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Found 37 of ic50 for UniProtKB: P11274
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM50086441(CHEMBL3426225 | US10266537, Compound 3)
Affinity DataIC50: <1nMAssay Description:The aim of this experiment is to detect the inhibitory activity of the compounds of the present invention against in vitro protein kinases using isot...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111473(4-Methyl-N-(4-(2-morpholinoethoxy) phenyl)-3-(4-(p...)
Affinity DataIC50:  10nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111449(4-Methyl-3-(4-(pyridin-3-yl) pyrimidin-2-ylamino)-...)
Affinity DataIC50:  136nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111466(4-Methyl-3-(4-(pyridin-3-yl) pyrimidin-2-ylamino)-...)
Affinity DataIC50:  210nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Affinity DataIC50:  214nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111456(N-(3-bromo-5-(trifluoromethyl) phenyl)-4-methyl-3-...)
Affinity DataIC50:  219nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111455(N-(3,5-bis(trifluoromethyl) phenyl)-4-methyl-3-(4-...)
Affinity DataIC50:  259nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111465(N-(5-chloropyridin-2-yl)-4-methyl-3-(4-(pyridin-3-...)
Affinity DataIC50:  305nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111452(N-(4-bromophenyl)-4-methyl-3-(4-(pyridin-3-yl) pyr...)
Affinity DataIC50:  483nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111460(N-(3-acetylphenyl)-4-methyl-3-(4-(pyridin-3-yl) py...)
Affinity DataIC50:  542nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111453(N-(2-fluorophenyl)-4-methyl-3-(4-(pyridin-3-yl) py...)
Affinity DataIC50:  569nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50155567(1-(3-Dimethylamino-phenyl)-3-[4-methyl-3-(4-pyridi...)
Affinity DataIC50:  573nMAssay Description:Inhibitory concentration required to inhibit Bcr-Abl tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50155562(1-[4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)...)
Affinity DataIC50:  720nMAssay Description:Inhibitory concentration required to inhibit Bcr-Abl tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111451(N-(4-methoxyphenyl)-4-methyl-3-(4-(pyridin-3-yl) p...)
Affinity DataIC50:  924nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111459(N-(2, 6-dimethylphenyl)-4-methyl-3-(4-(pyridin-3-y...)
Affinity DataIC50:  956nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50155568(1-(3-Diethylamino-phenyl)-3-[4-methyl-3-(4-pyridin...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibitory concentration required to inhibit Bcr-Abl tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50155560(1-(3-Chloro-phenyl)-3-[4-methyl-3-(4-pyridin-3-yl-...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibitory concentration required to inhibit Bcr-Abl tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111454(N-(3-fluorophenyl)-4-methyl-3-(4-(pyridin-3-yl) py...)
Affinity DataIC50:  1.07E+3nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111457(4-Methyl-3-(4-(pyridin-3-yl) pyrimidin-2-ylamino)-...)
Affinity DataIC50:  1.11E+3nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111450(N-(3, 4-dichlorophenyl)-4-methyl-3-(4-(pyridin-3-y...)
Affinity DataIC50:  1.51E+3nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111462(4-Methyl-3-(4-(pyridin-3-yl) pyrimidin-2-ylamino)-...)
Affinity DataIC50:  2.19E+3nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111464(4-Methyl-N-(pyridin-2-yl)-3-(4-(pyridin-3-yl) pyri...)
Affinity DataIC50:  3.58E+3nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111467(4-Methyl-3-(4-(pyridin-3-yl) pyrimidin-2-ylamino)-...)
Affinity DataIC50:  3.58E+3nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111463(4-Methyl-N-(pyridin-3-yl)-3-(4-(pyridin-3-yl) pyri...)
Affinity DataIC50:  4.03E+3nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50155561(4-Methyl-piperazine-1-carboxylic acid [4-methyl-3-...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibitory concentration required to inhibit Bcr-Abl tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111461(N-(3-methoxyphenyl)-4-methyl-3-(4-(pyridin-3-yl) p...)
Affinity DataIC50:  5.24E+3nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50155575(1-[4-Methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)...)
Affinity DataIC50: >9.00E+3nMAssay Description:Inhibitory concentration required to inhibit Bcr-Abl tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111448(N-(3-chloro-4-fluorophenyl)-4-methyl-3-(4-(pyridin...)
Affinity DataIC50:  9.57E+3nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50155559(1-(4-Dimethylamino-phenyl)-3-[4-methyl-3-(4-pyridi...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration required to inhibit Bcr-Abl tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50155557(1-(4-Diethylamino-phenyl)-3-[4-methyl-3-(4-pyridin...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration required to inhibit Bcr-Abl tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50155565(CHEMBL185775 | Piperidine-1-carboxylic acid [4-met...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibitory concentration required to inhibit Bcr-Abl tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111468(N-(4-(3-(dimethylamino)propoxy) phenyl)-4-methyl- ...)
Affinity DataIC50:  1.32E+4nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111469(N-(4-(2-(dimethylamino)ethoxy)phenyl)-4-methyl-3-(...)
Affinity DataIC50:  2.10E+4nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111474(4-Methyl-N-(4-(3-morpholinopropoxy) phenyl)-3-(4-(...)
Affinity DataIC50: >1.00E+5nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111470(N-(4-(2-(diethylamino)ethoxy)phenyl)-4-methyl-3-(4...)
Affinity DataIC50: >1.00E+5nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111472(4-Methyl-N-(4-(2-(piperidin-1-yl) ethoxy) phenyl)-...)
Affinity DataIC50: >1.00E+5nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein [1-693](Homo sapiens (Human))
St. Chuan University

US Patent
LigandPNGBDBM111471(4-Methyl-3-(4-(pyridin-3-yl) pyrimidin-2-ylamino)-...)
Affinity DataIC50: >1.00E+5nMAssay Description:ATP (6.021 μM) and substrate (457.7 nM) were used. Kinase, substrate peptide, and inhibitor were added in a 384-well plate. The reaction was s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed