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Compile Data Set for Download or QSAR

Found 688 hits of affinity data for UniProtKB/TrEMBL: P35557    Zinc 0: unavailable per Zinc DB. Zinc 1: purchasable, 2 weeks to supply. Zinc 2: made on demand. Zinc 4: potentially available
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucokinase


(Homo sapiens (Human))
CHEMBL584052
PNG
(10-(4-hydroxyphenyl)-8,13,15-triazatetracyclo[9.6....)
Show SMILES Oc1ccc(cc1)C1c2c[nH]c3nccc(-c4ccccc4NC1=O)c23
PDB
MMDB

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UniProtKB/SwissProt
UniProtKB/TrEMBL

B.MOAD
DrugBank
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
PDB
ZINC 0

Patents

AffyNet 
Article
PubMed
340.0n/an/an/an/an/an/an/an/a



Vertex Pharmaceuticals Inc.

Curated by ChEMBL


Assay Description
Inhibition of GCK


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens)
CHEMBL2064666
PNG
Show SMILES COc1c(Nc2ncc(Cl)c(N[C@@H]3[C@@H]4C[C@@H](C=C4)[C@@H]3C(N)=O)n2)ccc2CC[C@@H](CCc12)N1CCOCC1
PDB
MMDB

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CHEMBL
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/a 60.0n/an/an/an/an/an/a



Cephalon, Inc.

Curated by ChEMBL


Assay Description
Inhibition of human GCK


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens)
CHEMBL1080994
PNG
(4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-methylpipe...)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1cccc(\C=C\c2cncc(C#N)c2Nc2ccc3[nH]ccc3c2C)c1
PDB
MMDB

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AffyNet 
CHEMBL
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/a 1300.0n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of GCK


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase (GCK)


(Homo sapiens (Human))
Kinase inhibitor, A2
PNG
Show SMILES Nc1cnc2c(cccn2c1=O)-c1c(F)cccc1F
PDB
MMDB

UniProtKB/SwissProt
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B.MOAD
DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
ZINC 0
AffyNet 
Article
PubMed
n/an/a 4000.0n/an/an/an/an/an/a



University of Dundee



Assay Description
Selected compounds were screened against a panel of mammalian kinases. Compounds were supplied in DMSO and screened in duplicates at 100 uM concentr...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens)
CHEMBL1087650
PNG
(3-(7-(4-((1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]h...)
Show SMILES CN1C[C@@H]2C[C@H]1CN2c1ccc(cc1)-c1ccnc2c(c(nn12)-c1ccncc1)-c1cccc(O)c1
PDB
MMDB

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AffyNet 
CHEMBL
PC cid
PC sid
ZINC 0

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AffyNet 
Article
PubMed
n/an/a 4100.0n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of GCK


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase (GCK)


(Homo sapiens (Human))
Kinase inhibitor, B1
PNG
Show SMILES Nc1nc2cnc(cn2n1)-c1ccccc1
PDB
MMDB

UniProtKB/SwissProt
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PC cid
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ZINC 0
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Article
PubMed
n/an/a 6000.0n/an/an/an/an/an/a



University of Dundee



Assay Description
Selected compounds were screened against a panel of mammalian kinases. Compounds were supplied in DMSO and screened in duplicates at 100 uM concentr...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens)
CHEMBL1080995
PNG
(6-methyl-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(4-m...)
Show SMILES CN1CCN(CC1)S(=O)(=O)c1cccc(\C=C\c2c(C)ncc(C#N)c2Nc2ccc3[nH]ccc3c2C)c1
PDB
MMDB

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PC cid
PC sid
ZINC 0

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AffyNet 
Article
PubMed
n/an/a>50000.0n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of GCK


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens)
CHEMBL1092754
PNG
(4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)met...)
Show SMILES Cn1cc(\C=C2/Oc3cccc(O)c3C2=O)c2c(ccnc12)-c1ccc(cc1)C(=O)NCCO
PDB
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PC sid
ZINC 0

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Article
PubMed
n/an/a 50000.0n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of GCK


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens)
CHEMBL1095627
PNG
(tert-Butyl 4-(6-(4-aminophenyl)-4-morpholino-1H-py...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(N)cc1)N1CCOCC1
PDB
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PC sid
ZINC 0

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Article
PubMed
n/an/a>50000.0n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of GCK


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens)
CHEMBL1095626
PNG
(methyl 4-(6-(4-aminophenyl)-4-morpholino-1H-pyrazo...)
Show SMILES COC(=O)N1CCC(CC1)n1ncc2c(nc(nc12)-c1ccc(N)cc1)N1CCOCC1
PDB
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PC sid
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Article
PubMed
n/an/a>50000.0n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of GCK


