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Compile Data Set for Download or QSAR

Found 107 hits of ki for UniProtKB: P18298   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50228186
PNG
(CHEMBL3706404)
Show SMILES NC(CCSCC[C@@H](OP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)1-3-41-4-2-8(36-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(35-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,10+,11-,12-,15-/m1/s1
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110n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Compound was tested for inhibition constant with kidney form of M-2 variants of Rat methionine adenosyltransferase when ATP was the variable substrat...


J Med Chem 32: 885-90 (1989)


Article DOI: 10.1021/jm00124a026
BindingDB Entry DOI: 10.7270/Q2K939Q8
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50227269
PNG
(CHEMBL3706402)
Show SMILES NC(CCSC[C@H](OP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-3-7(35-39(32,33)36-38(30,31)21-37(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H4,21,27,28,29,30,31)/t6?,7-,9-,10+,11+,14+/m0/s1
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130n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Inhibition constant of ATP varied compound was measured on M-2 variate Methionine adenosyltransferase in rat kidney


J Med Chem 31: 384-9 (1988)


Article DOI: 10.1021/jm00397a020
BindingDB Entry DOI: 10.7270/Q2736T3C
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50226974
PNG
(CHEMBL603986)
Show SMILES NC(CCSC[C@@H](OP(O)(=O)OP(O)(=O)ONP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2C(N)N=CNc12)C(O)=O
Show InChI InChI=1S/C15H28N7O15P3S/c16-6(15(25)26)1-2-41-3-7(35-39(30,31)37-40(32,33)36-21-38(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-12,14,23-24H,1-3,16-17H2,(H,18,19)(H,25,26)(H,30,31)(H,32,33)(H3,21,27,28,29)/t6?,7-,9+,10-,11-,12?,14?/m1/s1
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130n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constants of M-2 Forms of rat methionine adenosyltransferase using ATP as the variable substrate; Inhibition is competitive type


J Med Chem 30: 1599-603 (1987)


Article DOI: 10.1021/jm00392a013
BindingDB Entry DOI: 10.7270/Q2CV4KZR
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50227269
PNG
(CHEMBL3706402)
Show SMILES NC(CCSC[C@H](OP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-3-7(35-39(32,33)36-38(30,31)21-37(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H4,21,27,28,29,30,31)/t6?,7-,9-,10+,11+,14+/m0/s1
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130n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Compound was tested for inhibition constant with kidney form of M-2 variants of Rat methionine adenosyltransferase when ATP was the variable substrat...


J Med Chem 32: 885-90 (1989)


Article DOI: 10.1021/jm00124a026
BindingDB Entry DOI: 10.7270/Q2K939Q8
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50228186
PNG
(CHEMBL3706404)
Show SMILES NC(CCSCC[C@@H](OP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)1-3-41-4-2-8(36-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(35-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,10+,11-,12-,15-/m1/s1
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160n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Compound was tested for inhibition constant with kidney form of M-T variants of Rat methionine adenosyltransferase when ATP was the variable substrat...


J Med Chem 32: 885-90 (1989)


Article DOI: 10.1021/jm00124a026
BindingDB Entry DOI: 10.7270/Q2K939Q8
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50227269
PNG
(CHEMBL3706402)
Show SMILES NC(CCSC[C@H](OP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-3-7(35-39(32,33)36-38(30,31)21-37(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H4,21,27,28,29,30,31)/t6?,7-,9-,10+,11+,14+/m0/s1
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210n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Compound was tested for inhibition constant with kidney form of M-T variants of Rat methionine adenosyltransferase when ATP was the variable substrat...


