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Compile Data Set for Download or QSAR

Found 70 hits of ic50 for UniProtKB: P62508   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM29608
PNG
(Bisphenol A (BPA) | Diphenylolpropane | US9688816,...)
Show SMILES CC(C)(c1ccc(O)cc1)c1ccc(O)cc1
Show InChI InChI=1S/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3
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n/an/a 4.90n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Binding affinity to human ERRgamma


Bioorg Med Chem 25: 5216-5237 (2017)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Estrogen-Related Receptor, gamma


(Homo sapiens (Human))
BDBM22427
PNG
(4-[(1Z)-4-azido-1-{4-[2-(dimethylamino)ethoxy]phen...)
Show SMILES CN(C)CCOc1ccc(cc1)C(=C(\CCN=[N+]=[N-])c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C26H28N4O2/c1-30(2)18-19-32-24-14-10-22(11-15-24)26(21-8-12-23(31)13-9-21)25(16-17-28-29-27)20-6-4-3-5-7-20/h3-15,31H,16-19H2,1-2H3/b26-25-
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n/an/a 5n/an/an/an/a7.422



GSK



Assay Description
Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...


Bioorg Med Chem Lett 16: 821-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.030
BindingDB Entry DOI: 10.7270/Q2WW7FZ7
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50233271
PNG
(CHEMBL4071073)
Show SMILES CC(C)C(=C(\c1ccc(OCCN(C)C)cc1)c1ccc(OC(C)=O)cc1)\c1ccccc1
Show InChI InChI=1S/C29H33NO3/c1-21(2)28(23-9-7-6-8-10-23)29(25-13-17-27(18-14-25)33-22(3)31)24-11-15-26(16-12-24)32-20-19-30(4)5/h6-18,21H,19-20H2,1-5H3/b29-28+
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n/an/a 10n/an/an/an/an/an/a



The Beckman Research Institute

Curated by ChEMBL


Assay Description
Inverse agonist activity at GAL4-DNA binding domain-fused mouse ERRgamma ligand binding domain expressed in African green monkey CV1 cells assessed a...


Bioorg Med Chem 25: 1585-1599 (2017)


Article DOI: 10.1016/j.bmc.2017.01.019
BindingDB Entry DOI: 10.7270/Q2DF6TFV
More data for this
Ligand-Target Pair
Estrogen-Related Receptor, gamma


(Homo sapiens (Human))
BDBM20608
PNG
(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)
Show SMILES CC\C(=C(/c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1
Show InChI InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
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n/an/a 10.3n/an/an/an/a7.425



Kyushu University



Assay Description
The receptor-binding assay was conducted using [3H]4-hydroxytamoxifen (4-OHT) as the radioligand. To estimate the binding affinity, the IC50 values (...


Biochem Biophys Res Commun 373: 408-13 (2008)


Article DOI: 10.1016/j.bbrc.2008.06.050
BindingDB Entry DOI: 10.7270/Q22R3Q0N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50276802
PNG
(4-OHT | AFIMOXIFENE | Afimoxifene | TamoGel)
Show SMILES CCC(=C(c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1
Show InChI InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3
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n/an/a 11n/an/an/an/an/an/a



Janssen Research and Development LLC

Curated by ChEMBL


Assay Description
Antagonist activity at ERRgamma (unknown origin) assessed as inhibition of co-activator peptide recruitment by TR-FRET assay


Eur J Med Chem 138: 830-853 (2017)

More data for this
Ligand-Target Pair
Estrogen-Related Receptor, gamma


(Homo sapiens (Human))
BDBM20608
PNG
(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)
Show SMILES CC\C(=C(/c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1
Show InChI InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
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n/an/a 13n/an/an/an/a7.422



GSK



Assay Description
Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...


Bioorg Med Chem Lett 16: 821-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.030
BindingDB Entry DOI: 10.7270/Q2WW7FZ7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Estrogen-Related Receptor, gamma


(Homo sapiens (Human))
BDBM22423
PNG
(4-[(1Z)-4-chloro-1-{4-[2-(dimethylamino)ethoxy]phe...)
Show SMILES CN(C)CCOc1ccc(cc1)C(=C(\CCCl)c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C26H28ClNO2/c1-28(2)18-19-30-24-14-10-22(11-15-24)26(21-8-12-23(29)13-9-21)25(16-17-27)20-6-4-3-5-7-20/h3-15,29H,16-19H2,1-2H3/b26-25-
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n/an/a 13n/an/an/an/a7.422



GSK



Assay Description
Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...


