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Compile Data Set for Download or QSAR

Found 14 hits of ic50 for Acetylcholine receptor
having polymerids = 50002849,50002857 and
complexids = 50000173   
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Acetylcholine receptor protein alpha/beta/delta/gamma chain


(Torpedo californica)
BDBM50023331
PNG
((+)-pyrido[3,4-b]homotropane | (+/-)-pyrido[3,4-b]...)
Show SMILES C1CC2NC1CCc1ccncc21
Show InChI InChI=1S/C11H14N2/c1-2-9-3-4-11(13-9)10-7-12-6-5-8(1)10/h5-7,9,11,13H,1-4H2
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n/an/a 0.100n/an/an/an/an/an/a



Stauffer Chemical Company

Curated by ChEMBL


Assay Description
inhibition of (-)-[3H]-nicotine binding to torpedo electroplax membranes


J Med Chem 31: 506-9 (1988)

More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha/beta/delta/gamma chain


(Torpedo californica)
BDBM50023330
PNG
(1-(9-Aza-bicyclo[4.2.1]non-2-en-2-yl)-ethanone | 1...)
Show SMILES CC(=O)C1=CCCC2CCC1N2
Show InChI InChI=1S/C10H15NO/c1-7(12)9-4-2-3-8-5-6-10(9)11-8/h4,8,10-11H,2-3,5-6H2,1H3
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n/an/a 0.100n/an/an/an/an/an/a



Stauffer Chemical Company

Curated by ChEMBL


Assay Description
Inhibition of (-)-[3H]-nicotine binding to rat brain membranes


J Med Chem 31: 506-9 (1988)

More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha/beta/delta/gamma chain


(Torpedo californica)
BDBM82070
PNG
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Show SMILES CN1CCC[C@H]1c1cccnc1
Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1
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n/an/a 1n/an/an/an/an/an/a



Stauffer Chemical Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-MCC binding to rat brain membranes


J Med Chem 31: 506-9 (1988)

More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha/beta/delta/gamma chain


(Torpedo californica)
BDBM50023330
PNG
(1-(9-Aza-bicyclo[4.2.1]non-2-en-2-yl)-ethanone | 1...)
Show SMILES CC(=O)C1=CCCC2CCC1N2
Show InChI InChI=1S/C10H15NO/c1-7(12)9-4-2-3-8-5-6-10(9)11-8/h4,8,10-11H,2-3,5-6H2,1H3
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n/an/a 1n/an/an/an/an/an/a



Stauffer Chemical Company

Curated by ChEMBL


Assay Description
inhibition of (-)-[3H]-nicotine binding to torpedo electroplax membranes


J Med Chem 31: 506-9 (1988)

More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha/beta/delta/gamma chain


(Torpedo californica)
BDBM50023331
PNG
((+)-pyrido[3,4-b]homotropane | (+/-)-pyrido[3,4-b]...)
Show SMILES C1CC2NC1CCc1ccncc21
Show InChI InChI=1S/C11H14N2/c1-2-9-3-4-11(13-9)10-7-12-6-5-8(1)10/h5-7,9,11,13H,1-4H2
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n/an/a 1n/an/an/an/an/an/a



Stauffer Chemical Company

Curated by ChEMBL


Assay Description
inhibition of (-)-[3H]-nicotine binding to torpedo electroplax membranes


J Med Chem 31: 506-9 (1988)

More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha/beta/delta/gamma chain


(Torpedo californica)
BDBM82070
PNG
(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Show SMILES CN1CCC[C@H]1c1cccnc1
Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3/t10-/m0/s1
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n/an/a 4n/an/an/an/an/an/a



Stauffer Chemical Company

Curated by ChEMBL


Assay Description
Inhibition of (-)-[3H]-nicotine binding to rat brain membranes


J Med Chem 31: 506-9 (1988)

More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha/beta/delta/gamma chain


(Torpedo californica)
BDBM50023328
PNG
(3-Pyrrolidin-2-yl-pyridine | CHEMBL1132 | Nornicot...)
Show SMILES C1CNC(C1)c1cccnc1
Show InChI InChI=1S/C9H12N2/c1-3-8(7-10-5-1)9-4-2-6-11-9/h1,3,5,7,9,11H,2,4,6H2
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n/an/a 100n/an/an/an/an/an/a



Stauffer Chemical Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-MCC binding to torpedo electroplax membranes


J Med Chem 31: 506-9 (1988)

More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha/beta/delta/gamma chain


(Torpedo californica)
BDBM50023327
PNG
(3-Methyl-4,13-diaza-tricyclo[8.2.1.0*2,7*]trideca-...)
Show SMILES Cc1nccc2CCC3CCC(N3)c12
Show InChI InChI=1S/C12H16N2/c1-8-12-9(6-7-13-8)2-3-10-4-5-11(12)14-10/h6-7,10-11,14H,2-5H2,1H3
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n/an/a 300n/an/an/an/an/an/a



Stauffer Chemical Company

Curated by ChEMBL


Assay Description
Inhibition of (-)-[3H]-nicotine binding to rat brain membranes


J Med Chem 31: 506-9 (1988)

More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha/beta/delta/gamma chain


(Torpedo californica)
BDBM50023327
PNG
(3-Methyl-4,13-diaza-tricyclo[8.2.1.0*2,7*]trideca-...)
Show SMILES Cc1nccc2CCC3CCC(N3)c12
Show InChI InChI=1S/C12H16N2/c1-8-12-9(6-7-13-8)2-3-10-4-5-11(12)14-10/h6-7,10-11,14H,2-5H2,1H3
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n/an/a 300n/an/an/an/an/an/a



Stauffer Chemical Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-MCC binding to rat brain membranes


J Med Chem 31: 506-9 (1988)

More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha/beta/delta/gamma chain


(Torpedo californica)
BDBM50023328
PNG
(3-Pyrrolidin-2-yl-pyridine | CHEMBL1132 | Nornicot...)
Show SMILES C1CNC(C1)c1cccnc1
Show InChI InChI=1S/C9H12N2/c1-3-8(7-10-5-1)9-4-2-6-11-9/h1,3,5,7,9,11H,2,4,6H2
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n/an/a 300n/an/an/an/an/an/a



Stauffer Chemical Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-MCC binding to rat brain membranes


J Med Chem 31: 506-9 (1988)

More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha/beta/delta/gamma chain


(Torpedo californica)
BDBM50023329
PNG
(13-Methyl-4,13-diaza-tricyclo[8.2.1.0*2,7*]trideca...)
Show SMILES CN1C2CCC1c1cnccc1CC2
Show InChI InChI=1S/C12H16N2/c1-14-10-3-2-9-6-7-13-8-11(9)12(14)5-4-10/h6-8,10,12H,2-5H2,1H3
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n/an/a 800n/an/an/an/an/an/a



Stauffer Chemical Company

Curated by ChEMBL


Assay Description
Inhibition of (-)-[3H]-nicotine binding to rat brain membranes


J Med Chem 31: 506-9 (1988)

More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha/beta/delta/gamma chain


(Torpedo californica)
BDBM50023329
PNG
(13-Methyl-4,13-diaza-tricyclo[8.2.1.0*2,7*]trideca...)
Show SMILES CN1C2CCC1c1cnccc1CC2
Show InChI InChI=1S/C12H16N2/c1-14-10-3-2-9-6-7-13-8-11(9)12(14)5-4-10/h6-8,10,12H,2-5H2,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Stauffer Chemical Company

Curated by ChEMBL


Assay Description
Inhibition of [3H]-MCC binding to rat brain membranes


J Med Chem 31: 506-9 (1988)

More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha/beta/delta/gamma chain


(Torpedo californica)
BDBM50125936
PNG
(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)
Show InChI InChI=1S/C16H18N4O2/c1-12(13-6-4-3-5-7-13)20-11-17-10-14(20)15(21)22-9-8-16(2)18-19-16/h3-7,10-12H,8-9H2,1-2H3/t12-/m1/s1
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n/an/a 2.30E+4n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
Inhibition of currents when compound wascoapplied with acetylcholine to recombinant Torpedo nAcChoR (from 6 oocytes)


Citation and Details
More data for this
Ligand-Target Pair
Acetylcholine receptor protein alpha/beta/delta/gamma chain


(Torpedo californica)
BDBM50125935
PNG
((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...)
Show SMILES CCOC(=O)c1cncn1[C@H](C)c1ccccc1
Show InChI InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1
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n/an/a 4.10E+4n/an/an/an/an/an/a



Massachusetts General Hospital

Curated by ChEMBL


Assay Description
In vitro inhibition of 5-[125I]-A-85,380 binding to alpha2 beta4 nicotinic acetylcholine receptor (nAChR) in rat brain


Citation and Details
More data for this
Ligand-Target Pair