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Found 7 of ic50 for UniProtKB: P00395
TargetCytochrome c oxidase subunit 1(Homo sapiens (Human))
Merck & Co. Inc

Curated by ChEMBL
LigandPNGBDBM50343721(3-(4-(4-(2-fluoro-4-methylphenyl)-5-(4-methoxyphen...)
Affinity DataIC50:  130nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Homo sapiens (Human))
Merck & Co. Inc

Curated by ChEMBL
LigandPNGBDBM50343722(3-(4-(5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-4-(2...)
Affinity DataIC50:  240nMAssay Description:Inhibition of COX1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Homo sapiens (Human))
Merck & Co. Inc

Curated by ChEMBL
LigandPNGBDBM50140321((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50:  280nMAssay Description:Inhibition of COX-1 in human whole blood assessed as reduction in thromboxane B2 production by immunoassayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 1(Homo sapiens (Human))
Merck & Co. Inc

Curated by ChEMBL
LigandPNGBDBM50140321((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50:  500nMAssay Description:Inhibition of human recombinant COX-1 using arachidonic acid as substrate preincubated for 15 mins followed by substrate addition and measured after ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 1(Homo sapiens (Human))
Merck & Co. Inc

Curated by ChEMBL
LigandPNGBDBM50140321((S)-2-[4-((1R,2S)-2-Hydroxy-cyclopentylmethyl)-phe...)
Affinity DataIC50:  1.47E+3nMAssay Description:Inhibition of human recombinant COX-1 using [1-14C] arachidonic acid as substrate preincubated for 15 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytochrome c oxidase subunit 1(Homo sapiens (Human))
Merck & Co. Inc

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibition of COX1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome c oxidase subunit 1(Homo sapiens (Human))
Merck & Co. Inc

Curated by ChEMBL
LigandPNGBDBM50589148(CHEMBL5187847)
Affinity DataIC50:  1.15E+5nMAssay Description:Inhibition of COX-1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed