Compile Data Set for Download or QSAR
maximum 50k data
Found 55 of ic50 for UniProtKB: A0A024R562
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM555343((R)-4-(4-((2-(3-(difluoromethyl)bicyclo[1.1.1]pent...)
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM50270877((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...)
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM552934((R)-4-(4-((2-(3-chlorobicyclo[1.1.1]pentan-1-yl)-5...)
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM552931((R)-4-(4-((5,5-dimethyl-2-(3-methylbicyclo[1.1.1]p...)
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM552935((R)-4-(4-((4,4-dimethyl-2-(3-methylbicyclo[1.1.1]p...)
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM552936((R)-4-(4-((2-(3-Ethylbicyclo[1.1.1]pentan-1-yl)-4,...)
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM555333((R)-4-(4-((2-(3-(difluoromethyl)bicyclo[1.1.1]pent...)
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM555342((R)-4-(4-((2-(3-(difluoromethyl)bicyclo[1.1.1]pent...)
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM552945((R)-4-(4-((6-(3-(difluoromethyl)bicyclo[1.1.1]pent...)
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM555340((R)-4-(4-((2-(3-(difluoromethyl)bicyclo[1.1.1]pent...)
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM555339((R)-4-(4-((2-(3-(Difluoromethyl)bicyclo[1.1.1]pent...)
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM555338((R)-4-(4-((2-(3-(Difluoromethyl)bicyclo[1.1.1]pent...)
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM555337((R)-4-(4-((2-(3-(Difluoromethyl)bicyclo[1.1.1]pent...)
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM555336((R)-4-(4-((2-(3-(difluoromethyl)bicyclo[1.1.1]pent...)
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM552939((R)-4-(4-((4,4-dimethyl-2-(3-methylbicyclo[1.1.1]p...)
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM555334((R)-4-(4-((2-(3-(difluoromethyl)bicyclo[1.1.1]pent...)
Affinity DataIC50: <10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50373072(CHEMBL402005)
Affinity DataIC50:  36nMAssay Description:Binding affinity to Bcl-XLMore data for this Ligand-Target Pair
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM555320(2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-4-(4-((2-(3...)
Affinity DataIC50:  55nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM60828(ABT-199 | BDBM189459 | US10213433, Compound 5 | US...)
Affinity DataIC50:  55nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM552911(2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((4,4-di...)
Affinity DataIC50: >100nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM552914(2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-4-(4-((4,4-di...)
Affinity DataIC50: >100nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50254587(1-(2-((S)-3-(aminomethyl)-1,2,3,4-tetrahydroisoqui...)
Affinity DataIC50:  250nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 16 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50254595(CHEMBL502066 | N,N-dibutyl-5-methyl-1-(4-(2-(pheny...)
Affinity DataIC50:  400nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 26 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50254536(1-(2-((S)-3-(aminomethyl)-1,2,3,4-tetrahydroisoqui...)
Affinity DataIC50:  808nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 26 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50424726(CHEMBL2314176 | US10093640, Example 6 | US10844032...)
Affinity DataIC50:  990nMpH: 7.5 T: 2°CAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50424725(CHEMBL2314177 | US10093640, Example 5 | US10844032...)
Affinity DataIC50:  1.10E+3nMpH: 7.5 T: 2°CAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50254585(1-(2-((S)-3-(aminomethyl)-1,2,3,4-tetrahydroisoqui...)
Affinity DataIC50:  1.61E+3nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 16 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50324474(CHEMBL1215012 | sodium(2S,2'S,5R,5'R,6R,6'R)-6,6'-...)
Affinity DataIC50:  1.76E+3nMAssay Description:Displacement of FITC-labeled Bak-BH3 peptide from Bcl-XL after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM50424727(CHEMBL2314173 | US10093640, Example 2 | US10844032...)
Affinity DataIC50:  1.90E+3nMpH: 7.5 T: 2°CAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM50254584(4-chloro-1-(2-((S)-3-(hydroxymethyl)-1,2,3,4-tetra...)
