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Compile Data Set for Download or QSAR

Found 141 hits of ec50 for UniProtKB: O14746   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134023
PNG
(CHEMBL337762 | N,N'-(9-(4-aminophenylamino)acridin...)
Show SMILES Nc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3ccc(NC(=O)CCN4CCCC4)cc23)cc1
Show InChI InChI=1S/C33H39N7O2/c34-23-5-7-24(8-6-23)37-33-27-11-9-26(36-32(42)14-20-40-17-3-4-18-40)22-30(27)38-29-12-10-25(21-28(29)33)35-31(41)13-19-39-15-1-2-16-39/h5-12,21-22H,1-4,13-20,34H2,(H,35,41)(H,36,42)(H,37,38)
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PubMed
n/an/an/an/a 2n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134027
PNG
(CHEMBL140180 | N,N'-(9-(2-(dimethylamino)ethylamin...)
Show SMILES CN(C)CCNc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2cc(NC(=O)CCN3CCCC3)ccc12
Show InChI InChI=1S/C31H43N7O2/c1-36(2)20-13-32-31-25-9-7-23(33-29(39)11-18-37-14-3-4-15-37)21-27(25)35-28-22-24(8-10-26(28)31)34-30(40)12-19-38-16-5-6-17-38/h7-10,21-22H,3-6,11-20H2,1-2H3,(H,32,35)(H,33,39)(H,34,40)
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PubMed
n/an/an/an/a 18n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134015
PNG
(CHEMBL44130 | N-[9-[2-(2-Amino-ethyl)-pyrrolidin-1...)
Show SMILES NCCC1CCCN1c1c2ccc(NC(=O)CCN3CCCC3)cc2nc2cc(NC(=O)CCN3CCCC3)ccc12
Show InChI InChI=1S/C33H45N7O2/c34-14-11-26-6-5-19-40(26)33-27-9-7-24(35-31(41)12-20-38-15-1-2-16-38)22-29(27)37-30-23-25(8-10-28(30)33)36-32(42)13-21-39-17-3-4-18-39/h7-10,22-23,26H,1-6,11-21,34H2,(H,35,41)(H,36,42)
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n/an/an/an/a 18n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134010
PNG
(CHEMBL139511 | N,N'-(9-(2-aminophenylamino)acridin...)
Show SMILES Nc1ccccc1Nc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2cc(NC(=O)CCN3CCCC3)ccc12
Show InChI InChI=1S/C33H39N7O2/c34-27-7-1-2-8-28(27)38-33-25-11-9-23(35-31(41)13-19-39-15-3-4-16-39)21-29(25)37-30-22-24(10-12-26(30)33)36-32(42)14-20-40-17-5-6-18-40/h1-2,7-12,21-22H,3-6,13-20,34H2,(H,35,41)(H,36,42)(H,37,38)
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n/an/an/an/a 20n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134011
PNG
(CHEMBL343609 | N,N'-(9-(2-aminophenylamino)acridin...)
Show SMILES Nc1ccccc1Nc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2ccc(NC(=O)CCN3CCCC3)cc12
Show InChI InChI=1S/C33H39N7O2/c34-27-7-1-2-8-29(27)38-33-25-11-9-24(36-32(42)14-20-40-17-5-6-18-40)22-30(25)37-28-12-10-23(21-26(28)33)35-31(41)13-19-39-15-3-4-16-39/h1-2,7-12,21-22H,3-6,13-20,34H2,(H,35,41)(H,36,42)(H,37,38)
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PubMed
n/an/an/an/a 21n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50133998
PNG
(CHEMBL137809 | N,N'-(9-(2-(methylthio)phenylamino)...)
Show SMILES CSc1ccccc1Nc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2cc(NC(=O)CCN3CCCC3)ccc12
Show InChI InChI=1S/C34H40N6O2S/c1-43-31-9-3-2-8-28(31)38-34-26-12-10-24(35-32(41)14-20-39-16-4-5-17-39)22-29(26)37-30-23-25(11-13-27(30)34)36-33(42)15-21-40-18-6-7-19-40/h2-3,8-13,22-23H,4-7,14-21H2,1H3,(H,35,41)(H,36,42)(H,37,38)
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PubMed
n/an/an/an/a 30n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50204461
PNG
(CHEMBL397746 | N-[9-(3,4-difluoro-benzylamino)-6-(...)
Show SMILES Fc1ccc(CNc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1F
Show InChI InChI=1S/C34H38F2N6O2/c35-28-10-5-23(19-29(28)36)22-37-34-26-8-6-24(38-32(43)11-17-41-13-1-2-14-41)20-30(26)40-31-21-25(7-9-27(31)34)39-33(44)12-18-42-15-3-4-16-42/h5-10,19-21H,1-4,11-18,22H2,(H,37,40)(H,38,43)(H,39,44)
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PubMed
n/an/an/an/a 30n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibition of human telomerase by TRAP assay


Bioorg Med Chem Lett 17: 2293-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.056
BindingDB Entry DOI: 10.7270/Q2JW8FQC
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134022
PNG
(CHEMBL336444 | N,N'-(9-(4-acetylphenylamino)acridi...)
Show SMILES CC(=O)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C35H40N6O3/c1-24(42)25-6-8-26(9-7-25)38-35-29-12-10-27(36-33(43)14-20-40-16-2-3-17-40)22-31(29)39-32-23-28(11-13-30(32)35)37-34(44)15-21-41-18-4-5-19-41/h6-13,22-23H,2-5,14-21H2,1H3,(H,36,43)(H,37,44)(H,38,39)
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PubMed
n/an/an/an/a 40n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134032
PNG
(CHEMBL138811 | N,N'-(9-(cyclopropylamino)acridine-...)
Show SMILES O=C(CCN1CCCC1)Nc1ccc2c(NC3CC3)c3ccc(NC(=O)CCN4CCCC4)cc3nc2c1
Show InChI InChI=1S/C30H38N6O2/c37-28(11-17-35-13-1-2-14-35)31-22-7-9-24-26(19-22)34-27-20-23(8-10-25(27)30(24)33-21-5-6-21)32-29(38)12-18-36-15-3-4-16-36/h7-10,19-21H,1-6,11-18H2,(H,31,37)(H,32,38)(H,33,34)
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PubMed
n/an/an/an/a 50n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134021
PNG
(CHEMBL138761 | N,N'-(9-(3-(methylthio)phenylamino)...)
Show SMILES CSc1cccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)c1
Show InChI InChI=1S/C34H40N6O2S/c1-43-27-8-6-7-24(21-27)37-34-28-11-9-25(35-32(41)13-19-39-15-2-3-16-39)22-30(28)38-31-23-26(10-12-29(31)34)36-33(42)14-20-40-17-4-5-18-40/h6-12,21-23H,2-5,13-20H2,1H3,(H,35,41)(H,36,42)(H,37,38)
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PubMed
n/an/an/an/a 60n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134009
PNG
(CHEMBL335132 | N,N'-(9-(3-(dimethylamino)propylami...)
Show SMILES CN(C)CCCNc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2cc(NC(=O)CCN3CCCC3)ccc12
Show InChI InChI=1S/C32H45N7O2/c1-37(2)15-7-14-33-32-26-10-8-24(34-30(40)12-20-38-16-3-4-17-38)22-28(26)36-29-23-25(9-11-27(29)32)35-31(41)13-21-39-18-5-6-19-39/h8-11,22-23H,3-7,12-21H2,1-2H3,(H,33,36)(H,34,40)(H,35,41)
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PubMed
n/an/an/an/a 60n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134019
PNG
(CHEMBL336417 | N,N'-(9-(3-aminophenylamino)acridin...)
Show SMILES Nc1cccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)c1
Show InChI InChI=1S/C33H39N7O2/c34-23-6-5-7-24(20-23)37-33-27-10-8-25(35-31(41)12-18-39-14-1-2-15-39)21-29(27)38-30-22-26(9-11-28(30)33)36-32(42)13-19-40-16-3-4-17-40/h5-11,20-22H,1-4,12-19,34H2,(H,35,41)(H,36,42)(H,37,38)
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PubMed
n/an/an/an/a 60n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50180770
PNG
(3,6-bis[3-(pyrrolidin-1-yl)propionamido]-9-{4'-[3'...)
Show SMILES O=C(CCN1CCCC1)Nc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C40H50N8O3/c49-37(15-24-46-18-1-2-19-46)41-29-7-9-30(10-8-29)44-40-33-13-11-31(42-38(50)16-25-47-20-3-4-21-47)27-35(33)45-36-28-32(12-14-34(36)40)43-39(51)17-26-48-22-5-6-23-48/h7-14,27-28H,1-6,15-26H2,(H,41,49)(H,42,50)(H,43,51)(H,44,45)
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PubMed
n/an/an/an/a 67n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibition of telomerase activity from human A2780 cells


J Med Chem 49: 582-99 (2006)


Article DOI: 10.1021/jm050555a
BindingDB Entry DOI: 10.7270/Q2CN73GR
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134025
PNG
(CHEMBL343795 | N,N'-(9-(4-fluorophenylamino)acridi...)
Show SMILES Fc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C33H37FN6O2/c34-23-5-7-24(8-6-23)37-33-27-11-9-25(35-31(41)13-19-39-15-1-2-16-39)21-29(27)38-30-22-26(10-12-28(30)33)36-32(42)14-20-40-17-3-4-18-40/h5-12,21-22H,1-4,13-20H2,(H,35,41)(H,36,42)(H,37,38)
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n/an/an/an/a 70n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134018
PNG
(CHEMBL335819 | N,N'-(9-(4-aminophenylamino)acridin...)
Show SMILES Nc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C33H39N7O2/c34-23-5-7-24(8-6-23)37-33-27-11-9-25(35-31(41)13-19-39-15-1-2-16-39)21-29(27)38-30-22-26(10-12-28(30)33)36-32(42)14-20-40-17-3-4-18-40/h5-12,21-22H,1-4,13-20,34H2,(H,35,41)(H,36,42)(H,37,38)
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PubMed
n/an/an/an/a 74n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50150618
PNG
(CHEMBL182871 | Hexanedioic acid {4-[3,6-bis-(3-pyr...)
Show SMILES CCN(CC)CCCCCCNC(=O)CCCCC(=O)Nc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C49H69N9O4/c1-3-56(4-2)28-10-6-5-9-27-50-45(59)15-7-8-16-46(60)51-37-17-19-38(20-18-37)54-49-41-23-21-39(52-47(61)25-33-57-29-11-12-30-57)35-43(41)55-44-36-40(22-24-42(44)49)53-48(62)26-34-58-31-13-14-32-58/h17-24,35-36H,3-16,25-34H2,1-2H3,(H,50,59)(H,51,60)(H,52,61)(H,53,62)(H,54,55)
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PubMed
n/an/an/an/a 80n/an/an/an/a



University of London School of Pharmacy

Curated by ChEMBL


Assay Description
Effective concentration against telomerase by TRAP


Bioorg Med Chem Lett 14: 4347-51 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.090
BindingDB Entry DOI: 10.7270/Q2KD1XDZ
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134008
PNG
(CHEMBL138187 | N,N'-(9-(3-(dimethylamino)propylami...)
Show SMILES CN(C)CCCNc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2ccc(NC(=O)CCN3CCCC3)cc12
Show InChI InChI=1S/C32H45N7O2/c1-37(2)15-7-14-33-32-26-10-8-25(35-31(41)13-21-39-18-5-6-19-39)23-29(26)36-28-11-9-24(22-27(28)32)34-30(40)12-20-38-16-3-4-17-38/h8-11,22-23H,3-7,12-21H2,1-2H3,(H,33,36)(H,34,40)(H,35,41)
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PubMed
n/an/an/an/a 80n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50155654
PNG
(3,6,9-Tri-pyrrolidin-1-yl-acridine | CHEMBL184103)
Show SMILES C1CCN(C1)c1ccc2c(N3CCCC3)c3ccc(cc3nc2c1)N1CCCC1
Show InChI InChI=1S/C25H30N4/c1-2-12-27(11-1)19-7-9-21-23(17-19)26-24-18-20(28-13-3-4-14-28)8-10-22(24)25(21)29-15-5-6-16-29/h7-10,17-18H,1-6,11-16H2
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n/an/an/an/a 90n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Concentration required to inhibit 50% of telomerase activity


Bioorg Med Chem Lett 14: 5845-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.037
BindingDB Entry DOI: 10.7270/Q26D5SG9
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134000
PNG
(CHEMBL139287 | N,N'-(9-(cyclohexylamino)acridine-3...)
Show SMILES O=C(CCN1CCCC1)Nc1ccc2c(NC3CCCCC3)c3ccc(NC(=O)CCN4CCCC4)cc3nc2c1
Show InChI InChI=1S/C33H44N6O2/c40-31(14-20-38-16-4-5-17-38)34-25-10-12-27-29(22-25)37-30-23-26(35-32(41)15-21-39-18-6-7-19-39)11-13-28(30)33(27)36-24-8-2-1-3-9-24/h10-13,22-24H,1-9,14-21H2,(H,34,40)(H,35,41)(H,36,37)
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n/an/an/an/a 90n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50150622
PNG
(CHEMBL184587 | Hexanedioic acid {4-[3,6-bis-(3-pyr...)
Show SMILES CCN(CC)CCNC(=O)CCCCC(=O)Nc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C45H61N9O4/c1-3-52(4-2)30-23-46-41(55)11-5-6-12-42(56)47-33-13-15-34(16-14-33)50-45-37-19-17-35(48-43(57)21-28-53-24-7-8-25-53)31-39(37)51-40-32-36(18-20-38(40)45)49-44(58)22-29-54-26-9-10-27-54/h13-20,31-32H,3-12,21-30H2,1-2H3,(H,46,55)(H,47,56)(H,48,57)(H,49,58)(H,50,51)
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n/an/an/an/a 98n/an/an/an/a



