Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Activin receptor type-1B (Homo sapiens) | BDBM280366![]() (Synthesis of 2-(5-chloro-2-fluorophenyl)-5-cyclopr...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280369![]() (Synthesis of 2-(5-chloro-2-fluorophenyl)-5-(propan...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280370![]() (Synthesis of 2-(5-chloro-2-fluorophenyl)-5-(propan...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280365![]() (Synthesis of 4-{[2-(5-chloro-2-fluorophenyl)-5-cyc...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 4.80 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280340![]() (Synthesis of (S)-4-(2-(5-chloro-2-fluorophenyl)-5-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 8.60 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280363![]() (Synthesis of 2-(3-fluoropyridin-2-yl)-5-(propan-2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 10.5 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280352![]() (Synthesis of N-(2-aminoethyl)-4-[[2-(5-chloro-2-fl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280360![]() (Synthesis of 4-[[2-(5-chloro-2-fluoro-phenyl)-5-is...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 11.5 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280348![]() (Synthesis of N-(2-amino-2-oxo-ethyl)-4-[[2-(5-chlo...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 11.7 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280341![]() (Synthesis of (S)-4-(2-(5-chloro-2-fluorophenyl)-5-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM50015639![]() (CHEMBL3260567) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Ewha Womans University Curated by ChEMBL | Assay Description Inhibition of ALK4 (unknown origin) by radioisotopic assay | J Med Chem 57: 4213-38 (2014) Article DOI: 10.1021/jm500115w BindingDB Entry DOI: 10.7270/Q2DV1MFM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM50252542![]() (3-((5-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Ewha Womans University Curated by ChEMBL | Assay Description Inhibition of ALK4 (unknown origin) by radioisotopic assay | J Med Chem 57: 4213-38 (2014) Article DOI: 10.1021/jm500115w BindingDB Entry DOI: 10.7270/Q2DV1MFM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280346![]() (Synthesis of 4-[[2-(5-chloro-2-fluoro-phenyl)-5-me...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 23.5 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280364![]() (Synthesis of 2-(3-fluoropyridin-2-yl)-5-(propan-2-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 23.7 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM143311![]() (US9682983, 11) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a | |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280345![]() (Synthesis of (S)-4-(2-(5-chloro-2-fluorophenyl)-5-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 30.4 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280338![]() (Synthesis of (S)-4-(2-(5-chloro-2-fluorophenyl)-5-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 31.5 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280337![]() (Synthesis of (S)-4-[[2-(5-chloro-2-fluoro-phenyl)-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 32.5 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280356![]() (Synthesis of 4-[[2-amino-6-(5-chloro-2-fluoro-phen...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 33.1 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280350![]() (Synthesis of 4-[[2-(5-chloro-2-fluoro-phenyl)-5-(1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 40.1 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280361![]() (Synthesis of 4-[[2-(5-chloro-2-fluoro-phenyl)-5-is...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 40.2 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280339![]() (Synthesis of (S)-4-(2-(5-chloro-2-fluorophenyl)-5-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 42.4 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280347![]() (Synthesis of N-(2-acetamidoethyl)-4-[[2-(5-chloro-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 45.1 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280355![]() (Synthesis of 4-[[2-(5-chloro-2-fluoro-phenyl)-5-is...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 56.7 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM50382317![]() (CHEMBL2024684) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 59 | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc. Curated by ChEMBL | Assay Description Inhibition of ALK4 | Bioorg Med Chem Lett 22: 3392-7 (2012) Article DOI: 10.1016/j.bmcl.2012.04.013 BindingDB Entry DOI: 10.7270/Q2QC04H9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM50298220![]() (2-(4-(benzo[d][1,3]dioxol-5-yl)-2-tert-butyl-1H-im...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Ewha Womans University Curated by ChEMBL | Assay Description Inhibition of ALK4 (unknown origin) by radioisotopic assay | J Med Chem 57: 4213-38 (2014) Article DOI: 10.1021/jm500115w BindingDB Entry DOI: 10.7270/Q2DV1MFM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280344![]() (Synthesis of (S)-4-(2-(5-chloro-2-fluorophenyl)-5-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 86.8 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280367![]() (Synthesis of 4-{[2-(5-chloro-2-fluorophenyl)-5-(py...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 89.6 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280351![]() (Synthesis of 4-[[2-(5-chloro-2-fluoro-phenyl)-5-is...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 105 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM161920![]() (US9682983, 52 | US9682983, 53) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a | |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280349![]() (Synthesis of (S)-4-(2-(5-chloro-2-fluorophenyl)-5-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 114 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM143282![]() (US9682983, 10) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 116 | n/a | n/a | n/a | n/a | n/a | n/a | |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM143566![]() (US9682983, 13) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 125 | n/a | n/a | n/a | n/a | n/a | n/a | |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280368![]() (Synthesis of 2-(5-chloro-2-fluorophenyl)-5-(prop-1...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 149 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280342![]() (Synthesis of 4-[[2-(5-chloro-2-fluoro-phenyl)-5-is...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 171 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM50434750![]() (CHEMBL2385596) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 183 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Inhibition of ALK4 (unknown origin) | Bioorg Med Chem Lett 23: 3248-52 (2013) Article DOI: 10.1016/j.bmcl.2013.03.113 BindingDB Entry DOI: 10.7270/Q2WW7K3P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM50015640![]() (GALUNISERTIB | LY-2157299) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 199 | n/a | n/a | n/a | n/a | n/a | n/a |
Ewha Womans University Curated by ChEMBL | Assay Description Inhibition of ALK4 (unknown origin) by radioisotopic assay | J Med Chem 57: 4213-38 (2014) Article DOI: 10.1021/jm500115w BindingDB Entry DOI: 10.7270/Q2DV1MFM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280357![]() (Synthesis of 4-[[2-(5-chloro-2-fluoro-phenyl)-5-is...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM143313![]() (US9682983, 12) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 259 | n/a | n/a | n/a | n/a | n/a | n/a | |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM50434752![]() (CHEMBL2385582) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 326 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Inhibition of ALK4 (unknown origin) | Bioorg Med Chem Lett 23: 3248-52 (2013) Article DOI: 10.1016/j.bmcl.2013.03.113 BindingDB Entry DOI: 10.7270/Q2WW7K3P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM143246![]() (US9682983, 8) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 353 | n/a | n/a | n/a | n/a | n/a | n/a | |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280343![]() (Synthesis of 4-[[2-(5-chloro-2-fluoro-phenyl)-5-is...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 502 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM111123![]() (US9682983, 2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 556 | n/a | n/a | n/a | n/a | n/a | n/a | |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM148353![]() (US9682983, 24) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 818 | n/a | n/a | n/a | n/a | n/a | n/a | |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM280362![]() (Synthesis of N-[(2S)-2-hydroxypropyl]-4-{[2-phenyl...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | UniChem | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a | |
Medivation Technologies LLC US Patent | Assay Description Compound of the invention were screened in an in vitro kinase assay against several members of the TGFβ family of Ser/Thr kinases. The kinases t... | US Patent US10030004 (2018) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM148372![]() (US9682983, 33) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 1.39E+3 | n/a | n/a | n/a | n/a | n/a | n/a | |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM50262079![]() (4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyri...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.83E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Inhibition of ALK4 (unknown origin) | Bioorg Med Chem Lett 23: 3248-52 (2013) Article DOI: 10.1016/j.bmcl.2013.03.113 BindingDB Entry DOI: 10.7270/Q2WW7K3P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM50262016![]() (4-(6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-y...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.84E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Vanderbilt University Medical Center Curated by ChEMBL | Assay Description Inhibition of ALK4 (unknown origin) | Bioorg Med Chem Lett 23: 3248-52 (2013) Article DOI: 10.1016/j.bmcl.2013.03.113 BindingDB Entry DOI: 10.7270/Q2WW7K3P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM148356![]() (US9682983, 27) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Activin receptor type-1B (Homo sapiens) | BDBM161922![]() (US9682983, 54) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | n/a | n/a | 2.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a | |
The Brigham and Women's Hospital, Inc.; Dept. of Health and Human Services, National Institutes of Health US Patent | Assay Description Specifically, compounds were assayed using LANCE® Ultra ULight¿ technology (Perkin Elmer) against human ALK1-6 enzymes (ALK1: Life Technologies, ALK2... | US Patent US9682983 (2017) BindingDB Entry DOI: 10.7270/Q28S4N3R | |||||||||||
More data for this Ligand-Target Pair |
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