Affinity DataIC50:  2.28E+3nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 16 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM50254590(CHEMBL449546 | N,N-dibutyl-4-chloro-5-methyl-1-(4-...)
Affinity DataIC50:  2.37E+3nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 26 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM50254591(CHEMBL504480 | N,N-dibutyl-4-chloro-5-methyl-1-(4-...)
Affinity DataIC50:  2.38E+3nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 26 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM50254583(4-bromo-1-(2-((S)-3-(hydroxymethyl)-1,2,3,4-tetrah...)
Affinity DataIC50:  2.41E+3nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 16 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50254596(CHEMBL451856 | N,N-dibutyl-5-methyl-1-(4-(2-phenox...)
Affinity DataIC50:  3.05E+3nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 26 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM50254593(1-[2-(3,4-Dihydro-1H-isoquinoline-2-carbonyl)-4-(2...)
Affinity DataIC50:  3.24E+3nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 26 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM50254521(CHEMBL516633 | N-cyclohexyl-5-methyl-N-phenyl-1-(2...)
Affinity DataIC50:  4.11E+3nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 16 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM50424737(CHEMBL2314519 | US10093640, Example 21 | US1084403...)
Affinity DataIC50:  4.60E+3nMpH: 7.5 T: 2°CAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM50254587(1-(2-((S)-3-(aminomethyl)-1,2,3,4-tetrahydroisoqui...)
Affinity DataIC50:  5.05E+3nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 26 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM50254529(CHEMBL453466 | methyl 2-((S)-2-(2-(3-(diphenylcarb...)
Affinity DataIC50:  5.17E+3nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 16 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM50254582(5-methyl-1-(2-((R)-3-methyl-1,2,3,4-tetrahydroisoq...)
Affinity DataIC50:  5.24E+3nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 16 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM50254525(1-(2-((S)-3-(methoxymethyl)-1,2,3,4-tetrahydroisoq...)
Affinity DataIC50:  5.57E+3nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 16 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM50254594(2-(4-(3-(dibutylcarbamoyl)-5-methyl-1H-pyrazol-1-y...)
Affinity DataIC50:  5.64E+3nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 26 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM50424738(CHEMBL2314516 | US10093640, Example 1 | US10844032...)
Affinity DataIC50:  5.80E+3nMpH: 7.5 T: 2°CAssay Description:Compound affinity was measured using a fluorescence polarization anisotropy competition assay. Anisotropy measurements were carried out in 384-well, ...More data for this Ligand-Target Pair
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM50254535(1-(4-amino-2-((S)-3-(aminomethyl)-1,2,3,4-tetrahyd...)
Affinity DataIC50:  6.16E+3nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 26 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM50254530(1-(2-((S)-3-((dimethylamino)methyl)-1,2,3,4-tetrah...)
Affinity DataIC50:  6.79E+3nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 16 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM50270876(3-((E)-2-Biphenyl-3-yl-vinyl)-4'-fluoro-biphenyl-4...)
Affinity DataIC50:  6.90E+3nMAssay Description:Binding affinity to BH3 binding groove of BclXLMore data for this Ligand-Target Pair
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TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM50254534(CHEMBL467229 | N,N-dibutyl-4-chloro-1-(2-((S)-3-(h...)
Affinity DataIC50:  6.94E+3nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 26 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM50254588(1-(4-amino-2-(1,2,3,4-tetrahydroisoquinoline-2-car...)
Affinity DataIC50:  7.99E+3nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 26 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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LigandPNGBDBM50254526(1-(2-((S)-3-(acetamidomethyl)-1,2,3,4-tetrahydrois...)
Affinity DataIC50:  9.69E+3nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 16 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))
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US Patent
LigandPNGBDBM50254524(1-(2-((S)-3-(aminomethyl)-1,2,3,4-tetrahydroisoqui...)
Affinity DataIC50:  1.14E+4nMAssay Description:Inhibition of GST fused Bcl-xL (unknown origin) binding to biotinylated 16 mer Bak-BH3 peptide by HTRF-LANCE assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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