28,29,31)/t23-/m1/s1
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n/an/a 6000.0n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL181294
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES CN(C)C(=O)[C@H](CCNC(=O)N1CCC(CC1)c1cc(nn1C)-c1cccc(Cl)c1Cl)N=C(N)N
Show InChI InChI=1S/C23H32Cl2N8O2/c1-31(2)21(34)17(29-22(26)27)7-10-28-23(35)33-11-8-14(9-12-33)19-13-18(30-32(19)3)15-5-4-6-16(24)20(15)25/h4-6,13-14,17H,7-12H2,1-3H3,(H,28,35)(H4,26,27,29)/t17-/m0/s1
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n/an/a 7000.0n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL362041
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES CCN(CC)C(=O)[C@H](CCNC(=O)N1CCC(CC1)c1cc(nn1C)-c1cccc(Cl)c1Cl)N=C(N)N
Show InChI InChI=1S/C25H36Cl2N8O2/c1-4-34(5-2)23(36)19(31-24(28)29)9-12-30-25(37)35-13-10-16(11-14-35)21-15-20(32-33(21)3)17-7-6-8-18(26)22(17)27/h6-8,15-16,19H,4-5,9-14H2,1-3H3,(H,30,37)(H4,28,29,31)/t19-/m0/s1
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PubMed
n/an/a 11000.0n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL179083
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES CN(CCCNS(=O)(=O)N1CCC(CC1)c1cc(nn1C)-c1cccc(Cl)c1Cl)C(N)=N
Show InChI InChI=1S/C20H29Cl2N7O2S/c1-27(20(23)24)10-4-9-25-32(30,31)29-11-7-14(8-12-29)18-13-17(26-28(18)2)15-5-3-6-16(21)19(15)22/h3,5-6,13-14,25H,4,7-12H2,1-2H3,(H3,23,24)
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n/an/a 14000.0n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL181692
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES CN(CCCNC(=O)N1CCC(CC1)c1cc(nn1C)-c1cccc(Cl)c1Cl)C(N)=N
Show InChI InChI=1S/C21H29Cl2N7O/c1-28(20(24)25)10-4-9-26-21(31)30-11-7-14(8-12-30)18-13-17(27-29(18)2)15-5-3-6-16(22)19(15)23/h3,5-6,13-14H,4,7-12H2,1-2H3,(H3,24,25)(H,26,31)
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PubMed
n/an/a 16000.0n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL181983
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES Cn1nc(cc1C1CCN(CC1)C(=O)NCC[C@H](N=C(N)N)C(=O)N1CCCC1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C25H34Cl2N8O2/c1-33-21(15-20(32-33)17-5-4-6-18(26)22(17)27)16-8-13-35(14-9-16)25(37)30-10-7-19(31-24(28)29)23(36)34-11-2-3-12-34/h4-6,15-16,19H,2-3,7-14H2,1H3,(H,30,37)(H4,28,29,31)/t19-/m0/s1
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ZINC 0

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PubMed
n/an/a 20000.0n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL180014
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES CC(C)C[C@H](CCNC(=O)N1CCC(CC1)c1cc(nn1C)-c1cccc(Cl)c1Cl)N=C(N)N
Show InChI InChI=1S/C24H35Cl2N7O/c1-15(2)13-17(30-23(27)28)7-10-29-24(34)33-11-8-16(9-12-33)21-14-20(31-32(21)3)18-5-4-6-19(25)22(18)26/h4-6,14-17H,7-13H2,1-3H3,(H,29,34)(H4,27,28,30)/t17-/m0/s1
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PubMed
n/an/a 23000.0n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL180601
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES Cn1nc(cc1C1CCN(CC1)S(=O)(=O)NCCCNC(N)=N)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C19H27Cl2N7O2S/c1-27-17(12-16(26-27)14-4-2-5-15(20)18(14)21)13-6-10-28(11-7-13)31(29,30)25-9-3-8-24-19(22)23/h2,4-5,12-13,25H,3,6-11H2,1H3,(H4,22,23,24)
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PubMed
n/an/a 23000.0n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL180756
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES Cn1nc(cc1C1CCN(CC1)C(=O)NCCCNC(N)=N)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C20H27Cl2N7O/c1-28-17(12-16(27-28)14-4-2-5-15(21)18(14)22)13-6-10-29(11-7-13)20(30)26-9-3-8-25-19(23)24/h2,4-5,12-13H,3,6-11H2,1H3,(H,26,30)(H4,23,24,25)
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PubMed
n/an/a 29000.0n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL361550
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES CC(C)C[C@H](CCNS(=O)(=O)N1CCC(CC1)c1cc(nn1C)-c1cccc(Cl)c1Cl)N=C(N)N
Show InChI InChI=1S/C23H35Cl2N7O2S/c1-15(2)13-17(29-23(26)27)7-10-28-35(33,34)32-11-8-16(9-12-32)21-14-20(30-31(21)3)18-5-4-6-19(24)22(18)25/h4-6,14-17,28H,7-13H2,1-3H3,(H4,26,27,29)/t17-/m0/s1
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PubMed
n/an/a 30000.0n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL178800
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES CCCN(CCCNS(=O)(=O)N1CCC(CC1)c1cc(nn1C)-c1cccc(Cl)c1Cl)C(N)=N
Show InChI InChI=1S/C22H33Cl2N7O2S/c1-3-11-30(22(25)26)12-5-10-27-34(32,33)31-13-8-16(9-14-31)20-15-19(28-29(20)2)17-6-4-7-18(23)21(17)24/h4,6-7,15-16,27H,3,5,8-14H2,1-2H3,(H3,25,26)
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PubMed
n/an/a 32000.0n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL182098
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES CC(C)N(CCCNS(=O)(=O)N1CCC(CC1)c1cc(nn1C)-c1cccc(Cl)c1Cl)C(N)=N
Show InChI InChI=1S/C22H33Cl2N7O2S/c1-15(2)31(22(25)26)11-5-10-27-34(32,33)30-12-8-16(9-13-30)20-14-19(28-29(20)3)17-6-4-7-18(23)21(17)24/h4,6-7,14-16,27H,5,8-13H2,1-3H3,(H3,25,26)
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n/an/a 48000.0n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL427132
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES CC(C)[C@H](CCNC(=O)N1CCC(CC1)c1cc(nn1C)-c1cccc(Cl)c1Cl)N=C(N)N
Show InChI InChI=1S/C23H33Cl2N7O/c1-14(2)18(29-22(26)27)7-10-28-23(33)32-11-8-15(9-12-32)20-13-19(30-31(20)3)16-5-4-6-17(24)21(16)25/h4-6,13-15,18H,7-12H2,1-3H3,(H,28,33)(H4,26,27,29)/t18-/m0/s1
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n/an/a 55000.0n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL181558
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES C[C@H](CCNC(=O)N1CCC(CC1)c1cc(nn1C)-c1cccc(Cl)c1Cl)NC(N)=N
Show InChI InChI=1S/C21H29Cl2N7O/c1-13(27-20(24)25)6-9-26-21(31)30-10-7-14(8-11-30)18-12-17(28-29(18)2)15-4-3-5-16(22)19(15)23/h3-5,12-14H,6-11H2,1-2H3,(H,26,31)(H4,24,25,27)/t13-/m1/s1
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Article
PubMed
n/an/a 57000.0n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL369721
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES CCN(CC1CC1)C(=O)[C@H](CCNC(=O)N1CCC(CC1)c1cc(nn1C)-c1cccc(Cl)c1Cl)N=C(N)N
Show InChI InChI=1S/C27H38Cl2N8O2/c1-3-36(16-17-7-8-17)25(38)21(33-26(30)31)9-12-32-27(39)37-13-10-18(11-14-37)23-15-22(34-35(23)2)19-5-4-6-20(28)24(19)29/h4-6,15,17-18,21H,3,7-14,16H2,1-2H3,(H,32,39)(H4,30,31,33)/t21-/m0/s1
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Article
PubMed
n/an/a 60000.0n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL181841
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES CC(=O)N1CCN(CC1)C(=O)[C@H](CCNC(=O)N1CCC(CC1)c1cc(nn1C)-c1cccc(Cl)c1Cl)N=C(N)N
Show InChI InChI=1S/C27H37Cl2N9O3/c1-17(39)36-12-14-37(15-13-36)25(40)21(33-26(30)31)6-9-32-27(41)38-10-7-18(8-11-38)23-16-22(34-35(23)2)19-4-3-5-20(28)24(19)29/h3-5,16,18,21H,6-15H2,1-2H3,(H,32,41)(H4,30,31,33)/t21-/m0/s1
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n/an/a 60000.0n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL181987
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES CC(C)[C@H](CCNS(=O)(=O)N1CCC(CC1)c1cc(nn1C)-c1cccc(Cl)c1Cl)N=C(N)N
Show InChI InChI=1S/C22H33Cl2N7O2S/c1-14(2)18(28-22(25)26)7-10-27-34(32,33)31-11-8-15(9-12-31)20-13-19(29-30(20)3)16-5-4-6-17(23)21(16)24/h4-6,13-15,18,27H,7-12H2,1-3H3,(H4,25,26,28)/t18-/m0/s1
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n/an/a 76000.0n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL179076
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES C[C@H](CCNS(=O)(=O)N1CCC(CC1)c1cc(nn1C)-c1cccc(Cl)c1Cl)NC(N)=N
Show InChI InChI=1S/C20H29Cl2N7O2S/c1-13(26-20(23)24)6-9-25-32(30,31)29-10-7-14(8-11-29)18-12-17(27-28(18)2)15-4-3-5-16(21)19(15)22/h3-5,12-14,25H,6-11H2,1-2H3,(H4,23,24,26)/t13-/m1/s1
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n/an/a 90000.0n/an/an/an/an/an/a



Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL179116
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES Cn1nc(cc1C1CCN(CC1)C(=O)NCCNC(N)=N)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C19H25Cl2N7O/c1-27-16(11-15(26-27)13-3-2-4-14(20)17(13)21)12-5-9-28(10-6-12)19(29)25-8-7-24-18(22)23/h2-4,11-12H,5-10H2,1H3,(H,25,29)(H4,22,23,24)
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Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL181513
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES CC(C)[C@@H](CCNS(=O)(=O)N1CCC(CC1)c1cc(nn1C)-c1cccc(Cl)c1Cl)N=C(N)N
Show InChI InChI=1S/C22H33Cl2N7O2S/c1-14(2)18(28-22(25)26)7-10-27-34(32,33)31-11-8-15(9-12-31)20-13-19(29-30(20)3)16-5-4-6-17(23)21(16)24/h4-6,13-15,18,27H,7-12H2,1-3H3,(H4,25,26,28)/t18-/m1/s1
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Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL360913
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES Cn1nc(cc1C1CCN(CC1)S(=O)(=O)NCCNC(N)=N)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C18H25Cl2N7O2S/c1-26-16(11-15(25-26)13-3-2-4-14(19)17(13)20)12-5-9-27(10-6-12)30(28,29)24-8-7-23-18(21)22/h2-4,11-12,24H,5-10H2,1H3,(H4,21,22,23)
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Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL181019
PNG
(4-({4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol...)
Show SMILES Cn1nc(cc1C1CCN(CC1)C(=O)NCC[C@H](N=C(N)N)C(O)=O)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C21H27Cl2N7O3/c1-29-17(11-16(28-29)13-3-2-4-14(22)18(13)23)12-6-9-30(10-7-12)21(33)26-8-5-15(19(31)32)27-20(24)25/h2-4,11-12,15H,5-10H2,1H3,(H,26,33)(H,31,32)(H4,24,25,27)/t15-/m0/s1
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Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL362026
PNG
(4-({4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol...)
Show SMILES COC(=O)[C@H](CCNC(=O)N1CCC(CC1)c1cc(nn1C)-c1cccc(Cl)c1Cl)N=C(N)N
Show InChI InChI=1S/C22H29Cl2N7O3/c1-30-18(12-17(29-30)14-4-3-5-15(23)19(14)24)13-7-10-31(11-8-13)22(33)27-9-6-16(20(32)34-2)28-21(25)26/h3-5,12-13,16H,6-11H2,1-2H3,(H,27,33)(H4,25,26,28)/t16-/m0/s1
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Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL360778
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES CC(C)[C@@H](CCNC(=O)N1CCC(CC1)c1cc(nn1C)-c1cccc(Cl)c1Cl)N=C(N)N
Show InChI InChI=1S/C23H33Cl2N7O/c1-14(2)18(29-22(26)27)7-10-28-23(33)32-11-8-15(9-12-32)20-13-19(30-31(20)3)16-5-4-6-17(24)21(16)25/h4-6,13-15,18H,7-12H2,1-3H3,(H,28,33)(H4,26,27,29)/t18-/m1/s1
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Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL359895
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES Cn1nc(cc1C1CCN(CC1)C(=O)NCC[C@H](N=C(N)N)C(=O)N1CCC2CCCCC2C1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C30H42Cl2N8O2/c1-38-26(17-25(37-38)22-7-4-8-23(31)27(22)32)20-11-14-39(15-12-20)30(42)35-13-9-24(36-29(33)34)28(41)40-16-10-19-5-2-3-6-21(19)18-40/h4,7-8,17,19-21,24H,2-3,5-6,9-16,18H2,1H3,(H,35,42)(H4,33,34,36)/t19?,21?,24-/m0/s1
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Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL361641
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES CNC(=O)[C@H](CCNC(=O)N1CCC(CC1)c1cc(nn1C)-c1cccc(Cl)c1Cl)N=C(N)N
Show InChI InChI=1S/C22H30Cl2N8O2/c1-27-20(33)16(29-21(25)26)6-9-28-22(34)32-10-7-13(8-11-32)18-12-17(30-31(18)2)14-4-3-5-15(23)19(14)24/h3-5,12-13,16H,6-11H2,1-2H3,(H,27,33)(H,28,34)(H4,25,26,29)/t16-/m0/s1
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Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL181189
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES CC(C)N(CCCNC(=O)N1CCC(CC1)c1cc(nn1C)-c1cccc(Cl)c1Cl)C(N)=N
Show InChI InChI=1S/C23H33Cl2N7O/c1-15(2)32(22(26)27)11-5-10-28-23(33)31-12-8-16(9-13-31)20-14-19(29-30(20)3)17-6-4-7-18(24)21(17)25/h4,6-7,14-16H,5,8-13H2,1-3H3,(H3,26,27)(H,28,33)
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Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL180764
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES Cn1nc(cc1C1CCN(CC1)S(=O)(=O)NCCCCNC(N)=N)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C20H29Cl2N7O2S/c1-28-18(13-17(27-28)15-5-4-6-16(21)19(15)22)14-7-11-29(12-8-14)32(30,31)26-10-3-2-9-25-20(23)24/h4-6,13-14,26H,2-3,7-12H2,1H3,(H4,23,24,25)
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Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL178466
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES Cn1nc(cc1C1CCN(CC1)C(=O)NCCCCNC(N)=N)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C21H29Cl2N7O/c1-29-18(13-17(28-29)15-5-4-6-16(22)19(15)23)14-7-11-30(12-8-14)21(31)27-10-3-2-9-26-20(24)25/h4-6,13-14H,2-3,7-12H2,1H3,(H,27,31)(H4,24,25,26)
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Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair
Interleukin-2 receptor alpha chain


(Homo sapiens)
CHEMBL178414
PNG
(4-[5-(2,3-Dichloro-phenyl)-2-methyl-2H-pyrazol-3-y...)
Show SMILES CCCN(CCCNC(=O)N1CCC(CC1)c1cc(nn1C)-c1cccc(Cl)c1Cl)C(N)=N
Show InChI InChI=1S/C23H33Cl2N7O/c1-3-11-31(22(26)27)12-5-10-28-23(33)32-13-8-16(9-14-32)20-15-19(29-30(20)2)17-6-4-7-18(24)21(17)25/h4,6-7,15-16H,3,5,8-14H2,1-2H3,(H3,26,27)(H,28,33)
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Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL


Assay Description
Inhibitory concentration against interleukin-2 binding


Citation and Details
More data for this
Ligand-Target Pair