University of London School of Pharmacy

Curated by ChEMBL


Assay Description
Effective concentration against telomerase by TRAP


Bioorg Med Chem Lett 14: 4347-51 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.090
BindingDB Entry DOI: 10.7270/Q2KD1XDZ
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50180768
PNG
(3,6-[4-(pyrrolidin-1-yl)butanamido]-9-[4'-(N,N-dim...)
Show SMILES CN(C)c1ccc(Nc2c3ccc(NC(=O)CCCN4CCCC4)cc3nc3cc(NC(=O)CCCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C37H47N7O2/c1-42(2)30-15-11-27(12-16-30)40-37-31-17-13-28(38-35(45)9-7-23-43-19-3-4-20-43)25-33(31)41-34-26-29(14-18-32(34)37)39-36(46)10-8-24-44-21-5-6-22-44/h11-18,25-26H,3-10,19-24H2,1-2H3,(H,38,45)(H,39,46)(H,40,41)
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n/an/an/an/a 99n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibition of telomerase activity from human A2780 cells


J Med Chem 49: 582-99 (2006)


Article DOI: 10.1021/jm050555a
BindingDB Entry DOI: 10.7270/Q2CN73GR
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134026
PNG
(CHEMBL138487 | N,N'-(9-(3-(dimethylamino)phenylami...)
Show SMILES CN(C)c1cccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)c1
Show InChI InChI=1S/C35H43N7O2/c1-40(2)28-9-7-8-25(22-28)38-35-29-12-10-26(36-33(43)14-20-41-16-3-4-17-41)23-31(29)39-32-24-27(11-13-30(32)35)37-34(44)15-21-42-18-5-6-19-42/h7-13,22-24H,3-6,14-21H2,1-2H3,(H,36,43)(H,37,44)(H,38,39)
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n/an/an/an/a 100n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134020
PNG
(CHEMBL141661 | N,N'-(9-(3-acetamidophenylamino)acr...)
Show SMILES CC(=O)Nc1cccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)c1
Show InChI InChI=1S/C35H41N7O3/c1-24(43)36-25-7-6-8-26(21-25)39-35-29-11-9-27(37-33(44)13-19-41-15-2-3-16-41)22-31(29)40-32-23-28(10-12-30(32)35)38-34(45)14-20-42-17-4-5-18-42/h6-12,21-23H,2-5,13-20H2,1H3,(H,36,43)(H,37,44)(H,38,45)(H,39,40)
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n/an/an/an/a 100n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134030
PNG
(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Show SMILES CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C35H43N7O2/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39)
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n/an/an/an/a 113n/an/an/an/a



University of London School of Pharmacy

Curated by ChEMBL


Assay Description
Effective concentration against telomerase by TRAP


Bioorg Med Chem Lett 14: 4347-51 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.090
BindingDB Entry DOI: 10.7270/Q2KD1XDZ
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134030
PNG
(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Show SMILES CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C35H43N7O2/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39)
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n/an/an/an/a 113n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibition of telomerase activity from human A2780 cells


J Med Chem 49: 582-99 (2006)


Article DOI: 10.1021/jm050555a
BindingDB Entry DOI: 10.7270/Q2CN73GR
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134030
PNG
(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Show SMILES CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C35H43N7O2/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39)
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n/an/an/an/a 115n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50180772
PNG
(3,6-bis[3-(pyrrolidin-1-yl)propionamido]-9-{4'-[3'...)
Show SMILES O=C(CCCN1CCCC1)Nc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C41H52N8O3/c50-38(8-7-25-47-19-1-2-20-47)42-30-9-11-31(12-10-30)45-41-34-15-13-32(43-39(51)17-26-48-21-3-4-22-48)28-36(34)46-37-29-33(14-16-35(37)41)44-40(52)18-27-49-23-5-6-24-49/h9-16,28-29H,1-8,17-27H2,(H,42,50)(H,43,51)(H,44,52)(H,45,46)
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n/an/an/an/a 117n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibition of telomerase activity from human A2780 cells


J Med Chem 49: 582-99 (2006)


Article DOI: 10.1021/jm050555a
BindingDB Entry DOI: 10.7270/Q2CN73GR
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134030
PNG
(9-[4-(N,N-dimethylamino)phenylamino]-3,6-bis(3-pyr...)
Show SMILES CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C35H43N7O2/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-26(36-33(43)15-21-41-17-3-4-18-41)23-31(29)39-32-24-27(10-14-30(32)35)37-34(44)16-22-42-19-5-6-20-42/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39)
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n/an/an/an/a 120n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibition of human telomerase by TRAP assay