Bioorg Med Chem Lett 16: 821-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.030
BindingDB Entry DOI: 10.7270/Q2WW7FZ7
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Estrogen-Related Receptor, gamma


(Homo sapiens (Human))
BDBM29608
PNG
(Bisphenol A (BPA) | Diphenylolpropane | US9688816,...)
Show SMILES CC(C)(c1ccc(O)cc1)c1ccc(O)cc1
Show InChI InChI=1S/C15H16O2/c1-15(2,11-3-7-13(16)8-4-11)12-5-9-14(17)10-6-12/h3-10,16-17H,1-2H3
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n/an/a 13.1n/an/an/an/a7.425



Kyushu University



Assay Description
The receptor-binding assay was conducted using [3H]4-hydroxytamoxifen (4-OHT) as the radioligand. To estimate the binding affinity, the IC50 values (...


Biochem Biophys Res Commun 373: 408-13 (2008)


Article DOI: 10.1016/j.bbrc.2008.06.050
BindingDB Entry DOI: 10.7270/Q22R3Q0N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Estrogen-Related Receptor, gamma


(Homo sapiens (Human))
BDBM29609
PNG
(4-alpha-Cumylphenol | 4-cumylphenol | US9688816, B)
Show SMILES CC(C)(c1ccccc1)c1ccc(O)cc1
Show InChI InChI=1S/C15H16O/c1-15(2,12-6-4-3-5-7-12)13-8-10-14(16)11-9-13/h3-11,16H,1-2H3
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n/an/a 13.9n/an/an/an/a7.425



Kyushu University



Assay Description
The receptor-binding assay was conducted using [3H]4-hydroxytamoxifen (4-OHT) as the radioligand. To estimate the binding affinity, the IC50 values (...


Biochem Biophys Res Commun 373: 408-13 (2008)


Article DOI: 10.1016/j.bbrc.2008.06.050
BindingDB Entry DOI: 10.7270/Q22R3Q0N
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193253
PNG
(CHEMBL3961676)
Show SMILES Cl.CN(C)CCOc1ccc(cc1)C(=C(\CCCF)c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C27H30FNO2.ClH/c1-29(2)19-20-31-25-16-12-23(13-17-25)27(22-10-14-24(30)15-11-22)26(9-6-18-28)21-7-4-3-5-8-21;/h3-5,7-8,10-17,30H,6,9,18-20H2,1-2H3;1H/b27-26-;
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n/an/a 20n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inhibition of fluorescien-conjugated coactivator PGC1a binding to GST-tagged human ERRgamma LBD after 1 hr by TR-FRET assay


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193253
PNG
(CHEMBL3961676)
Show SMILES Cl.CN(C)CCOc1ccc(cc1)C(=C(\CCCF)c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C27H30FNO2.ClH/c1-29(2)19-20-31-25-16-12-23(13-17-25)27(22-10-14-24(30)15-11-22)26(9-6-18-28)21-7-4-3-5-8-21;/h3-5,7-8,10-17,30H,6,9,18-20H2,1-2H3;1H/b27-26-;
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n/an/a 48n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inverse agonist activity at ERRgamma (unknown origin) expressed in human AD293 cells after 24 hrs by beta-galactosidase/luciferase reporter gene assa...


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193250
PNG
(CHEMBL3897416)
Show SMILES Cl.CN(C)CCCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C28H33NO3.ClH/c1-29(2)19-7-21-32-26-17-13-24(14-18-26)28(23-11-15-25(31)16-12-23)27(10-6-20-30)22-8-4-3-5-9-22;/h3-5,8-9,11-18,30-31H,6-7,10,19-21H2,1-2H3;1H/b28-27-;
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n/an/a 58n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inverse agonist activity at ERRgamma (unknown origin) expressed in human AD293 cells after 24 hrs by beta-galactosidase/luciferase reporter gene assa...


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM20607
PNG
((2-{4-[(1Z)-1,2-diphenylbut-1-en-1-yl]phenoxy}ethy...)
Show SMILES CC\C(=C(/c1ccccc1)c1ccc(OCCN(C)C)cc1)c1ccccc1
Show InChI InChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-
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n/an/a 62n/an/an/an/an/an/a



Kyushu University

Curated by ChEMBL


Assay Description
Binding affinity to human ERRgamma


Bioorg Med Chem 25: 5216-5237 (2017)

More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM22435
PNG
(4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...)
Show SMILES CN(C)CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C27H31NO3/c1-28(2)18-20-31-25-16-12-23(13-17-25)27(22-10-14-24(30)15-11-22)26(9-6-19-29)21-7-4-3-5-8-21/h3-5,7-8,10-17,29-30H,6,9,18-20H2,1-2H3/b27-26-
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n/an/a 77n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inverse agonist activity at ERRgamma (unknown origin) expressed in human AD293 cells after 24 hrs by beta-galactosidase/luciferase reporter gene assa...


