Compile Data Set for Download or QSAR
maximum 50k data
Found 36 of ic50 for UniProtKB: P06700
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146058(Benzo[de]isochromene-1,3-dione | CHEMBL316059)
Affinity DataIC50:  8.80E+3nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146048(2,3-Dihydro-1H-naphtho[2,1-b]oxepin-4-one | CHEMBL...)
Affinity DataIC50:  1.20E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146067(1,2-Dihydro-benzo[f]thiochromen-3-one | CHEMBL3143...)
Affinity DataIC50:  2.50E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146052(5-Benzyloxy-1,2-dihydro-benzo[f]chromen-3-one | CH...)
Affinity DataIC50:  2.70E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146063(2-Isobutyl-1,2-dihydro-benzo[f]chromen-3-one | CHE...)
Affinity DataIC50:  2.70E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146044(2-Allyl-1,2-dihydro-benzo[f]chromen-3-one | CHEMBL...)
Affinity DataIC50:  2.70E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50177984(CHEMBL372375 | para-Sirtinol)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibitory activity against recombinant yeast Sir2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146068(7-Methoxy-1,2-dihydro-benzo[f]chromen-3-one | CHEM...)
Affinity DataIC50:  3.90E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146062(9-Methoxy-1,2-dihydro-benzo[f]chromen-3-one | CHEM...)
Affinity DataIC50:  4.10E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146046(1-Phenyl-1,2-dihydro-benzo[f]chromen-3-one | 1-phe...)
Affinity DataIC50:  4.30E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146069(6-Methoxy-1,2-dihydro-benzo[f]chromen-3-one | CHEM...)
Affinity DataIC50:  4.40E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50156760((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Affinity DataIC50:  4.80E+4nMAssay Description:Inhibitory activity against recombinant yeast Sir2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM27507(3-Pyridinecarboxamide | CHEMBL1140 | NAM | niacina...)
Affinity DataIC50: <5.00E+4nMAssay Description:Non-competitive inhibition of recombinant yeast glutathione-S-transferase-tagged SIRT2 using acetylated histone as substrate measured after 30 mins b...More data for this Ligand-Target Pair
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146054(2-Methyl-1,2-dihydro-benzo[f]chromen-3-one | CHEMB...)
Affinity DataIC50:  5.20E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146060(1H-Naphtho[2,1-b]furan-2-one | CHEMBL314020)
Affinity DataIC50:  5.90E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM29590(1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one | CHEMBL8...)
Affinity DataIC50:  6.00E+4nMAssay Description:Inhibition of yeast Sir 2 proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50177983((R)-sirtinol | CHEMBL198582)
Affinity DataIC50:  6.20E+4nMAssay Description:Inhibitory activity against recombinant yeast Sir2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146047(3,4-Dihydro-benzo[h]chromen-2-one | CHEMBL91528)
Affinity DataIC50:  6.50E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50177986((S)-sirtinol | CHEMBL197282)
Affinity DataIC50:  6.60E+4nMAssay Description:Inhibitory activity against recombinant yeast Sir2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50156760((E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N...)
Affinity DataIC50:  6.80E+4nMAssay Description:Inhibition of recombinant yeast Sir2p using acetylated HeLa histones as substrate measured after 2 hrs in presence of NAD by scintillation counting m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146050(3,4,9,10-Tetrahydro-1,7-dioxa-chrysene-2,8-dione |...)
Affinity DataIC50:  7.00E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50177985(CHEMBL200762 | meta-Sirtinol)
Affinity DataIC50:  7.20E+4nMAssay Description:Inhibitory activity against recombinant yeast Sir2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146064(8-Methoxy-1,2-dihydro-benzo[f]chromen-3-one | CHEM...)
Affinity DataIC50:  7.30E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM29590(1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one | CHEMBL8...)
Affinity DataIC50:  7.40E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146059(3,4-Dihydro-2H-phenanthren-1-one | CHEMBL88130)
Affinity DataIC50:  8.10E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146053(Benzo[f]chromen-3-one | CHEMBL424248)
Affinity DataIC50:  8.60E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146061(CHEMBL89585 | {2-[2-(3-Oxo-2,3-dihydro-1H-benzo[f]...)
Affinity DataIC50:  8.60E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146049(3,4,9,10-Tetrahydro-1,12-dioxa-triphenylene-2,11-d...)
Affinity DataIC50:  8.90E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146066(3-(2-Hydroxy-naphthalen-1-yl)-propionic acid methy...)
Affinity DataIC50:  9.70E+4nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146056(5-Hydroxy-1,2-dihydro-benzo[f]chromen-3-one | CHEM...)
Affinity DataIC50:  1.11E+5nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146070(1,2-benzodihydropyrone | 2-chromanone | 2-hydroxyd...)
Affinity DataIC50:  1.22E+5nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146065(3-(2-Hydroxy-naphthalen-1-yl)-propionamide | CHEMB...)
Affinity DataIC50:  1.25E+5nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146057(CHEMBL313262 | N,N-Diethyl-3-(2-hydroxy-naphthalen...)
Affinity DataIC50:  1.25E+5nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146055(5-Methoxy-1,2-dihydro-benzo[f]chromen-3-one | CHEM...)
Affinity DataIC50:  1.28E+5nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146051(6-Hydroxy-1,2-dihydro-benzo[f]chromen-3-one | CHEM...)
Affinity DataIC50:  1.31E+5nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent histone deacetylase SIR2(Saccharomyces cerevisiae)
Fred Hutchinson Cancer Research Center

Curated by ChEMBL
LigandPNGBDBM50146045(9-Hydroxy-1,2-dihydro-benzo[f]chromen-3-one | CHEM...)
Affinity DataIC50:  1.34E+5nMAssay Description:In vitro inhibition of sirtuin 2 was evaluated using yeast whole cell lysatesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed