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Found 193 of ic50 for UniProtKB: Q99640
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598845(CHEMBL5201803)
Affinity DataIC50:  1nMAssay Description:Inhibition of full length Nano-luc fused PKMYT1 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598850(CHEMBL5196713)
Affinity DataIC50:  1nMAssay Description:Inhibition of full length Nano-luc fused PKMYT1 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598854(CHEMBL5174684)
Affinity DataIC50:  1nMAssay Description:Inhibition of full length Nano-luc fused PKMYT1 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598851(CHEMBL5199076)
Affinity DataIC50:  2nMAssay Description:Inhibition of full length Nano-luc fused PKMYT1 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598836(CHEMBL5190822)
Affinity DataIC50: <3nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598835(CHEMBL5169345)
Affinity DataIC50: <3nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598833(CHEMBL5181222)
Affinity DataIC50: <3nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598832(CHEMBL5185146)
Affinity DataIC50: <3nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598830(CHEMBL5186220)
Affinity DataIC50: <3nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598855(CHEMBL5190904)
Affinity DataIC50:  3nMAssay Description:Inhibition of full length Nano-luc fused PKMYT1 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598834(CHEMBL5198360)
Affinity DataIC50:  4nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598838(CHEMBL5172086)
Affinity DataIC50:  4nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598837(CHEMBL5187022)
Affinity DataIC50:  5nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598839(CHEMBL5184178)
Affinity DataIC50:  5nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598844(CHEMBL5200005)
Affinity DataIC50:  5nMAssay Description:Inhibition of full length Nano-luc fused PKMYT1 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598855(CHEMBL5190904)
Affinity DataIC50:  5nMAssay Description:Inhibition of N-terminal recombinant PKMYT1 (76 to 362 residues) in CCNE1 amplified human FU-OV-1 cells assessed as phosphorylation of CDK1 at Thr14 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598840(CHEMBL5199806)
Affinity DataIC50:  5nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598831(CHEMBL5195417)
Affinity DataIC50:  5nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598820(CHEMBL5191665)
Affinity DataIC50:  5nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization...More data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598841(CHEMBL5196095)
Affinity DataIC50:  6nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50506980(CHEMBL4583196)
Affinity DataIC50:  6nMAssay Description:Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluorescence polarization immuno assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598856(CHEMBL5174072)
Affinity DataIC50:  7nMAssay Description:Inhibition of N-terminal recombinant PKMYT1 (76 to 362 residues) in CCNE1 amplified human FU-OV-1 cells assessed as phosphorylation of CDK1 at Thr14 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM3096(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...)
Affinity DataIC50:  7nMAssay Description:Competitive inhibition of human Myt1 by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598822(CHEMBL5177087)
Affinity DataIC50:  8nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598842(CHEMBL5176413)
Affinity DataIC50:  8nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM3096(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...)