Bioorg Med Chem Lett 17: 2293-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.056
BindingDB Entry DOI: 10.7270/Q2JW8FQC
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134006
PNG
(CHEMBL335564 | N,N'-(9-(2-methoxyethylamino)acridi...)
Show SMILES COCCNc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2cc(NC(=O)CCN3CCCC3)ccc12
Show InChI InChI=1S/C30H40N6O3/c1-39-19-12-31-30-24-8-6-22(32-28(37)10-17-35-13-2-3-14-35)20-26(24)34-27-21-23(7-9-25(27)30)33-29(38)11-18-36-15-4-5-16-36/h6-9,20-21H,2-5,10-19H2,1H3,(H,31,34)(H,32,37)(H,33,38)
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n/an/an/an/a 140n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50180773
PNG
(3,6-bis[6-(pyrrolidin-1-yl)hexanamido]-9-{4'-[3''-...)
Show SMILES O=C(CCCCCN1CCCC1)Nc1ccc2c(Nc3ccc(NC(=O)CCN4CCCC4)cc3)c3ccc(NC(=O)CCCCCN4CCCC4)cc3nc2c1
Show InChI InChI=1S/C46H62N8O3/c55-43(13-3-1-5-24-52-26-7-8-27-52)48-37-19-21-39-41(33-37)51-42-34-38(49-44(56)14-4-2-6-25-53-28-9-10-29-53)20-22-40(42)46(39)50-36-17-15-35(16-18-36)47-45(57)23-32-54-30-11-12-31-54/h15-22,33-34H,1-14,23-32H2,(H,47,57)(H,48,55)(H,49,56)(H,50,51)
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n/an/an/an/a 146n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibition of telomerase activity from human A2780 cells


J Med Chem 49: 582-99 (2006)


Article DOI: 10.1021/jm050555a
BindingDB Entry DOI: 10.7270/Q2CN73GR
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50150620
PNG
(6-(4-Methyl-piperazin-1-yl)-6-oxo-hexanoic acid {4...)
Show SMILES CN1CCN(CC1)C(=O)CCCCC(=O)Nc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C44H57N9O4/c1-50-26-28-53(29-27-50)43(57)9-3-2-8-40(54)45-32-10-12-33(13-11-32)48-44-36-16-14-34(46-41(55)18-24-51-20-4-5-21-51)30-38(36)49-39-31-35(15-17-37(39)44)47-42(56)19-25-52-22-6-7-23-52/h10-17,30-31H,2-9,18-29H2,1H3,(H,45,54)(H,46,55)(H,47,56)(H,48,49)
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n/an/an/an/a 165n/an/an/an/a



University of London School of Pharmacy

Curated by ChEMBL


Assay Description
Effective concentration against telomerase by TRAP


Bioorg Med Chem Lett 14: 4347-51 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.090
BindingDB Entry DOI: 10.7270/Q2KD1XDZ
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50180767
PNG
(3,6-bis[3-(pyrrolidin-1-yl)propionamido]-9-{4'-[2'...)
Show SMILES O=C(CCN1CCCC1)Nc1ccc2c(Nc3ccc(NC(=O)CN4CCCC4)cc3)c3ccc(NC(=O)CCN4CCCC4)cc3nc2c1
Show InChI InChI=1S/C39H48N8O3/c48-36(15-23-45-17-1-2-18-45)41-30-11-13-32-34(25-30)44-35-26-31(42-37(49)16-24-46-19-3-4-20-46)12-14-33(35)39(32)43-29-9-7-28(8-10-29)40-38(50)27-47-21-5-6-22-47/h7-14,25-26H,1-6,15-24,27H2,(H,40,50)(H,41,48)(H,42,49)(H,43,44)
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n/an/an/an/a 167n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibition of telomerase activity from human A2780 cells


J Med Chem 49: 582-99 (2006)


Article DOI: 10.1021/jm050555a
BindingDB Entry DOI: 10.7270/Q2CN73GR
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50133999
PNG
(CHEMBL345035 | N,N'-(9-(2-aminophenylamino)acridin...)
Show SMILES Nc1ccccc1Nc1c2cc(NC(=O)CCN3CCCC3)ccc2nc2ccc(NC(=O)CCN3CCCC3)cc12
Show InChI InChI=1S/C33H39N7O2/c34-27-7-1-2-8-30(27)38-33-25-21-23(35-31(41)13-19-39-15-3-4-16-39)9-11-28(25)37-29-12-10-24(22-26(29)33)36-32(42)14-20-40-17-5-6-18-40/h1-2,7-12,21-22H,3-6,13-20,34H2,(H,35,41)(H,36,42)(H,37,38)
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n/an/an/an/a 170n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134017
PNG
(CHEMBL138357 | N,N'-(9-(4-(dimethylamino)phenylami...)
Show SMILES CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3ccc(NC(=O)CCN4CCCC4)cc23)cc1
Show InChI InChI=1S/C35H43N7O2/c1-40(2)28-11-7-25(8-12-28)38-35-29-13-9-27(37-34(44)16-22-42-19-5-6-20-42)24-32(29)39-31-14-10-26(23-30(31)35)36-33(43)15-21-41-17-3-4-18-41/h7-14,23-24H,3-6,15-22H2,1-2H3,(H,36,43)(H,37,44)(H,38,39)
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n/an/an/an/a 170n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134028
PNG
(CHEMBL142036 | N,N'-(9-(4-aminophenylamino)acridin...)
Show SMILES Nc1ccc(Nc2c3cc(NC(=O)CCN4CCCC4)ccc3nc3ccc(NC(=O)CCN4CCCC4)cc23)cc1
Show InChI InChI=1S/C33H39N7O2/c34-23-5-7-24(8-6-23)37-33-27-21-25(35-31(41)13-19-39-15-1-2-16-39)9-11-29(27)38-30-12-10-26(22-28(30)33)36-32(42)14-20-40-17-3-4-18-40/h5-12,21-22H,1-4,13-20,34H2,(H,35,41)(H,36,42)(H,37,38)
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n/an/an/an/a 200n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50155646
PNG
(3-(4-Hydroxy-piperidin-1-yl)-N-{6-[3-(4-hydroxy-pi...)
Show SMILES OC1CCN(CCC(=O)Nc2ccc3c(O)c4cc(NC(=O)CCN5CCC(O)CC5)ccc4nc3c2)CC1
Show InChI InChI=1S/C29H37N5O5/c35-21-5-11-33(12-6-21)15-9-27(37)30-19-2-4-25-24(17-19)29(39)23-3-1-20(18-26(23)32-25)31-28(38)10-16-34-13-7-22(36)8-14-34/h1-4,17-18,21-22,35-36H,5-16H2,(H,30,37)(H,31,38)(H,32,39)
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n/an/an/an/a 200n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Concentration required to inhibit 50% of telomerase activity