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193252
PNG
(CHEMBL3957546)
Show SMILES Cl.CCN(CC)CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C29H35NO3.ClH/c1-3-30(4-2)20-22-33-27-18-14-25(15-19-27)29(24-12-16-26(32)17-13-24)28(11-8-21-31)23-9-6-5-7-10-23;/h5-7,9-10,12-19,31-32H,3-4,8,11,20-22H2,1-2H3;1H/b29-28-;
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n/an/a 79n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inverse agonist activity at ERRgamma (unknown origin) expressed in human AD293 cells after 24 hrs by beta-galactosidase/luciferase reporter gene assa...


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-Related Receptor, gamma


(Homo sapiens (Human))
BDBM22435
PNG
(4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...)
Show SMILES CN(C)CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C27H31NO3/c1-28(2)18-20-31-25-16-12-23(13-17-25)27(22-10-14-24(30)15-11-22)26(9-6-19-29)21-7-4-3-5-8-21/h3-5,7-8,10-17,29-30H,6,9,18-20H2,1-2H3/b27-26-
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n/an/a 79n/an/an/an/a7.422



GSK



Assay Description
Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...


Bioorg Med Chem Lett 16: 821-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.030
BindingDB Entry DOI: 10.7270/Q2WW7FZ7
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193250
PNG
(CHEMBL3897416)
Show SMILES Cl.CN(C)CCCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C28H33NO3.ClH/c1-29(2)19-7-21-32-26-17-13-24(14-18-26)28(23-11-15-25(31)16-12-23)27(10-6-20-30)22-8-4-3-5-9-22;/h3-5,8-9,11-18,30-31H,6-7,10,19-21H2,1-2H3;1H/b28-27-;
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n/an/a 90n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inhibition of fluorescien-conjugated coactivator PGC1a binding to GST-tagged human ERRgamma LBD after 1 hr by TR-FRET assay


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM22435
PNG
(4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...)
Show SMILES CN(C)CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C27H31NO3/c1-28(2)18-20-31-25-16-12-23(13-17-25)27(22-10-14-24(30)15-11-22)26(9-6-19-29)21-7-4-3-5-8-21/h3-5,7-8,10-17,29-30H,6,9,18-20H2,1-2H3/b27-26-
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n/an/a 110n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inhibition of fluorescien-conjugated coactivator PGC1a binding to GST-tagged human ERRgamma LBD after 1 hr by TR-FRET assay


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193262
PNG
(CHEMBL3956562)
Show SMILES Cl.CN(C)CCOc1ccc(cc1)C(=C(\CCC(F)F)c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C27H29F2NO2.ClH/c1-30(2)18-19-32-24-14-10-22(11-15-24)27(21-8-12-23(31)13-9-21)25(16-17-26(28)29)20-6-4-3-5-7-20;/h3-15,26,31H,16-19H2,1-2H3;1H/b27-25-;
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n/an/a 111n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inverse agonist activity at ERRgamma (unknown origin) expressed in human AD293 cells after 24 hrs by beta-galactosidase/luciferase reporter gene assa...


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193251
PNG
(CHEMBL3978054)
Show SMILES Cl.CN(C)CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(Br)cc1
Show InChI InChI=1S/C27H30BrNO2.ClH/c1-29(2)18-20-31-25-16-12-23(13-17-25)27(22-10-14-24(28)15-11-22)26(9-6-19-30)21-7-4-3-5-8-21;/h3-5,7-8,10-17,30H,6,9,18-20H2,1-2H3;1H/b27-26-;
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n/an/a 117n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inhibition of fluorescien-conjugated coactivator PGC1a binding to GST-tagged human ERRgamma LBD after 1 hr by TR-FRET assay


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-Related Receptor, gamma


(Homo sapiens (Human))
BDBM22424
PNG
(4-[(1Z)-5-chloro-1-{4-[2-(dimethylamino)ethoxy]phe...)
Show SMILES CN(C)CCOc1ccc(cc1)C(=C(\CCCCl)c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C27H30ClNO2/c1-29(2)19-20-31-25-16-12-23(13-17-25)27(22-10-14-24(30)15-11-22)26(9-6-18-28)21-7-4-3-5-8-21/h3-5,7-8,10-17,30H,6,9,18-20H2,1-2H3/b27-26-
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n/an/a 130n/an/an/an/a7.422



GSK



Assay Description
Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...