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens)
CHEMBL1089082
PNG
(N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...)
Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1ccncc1
PDB
MMDB

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Article
PubMed
n/an/a>50000.0n/an/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
Inhibition of GCK


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13m
PNG
Show SMILES Nc1cc(F)c(Sc2nccs2)cc1C(=O)Nc1cccc(c1)C#N
PDB
MMDB

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Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13n
PNG
Show SMILES Cc1csc(Sc2cc(C(=O)Nc3cccc(c3)C#N)c(N)cc2F)n1
PDB
MMDB

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Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13v
PNG
Show SMILES COc1ccc(NC(=O)c2cc(Sc3nccn3C)c(F)cc2N)cc1
PDB
MMDB

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Article
PubMed
n/an/an/an/a 1360n/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13w
PNG
Show SMILES COc1cccc(NC(=O)c2cc(Sc3nccn3C)c(F)cc2N)c1
PDB
MMDB

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PC sid
ZINC 0

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Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13x
PNG
Show SMILES COc1ccc(NC(=O)c2cc(Sc3nccn3C)c(F)cc2N)cc1OC
PDB
MMDB

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Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 14a
PNG
Show SMILES Nc1cccc(NC(=O)CN2CCN(CC2)c2ccccc2F)c1
PDB
MMDB

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Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 14b
PNG
Show SMILES Fc1ccccc1N1CCN(CC(=O)Nc2cccc(c2)C(F)(F)F)CC1
PDB
MMDB

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Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 14c
PNG
Show SMILES Fc1cccc(NC(=O)CN2CCN(CC2)c2ccccc2F)c1
PDB
MMDB

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Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 14d
PNG
Show SMILES Fc1ccccc1N1CCN(CC(=O)Nc2cccc(c2)C#N)CC1
PDB
MMDB

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PC sid
ZINC 0
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Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative 15c
PNG
Show SMILES COc1ccc(NC(=O)c2cccc(c2)C(=O)Nc2ccc(OC)cc2)cc1
PDB
MMDB

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PC sid
ZINC 0

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Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 6
PNG
Show SMILES Cn1ccnc1Sc1cc(C(=O)Nc2nccs2)c(N)cc1F
PDB
MMDB

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PC cid
PC sid
PDB
ZINC 0

Patents


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AffyNet 
DrugBank
MMDB
PDB
Article
PubMed
n/an/an/an/a 67.11n/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 12
PNG
Show SMILES Cn1ccnc1Sc1cc(C(=O)Nc2cccc(N)c2)c(N)cc1F
PDB
MMDB

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Article
PubMed
n/an/an/an/a 12560n/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13a
PNG
Show SMILES Nc1cccc(NC(=O)c2cc(Sc3nccs3)c(F)cc2N)c1
PDB
MMDB

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Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13b
PNG
Show SMILES Cc1csc(Sc2cc(C(=O)Nc3cccc(N)c3)c(N)cc2F)n1
PDB
MMDB

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Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13c
PNG
Show SMILES Nc1cccc(NC(=O)c2cc(Sc3nncs3)c(F)cc2N)c1
PDB
MMDB

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Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13d
PNG
Show SMILES Nc1cccc(NC(=O)c2cc(Sc3ccccn3)c(F)cc2N)c1
PDB
MMDB

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ZINC 0

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Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13e
PNG
Show SMILES Cc1cc(C)nc(Sc2cc(C(=O)Nc3cccc(N)c3)c(N)cc2F)n1
PDB
MMDB

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ZINC 0

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Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13f
PNG
Show SMILES Cn1ccnc1Sc1cc(NC(=O)c2cccc(N)c2)c(N)cc1F
PDB
MMDB

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PC sid
ZINC 0
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Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13g
PNG
Show SMILES Cn1ccnc1Sc1cc(C(=O)Nc2cccc(CN)c2)c(N)cc1F
PDB
MMDB

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PC sid
ZINC 0

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AffyNet 
Article
PubMed
n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13h
PNG
Show SMILES Cn1ccnc1Sc1cc(C(=O)Nc2cccc(c2)C(F)(F)F)c(N)cc1F
PDB
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n/an/an/an/a 1870n/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13i
PNG
Show SMILES Nc1cc(F)c(Sc2nccs2)cc1C(=O)Nc1cccc(c1)C(F)(F)F
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n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13j
PNG
Show SMILES Cc1csc(Sc2cc(C(=O)Nc3cccc(c3)C(F)(F)F)c(N)cc2F)n1
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n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13k
PNG
Show SMILES Nc1cc(F)c(Sc2nncs2)cc1C(=O)Nc1cccc(c1)C(F)(F)F
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n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13l
PNG
Show SMILES Cn1ccnc1Sc1cc(C(=O)Nc2cccc(c2)C#N)c(N)cc1F
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n/an/an/an/a 2530n/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13o
PNG
Show SMILES Nc1cc(F)c(Sc2nncs2)cc1C(=O)Nc1cccc(c1)C#N
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n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13p
PNG
Show SMILES Cc1cc(C)nc(Sc2cc(C(=O)Nc3cccc(c3)C#N)c(N)cc2F)n1
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n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13q
PNG
Show SMILES Cn1ccnc1Sc1cc(C(=O)Nc2cccc(F)c2)c(N)cc1F
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n/an/an/an/a 2130n/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13r
PNG
Show SMILES Nc1cc(F)c(Sc2nccs2)cc1C(=O)Nc1cccc(F)c1
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n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13s
PNG
Show SMILES Nc1cc(F)c(Sc2nncs2)cc1C(=O)Nc1cccc(F)c1
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n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13t
PNG
Show SMILES Nc1cc(F)c(Sc2ccccn2)cc1C(=O)Nc1cccc(F)c1
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n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 13u
PNG
Show SMILES Nc1cc(F)c(Sc2nc3ccccc3o2)cc1C(=O)Nc1cccc(F)c1
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n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative, 14e
PNG
Show SMILES COc1ccc(NC(=O)CN2CCN(CC2)c2ccc(F)cc2F)cc1OC
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n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative 15a
PNG
Show SMILES COc1ccccc1NC(=O)c1cccc(c1)C(=O)Nc1ccccc1OC
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n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens (Human))
benzamide derivative 15b
PNG
Show SMILES COc1cccc(NC(=O)c2cccc(c2)C(=O)Nc2cccc(OC)c2)c1
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n/an/an/an/an/an/an/a7.423



Shanghai Institutes for Biological Sciences



Assay Description
The GK activity was assessed spectrometrically by a coupled reaction with glucose-6-phosphate dehydrogenase (G6PDH). Briefly, GK catalyzes glucose ph...


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens)
CHEMBL372883
PNG
(6-(2-Benzyloxy-5-methylsulfanyl-phenylcarbamoyl)-n...)
Show SMILES CSc1ccc(OCc2ccccc2)c(NC(=O)c2ccc(cn2)C(O)=O)c1
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n/an/an/an/a>10000n/an/an/an/a



AstraZeneca UK

Curated by ChEMBL


Assay Description
Potency in Glucokinase activation assay


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens)
CHEMBL193718
PNG
(6-[3-Isopropoxy-5-(2-pyridin-4-yl-ethoxy)-benzoyla...)
Show SMILES CC(C)Oc1cc(OCCc2ccncc2)cc(c1)C(=O)Nc1ccc(cn1)C(O)=O
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n/an/an/an/a 1780n/an/an/an/a



AstraZeneca UK

Curated by ChEMBL


Assay Description
Potency in Glucokinase activation assay


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens)
CHEMBL193349
PNG
(6-[2,3-Bis-(2-chloro-benzyloxy)-benzoylamino]-nico...)
Show SMILES OC(=O)c1ccc(NC(=O)c2cccc(OCc3ccccc3Cl)c2OCc2ccccc2Cl)nc1
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n/an/an/an/a>10000n/an/an/an/a



AstraZeneca UK

Curated by ChEMBL


Assay Description
Potency in Glucokinase activation assay


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens)
CHEMBL191239
PNG
(6-[3-(2-Fluoro-benzyloxy)-5-isopropoxy-benzoylamin...)
Show SMILES CC(C)Oc1cc(OCc2ccccc2F)cc(c1)C(=O)Nc1ccc(cn1)C(O)=O
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n/an/an/an/a 100n/an/an/an/a



AstraZeneca UK

Curated by ChEMBL


Assay Description
Potency in Glucokinase activation assay


Citation and Details
More data for this
Ligand-Target Pair
Glucokinase


(Homo sapiens)
CHEMBL381434
PNG
(6-(3-Isobutoxy-5-isopropoxy-benzoylamino)-nicotini...)
Show SMILES CC(C)COc1cc(OC(C)C)cc(c1)C(=O)Nc1ccc(cn1)C(O)=O
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n/an/an/an/a 570.0n/an/an/an/a



AstraZeneca UK

Curated by ChEMBL


Assay Description
Potency in Glucokinase activation assay


Citation and Details
More data for this
Ligand-Target Pair
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