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Compile Data Set for Download or QSAR

Found 117 hits of affinity data for UniProtKB/TrEMBL: O94921    Zinc 0: unavailable per Zinc DB. Zinc 1: purchasable, 2 weeks to supply. Zinc 2: made on demand. Zinc 4: potentially available
Target
(Institution)
LigandTarget
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
ABT-869
PNG
(3-[4-(3-amino-1H-indazol-4-yl)phenyl]-1-(2-fluoro-...)
Show SMILES Cc1ccc(F)c(NC(=O)Nc2ccc(cc2)-c2cccc3[nH]nc(N)c23)c1
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
IUPHAR‑DB
KEGG
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
AMG 706
PNG
(AMG-706 | Motesanib | N-(3,3-dimethyl-2,3-dihydro-...)
Show SMILES CC1(C)CNc2cc(NC(=O)c3cccnc3NCc3ccncc3)ccc12
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
ChEBI
IUPHAR‑DB
KEGG
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
cid_11409972
PNG
(AST-487)
Show SMILES CCN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4cc(NC)ncn4)cc3)cc2C(F)(F)F)CC1
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
IUPHAR‑DB
PC cid
PC sid
ZINC 0
AffyNet 
Article
PubMed
n/an/an/a 17n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
pyrazoloquinazoline deriv., 34
PNG
(2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}qu...)
Show SMILES CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
IUPHAR‑DB
MMDB
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
BIRB-796
PNG
(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Show SMILES Cc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(OCCN2CCOCC2)c2ccccc12)C(C)(C)C
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
DrugBank
IUPHAR‑DB
KEGG
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
BMS-387072
PNG
(CHEMBL296468 | N-(5-{[(5-tert-butyl-1,3-oxazol-2-y...)
Show SMILES CC(C)(C)c1cnc(CSc2cnc(NC(=O)C3CCNCC3)s2)o1
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
IUPHAR‑DB
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a 690n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
CHEMBL522892
PNG
(4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-...)
Show SMILES CN1CCN(CC1)c1ccc2[nH]c(nc2c1)-c1c(N)c2c(F)cccc2[nH]c1=O
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
ZINC 0

Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
cid_11656518
PNG
(CHIR-265)
Show SMILES Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
IUPHAR‑DB
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
CI-1033
PNG
(CHEMBL31965 | N-{4-[(3-chloro-4-fluorophenyl)amino...)
Show SMILES Fc1ccc(Nc2ncnc3cc(OCCCN4CCOCC4)c(NC(=O)C=C)cc23)cc1Cl
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
ChEBI
DrugBank
IUPHAR‑DB
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
CHEMBL221959
PNG
(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
ChEBI
CHEMBL
DrugBank
IUPHAR‑DB
KEGG
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
cid_9874913
PNG
(CHEMBL483321 | CP-724714)
Show SMILES COCC(=O)NC\C=C\c1ccc2ncnc(Nc3ccc(Oc4ccc(C)nc4)c(C)c3)c2c1
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
PC cid
PC sid
ZINC 0