J Med Chem 32: 885-90 (1989)


Article DOI: 10.1021/jm00124a026
BindingDB Entry DOI: 10.7270/Q2K939Q8
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50226974
PNG
(CHEMBL603986)
Show SMILES NC(CCSC[C@@H](OP(O)(=O)OP(O)(=O)ONP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2C(N)N=CNc12)C(O)=O
Show InChI InChI=1S/C15H28N7O15P3S/c16-6(15(25)26)1-2-41-3-7(35-39(30,31)37-40(32,33)36-21-38(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-12,14,23-24H,1-3,16-17H2,(H,18,19)(H,25,26)(H,30,31)(H,32,33)(H3,21,27,28,29)/t6?,7-,9+,10-,11-,12?,14?/m1/s1
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210n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constants of MT Forms of rat Novikoff Ascitic Hepatomae using ATP as the variable substrate; Inhibition is competitive type


J Med Chem 30: 1599-603 (1987)


Article DOI: 10.1021/jm00392a013
BindingDB Entry DOI: 10.7270/Q2CV4KZR
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50227269
PNG
(CHEMBL3706402)
Show SMILES NC(CCSC[C@H](OP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-3-7(35-39(32,33)36-38(30,31)21-37(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H4,21,27,28,29,30,31)/t6?,7-,9-,10+,11+,14+/m0/s1
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210n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Inhibition constant of ATP varied compound was measured on MT variant methionine adenosyltransferase in rat ascitic hepatoma cells


J Med Chem 31: 384-9 (1988)


Article DOI: 10.1021/jm00397a020
BindingDB Entry DOI: 10.7270/Q2736T3C
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50226770
PNG
(CHEMBL609078)
Show SMILES NC(CCS[C@@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9-,10+,11+,14?/m0/s1
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270n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constant of compound with Novikoff ascitic hepatoma (M-T) form of rat methionine adenosyltransferase when ATP was used as variable substra...


J Med Chem 30: 888-94 (1987)


Article DOI: 10.1021/jm00388a024
BindingDB Entry DOI: 10.7270/Q22J6F29
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50228185
PNG
(CHEMBL3706405)
Show SMILES NC(CCSCC[C@H](OP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)1-3-41-4-2-8(36-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(35-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,10-,11+,12+,15+/m0/s1
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270n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Compound was tested for inhibition constant with kidney form of M-2 variants of Rat methionine adenosyltransferase when ATP was the variable substrat...


J Med Chem 32: 885-90 (1989)


Article DOI: 10.1021/jm00124a026
BindingDB Entry DOI: 10.7270/Q2K939Q8
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50226972
PNG
(CHEMBL606493)
Show SMILES NC(CCS[C@@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2C(N)N=CNc12)C(O)=O
Show InChI InChI=1S/C15H28N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-12,14,23-24H,1-3,16-17H2,(H,18,19)(H,25,26)(H,32,33)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9-,10+,11+,12?,14?/m0/s1
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270n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constants of MT Forms of rat Novikoff Ascitic Hepatomae using ATP as the variable substrate; Inhibition is competitive type


J Med Chem 30: 1599-603 (1987)


Article DOI: 10.1021/jm00392a013
BindingDB Entry DOI: 10.7270/Q2CV4KZR
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50226768
PNG
(CHEMBL1791426)
Show SMILES NC(CCS[C@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9+,10-,11-,14-/m1/s1
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270n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Inhibition constant of ATP varied compound was measured on MT variant methionine adenosyltransferase in rat ascitic hepatoma cells


J Med Chem 31: 384-9 (1988)


Article DOI: 10.1021/jm00397a020
BindingDB Entry DOI: 10.7270/Q2736T3C
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50226972
PNG
(CHEMBL606493)
Show SMILES NC(CCS[C@@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2C(N)N=CNc12)C(O)=O
Show InChI InChI=1S/C15H28N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-12,14,23-24H,1-3,16-17H2,(H,18,19)(H,25,26)(H,32,33)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9-,10+,11+,12?,14?/m0/s1
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360n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constants of M-2 Forms of rat methionine adenosyltransferase using ATP as the variable substrate; Inhibition is competitive type


J Med Chem 30: 1599-603 (1987)


Article DOI: 10.1021/jm00392a013
BindingDB Entry DOI: 10.7270/Q2CV4KZR
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50226770
PNG
(CHEMBL609078)
Show SMILES NC(CCS[C@@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9-,10+,11+,14?/m0/s1
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360n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constant of compound with kidney (M-2) form of rat methionine adenosyltransferase when ATP was used as variable substrate;Competitive type...


J Med Chem 30: 888-94 (1987)


Article DOI: 10.1021/jm00388a024
BindingDB Entry DOI: 10.7270/Q22J6F29
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50226768
PNG
(CHEMBL1791426)
Show SMILES NC(CCS[C@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9+,10-,11-,14-/m1/s1
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360n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Inhibition constant of ATP varied compound was measured on M-2 variate methionine adenosyltransferase in rat kidney


J Med Chem 31: 384-9 (1988)


Article DOI: 10.1021/jm00397a020
BindingDB Entry DOI: 10.7270/Q2736T3C
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50227270
PNG
(CHEMBL3706403)
Show SMILES N[C@@H](CCSCC(C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)OP(O)(=O)OP(O)(=O)NP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C16H28N7O14P3S/c17-8(16(26)27)1-2-41-4-7(36-40(33,34)37-39(31,32)22-38(28,29)30)3-9-11(24)12(25)15(35-9)23-6-21-10-13(18)19-5-20-14(10)23/h5-9,11-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,9+,11+,12+,15+/m0/s1
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390n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Inhibition constant of ATP varied compound was measured on M-2 variate methionine adenosyltransferase in rat kidney


J Med Chem 31: 384-9 (1988)


Article DOI: 10.1021/jm00397a020
BindingDB Entry DOI: 10.7270/Q2736T3C
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50228185
PNG
(CHEMBL3706405)
Show SMILES NC(CCSCC[C@H](OP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)1-3-41-4-2-8(36-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(35-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,10-,11+,12+,15+/m0/s1
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410n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Compound was tested for inhibition constant with kidney form of M-T variants of Rat methionine adenosyltransferase when ATP was the variable substrat...


J Med Chem 32: 885-90 (1989)


Article DOI: 10.1021/jm00124a026
BindingDB Entry DOI: 10.7270/Q2K939Q8
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50227271
PNG
(CHEMBL1791425)
Show SMILES NC(CCSC(CCOP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)2-4-41-8(1-3-35-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(36-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8?,10-,11+,12+,15+/m0/s1
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440n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Inhibition constant of ATP varied compound was measured on M-2 variate methionine adenosyltransferase in rat kidney


J Med Chem 31: 384-9 (1988)


Article DOI: 10.1021/jm00397a020
BindingDB Entry DOI: 10.7270/Q2736T3C
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50227270
PNG
(CHEMBL3706403)
Show SMILES N[C@@H](CCSCC(C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)OP(O)(=O)OP(O)(=O)NP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C16H28N7O14P3S/c17-8(16(26)27)1-2-41-4-7(36-40(33,34)37-39(31,32)22-38(28,29)30)3-9-11(24)12(25)15(35-9)23-6-21-10-13(18)19-5-20-14(10)23/h5-9,11-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,9+,11+,12+,15+/m0/s1
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630n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Inhibition constant of ATP varied compound was measured on MT variant methionine adenosyltransferase in rat ascitic hepatoma cells


J Med Chem 31: 384-9 (1988)


Article DOI: 10.1021/jm00397a020
BindingDB Entry DOI: 10.7270/Q2736T3C
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50227269
PNG
(CHEMBL3706402)
Show SMILES NC(CCSC[C@H](OP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-3-7(35-39(32,33)36-38(30,31)21-37(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H4,21,27,28,29,30,31)/t6?,7-,9-,10+,11+,14+/m0/s1
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650n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Inhibition constant of Met varied compound was measured on M-2 variant Methionine adenosyltransferase in rat kidney


J Med Chem 31: 384-9 (1988)


Article DOI: 10.1021/jm00397a020
BindingDB Entry DOI: 10.7270/Q2736T3C
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50227269
PNG
(CHEMBL3706402)
Show SMILES NC(CCSC[C@H](OP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-3-7(35-39(32,33)36-38(30,31)21-37(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H4,21,27,28,29,30,31)/t6?,7-,9-,10+,11+,14+/m0/s1
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650n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Compound was tested for inhibition constant with kidney form of M-2 variants of Rat methionine adenosyltransferase when Methionine was the variable s...


J Med Chem 32: 885-90 (1989)


Article DOI: 10.1021/jm00124a026
BindingDB Entry DOI: 10.7270/Q2K939Q8
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50226974
PNG
(CHEMBL603986)
Show SMILES NC(CCSC[C@@H](OP(O)(=O)OP(O)(=O)ONP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2C(N)N=CNc12)C(O)=O
Show InChI InChI=1S/C15H28N7O15P3S/c16-6(15(25)26)1-2-41-3-7(35-39(30,31)37-40(32,33)36-21-38(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-12,14,23-24H,1-3,16-17H2,(H,18,19)(H,25,26)(H,30,31)(H,32,33)(H3,21,27,28,29)/t6?,7-,9+,10-,11-,12?,14?/m1/s1
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650n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constants of M-2 Forms of rat methionine adenosyltransferase using Methionine as the variable substrate; Inhibition is non competitive typ...


J Med Chem 30: 1599-603 (1987)


Article DOI: 10.1021/jm00392a013
BindingDB Entry DOI: 10.7270/Q2CV4KZR
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50227269
PNG
(CHEMBL3706402)
Show SMILES NC(CCSC[C@H](OP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-3-7(35-39(32,33)36-38(30,31)21-37(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H4,21,27,28,29,30,31)/t6?,7-,9-,10+,11+,14+/m0/s1
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670n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Inhibition constant of Met varied compound was measured on MT variant methionine adenosyltransferase in rat ascitic hepatoma cells


J Med Chem 31: 384-9 (1988)


Article DOI: 10.1021/jm00397a020
BindingDB Entry DOI: 10.7270/Q2736T3C
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50227269
PNG
(CHEMBL3706402)
Show SMILES NC(CCSC[C@H](OP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-3-7(35-39(32,33)36-38(30,31)21-37(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H4,21,27,28,29,30,31)/t6?,7-,9-,10+,11+,14+/m0/s1
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670n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Compound was tested for inhibition constant with kidney form of M-T variants of Rat methionine adenosyltransferase when Methionine was the variable s...


J Med Chem 32: 885-90 (1989)


Article DOI: 10.1021/jm00124a026
BindingDB Entry DOI: 10.7270/Q2K939Q8
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50226974
PNG
(CHEMBL603986)
Show SMILES NC(CCSC[C@@H](OP(O)(=O)OP(O)(=O)ONP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2C(N)N=CNc12)C(O)=O
Show InChI InChI=1S/C15H28N7O15P3S/c16-6(15(25)26)1-2-41-3-7(35-39(30,31)37-40(32,33)36-21-38(27,28)29)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-12,14,23-24H,1-3,16-17H2,(H,18,19)(H,25,26)(H,30,31)(H,32,33)(H3,21,27,28,29)/t6?,7-,9+,10-,11-,12?,14?/m1/s1
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670n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constants of MT Forms of rat Novikoff Ascitic Hepatomae using Methionine as the variable substrate; Inhibition is non competitive type


J Med Chem 30: 1599-603 (1987)


Article DOI: 10.1021/jm00392a013
BindingDB Entry DOI: 10.7270/Q2CV4KZR
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50227271
PNG
(CHEMBL1791425)
Show SMILES NC(CCSC(CCOP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)2-4-41-8(1-3-35-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(36-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8?,10-,11+,12+,15+/m0/s1
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810n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Inhibition constant of ATP varied compound was measured on MT variant methionine adenosyltransferase in rat ascitic hepatoma cells


J Med Chem 31: 384-9 (1988)


Article DOI: 10.1021/jm00397a020
BindingDB Entry DOI: 10.7270/Q2736T3C
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50228186
PNG
(CHEMBL3706404)
Show SMILES NC(CCSCC[C@@H](OP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)1-3-41-4-2-8(36-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(35-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,10+,11-,12-,15-/m1/s1
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1.10E+3n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Compound was tested for inhibition constant with kidney form of M-T variants of Rat methionine adenosyltransferase when Methionine was the variable s...