Bioorg Med Chem Lett 14: 5845-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.037
BindingDB Entry DOI: 10.7270/Q26D5SG9
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50155662
PNG
(3-(2-Hydroxymethyl-piperidin-1-yl)-N-{7-[3-(2-hydr...)
Show SMILES OCC1CCCCN1CCC(=O)Nc1ccc2c(O)c3cc(NC(=O)CCN4CCCCC4CO)ccc3nc2c1
Show InChI InChI=1S/C31H41N5O5/c37-19-23-5-1-3-13-35(23)15-11-29(39)32-21-8-10-27-26(17-21)31(41)25-9-7-22(18-28(25)34-27)33-30(40)12-16-36-14-4-2-6-24(36)20-38/h7-10,17-18,23-24,37-38H,1-6,11-16,19-20H2,(H,32,39)(H,33,40)(H,34,41)
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n/an/an/an/a 200n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Concentration required to inhibit 50% of telomerase activity


Bioorg Med Chem Lett 14: 5845-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.037
BindingDB Entry DOI: 10.7270/Q26D5SG9
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50155661
PNG
(3-(4-Methyl-piperidin-1-yl)-N-{6-[3-(4-methyl-pipe...)
Show SMILES CC1CCN(CCC(=O)Nc2ccc3c(O)c4cc(NC(=O)CCN5CCC(C)CC5)ccc4nc3c2)CC1
Show InChI InChI=1S/C31H41N5O3/c1-21-7-13-35(14-8-21)17-11-29(37)32-23-4-6-27-26(19-23)31(39)25-5-3-24(20-28(25)34-27)33-30(38)12-18-36-15-9-22(2)10-16-36/h3-6,19-22H,7-18H2,1-2H3,(H,32,37)(H,33,38)(H,34,39)
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n/an/an/an/a 200n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Concentration required to inhibit 50% of telomerase activity


Bioorg Med Chem Lett 14: 5845-9 (2004)


Article DOI: 10.1016/j.bmcl.2004.09.037
BindingDB Entry DOI: 10.7270/Q26D5SG9
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134031
PNG
(CHEMBL137973 | N,N'-(9-(cyclohexylamino)acridine-2...)
Show SMILES O=C(CCN1CCCC1)Nc1ccc2c(NC3CCCCC3)c3cc(NC(=O)CCN4CCCC4)ccc3nc2c1
Show InChI InChI=1S/C33H44N6O2/c40-31(14-20-38-16-4-5-17-38)34-25-11-13-29-28(22-25)33(36-24-8-2-1-3-9-24)27-12-10-26(23-30(27)37-29)35-32(41)15-21-39-18-6-7-19-39/h10-13,22-24H,1-9,14-21H2,(H,34,40)(H,35,41)(H,36,37)
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n/an/an/an/a 210n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134012
PNG
(CHEMBL342480 | N,N'-(9-(3-aminophenylamino)acridin...)
Show SMILES Nc1cccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3ccc(NC(=O)CCN4CCCC4)cc23)c1
Show InChI InChI=1S/C33H39N7O2/c34-23-6-5-7-24(20-23)37-33-27-10-8-26(36-32(42)13-19-40-16-3-4-17-40)22-30(27)38-29-11-9-25(21-28(29)33)35-31(41)12-18-39-14-1-2-15-39/h5-11,20-22H,1-4,12-19,34H2,(H,35,41)(H,36,42)(H,37,38)
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n/an/an/an/a 210n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134007
PNG
(CHEMBL337123 | N-[9-Heptylamino-6-(3-pyrrolidin-1-...)
Show SMILES CCCCCCCNc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2cc(NC(=O)CCN3CCCC3)ccc12
Show InChI InChI=1S/C34H48N6O2/c1-2-3-4-5-6-17-35-34-28-13-11-26(36-32(41)15-22-39-18-7-8-19-39)24-30(28)38-31-25-27(12-14-29(31)34)37-33(42)16-23-40-20-9-10-21-40/h11-14,24-25H,2-10,15-23H2,1H3,(H,35,38)(H,36,41)(H,37,42)
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n/an/an/an/a 210n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50204464
PNG
(CHEMBL239793 | N-[9-(3-methyl-benzylamino)-6-(3-pi...)
Show SMILES Cc1cccc(CNc2c3ccc(NC(=O)CCN4CCCCC4)cc3nc3cc(NC(=O)CCN4CCCCC4)ccc23)c1
Show InChI InChI=1S/C37H46N6O2/c1-27-9-8-10-28(23-27)26-38-37-31-13-11-29(39-35(44)15-21-42-17-4-2-5-18-42)24-33(31)41-34-25-30(12-14-32(34)37)40-36(45)16-22-43-19-6-3-7-20-43/h8-14,23-25H,2-7,15-22,26H2,1H3,(H,38,41)(H,39,44)(H,40,45)
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n/an/an/an/a 230n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibition of human telomerase by TRAP assay