Patents

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
BMS-354825
PNG
(CHEMBL1421 | Dasatinib | N-(2-Chloro-6-methylpheny...)
Show SMILES Cc1nc(Nc2ncc(s2)C(=O)Nc2c(C)cccc2Cl)cc(n1)N1CCN(CCO)CC1
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
ChEBI
DrugBank
IUPHAR‑DB
KEGG
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
cid_6445562
PNG
(EKB-569)
Show SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
ChEBI
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
Tarceva
PNG
(CHEMBL553 | Erlotinib | N-(3-Ethynylphenyl)-6,7-bi...)
Show SMILES COCCOc1cc2ncnc(Nc3cccc(c3)C#C)c2cc1OCCOC
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
ChEBI
DrugBank
IUPHAR‑DB
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
Flavopiridol
PNG
(2-(2-chlorophenyl)-5,7-dihydroxy-8-[(3S,4R)-3-hydr...)
Show SMILES CN1CC[C@@H]([C@H](O)C1)c1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1Cl
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
DrugBank
IUPHAR‑DB
KEGG
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a 110n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
CHEMBL939
PNG
((3-Chloro-4-fluoro-phenyl)-[7-methoxy-6-(2-morphol...)
Show SMILES COc1cc2[nH]cn\c(=N/c3ccc(F)c(Cl)c3)c2cc1OCCCN1CCOCC1
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
IUPHAR‑DB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
cid_11617559
PNG
(GW-2580)
Show SMILES COc1ccc(COc2ccc(Cc3cnc(N)nc3N)cc2OC)cc1
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
IUPHAR‑DB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
Pazopanib
PNG
(5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino...)
Show SMILES CN(c1ccc2c(C)n(C)nc2c1)c1ccnc(Nc2ccc(C)c(c2)S(N)(=O)=O)n1
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
ChEBI
DrugBank
IUPHAR‑DB
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
Imatinib
PNG
(4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[...)
Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
ChEBI
DrugBank
IUPHAR‑DB
KEGG
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
JNJ-7706621
PNG
(1-Acyl-1H-[1,2,4]triazole-3,5-diamine Analogue 3b ...)
Show SMILES Nc1nc(Nc2ccc(cc2)S(N)(=O)=O)nn1C(=O)c1c(F)cccc1F
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a 3600n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
GW572016
PNG
(CHEMBL554 | Lapatinib | N-{3-chloro-4-[(3-fluoro-...)
Show SMILES CS(=O)(=O)CCNCc1ccc(o1)-c1ccc2ncnc(Nc3ccc(OCc4cccc(F)c4)c(Cl)c3)c2c1
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
ChEBI
DrugBank
IUPHAR‑DB
KEGG
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
LY333531
PNG
((18S)-18-[(dimethylamino)methyl]-17-oxa-4,14,21-tr...)
Show SMILES CN(C)C[C@@H]1CCn2cc(C3=C(C(=O)NC3=O)c3cn(CCO1)c1ccccc31)c1ccccc21
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
IUPHAR‑DB
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
MLN-518
PNG
(4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin...)
Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
DrugBank
KEGG
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
cid_11712649
PNG
(CHEMBL259084 | MLN-8054)
Show SMILES OC(=O)c1ccc(Nc2ncc3CN=C(c4cc(Cl)ccc4-c3n2)c2c(F)cccc2F)cc1
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
IUPHAR‑DB
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
pyridofuropyrimidine derivative, 2
PNG
(3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyr...)
Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
IUPHAR‑DB
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
CGP 79787
PNG
(CHEMBL101253 | N-(4-chlorophenyl)-4-(pyridin-4-ylm...)
Show SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
DrugBank
IUPHAR‑DB
KEGG
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
(R)-Roscovitine
PNG
((2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-...)
Show SMILES CC[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
DrugBank
IUPHAR‑DB
MMDB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
SB-202190
PNG
(4-(4-(4-fluorophenyl)-5-(pyridin-4-yl)-1H-imidazol...)
Show SMILES Oc1ccc(cc1)-c1nc(c([nH]1)-c1ccncc1)-c1ccc(F)cc1
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
IUPHAR‑DB
PC cid
PC sid
PDB
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
CHEMBL10
PNG
(4-(2-(4-(methylsulfinyl)phenyl)-4-phenyl-1H-imidaz...)
Show SMILES C[S+]([O-])c1ccc(cc1)-c1nc(c([nH]1)-c1ccncc1)-c1ccc(F)cc1
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
IUPHAR‑DB
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
CHEMBL440084
PNG
(4-(4-(benzo[d][1,3]dioxol-5-yl)-5-(pyridin-2-yl)-1...)
Show SMILES NC(=O)c1ccc(cc1)-c1nc(c([nH]1)-c1ccccn1)-c1ccc2OCOc2c1
KEGG

UniProtKB/SwissProt
UniProtKB/TrEMBL

GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
ZINC 0

Patents


Similars

AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
BAY 439006
PNG
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
KEGG

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n/an/an/a 2900n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
CHEMBL162
PNG
((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)
Show SMILES CN[C@@H]1CC2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
KEGG

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n/an/an/a 160n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
cid_10138259
PNG
(SU-14813)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1
KEGG