J Med Chem 32: 885-90 (1989)


Article DOI: 10.1021/jm00124a026
BindingDB Entry DOI: 10.7270/Q2K939Q8
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50227271
PNG
(CHEMBL1791425)
Show SMILES NC(CCSC(CCOP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)2-4-41-8(1-3-35-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(36-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8?,10-,11+,12+,15+/m0/s1
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1.50E+3n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Inhibition constant of Met varied compound was measured on MT variant methionine adenosyltransferase in rat ascitic hepatoma cells


J Med Chem 31: 384-9 (1988)


Article DOI: 10.1021/jm00397a020
BindingDB Entry DOI: 10.7270/Q2736T3C
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50227271
PNG
(CHEMBL1791425)
Show SMILES NC(CCSC(CCOP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)2-4-41-8(1-3-35-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(36-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8?,10-,11+,12+,15+/m0/s1
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2.10E+3n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Inhibition constant of Met varied compound was measured on M-2 variant methionine adenosyltransferase in rat kidney


J Med Chem 31: 384-9 (1988)


Article DOI: 10.1021/jm00397a020
BindingDB Entry DOI: 10.7270/Q2736T3C
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50228186
PNG
(CHEMBL3706404)
Show SMILES NC(CCSCC[C@@H](OP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)1-3-41-4-2-8(36-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(35-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,10+,11-,12-,15-/m1/s1
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2.10E+3n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Compound was tested for inhibition constant with kidney form of M-2 variants of Rat methionine adenosyltransferase when Methionine was the variable s...


J Med Chem 32: 885-90 (1989)


Article DOI: 10.1021/jm00124a026
BindingDB Entry DOI: 10.7270/Q2K939Q8
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50227270
PNG
(CHEMBL3706403)
Show SMILES N[C@@H](CCSCC(C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)OP(O)(=O)OP(O)(=O)NP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C16H28N7O14P3S/c17-8(16(26)27)1-2-41-4-7(36-40(33,34)37-39(31,32)22-38(28,29)30)3-9-11(24)12(25)15(35-9)23-6-21-10-13(18)19-5-20-14(10)23/h5-9,11-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,9+,11+,12+,15+/m0/s1
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2.20E+3n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Inhibition constant of Met varied compound was measured on M-2 variant methionine adenosyltransferase in rat kidney


J Med Chem 31: 384-9 (1988)


Article DOI: 10.1021/jm00397a020
BindingDB Entry DOI: 10.7270/Q2736T3C
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50226768
PNG
(CHEMBL1791426)
Show SMILES NC(CCS[C@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9+,10-,11-,14-/m1/s1
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2.30E+3n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Inhibition constant of Met varied compound was measured on MT variant methionine adenosyltransferase in rat ascitic hepatoma cells


J Med Chem 31: 384-9 (1988)


Article DOI: 10.1021/jm00397a020
BindingDB Entry DOI: 10.7270/Q2736T3C
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50226770
PNG
(CHEMBL609078)
Show SMILES NC(CCS[C@@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9-,10+,11+,14?/m0/s1
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2.30E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constant of compound with Novikoff ascitic hepatoma (M-T) form of rat methionine adenosyltransferase when methionine was used as variable ...


J Med Chem 30: 888-94 (1987)


Article DOI: 10.1021/jm00388a024
BindingDB Entry DOI: 10.7270/Q22J6F29
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50226972
PNG
(CHEMBL606493)
Show SMILES NC(CCS[C@@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2C(N)N=CNc12)C(O)=O
Show InChI InChI=1S/C15H28N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-12,14,23-24H,1-3,16-17H2,(H,18,19)(H,25,26)(H,32,33)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9-,10+,11+,12?,14?/m0/s1
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2.30E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constants of MT Forms of rat Novikoff Ascitic Hepatomae using Methionine as the variable substrate; Inhibition is non competitive type


J Med Chem 30: 1599-603 (1987)