Affinity DataIC50:  8nMAssay Description:Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluorescence polarization immuno assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM3096(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598810(CHEMBL5202826)
Affinity DataIC50:  8nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598833(CHEMBL5181222)
Affinity DataIC50:  9nMAssay Description:Inhibition of full length Nano-luc fused PKMYT1 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598821(CHEMBL5202444)
Affinity DataIC50:  10nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598808(CHEMBL5193896)
Affinity DataIC50:  10nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598826(CHEMBL5184635)
Affinity DataIC50:  11nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598829(CHEMBL5203261)
Affinity DataIC50:  12nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598843(CHEMBL5208938)
Affinity DataIC50:  12nMAssay Description:Inhibition of full length Nano-luc fused PKMYT1 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598851(CHEMBL5199076)
Affinity DataIC50:  14nMAssay Description:Inhibition of N-terminal recombinant PKMYT1 (76 to 362 residues) in CCNE1 amplified human FU-OV-1 cells assessed as phosphorylation of CDK1 at Thr14 ...More data for this Ligand-Target Pair
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598850(CHEMBL5196713)
Affinity DataIC50:  17nMAssay Description:Inhibition of N-terminal recombinant PKMYT1 (76 to 362 residues) in CCNE1 amplified human FU-OV-1 cells assessed as phosphorylation of CDK1 at Thr14 ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598833(CHEMBL5181222)
Affinity DataIC50:  20nMAssay Description:Inhibition of N-terminal recombinant PKMYT1 (76 to 362 residues) in CCNE1 amplified human FU-OV-1 cells assessed as phosphorylation of CDK1 at Thr14 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598833(CHEMBL5181222)
Affinity DataIC50:  21nMAssay Description:Inhibition of N-terminal recombinant PKMYT1 (76 to 362 residues) in CCNE1 amplified human FU-OV-1 cells assessed as phosphorylation of CDK1 at Thr14 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598846(CHEMBL5179743)
Affinity DataIC50:  23nMAssay Description:Inhibition of full length Nano-luc fused PKMYT1 in human HEK-293T cells incubated for 2 hrs by cell based NanoBRET target engagement assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598854(CHEMBL5174684)
Affinity DataIC50:  24nMAssay Description:Inhibition of N-terminal recombinant PKMYT1 (76 to 362 residues) in CCNE1 amplified human FU-OV-1 cells assessed as phosphorylation of CDK1 at Thr14 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataIC50:  24nMAssay Description:Displacement of (6-FAM)KI(pY)VV from full length PKMYT1 (unknown origin) by fluorescence polarization immuno assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM4213(6-(2,6-dichlorophenyl)-8-methyl-2-{[4-(morpholin-4...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human full length PKMYT1 expressed in HEK293 cells using EFS (247 to 259 residues) as substrate after 1 hr by fluorescence polarization...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598847(CHEMBL5200849)
Affinity DataIC50:  25nMAssay Description:Inhibition of N-terminal recombinant PKMYT1 (76 to 362 residues) in CCNE1 amplified human FU-OV-1 cells assessed as phosphorylation of CDK1 at Thr14 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598846(CHEMBL5179743)
Affinity DataIC50:  26nMAssay Description:Inhibition of N-terminal recombinant PKMYT1 (76 to 362 residues) in CCNE1 amplified human FU-OV-1 cells assessed as phosphorylation of CDK1 at Thr14 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598828(CHEMBL5196592)
Affinity DataIC50:  29nMAssay Description:Inhibition of N-terminal human recombinant PKMYT1 (76 to 362 residues) expressed in Escherichia coli (DE3) RIL preincubated with compound for 15 mins...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM3096(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...)
Affinity DataIC50:  31nMAssay Description:Displacement of (6-FAM)KI(pY)VV from PKMYT1 kinase domain (unknown origin) by fluorescence polarization binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM3096(2-aminopyrido[2,3-d]pyrimidin-7(8H)-one deriv. | 6...)
Affinity DataIC50:  31nMAssay Description:Inhibition of N-[3',6'-dihydroxy-3-oxo-3H-spiro(2-benzofuran-1,9'-xanthen)-5-yl]-N'-[2-(4-{4-[N-(2-chloro-6-methylphenyl)-5-carboxamido]-thiazol-2-yl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598840(CHEMBL5199806)
Affinity DataIC50:  34nMAssay Description:Inhibition of N-terminal recombinant PKMYT1 (76 to 362 residues) in CCNE1 amplified human FU-OV-1 cells assessed as phosphorylation of CDK1 at Thr14 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetMembrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase(Homo sapiens (Human))
Repare Therapeutics

Curated by ChEMBL
LigandPNGBDBM50598849(CHEMBL5204520)
Affinity DataIC50:  34nMAssay Description:Inhibition of N-terminal recombinant PKMYT1 (76 to 362 residues) in CCNE1 amplified human FU-OV-1 cells assessed as phosphorylation of CDK1 at Thr14 ...More data for this Ligand-Target Pair
In DepthDetails PubMed
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