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n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
SU11248
PNG
(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Show SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
KEGG

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n/an/an/a 270n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
VX-680
PNG
(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Show SMILES CN1CCN(CC1)c1cc(Nc2cc(C)n[nH]2)nc(Sc2ccc(NC(=O)C3CC3)cc2)n1
KEGG

UniProtKB/SwissProt
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n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
VX-745
PNG
(5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulf...)
Show SMILES Fc1ccc(Sc2ccc3c(-c4c(Cl)cccc4Cl)c(=O)ncn3n2)c(F)c1
KEGG

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n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
CHEMBL24828
PNG
((4-Bromo-2-fluoro-phenyl)-[6-methoxy-7-(1-methyl-p...)
Show SMILES COc1cc2c(cc1OCC1CCN(C)CC1)[nH]cn\c2=N/c1ccc(Br)cc1F
KEGG

UniProtKB/SwissProt
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n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for full-length PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
CHEMBL1240703
PNG
(NA)
Show SMILES CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4[C@H](O)NC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1
KEGG

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n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
BAY 439006
PNG
(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)
Show SMILES CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)cc2)ccn1
KEGG

UniProtKB/SwissProt
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PubMed
n/an/an/a 2900n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
MIDOSTAURIN
PNG
(CGP-41251 | PKC-412)
Show SMILES CO[C@H]1[C@@H](C[C@H]2O[C@@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1
KEGG

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n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PFTK1 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
CHEMBL576982
PNG
(N-(5-tert-Butyl-isoxazol-3-yl)-N'-{4-[7-(2-morphol...)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1
KEGG

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n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
MLN-518
PNG
(4-[6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin...)
Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCCCC1)N1CCN(CC1)C(=O)Nc1ccc(OC(C)C)cc1
KEGG

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PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
SU11248
PNG
(CHEMBL535 | N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fl...)
Show SMILES CCN(CC)CCNC(=O)c1c(C)[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c1C
KEGG

UniProtKB/SwissProt
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Article
PubMed
n/an/an/a 270n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding affinity to PFTK1


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
pyrazoloquinazoline deriv., 34
PNG
(2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}qu...)
Show SMILES CCN(CCO)CCCOc1ccc2c(Nc3cc(CC(=O)Nc4cccc(F)c4)[nH]n3)ncnc2c1
KEGG

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n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PFTK1 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
CHEMBL601719
PNG
((R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1...)
Show SMILES C[C@@H](Oc1cc(cnc1N)-c1cnn(c1)C1CCNCC1)c1c(Cl)ccc(F)c1Cl
KEGG

UniProtKB/SwissProt
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PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PFTK1 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
CHEMBL221959
PNG
(3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyr...)
Show SMILES C[C@@H]1CCN(C[C@@H]1N(C)c1ncnc2[nH]ccc12)C(=O)CC#N
KEGG

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PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PFTK1 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
pyridofuropyrimidine derivative, 2
PNG
(3-(4-morpholin-4-ylpyrido[3 ,2 :4,5]furo[3,2-d]pyr...)
Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
KEGG

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PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PFTK1 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
CHEMBL1908391
PNG
Show SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nc(cs3)-c3cccnc3)c2)CC1
KEGG

UniProtKB/SwissProt
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PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PFTK1 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
CHEMBL255863
PNG
(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Show SMILES Cc1cn(cn1)-c1cc(NC(=O)c2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)cc(c1)C(F)(F)F
KEGG

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AffyNet 
Article
PubMed
n/an/an/a>10000n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PFTK1 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase PFTAIRE-1


(Homo sapiens)
cid_10138259
PNG
(SU-14813)
Show SMILES Cc1[nH]c(\C=C2/C(=O)Nc3ccc(F)cc23)c(C)c1C(=O)NC[C@H](O)CN1CCOCC1
KEGG

UniProtKB/SwissProt
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Article
PubMed
n/an/an/a 1100n/an/an/an/an/a



Ambit Biosciences

Curated by ChEMBL


Assay Description
Binding constant for PFTK1 kinase domain


Citation and Details
More data for this
Ligand-Target Pair
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