Bioorg Med Chem Lett 16: 821-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.030
BindingDB Entry DOI: 10.7270/Q2WW7FZ7
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Estrogen-Related Receptor, gamma


(Homo sapiens (Human))
BDBM22428
PNG
(4-[(1Z)-5-azido-1-{4-[2-(dimethylamino)ethoxy]phen...)
Show SMILES CN(C)CCOc1ccc(cc1)C(=C(\CCCN=[N+]=[N-])c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C27H30N4O2/c1-31(2)19-20-33-25-16-12-23(13-17-25)27(22-10-14-24(32)15-11-22)26(9-6-18-29-30-28)21-7-4-3-5-8-21/h3-5,7-8,10-17,32H,6,9,18-20H2,1-2H3/b27-26-
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n/an/a 160n/an/an/an/a7.422



GSK



Assay Description
Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...


Bioorg Med Chem Lett 16: 821-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.030
BindingDB Entry DOI: 10.7270/Q2WW7FZ7
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193252
PNG
(CHEMBL3957546)
Show SMILES Cl.CCN(CC)CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C29H35NO3.ClH/c1-3-30(4-2)20-22-33-27-18-14-25(15-19-27)29(24-12-16-26(32)17-13-24)28(11-8-21-31)23-9-6-5-7-10-23;/h5-7,9-10,12-19,31-32H,3-4,8,11,20-22H2,1-2H3;1H/b29-28-;
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n/an/a 180n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inhibition of fluorescien-conjugated coactivator PGC1a binding to GST-tagged human ERRgamma LBD after 1 hr by TR-FRET assay


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193264
PNG
(CHEMBL3968559)
Show SMILES Cl.CNCCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C26H29NO3.ClH/c1-27-17-19-30-24-15-11-22(12-16-24)26(21-9-13-23(29)14-10-21)25(8-5-18-28)20-6-3-2-4-7-20;/h2-4,6-7,9-16,27-29H,5,8,17-19H2,1H3;1H/b26-25-;
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n/an/a 187n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inverse agonist activity at ERRgamma (unknown origin) expressed in human AD293 cells after 24 hrs by beta-galactosidase/luciferase reporter gene assa...


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193264
PNG
(CHEMBL3968559)
Show SMILES Cl.CNCCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C26H29NO3.ClH/c1-27-17-19-30-24-15-11-22(12-16-24)26(21-9-13-23(29)14-10-21)25(8-5-18-28)20-6-3-2-4-7-20;/h2-4,6-7,9-16,27-29H,5,8,17-19H2,1H3;1H/b26-25-;
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n/an/a 190n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inhibition of fluorescien-conjugated coactivator PGC1a binding to GST-tagged human ERRgamma LBD after 1 hr by TR-FRET assay


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-Related Receptor, gamma


(Homo sapiens (Human))
BDBM22426
PNG
((5Z)-6-{4-[2-(dimethylamino)ethoxy]phenyl}-6-(4-hy...)
Show SMILES CN(C)CCOc1ccc(cc1)C(=C(\CCCC#N)c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C28H30N2O2/c1-30(2)20-21-32-26-17-13-24(14-18-26)28(23-11-15-25(31)16-12-23)27(10-6-7-19-29)22-8-4-3-5-9-22/h3-5,8-9,11-18,31H,6-7,10,20-21H2,1-2H3/b28-27-
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n/an/a 200n/an/an/an/a7.422



GSK



Assay Description
Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...


Bioorg Med Chem Lett 16: 821-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.030
BindingDB Entry DOI: 10.7270/Q2WW7FZ7
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Estrogen-Related Receptor, gamma


(Homo sapiens (Human))
BDBM22434
PNG
(4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-4-hy...)
Show SMILES CN(C)CCOc1ccc(cc1)C(=C(\CCO)c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C26H29NO3/c1-27(2)17-19-30-24-14-10-22(11-15-24)26(21-8-12-23(29)13-9-21)25(16-18-28)20-6-4-3-5-7-20/h3-15,28-29H,16-19H2,1-2H3/b26-25-
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n/an/a 250n/an/an/an/a7.422



GSK



Assay Description
Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...


Bioorg Med Chem Lett 16: 821-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.030
BindingDB Entry DOI: 10.7270/Q2WW7FZ7
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193255
PNG
(CHEMBL3973526)
Show SMILES Cl.CN(C)CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(C)cc1
Show InChI InChI=1S/C28H33NO2.ClH/c1-22-11-13-24(14-12-22)28(27(10-7-20-30)23-8-5-4-6-9-23)25-15-17-26(18-16-25)31-21-19-29(2)3;/h4-6,8-9,11-18,30H,7,10,19-21H2,1-3H3;1H/b28-27-;
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n/an/a 270n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inhibition of fluorescien-conjugated coactivator PGC1a binding to GST-tagged human ERRgamma LBD after 1 hr by TR-FRET assay


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50233266
PNG
(CHEMBL4092854)
Show SMILES CC(C)C(=C(/c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)\c1ccccc1
Show InChI InChI=1S/C27H31NO2/c1-20(2)26(21-8-6-5-7-9-21)27(22-10-14-24(29)15-11-22)23-12-16-25(17-13-23)30-19-18-28(3)4/h5-17,20,29H,18-19H2,1-4H3/b27-26-
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n/an/a 290n/an/an/an/an/an/a



The Beckman Research Institute

Curated by ChEMBL


Assay Description
Inverse agonist activity at GAL4-DNA binding domain-fused mouse ERRgamma ligand binding domain expressed in African green monkey CV1 cells assessed a...


Bioorg Med Chem 25: 1585-1599 (2017)


Article DOI: 10.1016/j.bmc.2017.01.019
BindingDB Entry DOI: 10.7270/Q2DF6TFV
More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50233272
PNG
(CHEMBL4064246)
Show SMILES CN(C)CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(OC(C)=O)cc1
Show InChI InChI=1S/C29H33NO4/c1-22(32)34-27-17-13-25(14-18-27)29(28(10-7-20-31)23-8-5-4-6-9-23)24-11-15-26(16-12-24)33-21-19-30(2)3/h4-6,8-9,11-18,31H,7,10,19-21H2,1-3H3/b29-28+
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n/an/a 300n/an/an/an/an/an/a



The Beckman Research Institute

Curated by ChEMBL


Assay Description
Inverse agonist activity at GAL4-DNA binding domain-fused mouse ERRgamma ligand binding domain expressed in African green monkey CV1 cells assessed a...


Bioorg Med Chem 25: 1585-1599 (2017)


Article DOI: 10.1016/j.bmc.2017.01.019
BindingDB Entry DOI: 10.7270/Q2DF6TFV
More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50233273
PNG
(CHEMBL4064664)
Show SMILES CC(CO)C\C(=C(\c1ccc(OCCN(C)C)cc1)c1ccc(OC(C)=O)cc1)c1ccccc1
Show InChI InChI=1/C30H35NO4/c1-22(21-32)20-29(24-8-6-5-7-9-24)30(26-12-16-28(17-13-26)35-23(2)33)25-10-14-27(15-11-25)34-19-18-31(3)4/h5-17,22,32H,18-21H2,1-4H3/b30-29+
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n/an/a 350n/an/an/an/an/an/a



The Beckman Research Institute

Curated by ChEMBL


Assay Description
Inverse agonist activity at GAL4-DNA binding domain-fused mouse ERRgamma ligand binding domain expressed in African green monkey CV1 cells assessed a...


Bioorg Med Chem 25: 1585-1599 (2017)


Article DOI: 10.1016/j.bmc.2017.01.019
BindingDB Entry DOI: 10.7270/Q2DF6TFV
More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193263
PNG
(CHEMBL3891326)
Show SMILES Cl.CN(C)CCOc1ccc(cc1)C(=C(\CCCF)c1ccccc1)\c1ccc(Br)cc1
Show InChI InChI=1S/C27H29BrFNO.ClH/c1-30(2)19-20-31-25-16-12-23(13-17-25)27(22-10-14-24(28)15-11-22)26(9-6-18-29)21-7-4-3-5-8-21;/h3-5,7-8,10-17H,6,9,18-20H2,1-2H3;1H/b27-26-;
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n/an/a 480n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inhibition of fluorescien-conjugated coactivator PGC1a binding to GST-tagged human ERRgamma LBD after 1 hr by TR-FRET assay