Article DOI: 10.1021/jm00392a013
BindingDB Entry DOI: 10.7270/Q2CV4KZR
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50227270
PNG
(CHEMBL3706403)
Show SMILES N[C@@H](CCSCC(C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)OP(O)(=O)OP(O)(=O)NP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C16H28N7O14P3S/c17-8(16(26)27)1-2-41-4-7(36-40(33,34)37-39(31,32)22-38(28,29)30)3-9-11(24)12(25)15(35-9)23-6-21-10-13(18)19-5-20-14(10)23/h5-9,11-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,9+,11+,12+,15+/m0/s1
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2.70E+3n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Inhibition constant of Met varied compound was measured on MT variant methionine adenosyltransferase in rat ascitic hepatoma cells


J Med Chem 31: 384-9 (1988)


Article DOI: 10.1021/jm00397a020
BindingDB Entry DOI: 10.7270/Q2736T3C
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50228185
PNG
(CHEMBL3706405)
Show SMILES NC(CCSCC[C@H](OP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)1-3-41-4-2-8(36-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(35-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,10-,11+,12+,15+/m0/s1
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2.70E+3n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Compound was tested for inhibition constant with kidney form of M-T variants of Rat methionine adenosyltransferase when Methionine was the variable s...


J Med Chem 32: 885-90 (1989)


Article DOI: 10.1021/jm00124a026
BindingDB Entry DOI: 10.7270/Q2K939Q8
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50226770
PNG
(CHEMBL609078)
Show SMILES NC(CCS[C@@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9-,10+,11+,14?/m0/s1
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3.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constant of compound with kidney (M-2) form of rat methionine adenosyltransferase when methionine was used as variable substrate;Simple no...


J Med Chem 30: 888-94 (1987)


Article DOI: 10.1021/jm00388a024
BindingDB Entry DOI: 10.7270/Q22J6F29
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50226972
PNG
(CHEMBL606493)
Show SMILES NC(CCS[C@@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1OC([C@H](O)[C@@H]1O)n1cnc2C(N)N=CNc12)C(O)=O
Show InChI InChI=1S/C15H28N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-12,14,23-24H,1-3,16-17H2,(H,18,19)(H,25,26)(H,32,33)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9-,10+,11+,12?,14?/m0/s1
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3.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constants of M-2 Forms of rat methionine adenosyltransferase using Methionine as the variable substrate; Inhibition is non competitive typ...


J Med Chem 30: 1599-603 (1987)


Article DOI: 10.1021/jm00392a013
BindingDB Entry DOI: 10.7270/Q2CV4KZR
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50226768
PNG
(CHEMBL1791426)
Show SMILES NC(CCS[C@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9+,10-,11-,14-/m1/s1
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3.00E+3n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Inhibition constant of Met varied compound was measured on M-2 variant methionine adenosyltransferase in rat kidney


J Med Chem 31: 384-9 (1988)


Article DOI: 10.1021/jm00397a020
BindingDB Entry DOI: 10.7270/Q2736T3C
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM18134
PNG
(({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C10H17N6O12P3/c11-8-5-9(13-2-12-8)16(3-14-5)10-7(18)6(17)4(27-10)1-26-31(24,25)28-30(22,23)15-29(19,20)21/h2-4,6-7,10,17-18H,1H2,(H,24,25)(H2,11,12,13)(H4,15,19,20,21,22,23)/t4-,6-,7-,10-/m1/s1
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4.00E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory constant against rat Methionine adenosyltransferase was reported


J Med Chem 29: 318-22 (1986)


Article DOI: 10.1021/jm00153a003
BindingDB Entry DOI: 10.7270/Q2DF6RSH
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50228185
PNG
(CHEMBL3706405)
Show SMILES NC(CCSCC[C@H](OP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C16H28N7O14P3S/c17-7(16(26)27)1-3-41-4-2-8(36-40(33,34)37-39(31,32)22-38(28,29)30)12-10(24)11(25)15(35-12)23-6-21-9-13(18)19-5-20-14(9)23/h5-8,10-12,15,24-25H,1-4,17H2,(H,26,27)(H,33,34)(H2,18,19,20)(H4,22,28,29,30,31,32)/t7?,8-,10-,11+,12+,15+/m0/s1
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5.40E+3n/an/an/an/an/an/an/an/a



Fox Chase Cancer Center

Curated by ChEMBL


Assay Description
Compound was tested for inhibition constant with kidney form of M-2 variants of Rat methionine adenosyltransferase when Methionine was the variable s...