Bioorg Med Chem Lett 17: 2293-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.056
BindingDB Entry DOI: 10.7270/Q2JW8FQC
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50204466
PNG
(CHEMBL397768 | N-[9-(3-fluoro-5-trifluoromethyl-be...)
Show SMILES Fc1cc(CNc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc(c1)C(F)(F)F
Show InChI InChI=1S/C35H38F4N6O2/c36-25-18-23(17-24(19-25)35(37,38)39)22-40-34-28-7-5-26(41-32(46)9-15-44-11-1-2-12-44)20-30(28)43-31-21-27(6-8-29(31)34)42-33(47)10-16-45-13-3-4-14-45/h5-8,17-21H,1-4,9-16,22H2,(H,40,43)(H,41,46)(H,42,47)
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n/an/an/an/a 240n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibition of human telomerase by TRAP assay


Bioorg Med Chem Lett 17: 2293-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.056
BindingDB Entry DOI: 10.7270/Q2JW8FQC
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50180763
PNG
(3,6-bis[5-(pyrrolidin-1-yl)pentanamido]-9-{4'-[3''...)
Show SMILES O=C(CCCCN1CCCC1)Nc1ccc2c(Nc3ccc(NC(=O)CCN4CCCC4)cc3)c3ccc(NC(=O)CCCCN4CCCC4)cc3nc2c1
Show InChI InChI=1S/C44H58N8O3/c53-41(11-1-3-22-50-24-5-6-25-50)46-35-17-19-37-39(31-35)49-40-32-36(47-42(54)12-2-4-23-51-26-7-8-27-51)18-20-38(40)44(37)48-34-15-13-33(14-16-34)45-43(55)21-30-52-28-9-10-29-52/h13-20,31-32H,1-12,21-30H2,(H,45,55)(H,46,53)(H,47,54)(H,48,49)
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n/an/an/an/a 255n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibition of telomerase activity from human A2780 cells


J Med Chem 49: 582-99 (2006)


Article DOI: 10.1021/jm050555a
BindingDB Entry DOI: 10.7270/Q2CN73GR
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50150619
PNG
(6-Morpholin-4-yl-6-oxo-hexanoic acid {4-[3,6-bis-(...)
Show SMILES O=C(CCCCC(=O)N1CCOCC1)Nc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C43H54N8O5/c52-39(7-1-2-8-42(55)51-25-27-56-28-26-51)44-31-9-11-32(12-10-31)47-43-35-15-13-33(45-40(53)17-23-49-19-3-4-20-49)29-37(35)48-38-30-34(14-16-36(38)43)46-41(54)18-24-50-21-5-6-22-50/h9-16,29-30H,1-8,17-28H2,(H,44,52)(H,45,53)(H,46,54)(H,47,48)
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n/an/an/an/a 267n/an/an/an/a



University of London School of Pharmacy

Curated by ChEMBL


Assay Description
Effective concentration against telomerase by TRAP


Bioorg Med Chem Lett 14: 4347-51 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.090
BindingDB Entry DOI: 10.7270/Q2KD1XDZ
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50134001
PNG
(CHEMBL140084 | N,N'-(9-(2-(dimethylamino)ethylamin...)
Show SMILES CN(C)CCNc1c2ccc(NC(=O)CCN3CCCC3)cc2nc2ccc(NC(=O)CCN3CCCC3)cc12
Show InChI InChI=1S/C31H43N7O2/c1-36(2)20-13-32-31-25-9-7-24(34-30(40)12-19-38-16-5-6-17-38)22-28(25)35-27-10-8-23(21-26(27)31)33-29(39)11-18-37-14-3-4-15-37/h7-10,21-22H,3-6,11-20H2,1-2H3,(H,32,35)(H,33,39)(H,34,40)
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n/an/an/an/a 270n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibitory activity against human telomerase


J Med Chem 46: 4463-76 (2003)


Article DOI: 10.1021/jm0308693
BindingDB Entry DOI: 10.7270/Q2RR1XN3
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50150621
PNG
(6-Oxo-6-pyrrolidin-1-yl-hexanoic acid {4-[3,6-bis-...)
Show SMILES O=C(CCCCC(=O)N1CCCC1)Nc1ccc(Nc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc1
Show InChI InChI=1S/C43H54N8O4/c52-39(9-1-2-10-42(55)51-25-7-8-26-51)44-31-11-13-32(14-12-31)47-43-35-17-15-33(45-40(53)19-27-49-21-3-4-22-49)29-37(35)48-38-30-34(16-18-36(38)43)46-41(54)20-28-50-23-5-6-24-50/h11-18,29-30H,1-10,19-28H2,(H,44,52)(H,45,53)(H,46,54)(H,47,48)
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n/an/an/an/a 318n/an/an/an/a



University of London School of Pharmacy

Curated by ChEMBL


Assay Description
Effective concentration against telomerase by TRAP


Bioorg Med Chem Lett 14: 4347-51 (2004)


Article DOI: 10.1016/j.bmcl.2004.05.090
BindingDB Entry DOI: 10.7270/Q2KD1XDZ
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50180766
PNG
(3,6-bis[4-(pyrrolidin-1-yl)butanamido]-9-{4'-[3''-...)
Show SMILES O=C(CCCN1CCCC1)Nc1ccc2c(Nc3ccc(NC(=O)CCN4CCCC4)cc3)c3ccc(NC(=O)CCCN4CCCC4)cc3nc2c1
Show InChI InChI=1S/C42H54N8O3/c51-39(9-7-26-48-20-1-2-21-48)44-33-15-17-35-37(29-33)47-38-30-34(45-40(52)10-8-27-49-22-3-4-23-49)16-18-36(38)42(35)46-32-13-11-31(12-14-32)43-41(53)19-28-50-24-5-6-25-50/h11-18,29-30H,1-10,19-28H2,(H,43,53)(H,44,51)(H,45,52)(H,46,47)
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n/an/an/an/a 326n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibition of telomerase activity from human A2780 cells


J Med Chem 49: 582-99 (2006)


Article DOI: 10.1021/jm050555a
BindingDB Entry DOI: 10.7270/Q2CN73GR
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50204469
PNG
(CHEMBL397767 | N-[9-(3,5-dimethoxy-benzylamino)-6-...)
Show SMILES COc1cc(CNc2c3ccc(NC(=O)CCN4CCCC4)cc3nc3cc(NC(=O)CCN4CCCC4)ccc23)cc(OC)c1
Show InChI InChI=1S/C36H44N6O4/c1-45-28-19-25(20-29(23-28)46-2)24-37-36-30-9-7-26(38-34(43)11-17-41-13-3-4-14-41)21-32(30)40-33-22-27(8-10-31(33)36)39-35(44)12-18-42-15-5-6-16-42/h7-10,19-23H,3-6,11-18,24H2,1-2H3,(H,37,40)(H,38,43)(H,39,44)
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n/an/an/an/a 350n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibition of human telomerase by TRAP assay


Bioorg Med Chem Lett 17: 2293-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.056
BindingDB Entry DOI: 10.7270/Q2JW8FQC
More data for this
Ligand-Target Pair
Telomerase reverse transcriptase


(Homo sapiens (Human))
BDBM50204460
PNG
(CHEMBL396326 | N-[9-(4-dimethylamino-phenylamino)-...)
Show SMILES CN(C)c1ccc(Nc2c3ccc(NC(=O)CCN4CCCCC4)cc3nc3cc(NC(=O)CCN4CCCCC4)ccc23)cc1
Show InChI InChI=1S/C37H47N7O2/c1-42(2)30-13-9-27(10-14-30)40-37-31-15-11-28(38-35(45)17-23-43-19-5-3-6-20-43)25-33(31)41-34-26-29(12-16-32(34)37)39-36(46)18-24-44-21-7-4-8-22-44/h9-16,25-26H,3-8,17-24H2,1-2H3,(H,38,45)(H,39,46)(H,40,41)
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n/an/an/an/a 360n/an/an/an/a



University of London

Curated by ChEMBL


Assay Description
Inhibition of human telomerase by TRAP assay


Bioorg Med Chem Lett 17: 2293-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.01.056
BindingDB Entry DOI: 10.7270/Q2JW8FQC
More data for this
Ligand-Target Pair
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