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193262
PNG
(CHEMBL3956562)
Show SMILES Cl.CN(C)CCOc1ccc(cc1)C(=C(\CCC(F)F)c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C27H29F2NO2.ClH/c1-30(2)18-19-32-24-14-10-22(11-15-24)27(21-8-12-23(31)13-9-21)25(16-17-26(28)29)20-6-4-3-5-7-20;/h3-15,26,31H,16-19H2,1-2H3;1H/b27-25-;
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n/an/a 480n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inhibition of fluorescien-conjugated coactivator PGC1a binding to GST-tagged human ERRgamma LBD after 1 hr by TR-FRET assay


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193273
PNG
(CHEMBL3982516)
Show SMILES Cl.CN(C)CCOc1ccc(cc1)C(=C(\CCCO)c1cccc(F)c1)\c1ccc(C)cc1
Show InChI InChI=1S/C28H32FNO2.ClH/c1-21-9-11-22(12-10-21)28(23-13-15-26(16-14-23)32-19-17-30(2)3)27(8-5-18-31)24-6-4-7-25(29)20-24;/h4,6-7,9-16,20,31H,5,8,17-19H2,1-3H3;1H/b28-27-;
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n/an/a 500n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inhibition of fluorescien-conjugated coactivator PGC1a binding to GST-tagged human ERRgamma LBD after 1 hr by TR-FRET assay


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193266
PNG
(CHEMBL3940124)
Show SMILES Cl.CN(C)CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(Cl)cc1
Show InChI InChI=1S/C27H30ClNO2.ClH/c1-29(2)18-20-31-25-16-12-23(13-17-25)27(22-10-14-24(28)15-11-22)26(9-6-19-30)21-7-4-3-5-8-21;/h3-5,7-8,10-17,30H,6,9,18-20H2,1-2H3;1H/b27-26-;
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n/an/a 520n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inhibition of fluorescien-conjugated coactivator PGC1a binding to GST-tagged human ERRgamma LBD after 1 hr by TR-FRET assay


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM20608
PNG
(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)
Show SMILES CC\C(=C(/c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1
Show InChI InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
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n/an/a 600n/an/an/an/an/an/a



The Beckman Research Institute

Curated by ChEMBL


Assay Description
Inverse agonist activity at GAL4-DNA binding domain-fused mouse ERRgamma ligand binding domain expressed in African green monkey CV1 cells assessed a...


Bioorg Med Chem 25: 1585-1599 (2017)


Article DOI: 10.1016/j.bmc.2017.01.019
BindingDB Entry DOI: 10.7270/Q2DF6TFV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193255
PNG
(CHEMBL3973526)
Show SMILES Cl.CN(C)CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(C)cc1
Show InChI InChI=1S/C28H33NO2.ClH/c1-22-11-13-24(14-12-22)28(27(10-7-20-30)23-8-5-4-6-9-23)25-15-17-26(18-16-25)31-21-19-29(2)3;/h4-6,8-9,11-18,30H,7,10,19-21H2,1-3H3;1H/b28-27-;
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n/an/a 669n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inverse agonist activity at ERRgamma (unknown origin) expressed in human AD293 cells after 24 hrs by beta-galactosidase/luciferase reporter gene assa...


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193251
PNG
(CHEMBL3978054)
Show SMILES Cl.CN(C)CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(Br)cc1
Show InChI InChI=1S/C27H30BrNO2.ClH/c1-29(2)18-20-31-25-16-12-23(13-17-25)27(22-10-14-24(28)15-11-22)26(9-6-19-30)21-7-4-3-5-8-21;/h3-5,7-8,10-17,30H,6,9,18-20H2,1-2H3;1H/b27-26-;
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n/an/a 719n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inverse agonist activity at ERRgamma (unknown origin) expressed in human AD293 cells after 24 hrs by beta-galactosidase/luciferase reporter gene assa...


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-Related Receptor, gamma


(Homo sapiens (Human))
BDBM22436
PNG
(4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-6-hy...)
Show SMILES CN(C)CCOc1ccc(cc1)C(=C(\CCCCO)c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C28H33NO3/c1-29(2)19-21-32-26-17-13-24(14-18-26)28(23-11-15-25(31)16-12-23)27(10-6-7-20-30)22-8-4-3-5-9-22/h3-5,8-9,11-18,30-31H,6-7,10,19-21H2,1-2H3/b28-27-
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n/an/a 790n/an/an/an/a7.422



GSK



Assay Description
Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...


Bioorg Med Chem Lett 16: 821-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.030
BindingDB Entry DOI: 10.7270/Q2WW7FZ7
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193269
PNG
(CHEMBL3965511)
Show SMILES Cl.CN(C)CCOc1ccc(cc1)C(=C(\CCC(F)F)c1ccccc1)\c1ccc(Br)cc1
Show InChI InChI=1S/C27H28BrF2NO.ClH/c1-31(2)18-19-32-24-14-10-22(11-15-24)27(21-8-12-23(28)13-9-21)25(16-17-26(29)30)20-6-4-3-5-7-20;/h3-15,26H,16-19H2,1-2H3;1H/b27-25-;
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n/an/a 890n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inhibition of fluorescien-conjugated coactivator PGC1a binding to GST-tagged human ERRgamma LBD after 1 hr by TR-FRET assay


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-Related Receptor, gamma


(Homo sapiens (Human))
BDBM22429
PNG
(4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-(m...)
Show SMILES CSCCC\C(=C(/c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1
Show InChI InChI=1S/C28H33NO2S/c1-29(2)19-20-31-26-17-13-24(14-18-26)28(23-11-15-25(30)16-12-23)27(10-7-21-32-3)22-8-5-4-6-9-22/h4-6,8-9,11-18,30H,7,10,19-21H2,1-3H3/b28-27-
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n/an/a 1.00E+3n/an/an/an/a7.422



GSK



Assay Description
Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...


Bioorg Med Chem Lett 16: 821-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.030
BindingDB Entry DOI: 10.7270/Q2WW7FZ7
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193256
PNG
(CHEMBL3893563)
Show SMILES Cl.COc1ccc(cc1)C(=C(/CCCO)c1ccccc1)\c1ccc(OCCN(C)C)cc1
Show InChI InChI=1S/C28H33NO3.ClH/c1-29(2)19-21-32-26-17-13-24(14-18-26)28(23-11-15-25(31-3)16-12-23)27(10-7-20-30)22-8-5-4-6-9-22;/h4-6,8-9,11-18,30H,7,10,19-21H2,1-3H3;1H/b28-27-;
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n/an/a 1.00E+3n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inhibition of fluorescien-conjugated coactivator PGC1a binding to GST-tagged human ERRgamma LBD after 1 hr by TR-FRET assay


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50233268
PNG
(CHEMBL4073790)
Show SMILES CC(C)C\C(=C(/c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1
Show InChI InChI=1S/C28H33NO2/c1-21(2)20-27(22-8-6-5-7-9-22)28(23-10-14-25(30)15-11-23)24-12-16-26(17-13-24)31-19-18-29(3)4/h5-17,21,30H,18-20H2,1-4H3/b28-27-
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n/an/a 1.00E+3n/an/an/an/an/an/a



The Beckman Research Institute

Curated by ChEMBL


Assay Description
Inverse agonist activity at GAL4-DNA binding domain-fused mouse ERRgamma ligand binding domain expressed in African green monkey CV1 cells assessed a...


Bioorg Med Chem 25: 1585-1599 (2017)


Article DOI: 10.1016/j.bmc.2017.01.019
BindingDB Entry DOI: 10.7270/Q2DF6TFV
More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193258
PNG
(CHEMBL3953814)
Show SMILES Cl.CN(C)CCOc1ccc(cc1)C(=C(\CCCO)c1cccc(F)c1)\c1ccc(Br)cc1
Show InChI InChI=1S/C27H29BrFNO2.ClH/c1-30(2)16-18-32-25-14-10-21(11-15-25)27(20-8-12-23(28)13-9-20)26(7-4-17-31)22-5-3-6-24(29)19-22;/h3,5-6,8-15,19,31H,4,7,16-18H2,1-2H3;1H/b27-26-;
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n/an/a 1.10E+3n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inhibition of fluorescien-conjugated coactivator PGC1a binding to GST-tagged human ERRgamma LBD after 1 hr by TR-FRET assay


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-Related Receptor, gamma


(Homo sapiens (Human))
BDBM22425
PNG
((4Z)-5-{4-[2-(dimethylamino)ethoxy]phenyl}-5-(4-hy...)
Show SMILES CN(C)CCOc1ccc(cc1)C(=C(\CCC#N)c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C27H28N2O2/c1-29(2)19-20-31-25-16-12-23(13-17-25)27(22-10-14-24(30)15-11-22)26(9-6-18-28)21-7-4-3-5-8-21/h3-5,7-8,10-17,30H,6,9,19-20H2,1-2H3/b27-26-
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n/an/a 1.30E+3n/an/an/an/a7.422



GSK



Assay Description
Binding affinity was measured by a scintillation proximity binding assay using [3H]4-OHT (for ERRgamma) or [3H]estradiol (for ERalpha) as radioligand...


Bioorg Med Chem Lett 16: 821-4 (2006)


Article DOI: 10.1016/j.bmcl.2005.11.030
BindingDB Entry DOI: 10.7270/Q2WW7FZ7
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193270
PNG
(CHEMBL3904163)
Show SMILES Cl.CN(C)CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C28H30F3NO2.ClH/c1-32(2)18-20-34-25-16-12-23(13-17-25)27(22-10-14-24(15-11-22)28(29,30)31)26(9-6-19-33)21-7-4-3-5-8-21;/h3-5,7-8,10-17,33H,6,9,18-20H2,1-2H3;1H/b27-26-;
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n/an/a 1.30E+3n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inhibition of fluorescien-conjugated coactivator PGC1a binding to GST-tagged human ERRgamma LBD after 1 hr by TR-FRET assay


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM20608
PNG
(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)
Show SMILES CC\C(=C(/c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1
Show InChI InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-
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n/an/a 1.35E+3n/an/an/an/an/an/a



Phenex Pharmaceuticals AG

Curated by ChEMBL


Assay Description
Agonist activity at human estrogen related receptor gamma expressed in HEK293 cells by luciferase reporter gene assay


Bioorg Med Chem Lett 24: 5265-7 (2014)


Article DOI: 10.1016/j.bmcl.2014.09.053
BindingDB Entry DOI: 10.7270/Q2S46TKZ
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50193249
PNG
(CHEMBL3986248)
Show SMILES Cl.CN(C)CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccccc1
Show InChI InChI=1S/C27H31NO2.ClH/c1-28(2)19-21-30-25-17-15-24(16-18-25)27(23-12-7-4-8-13-23)26(14-9-20-29)22-10-5-3-6-11-22;/h3-8,10-13,15-18,29H,9,14,19-21H2,1-2H3;1H/b27-26-;
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n/an/a 1.50E+3n/an/an/an/an/an/a



Daegu-Gyeongbuk Medical Innovation Foundation

Curated by ChEMBL


Assay Description
Inhibition of fluorescien-conjugated coactivator PGC1a binding to GST-tagged human ERRgamma LBD after 1 hr by TR-FRET assay


Eur J Med Chem 120: 338-52 (2016)


Article DOI: 10.1016/j.ejmech.2016.04.076
BindingDB Entry DOI: 10.7270/Q2TH8PN2
More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM50233270
PNG
(CHEMBL4091901)
Show SMILES CC(CO)C\C(=C(/c1ccc(O)cc1)c1ccc(OCCN(C)C)cc1)c1ccccc1
Show InChI InChI=1/C28H33NO3/c1-21(20-30)19-27(22-7-5-4-6-8-22)28(23-9-13-25(31)14-10-23)24-11-15-26(16-12-24)32-18-17-29(2)3/h4-16,21,30-31H,17-20H2,1-3H3/b28-27-
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n/an/a 2.50E+3n/an/an/an/an/an/a



The Beckman Research Institute

Curated by ChEMBL


Assay Description
Inverse agonist activity at GAL4-DNA binding domain-fused mouse ERRgamma ligand binding domain expressed in African green monkey CV1 cells assessed a...


Bioorg Med Chem 25: 1585-1599 (2017)


Article DOI: 10.1016/j.bmc.2017.01.019
BindingDB Entry DOI: 10.7270/Q2DF6TFV
More data for this
Ligand-Target Pair
Estrogen-related receptor gamma


(Homo sapiens (Human))
BDBM22435
PNG
(4-[(1Z)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-5-hy...)
Show SMILES CN(C)CCOc1ccc(cc1)C(=C(\CCCO)c1ccccc1)\c1ccc(O)cc1
Show InChI InChI=1S/C27H31NO3/c1-28(2)18-20-31-25-16-12-23(13-17-25)27(22-10-14-24(30)15-11-22)26(9-6-19-29)21-7-4-3-5-8-21/h3-5,7-8,10-17,29-30H,6,9,18-20H2,1-2H3/b27-26-
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n/an/a 2.70E+3n/an/an/an/an/an/a



The Beckman Research Institute

Curated by ChEMBL


Assay Description
Inverse agonist activity at GAL4-DNA binding domain-fused mouse ERRgamma ligand binding domain expressed in African green monkey CV1 cells assessed a...


Bioorg Med Chem 25: 1585-1599 (2017)


Article DOI: 10.1016/j.bmc.2017.01.019
BindingDB Entry DOI: 10.7270/Q2DF6TFV
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
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