J Med Chem 32: 885-90 (1989)


Article DOI: 10.1021/jm00124a026
BindingDB Entry DOI: 10.7270/Q2K939Q8
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM18134
PNG
(({[({[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-...)
Show SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C10H17N6O12P3/c11-8-5-9(13-2-12-8)16(3-14-5)10-7(18)6(17)4(27-10)1-26-31(24,25)28-30(22,23)15-29(19,20)21/h2-4,6-7,10,17-18H,1H2,(H,24,25)(H2,11,12,13)(H4,15,19,20,21,22,23)/t4-,6-,7-,10-/m1/s1
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5.50E+3n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibitory constant against rat kidney Methionine adenosyltransferase II


J Med Chem 29: 318-22 (1986)


Article DOI: 10.1021/jm00153a003
BindingDB Entry DOI: 10.7270/Q2DF6RSH
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM85447
PNG
(Epoxy analogue, I(a))
Show SMILES N[C@@H](C[C@H]1CO1)C(O)=O
Show InChI InChI=1S/C5H9NO3/c6-4(5(7)8)1-3-2-9-3/h3-4H,1-2,6H2,(H,7,8)/t3-,4-/m0/s1
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7.00E+3 -7.31 5.00E+4n/an/an/an/a7.537



Laboratoire de chimie bioorganique



Assay Description
AdoMet synthetase activity was measured by a radioactive assay using (14C-methyl)-L-methionine as described by Sullivan and Hoffman with minor modifi...


J Enzym Inhib 13: 361-7 (1998)


Article DOI: 10.3109/14756369809021481
BindingDB Entry DOI: 10.7270/Q2668BQ4
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50367328
PNG
(CHEMBL1791415)
Show SMILES NC(CCSC(CP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O13P3S/c16-6(15(25)26)1-2-39-7(3-36(27,28)35-38(32,33)21-37(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,27,28)(H2,17,18,19)(H4,21,29,30,31,32,33)/t6?,7?,9-,10+,11+,14+/m0/s1
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1.10E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constant was evaluated on novikoff hepatoma (MAT-T) form of rat methionine adenosyltransferase, when ATP was the variable substrate (60 uM...


J Med Chem 29: 1030-8 (1986)


Article DOI: 10.1021/jm00156a022
BindingDB Entry DOI: 10.7270/Q2CF9QN4
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50226973
PNG
(CHEMBL1791411)
Show SMILES NC(CCSC(CP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2C(N)N=CNc12)C(O)=O
Show InChI InChI=1S/C15H28N7O13P3S/c16-6(15(25)26)1-2-39-7(3-36(27,28)35-38(32,33)21-37(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-12,14,23-24H,1-3,16-17H2,(H,18,19)(H,25,26)(H,27,28)(H4,21,29,30,31,32,33)/t6?,7?,9-,10+,11+,12?,14+/m0/s1
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1.10E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constants of MT Forms of rat Novikoff Ascitic Hepatomae using ATP as the variable substrate; Inhibition is competitive type


J Med Chem 30: 1599-603 (1987)


Article DOI: 10.1021/jm00392a013
BindingDB Entry DOI: 10.7270/Q2CV4KZR
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50226769
PNG
(CHEMBL607665)
Show SMILES Nc1ncnc2n(cnc12)C1O[C@H](CCNP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C11H19N6O12P3/c12-9-6-10(14-3-13-9)17(4-15-6)11-8(19)7(18)5(27-11)1-2-16-30(20,21)28-32(25,26)29-31(22,23)24/h3-5,7-8,11,18-19H,1-2H2,(H,25,26)(H2,12,13,14)(H2,16,20,21)(H2,22,23,24)/t5-,7-,8-,11?/m1/s1
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1.40E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constant of compound with kidney (M-2) form of rat methionine adenosyltransferase when ATP was used as variable substrate;Competitive type...


J Med Chem 30: 888-94 (1987)


Article DOI: 10.1021/jm00388a024
BindingDB Entry DOI: 10.7270/Q22J6F29
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50226973
PNG
(CHEMBL1791411)
Show SMILES NC(CCSC(CP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2C(N)N=CNc12)C(O)=O
Show InChI InChI=1S/C15H28N7O13P3S/c16-6(15(25)26)1-2-39-7(3-36(27,28)35-38(32,33)21-37(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-12,14,23-24H,1-3,16-17H2,(H,18,19)(H,25,26)(H,27,28)(H4,21,29,30,31,32,33)/t6?,7?,9-,10+,11+,12?,14+/m0/s1
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1.60E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constants of M-2 Forms of rat methionine adenosyltransferase using ATP as the variable substrate; Inhibition is competitive type


J Med Chem 30: 1599-603 (1987)


Article DOI: 10.1021/jm00392a013
BindingDB Entry DOI: 10.7270/Q2CV4KZR
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-2


(Rattus norvegicus)
BDBM50367328
PNG
(CHEMBL1791415)
Show SMILES NC(CCSC(CP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O13P3S/c16-6(15(25)26)1-2-39-7(3-36(27,28)35-38(32,33)21-37(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,27,28)(H2,17,18,19)(H4,21,29,30,31,32,33)/t6?,7?,9-,10+,11+,14+/m0/s1
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1.60E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constant was evaluated with kidney Methionine adenosyltransferase II form of rat methionine adenosyltransferase, when ATP was the variable...


J Med Chem 29: 1030-8 (1986)


Article DOI: 10.1021/jm00156a022
BindingDB Entry DOI: 10.7270/Q2CF9QN4
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50226768
PNG
(CHEMBL1791426)
Show SMILES NC(CCS[C@H](CNP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12)C(O)=O
Show InChI InChI=1S/C15H26N7O14P3S/c16-6(15(25)26)1-2-40-7(3-21-37(27,28)35-39(32,33)36-38(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-11,14,23-24H,1-3,16H2,(H,25,26)(H,32,33)(H2,17,18,19)(H2,21,27,28)(H2,29,30,31)/t6?,7-,9+,10-,11-,14-/m1/s1
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2.00E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constant of compound with Novikoff ascitic hepatoma (M-T) form of rat methionine adenosyltransferase when ATP was used as variable substra...


J Med Chem 30: 888-94 (1987)


Article DOI: 10.1021/jm00388a024
BindingDB Entry DOI: 10.7270/Q22J6F29
More data for this
Ligand-Target Pair
S-adenosylmethionine synthase isoform type-1/type-2


(Rattus norvegicus)
BDBM50226973
PNG
(CHEMBL1791411)
Show SMILES NC(CCSC(CP(O)(=O)OP(O)(=O)NP(O)(O)=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2C(N)N=CNc12)C(O)=O
Show InChI InChI=1S/C15H28N7O13P3S/c16-6(15(25)26)1-2-39-7(3-36(27,28)35-38(32,33)21-37(29,30)31)11-9(23)10(24)14(34-11)22-5-20-8-12(17)18-4-19-13(8)22/h4-7,9-12,14,23-24H,1-3,16-17H2,(H,18,19)(H,25,26)(H,27,28)(H4,21,29,30,31,32,33)/t6?,7?,9-,10+,11+,12?,14+/m0/s1
PDB

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Article
PubMed
2.60E+4n/an/an/an/an/an/an/an/a



TBA

Curated by ChEMBL


Assay Description
Inhibition constants of M-2 Forms of rat methionine adenosyltransferase using Methionine as the variable substrate; Inhibition is competitive type


J Med Chem 30: 1599-603 (1987)


Article DOI: 10.1021/jm00392a013
BindingDB Entry DOI: 10.7270/Q2CV4KZR
More data for this
Ligand-Target Pair
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